Time to smoke first morning cigarette and lung cancer in a case-control study.
- Authors
- Gu, Fangyi; Wacholder, Sholom; Kovalchik, Stephanie; Panagiotou, Orestis A; Reyes-Guzman, Carolyn; Freedman, Neal D; De Matteis, Sara; Consonni, Dario; Bertazzi, Pier Alberto; Bergen, Andrew W; Landi, Maria Teresa; Caporaso, Neil E
- Year
- 2014
- Journal
- Journal of the National Cancer Institute
- PMID
- 24948709
- DOI
- 10.1093/jnci/dju118
- PMCID
- PMC4072901
BACKGROUND: Targeting smokers at higher lung cancer risk can improve efficiency and reduce false-positive detection in lung cancer screening. We evaluated whether time to first cigarette after waking (TTFC), a single-item measure of nicotine dependency, could improve stratification of lung cancer risk beyond standard smoking metrics (intensity, duration, and pack-years). METHODS: In 3249 ever-smokers (n = 1812 case subjects; n = 1437 control subjects) from a population-based case-control study in Italy, we examined the association between TTFC and lung cancer using logistic regression and estimated lung cancer incidence by levels of TTFC, and intensity, duration, and pack-years using absolute risk regression. Significance tests were two-sided. RESULTS: Compared with smokers with TTFC greater than 60 minutes, the lung cancer odds ratios for TTFC of 31 to 60 minutes, 6 to 30 minutes, and 5 or fewer minutes (by increasing dependency) were 2.57 (95% confidence interval [CI] = 2.03 to 3.26), 2.27 (95% CI = 1.79 to 2.88), and 3.50 (95% CI = 2.64 to 4.64), respectively (P trend < .0001). The average lung cancer incidence rates for smokers of 1 to 10, 11 to 20, 21 to 30 and more than 30 cigarettes per day were consistently higher among smokers with TTFC of 60 or fewer minutes vs more than 60 minutes (64.1 vs 11.7; 125.6 vs 28.6; 130.1 vs 40.7; and 260.8 vs 108.9 per 100000 person-years, respectively). The slopes of increase in lung cancer rates with smoking duration and pack-years were statistically significantly greater among smokers with higher dependency (P interaction < .001). CONCLUSIONS: Lung cancer risk increases with shorter TTFC; this simple nicotine dependency measure increases lung cancer risk stratification beyond standard smoking measures. Assessing TTFC may improve lung cancer risk prediction and could be useful in lung cancer screening and smoking cessation programs.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Time from waking to first cigarette, genetic susceptibility, and the risk of COPD: A Prospective cohort study from UK Biobank. | Qiqi L et al. | — | 2026 | → |
| APOBEC affects tumor evolution and age at onset of lung cancer in smokers. | Zhang T et al. | — | 2025 | → |
| Client's perception toward services of smoking cessation clinics in Riyadh, Saudi Arabia. | Alrowais FS et al. | — | 2024 | → |
| Smoking, Lung Cancer Stage, and Prognostic Factors-Findings from the National Lung Screening Trial. | Zhu J et al. | — | 2024 | → |
| Alcohol and Nicotine Dependence and Time to Death in a General Adult Population: A Mortality Cohort Study. | John U et al. | — | 2023 | → |
| Association of nicotine dependence and gut microbiota: a bidirectional two-sample Mendelian randomization study. | Chen Y et al. | — | 2023 | → |
| Cigarette dependence is more prevalent and increasing among US adolescents and adults who use cannabis, 2002-2019. | Weinberger AH et al. | — | 2023 | → |
| Association of the Time to First Cigarette and the Prevalence of Chronic Respiratory Diseases in Chinese Elderly Population. | Wang C et al. | — | 2022 | → |
| Comparison of Nicotine Dependence and Biomarker Levels among Traditional Cigarette, Heat-Not-Burn Cigarette, and Liquid E-Cigarette Users: Results from the Think Study. | Rudasingwa G et al. | — | 2021 | → |
| Genome-wide gene-smoking interaction study identified novel susceptibility loci for non-small cell lung cancer in Chinese populations. | Wang Y et al. | — | 2021 | → |
| Individual 5-Year Lung Cancer Risk Prediction Model in Korea Using a Nationwide Representative Database. | Yeo Y et al. | — | 2021 | → |
| Risk of lung cancer among women in relation to lifetime history of tobacco smoking: a population-based case-control study in France (the WELCA study). | Rusmaully J et al. | — | 2021 | → |
| Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. | Quach BC et al. | — | 2020 | → |
| Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium | Quach BC et al. | — | 2020 | — |
| Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. | Chen J et al. | — | 2020 | → |
| Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis. | Thomas S et al. | — | 2020 | → |
| Nicotine dependence as an independent risk factor for atherosclerosis in the National Lung Screening Trial. | Zhu J et al. | — | 2019 | → |
| Time to First Cigarette and Self-Reported Health Among US Adult Smokers. | Sung B | — | 2019 | → |
| CYP2A6 metabolism in the development of smoking behaviors in young adults. | Olfson E et al. | — | 2018 | → |
| Finding paths with the greatest chance of success: enabling and focusing lung cancer screening and cessation in resource-constrained areas. | Jenkins WD et al. | — | 2018 | → |
| Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence. | Hancock DB et al. | — | 2018 | → |
| Tobacco Dependence Predicts Higher Lung Cancer and Mortality Rates and Lower Rates of Smoking Cessation in the National Lung Screening Trial. | Rojewski AM et al. | — | 2018 | → |
| Determinants of Light and Intermittent Smoking in the United States: Results from Three Pooled National Health Surveys. | Reyes-Guzman CM et al. | — | 2017 | → |
| Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers. | Stueve TR et al. | — | 2017 | → |
| Lung Cancer Risk Prediction Model Incorporating Lung Function: Development and Validation in the UK Biobank Prospective Cohort Study. | Muller DC et al. | — | 2017 | → |
| Potential Impact of Including Time to First Cigarette in Risk Models for Selecting Ever-Smokers for Lung Cancer Screening. | Gu F et al. | — | 2017 | → |
| Time to first cigarette and serum cholesterol levels. | Selya AS et al. | — | 2017 | → |
| Time to First Cigarette, a Proxy of Nicotine Dependence, Increases the Risk of Pulmonary Impairment, Independently of Current and Lifetime Smoking Behavior. | Selya AS et al. | — | 2016 | → |
| Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. | Hancock DB et al. | — | 2015 | → |
| Global and Regional Patterns of Tobacco Smoking and Tobacco Control Policies. | Islami F et al. | — | 2015 | → |
| NADPH oxidases: an overview from structure to innate immunity-associated pathologies. | Panday A et al. | — | 2015 | → |
| Time to First Cigarette and Hypertension in Korean Male Smokers. | Lee S et al. | — | 2015 | → |
| Time to First Morning Cigarette and Risk of Chronic Obstructive Pulmonary Disease: Smokers in the PLCO Cancer Screening Trial. | Guertin KA et al. | — | 2015 | → |
| Response. | Gu F et al. | — | 2014 | → |
| Stronger nicotine addiction associated with higher risk of lung cancer. | Printz C | — | 2014 | → |