Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.
paper
Cited
Public
Unavailable
- Authors
- Giros, B; Jaber, M; Jones, S R; Wightman, R M; Caron, M G
- Year
- 1996
- Journal
- Nature
- PMID
- 8628395
- DOI
- 10.1038/379606a0
Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.
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| Prolonged dopamine D<sub>3</sub> receptor stimulation promotes dopamine transporter ubiquitination and degradation through a PKC-dependent mechanism. | Luis-Ravelo D et al. | β | 2021 | β |
| Sex-dependent alterations in behavior, drug responses and dopamine transporter expression in heterozygous DAT-Cre mice. | Costa KM et al. | β | 2021 | β |
| Sex differences in dopamine release regulation in the striatum. | Zachry JE et al. | β | 2021 | β |
| Social Interactions of Dat-Het Epi-Genotypes Differing for Maternal Origins: The Development of a New Preclinical Model of Socio-Sexual Apathy. | Brancato A et al. | β | 2021 | β |
| Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism. | Cagle BS et al. | β | 2021 | β |
| Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters. | Pidathala S et al. | β | 2021 | β |
| Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications. | Park D et al. | β | 2021 | β |
| The Dopamine System and Automatization of Movement Sequences: A Review With Relevance for Speech and Stuttering. | Alm PA | β | 2021 | β |
| The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. | Jehasse K et al. | β | 2021 | β |
| Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase. | Recart VM et al. | β | 2021 | β |
| Altered baseline and amphetamine-mediated behavioral profiles in dopamine transporter Cre (DAT-Ires-Cre) mice compared to tyrosine hydroxylase Cre (TH-Cre) mice. | Chohan MO et al. | β | 2020 | β |
| Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism. | Chao OY et al. | β | 2020 | β |
| Behavioral effects of SGK1 knockout in VTA and dopamine neurons. | Doyle MA et al. | β | 2020 | β |
| Brain NMDA Receptors in Schizophrenia and Depression. | Adell A | β | 2020 | β |
| Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions. | Okada M et al. | β | 2020 | β |
| Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine. | Schoenrock SA et al. | β | 2020 | β |
| Circadian regulation of membrane physiology in neural oscillators throughout the brain. | Paul JR et al. | β | 2020 | β |
| Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System. | Hunker AC et al. | β | 2020 | β |
| Deficit in working memory and abnormal behavioral tactics in dopamine transporter knockout rats during training in the 8-arm maze. | Kurzina NP et al. | β | 2020 | β |
| Direct dopamine terminal regulation by local striatal microcircuitry. | Nolan SO et al. | β | 2020 | β |
| Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection. | Bono F et al. | β | 2020 | β |
| Dopamine transporter availability in alcohol and opioid dependent subjects - a <sup>99m</sup>Tc-TRODAT-1SPECT imaging and genetic association study. | Grover T et al. | β | 2020 | β |
| Dopamine transporter gene expression within the nucleus accumbens plays important role in the acquisition and reinstatement of ethanol-seeking behavior in mice. | Bahi A | β | 2020 | β |
| Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and <i>in vivo</i> impact. | Fagan RR et al. | β | 2020 | β |
| Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments. | Petrelli F et al. | β | 2020 | β |
| Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor. | Sotnikova TD et al. | β | 2020 | β |
| Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking. | Collins AL et al. | β | 2020 | β |
| Heterogeneity of dopamine release sites in health and degeneration. | Lebowitz JJ et al. | β | 2020 | β |
| Intranasal Insulin: a Treatment Strategy for Addiction. | Kashyap B et al. | β | 2020 | β |
| In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats. | Kreisler AD et al. | β | 2020 | β |
| Motor Transitions' Peculiarity of Heterozygous DAT Rats When Offspring of an Unconventional KOxWT Mating. | Carbone C et al. | β | 2020 | β |
