Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output.
paper
Cited
Public
Unavailable
- Authors
- Hill, Matthew N; Patel, Sachin; Campolongo, Patrizia; Tasker, Jeffrey G; Wotjak, Carsten T; Bains, Jaideep S
- Year
- 2010
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 21068301
- DOI
- 10.1523/JNEUROSCI.4283-10.2010
- PMCID
- PMC3073528
Endocannabinoid signaling is distributed throughout the brain, regulating synaptic release of both excitatory and inhibitory neurotransmitters. The presence of endocannabinoid signaling within stress-sensitive nuclei of the hypothalamus, as well as upstream limbic structures such as the amygdala, suggests it may play an important role in regulating the neuroendocrine and behavioral effects of stress. The evidence reviewed here demonstrates that endocannabinoid signaling is involved in both activating and terminating the hypothalamic-pituitary-adrenal axis response to both acute and repeated stress. In addition to neuroendocrine function, however, endocannabinoid signaling is also recruited by stress and glucocorticoid hormones to modulate cognitive and emotional processes such as memory consolidation and extinction. Collectively, these data demonstrate the importance of endocannabinoid signaling at multiple levels as both a regulator and an effector of the stress response.
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|---|---|---|---|---|
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| Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress | Xapelli S et al. | β | 2023 | β |
| Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation. | Kondev V et al. | β | 2023 | β |
| Inhibition of FAAH suppresses RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss partially through repressing the IL17 pathway. | Zhu M et al. | β | 2023 | β |
| Metabolic and Transcriptomic Signatures of the Acute Psychological Stress Response in the Mouse Brain. | Lee H et al. | β | 2023 | β |
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| Wistar-Kyoto rats and chronically stressed Wistar rats present similar depression- and anxiety-like behaviors but different corticosterone and endocannabinoid system modulation. | Wang Z et al. | β | 2023 | β |
| Acute stress and alcohol exposure during adolescence result in an anxious phenotype in adulthood: Role of altered glutamate/endocannabinoid transmission mechanisms. | SΓ‘nchez-MarΓn L et al. | β | 2022 | β |
| Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2). | Jayanthi S et al. | β | 2022 | β |
| Lipid endocannabinoids in energy metabolism, stress and developmental programming. | Almeida MM et al. | β | 2022 | β |
| Prenatal THC Exposure Induces Sex-Dependent Neuropsychiatric Endophenotypes in Offspring and Long-Term Disruptions in Fatty-Acid Signaling Pathways Directly in the Mesolimbic Circuitry. | Sarikahya MH et al. | β | 2022 | β |
| Rapid treatments for depression: Endocannabinoid system as a therapeutic target. | Sharafi A et al. | β | 2022 | β |
| The assessment of endocannabinoids and N-acylethanolamines in human hair: Associations with sociodemographic and psychological variables. | Gao W et al. | β | 2022 | β |
| The Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure. | Kondev V et al. | β | 2022 | β |
| The Synaptic Interactions of Alcohol and the Endogenous Cannabinoid System. | Wolfe SA et al. | β | 2022 | β |
| A role for amygdala endocannabinoid signaling in reconsolidation of cocaine-associated memories. | Hafenbreidel M et al. | β | 2021 | β |
| Cannabinoid type 1 receptors in A2a neurons contribute to cocaine-environment association. | Turner BD et al. | β | 2021 | β |
| Cannabis use and posttraumatic stress disorder comorbidity: Epidemiology, biology and the potential for novel treatment approaches. | Kondev V et al. | β | 2021 | β |
| Do Adolescent Exposure to Cannabinoids and Early Adverse Experience Interact to Increase the Risk of Psychiatric Disorders: Evidence from Rodent Models. | Portugalov A et al. | β | 2021 | β |
| Early life stress and development of the endocannabinoid system: A bidirectional process in programming future coping. | Goldstein Ferber S et al. | β | 2021 | β |
| Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis. | Sainsbury B et al. | β | 2021 | β |
| Enhancing Endocannabinoid Control of Stress with Cannabidiol. | Henson JD et al. | β | 2021 | β |
| Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping. | al'Absi M et al. | β | 2021 | β |
| Impact of Endocannabinoid System Manipulation on Neurodevelopmental Processes Relevant to Schizophrenia. | Zamberletti E et al. | β | 2021 | β |
| Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome. | Forteza F et al. | β | 2021 | β |
| Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain. | Piggott VM et al. | β | 2021 | β |
| Vasopressin and central control of the cardiovascular system: A 40-year retrospective. | Pittman QJ | β | 2021 | β |
| Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms. | DeVuono MV et al. | β | 2020 | β |
| Endocannabinoid concentrations in hair and mental health of unaccompanied refugee minors. | Croissant M et al. | β | 2020 | β |
| Hippocampal 2-Arachidonoyl Glycerol Signaling Regulates Time-of-Day- and Stress-Dependent Effects on Rat Short-Term Memory. | Santori A et al. | β | 2020 | β |
| Remote CB1 receptor antagonist administration reveals multiple sites of tonic and phasic endocannabinoid neuroendocrine regulation. | Newsom RJ et al. | β | 2020 | β |
| A review on inflammatory cytokine-induced alterations of the brain as potential neural biomarkers in post-traumatic stress disorder. | Kim YK et al. | β | 2019 | β |
| Cell signaling dependence of rapid glucocorticoid-induced endocannabinoid synthesis in hypothalamic neuroendocrine cells. | Harris C et al. | β | 2019 | β |
| Comprehensive review on the interaction between natural compounds and brain receptors: Benefits and toxicity. | Silva AR et al. | β | 2019 | β |
| Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system. | Wyrofsky RR et al. | β | 2019 | β |
| FAAH genotype, CRFR1 genotype, and cortisol interact to predict anxiety in an aging, rural Hispanic population: A Project FRONTIER study. | Harris BN et al. | β | 2019 | β |
| Sex differences in fear extinction. | Velasco ER et al. | β | 2019 | β |
| Stress during Lactation Induces Insulin Resistance Associated with an Increase in Type 1 Cannabinoid Receptors in Liver and Adipose Tissue. | Fonseca L et al. | β | 2019 | β |
| Corticosterone impairs flexible adjustment of spatial navigation in an associative place-reward learning task. | Rusu SI et al. | β | 2018 | β |
| Effects of an early life experience on rat brain cannabinoid receptors in adolescence and adulthood. | Vangopoulou C et al. | β | 2018 | β |
| Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation. | de la Tremblaye PB et al. | β | 2018 | β |
| Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels. | Hamilton J et al. | β | 2018 | β |
| Sex differences in the effect of cannabinoid type 1 receptor deletion on locus coeruleus-norepinephrine neurons and corticotropin releasing factor-mediated responses. | Wyrofsky RR et al. | β | 2018 | β |
| Acute Stress Shapes Synaptic Inhibition within an Amygdala Microcircuit. | Lynn M et al. | β | 2017 | β |
| Cannabidiol in medical marijuana: Research vistas and potential opportunities. | Rong C et al. | β | 2017 | β |
| Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. | Lange MD et al. | β | 2017 | β |
| Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 ameliorate neuroinflammatory responses in chronic cerebral hypoperfusion model by blocking NF-ΞΊB pathways. | Su SH et al. | β | 2017 | β |
| Chronic alcohol exposure disrupts CB<sub>1</sub> regulation of GABAergic transmission in the rat basolateral amygdala. | Varodayan FP et al. | β | 2017 | β |
| Co-localization of the cannabinoid type 1 receptor with corticotropin-releasing factor-containing afferents in the noradrenergic nucleus locus coeruleus: implications for the cognitive limb of the stress response. | R Wyrofsky R et al. | β | 2017 | β |
| Effects of oral Ξ<sup>9</sup>-tetrahydrocannabinol on the cerebral processing of olfactory input in healthy non-addicted subjects. | Walter C et al. | β | 2017 | β |
| Endocannabinoid and Mood Responses to Exercise in Adults with Varying Activity Levels. | Brellenthin AG et al. | β | 2017 | β |
| Endocannabinoids: Effectors of glucocorticoid signaling. | Balsevich G et al. | β | 2017 | β |
| Endocannabinoid System: the Direct and Indirect Involvement in the Memory and Learning Processes-a Short Review. | Kruk-Slomka M et al. | β | 2017 | β |
| Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle. | Heinz DE et al. | β | 2017 | β |
| Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. | Fuss J et al. | β | 2017 | β |
| Pharmacological Inhibition of Brain Fatty Acid Binding Protein Reduces Ethanol Consumption in Mice. | Figueiredo A et al. | β | 2017 | β |
| The effects of cannabinoid receptors activation and glucocorticoid receptors deactivation in the amygdala and hippocampus on the consolidation of a traumatic event. | Shoshan N et al. | β | 2017 | β |
| The Endocannabinoid System Differentially Regulates Escape Behavior in Mice. | Genewsky AJ et al. | β | 2017 | β |
| 2-arachidonoylglycerol signaling impairs short-term fear extinction. | Hartley ND et al. | β | 2016 | β |
| Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. | Di S et al. | β | 2016 | β |
| Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling. | Su SH et al. | β | 2016 | β |
| CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. | McReynolds JR et al. | β | 2016 | β |
| Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism. | de Kloet ER et al. | β | 2016 | β |
| Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity. | Knowles MD et al. | β | 2016 | β |
| Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. | Lim J et al. | β | 2016 | β |
| Endocannabinoid signaling in social functioning: an RDoC perspective. | Karhson DS et al. | β | 2016 | β |
| Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. | Busquets-Garcia A et al. | β | 2016 | β |
| Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors. | Yi B et al. | β | 2016 | β |