| Neonatal 6-OHDA Lesion Model in Mouse Induces Cognitive Dysfunctions of Attention-Deficit/Hyperactivity Disorder (ADHD) During Young Age. | Bouchatta O et al. | β | 2020 | β |
| Neural Circuits for Reward. | Zhang W | β | 2020 | β |
| Neurobehavioral changes arising from early life dopamine signaling perturbations. | Areal LB et al. | β | 2020 | β |
| Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens. | Holleran KM et al. | β | 2020 | β |
| Own or dam's genotype? Classical colony breeding may bias spontaneous and stress-challenged activity in DAT-mutant rats. | Mariano S et al. | β | 2020 | β |
| Rats Lacking Dopamine Transporter Display Increased Vulnerability and Aberrant Autonomic Response to Acute Stress. | Illiano P et al. | β | 2020 | β |
| The Association Between Parkinson's Disease and Attention-Deficit Hyperactivity Disorder. | Fan HC et al. | β | 2020 | β |
| Ξ²-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. | Slosky LM et al. | β | 2020 | β |
| Abnormal Behavior of Zebrafish Mutant in Dopamine Transporter Is Rescued by Clozapine. | Wang G et al. | β | 2019 | β |
| Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling. | Muntean BS et al. | β | 2019 | β |
| Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia. | Sekiguchi H et al. | β | 2019 | β |
| A Neurodevelopmental Model of Combined Pyrethroid and Chronic Stress Exposure. | Vester AI et al. | β | 2019 | β |
| Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. | DiCarlo GE et al. | β | 2019 | β |
| Behavioral characterization of DAT-KO rats and evidence of asocial-like phenotypes in DAT-HET rats: The potential involvement of norepinephrine system. | Adinolfi A et al. | β | 2019 | β |
| Bipolar Disorder: Its Etiology and How to Model in Rodents. | Freund N et al. | β | 2019 | β |
| Clustered Kv2.1 decreases dopamine transporter activity and internalization. | Lebowitz JJ et al. | β | 2019 | β |
| Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. | Fraser-Spears R et al. | β | 2019 | β |
| Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity. | Chee MJ et al. | β | 2019 | β |
| Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine. | van Gaalen MM et al. | β | 2019 | β |
| Discovery of Ξ²-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. | Pinkerton AB et al. | β | 2019 | β |
| Dopamine and addiction: what have we learned from 40Β years of research. | Solinas M et al. | β | 2019 | β |
| Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1. | Robinson SB et al. | β | 2019 | β |
| Dopamine: Functions, Signaling, and Association with Neurological Diseases. | Klein MO et al. | β | 2019 | β |
| Dopamine-mediated immunomodulation affects choroid plexus function. | Castellani G et al. | β | 2019 | β |
| Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice. | Bahi A et al. | β | 2019 | β |
| Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol 4,5-bisphosphate-independent manner. | Das AK et al. | β | 2019 | β |
| Dysfunctional striatal dopamine signaling in Huntington's disease. | Koch ET et al. | β | 2019 | β |
| Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior. | Reynolds LM et al. | β | 2019 | β |
| Episodic Ultradian Events-Ultradian Rhythms. | Goh GH et al. | β | 2019 | β |
| FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors. | Lei X et al. | β | 2019 | β |
| Family-based association study on functional Ξ±-synuclein polymorphisms in attention-deficit/hyperactivity disorder. | Gerlach M et al. | β | 2019 | β |
| Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission. | Peng C et al. | β | 2019 | β |
| Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior. | Hunn BHM et al. | β | 2019 | β |
| Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol. | Runegaard AH et al. | β | 2019 | β |
| Integrated analysis of the critical region 5p15.3-p15.2 associated with cri-du-chat syndrome. | CorrΓͺa T et al. | β | 2019 | β |
| Mediterranean X Western based diets: Opposite influences on opioid reinstatement. | Milanesi LH et al. | β | 2019 | β |