| Stress and Fear Extinction. | Maren S et al. | β | 2016 | β |
| Targeting the endocannabinoid system to treat anxiety-related disorders. | Korem N et al. | β | 2016 | β |
| The Role of the Endocannabinoid System in the Brain-Gut Axis. | Sharkey KA et al. | β | 2016 | β |
| 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. | Llorente-Berzal A et al. | β | 2015 | β |
| Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling. | Su SH et al. | β | 2015 | β |
| Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease. | Wyrofsky R et al. | β | 2015 | β |
| Endocannabinoid Regulation of Neuroendocrine Systems. | Tasker JG et al. | β | 2015 | β |
| Endocannabinoid signaling within the basolateral amygdala integrates multiple stress hormone effects on memory consolidation. | Atsak P et al. | β | 2015 | β |
| Hypothalamic-Pituitary--Adrenal Axis-Feedback Control. | Keller-Wood M | β | 2015 | β |
| Is there a "metabolic-mood syndrome"? A review of the relationship between obesity and mood disorders. | Mansur RB et al. | β | 2015 | β |
| Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior. | Rainville J et al. | β | 2015 | β |
| Modulation of Fear Extinction by Stress, Stress Hormones and Estradiol: A Review. | Stockhorst U et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |
| Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. | La Porta C et al. | β | 2015 | β |
| The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction. | Sachser RM et al. | β | 2015 | β |
| The endocannabinoid anandamide during lactation increases body fat content and CB1 receptor levels in mice adipose tissue. | Aguirre CA et al. | β | 2015 | β |
| Transcriptome comparison in the pituitary-adrenal axis between Beagle and Chinese Field dogs after chronic stress exposure. | Luo W et al. | β | 2015 | β |
| Cannabidiol as a potential treatment for psychosis. | Schubart CD et al. | β | 2014 | β |
| Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice. | Terzian AL et al. | β | 2014 | β |
| Cannabis use and anxiety: is stress the missing piece of the puzzle? | Temple EC et al. | β | 2014 | β |
| Changes in cerebral CB1 receptor availability after acute and chronic alcohol abuse and monitored abstinence. | Ceccarini J et al. | β | 2014 | β |
| Changes in endocannabinoid and N-acylethanolamine levels in rat brain structures following cocaine self-administration and extinction training. | Bystrowska B et al. | β | 2014 | β |
| Childhood maltreatment and obesity: systematic review and meta-analysis. | Danese A et al. | β | 2014 | β |
| Control of synaptic function by endocannabinoid-mediated retrograde signaling. | Kano M | β | 2014 | β |
| Endocannabinoid-mediated retrograde modulation of synaptic transmission. | Ohno-Shosaku T et al. | β | 2014 | β |
| Experience salience gates endocannabinoid signaling at hypothalamic synapses. | Wamsteeker Cusulin JI et al. | β | 2014 | β |
| Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. | Shonesy BC et al. | β | 2014 | β |
| Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis. | Handa RJ et al. | β | 2014 | β |
| Impact of stress on prefrontal glutamatergic, monoaminergic and cannabinoid systems. | Lapiz-Bluhm MD | β | 2014 | β |
| Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses. | Ramikie TS et al. | β | 2014 | β |
| Prenatal corticosterone and adolescent URB597 administration modulate emotionality and CB1 receptor expression in mice. | Ceci C et al. | β | 2014 | β |
| Research progress on the central mechanism underlying regulation of visceral biological rhythm by per2 (Review). | Zhu L et al. | β | 2014 | β |
| Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies. | Finsterwald C et al. | β | 2014 | β |
| Synthesis and preliminary evaluation of N-(16-18F-fluorohexadecanoyl)ethanolamine (18F-FHEA) as a PET probe of N-acylethanolamine metabolism in mouse brain. | Pandey MK et al. | β | 2014 | β |
| Systemic administration of oleoylethanolamide protects from neuroinflammation and anhedonia induced by LPS in rats. | Sayd A et al. | β | 2014 | β |
| The endocannabinoid system: an emotional buffer in the modulation of memory function. | Morena M et al. | β | 2014 | β |
| The neurobiological bases of memory formation: from physiological conditions to psychopathology. | Bisaz R et al. | β | 2014 | β |
| A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers. | de Bitencourt RM et al. | β | 2013 | β |
| Age of stress exposure modulates the immediate and sustained effects of repeated stress on corticolimbic cannabinoid CBβ receptor binding in male rats. | Lee TT et al. | β | 2013 | β |
| Amygdala FAAH and anandamide: mediating protection and recovery from stress. | Gunduz-Cinar O et al. | β | 2013 | β |
| Cannabinoid modulation of chronic mild stress-induced selective enhancement of trace fear conditioning in adolescent rats. | Reich CG et al. | β | 2013 | β |
| CB1 receptor signaling regulates social anxiety and memory. | Litvin Y et al. | β | 2013 | β |
| Dissociable effects of CB1 receptor blockade on anxiety-like and consummatory behaviors in the novelty-induced hypophagia test in mice. | Gamble-George JC et al. | β | 2013 | β |