| Model systems for analysis of dopamine transporter function and regulation. | Hovde MJ et al. | β | 2019 | β |
| Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders. | Ratner MH et al. | β | 2019 | β |
| No effect of sex on ethanol intake and preference after dopamine transporter (DAT) knockdown in adult mice. | Bahi A et al. | β | 2019 | β |
| Palmitoylation by Multiple DHHC Enzymes Enhances Dopamine Transporter Function and Stability. | Bolland DE et al. | β | 2019 | β |
| Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment. | Ye J et al. | β | 2019 | β |
| Presence of recombination hotspots throughout SLC6A3. | Zhao J et al. | β | 2019 | β |
| Presynaptic regulation of dopamine release: Role of the DAT and VMAT2 transporters. | Mulvihill KG | β | 2019 | β |
| Reduced expression of synapsin II in a chronic phencyclidine preclinical rat model of schizophrenia. | Thomson S et al. | β | 2019 | β |
| Re-examining the role of ventral tegmental area dopaminergic neurons in motor activity and reinforcement by chemogenetic and optogenetic manipulation in mice. | Jing MY et al. | β | 2019 | β |
| Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction. | Nakao K et al. | β | 2019 | β |
| Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention. | Marshall CA et al. | β | 2019 | β |
| Selective C-C and C-N bond activation in dopamine and norepinephrine under deep ultraviolet laser irradiation. | Wu H et al. | β | 2019 | β |
| Serotonin transporter inhibition and 5-HT<sub>2C</sub> receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice. | Stewart A et al. | β | 2019 | β |
| Single Quantum Dot Imaging Reveals PKCΞ²-Dependent Alterations in Membrane Diffusion and Clustering of an Attention-Deficit Hyperactivity Disorder/Autism/Bipolar Disorder-Associated Dopamine Transporter Variant. | Thal LB et al. | β | 2019 | β |
| The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice. | Kim M et al. | β | 2019 | β |
| The high efficacy of muscarinic M4 receptor in D1 medium spiny neurons reverses striatal hyperdopaminergia. | Nair AG et al. | β | 2019 | β |
| Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations. | Cheng MH et al. | β | 2019 | β |
| Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency. | Salvatore MF et al. | β | 2019 | β |
| Variability in the Drug Response of M<sub>4</sub> Muscarinic Receptor Knockout Mice During Day and Night Time. | Valuskova P et al. | β | 2019 | β |
| Viral vector-mediated Cre recombinase expression in substantia nigra induces lesions of the nigrostriatal pathway associated with perturbations of dopamine-related behaviors and hallmarks of programmed cell death. | Rezai Amin S et al. | β | 2019 | β |
| Zebrafish models for attention deficit hyperactivity disorder (ADHD). | Fontana BD et al. | β | 2019 | β |
| Antipsychotics for aggression in adults: A meta-analysis. | van Schalkwyk GI et al. | β | 2018 | β |
| An unsuspected role for organic cation transporter 3 in the actions of amphetamine. | Mayer FP et al. | β | 2018 | β |
| Associations of Food Addiction in a Sample Recruited to Be Nationally Representative of the United States. | Schulte EM et al. | β | 2018 | β |
| Behavioral Phenotyping of Dopamine Transporter Knockout Rats: Compulsive Traits, Motor Stereotypies, and Anhedonia. | Cinque S et al. | β | 2018 | β |
| Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397. | Espinoza S et al. | β | 2018 | β |
| Brain hyperserotonemia causes autism-relevant social deficits in mice. | Tanaka M et al. | β | 2018 | β |
| Characterization of Dopaminergic System in the Striatum of Young Adult Park2<sup>-/-</sup> Knockout Rats. | Gemechu JM et al. | β | 2018 | β |
| Chronic Toxoplasma gondii Infection Induces Anti-<i>N</i>-Methyl-d-Aspartate Receptor Autoantibodies and Associated Behavioral Changes and Neuropathology. | Li Y et al. | β | 2018 | β |
| Deletion of <i>Maged1</i> in mice abolishes locomotor and reinforcing effects of cocaine. | De Backer JF et al. | β | 2018 | β |