| Effects of dietary nucleotides on acute stress response and cannabinoid receptor 1 mRNAs in sole, Solea solea. | Palermo FA et al. | β | 2013 | β |
| Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. | Neumeister A et al. | β | 2013 | β |
| Emotional, endocrine and brain anandamide response to social challenge in infant male rats. | Marco EM et al. | β | 2013 | β |
| Endocannabinoid receptor deficiency affects maternal care and alters the dam's hippocampal oxytocin receptor and brain-derived neurotrophic factor expression. | Schechter M et al. | β | 2013 | β |
| Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area. | Butts KA et al. | β | 2013 | β |
| Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction. | Panlilio LV et al. | β | 2013 | β |
| Novelty-induced emotional arousal modulates cannabinoid effects on recognition memory and adrenocortical activity. | Campolongo P et al. | β | 2013 | β |
| Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. | Hirvonen J et al. | β | 2013 | β |
| Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis. | Glangetas C et al. | β | 2013 | β |
| The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area. | Buczynski MW et al. | β | 2013 | β |
| Transient changes in the endocannabinoid system after acute and chronic ethanol exposure and abstinence in the rat: a combined PET and microdialysis study. | Ceccarini J et al. | β | 2013 | β |
| Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans. | Dlugos A et al. | β | 2012 | β |
| A theoretical framework informing research about the role of stress in the pathophysiology of bipolar disorder. | Brietzke E et al. | β | 2012 | β |
| Cannabinoid-1 receptor (CB1R) blockers as medicines: beyond obesity and cardiometabolic disorders to substance abuse/drug addiction with CB1R neutral antagonists. | Janero DR | β | 2012 | β |
| Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo. | Jacob W et al. | β | 2012 | β |
| Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress. | Derks NM et al. | β | 2012 | β |
| Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic-pituitary-adrenal axis responses in male Sprague-Dawley rats. | Newsom RJ et al. | β | 2012 | β |
| CB1 receptor-deficient mice as a model for depression. | Valverde O et al. | β | 2012 | β |
| Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice. | Bowles NP et al. | β | 2012 | β |
| Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. | Hillard CJ et al. | β | 2012 | β |
| Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis. | Hill MN et al. | β | 2012 | β |
| Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice. | Aguirre CA et al. | β | 2012 | β |
| Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it. | Riebe CJ et al. | β | 2012 | β |
| Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. | Dubreucq S et al. | β | 2012 | β |
| Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory. | Atsak P et al. | β | 2012 | β |
| Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. | Heyman E et al. | β | 2012 | β |
| Interactions between noradrenaline and corticosteroids in the brain: from electrical activity to cognitive performance. | Krugers HJ et al. | β | 2012 | β |
| Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence. | Passie T et al. | β | 2012 | β |
| Modulating the modulators: interaction of brain norepinephrine and cannabinoids in stress. | Morilak DA | β | 2012 | β |
| Neuronal populations mediating the effects of endocannabinoids on stress and emotionality. | HΓ€ring M et al. | β | 2012 | β |
| Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. | McLaughlin RJ et al. | β | 2012 | β |
| Role of the endocannabinoid system in regulating glucocorticoid effects on memory for emotional experiences. | Atsak P et al. | β | 2012 | β |
| The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness. | Campolongo P et al. | β | 2012 | β |
| Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic-pituitary-adrenal axis activity across developmental periods. | Lee TT et al. | β | 2012 | β |
| Cb1 receptor-mediated signaling emerges as a novel lead to evidence-based treatment development for stress-related psychopathology. | Bailey CR et al. | β | 2011 | β |
| Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. | Busquets-Garcia A et al. | β | 2011 | β |
| Early exposure to environmental enrichment alters the expression of genes of the endocannabinoid system. | El Rawas R et al. | β | 2011 | β |
| Intermittent ethanol consumption depresses endocannabinoid-signaling in the dorsolateral striatum of rat. | Adermark L et al. | β | 2011 | β |
| Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis. | Tasker JG et al. | β | 2011 | β |
| Propofol enhances memory formation via an interaction with the endocannabinoid system. | Hauer D et al. | β | 2011 | β |
| Reframing sexual differentiation of the brain. | McCarthy MM et al. | β | 2011 | β |
| The role of cannabinoids in modulating emotional and non-emotional memory processes in the hippocampus. | Akirav I | β | 2011 | β |
| The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. | Popoli M et al. | β | 2011 | β |