| Development of a peptide targeting dopamine transporter to improve ADHD-like deficits. | Lai TKY et al. | β | 2018 | β |
| Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts. | Guo X et al. | β | 2018 | β |
| Dopamine release in mushroom bodies of the honey bee (Apis mellifera L.) in response to aversive stimulation. | Jarriault D et al. | β | 2018 | β |
| Dopamine, the antipsychotic molecule: A perspective on mechanisms underlying antipsychotic response variability. | Amato D et al. | β | 2018 | β |
| Dopamine Transporter Gene Methylation is Associated with Nucleus Accumbens Activation During Reward Processing in Healthy but not Alcohol-Dependent Individuals. | Muench C et al. | β | 2018 | β |
| Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period. | Lieberman OJ et al. | β | 2018 | β |
| Evolution of the HIV-1 transgenic rat: utility in assessing the progression of HIV-1-associated neurocognitive disorders. | McLaurin KA et al. | β | 2018 | β |
| High Throughput Measurement of Locomotor Sensitization to Volatilized Cocaine in <i>Drosophila melanogaster</i>. | FiloΕ‘eviΔ A et al. | β | 2018 | β |
| Improved Generation of Induced Pluripotent Stem Cells From Hair Derived Keratinocytes - A Tool to Study Neurodevelopmental Disorders as ADHD. | Re S et al. | β | 2018 | β |
| Interference of norepinephrine transporter trafficking motif attenuates amphetamine-induced locomotor hyperactivity and conditioned place preference. | Mannangatti P et al. | β | 2018 | β |
| Membrane cholesterol removal and replenishment affect rat and monkey brain monoamine transporters. | Morissette M et al. | β | 2018 | β |
| Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in <i>Fez1</i>-Deficient Mice. | Sumitomo A et al. | β | 2018 | β |
| MicroRNAs regulate synaptic plasticity underlying drug addiction. | Smith ACW et al. | β | 2018 | β |
| Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons in <i>Drosophila</i>. | Sun J et al. | β | 2018 | β |
| Novel translational rat models of dopamine transporter deficiency. | Leo D et al. | β | 2018 | β |
| Peripheral Dopamine in Restless Legs Syndrome. | Mitchell UH et al. | β | 2018 | β |
| PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis. | Jensen KL et al. | β | 2018 | β |
| Pleasure: The missing link in the regulation of sleep. | Rial RV et al. | β | 2018 | β |
| Precise mono-Cu<sup>+</sup> ion doping enhanced electrogenerated chemiluminescence from Cd-In-S supertetrahedral chalcogenide nanoclusters for dopamine detection. | Wang F et al. | β | 2018 | β |
| Pronounced Hyperactivity, Cognitive Dysfunctions, and BDNF Dysregulation in Dopamine Transporter Knock-out Rats. | Leo D et al. | β | 2018 | β |
| Reduced Efficacy of d-Amphetamine and 3,4-Methylenedioxymethamphetamine in Inducing Hyperactivity in Mice Lacking the Postsynaptic Scaffolding Protein SHANK1. | Sungur AΓ et al. | β | 2018 | β |
| Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens. | Marcott PF et al. | β | 2018 | β |
| Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D<sub>2</sub> Autoreceptors Shapes the <i>In Vivo</i> Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559. | Gowrishankar R et al. | β | 2018 | β |
| Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. | Gross JD et al. | β | 2018 | β |
| Structural and Functional Characterization of the Interaction of Snapin with the Dopamine Transporter: Differential Modulation of Psychostimulant Actions. | Erdozain AM et al. | β | 2018 | β |
| The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease. | Mackie P et al. | β | 2018 | β |
| The dopamine transporter role in psychiatric phenotypes. | Salatino-Oliveira A et al. | β | 2018 | β |
| The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction. | Sambo DO et al. | β | 2018 | β |
| Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases. | Schwartz MD et al. | β | 2018 | β |
| Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects. | MΓ€tlik K et al. | β | 2018 | β |
| Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults. | Smith CT et al. | β | 2018 | β |
| VTA mTOR Signaling Regulates Dopamine Dynamics, Cocaine-Induced Synaptic Alterations, and Reward. | Liu X et al. | β | 2018 | β |
| A Caenorhabditis elegans model to study dopamine transporter deficiency syndrome. | Illiano P et al. | β | 2017 | β |
| Aggregated Single-Walled Carbon Nanotubes Absorb and Deform Dopamine-Related Proteins Based on Molecular Dynamics Simulations. | Yu Y et al. | β | 2017 | β |
| Alpha-synuclein modulates dopamine neurotransmission. | Butler B et al. | β | 2017 | β |
| Animal models for bipolar disorder: from bedside to the cage. | Beyer DKE et al. | β | 2017 | β |
| A peptide disrupting the D2R-DAT interaction protects against dopamine neurotoxicity. | Su P et al. | β | 2017 | β |
| Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo. | Taylor IM et al. | β | 2017 | β |
| Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake. | Jensen KL et al. | β | 2017 | β |
| Autoimmune Aspects of Neurodegenerative and Psychiatric Diseases: A Template for Innovative Therapy. | de Haan P et al. | β | 2017 | β |
| Binge ethanol drinking during adolescence modifies cocaine responses in mice. | Esteve-Arenys A et al. | β | 2017 | β |
| Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity. | Klein M et al. | β | 2017 | β |
| Cocaine modulates allosteric D<sub>2</sub>-Ο<sub>1</sub> receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum. | Beggiato S et al. | β | 2017 | β |
| Control of Rest:Activity by a Dopaminergic Ultradian Oscillator and the Circadian Clock. | Bourguignon C et al. | β | 2017 | β |
| Decreased lymphocyte dopamine transporter in romantic lovers. | Marazziti D et al. | β | 2017 | β |
| Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation. | Ide S et al. | β | 2017 | β |
| Dopamine D3 and acetylcholine nicotinic receptor heteromerization in midbrain dopamine neurons: Relevance for neuroplasticity. | Bontempi L et al. | β | 2017 | β |
| Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder. | Mereu M et al. | β | 2017 | β |
| Dopamine transporter phosphorylation site threonine 53 is stimulated by amphetamines and regulates dopamine transport, efflux, and cocaine analog binding. | Challasivakanaka S et al. | β | 2017 | β |
| Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function. | Vaccaro A et al. | β | 2017 | β |
| Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes. | Taylor IM et al. | β | 2017 | β |
| Functional Polymorphisms in Dopaminergic Genes Modulate Neurobehavioral and Neurophysiological Consequences of Sleep Deprivation. | Holst SC et al. | β | 2017 | β |
| Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson's disease motor symptoms without neuronal degeneration in adult mice. | Isingrini E et al. | β | 2017 | β |
| GΞ²Ξ³ subunit activation promotes dopamine efflux through the dopamine transporter. | Garcia-Olivares J et al. | β | 2017 | β |
| Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. | Dai H et al. | β | 2017 | β |
| Loss of Action via Neurotensin-Leptin Receptor Neurons Disrupts Leptin and Ghrelin-Mediated Control of Energy Balance. | Brown JA et al. | β | 2017 | β |
| Membrane proteins structures: A review on computational modeling tools. | Almeida JG et al. | β | 2017 | β |
| Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease. | Lohr KM et al. | β | 2017 | β |
| Methamphetamine induces Shati/Nat8L expression in the mouse nucleus accumbens via CREB- and dopamine D1 receptor-dependent mechanism. | Uno K et al. | β | 2017 | β |
| Neuropsychological performance measures as intermediate phenotypes for attention-deficit/hyperactivity disorder: A multiple mediation analysis. | Kamradt JM et al. | β | 2017 | β |
| No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs. | Geissler JM et al. | β | 2017 | β |
| Palmitoylation mechanisms in dopamine transporter regulation. | Rastedt DE et al. | β | 2017 | β |
| Paraquat exposure-induced Parkinson's disease-like symptoms and oxidative stress in Drosophila melanogaster: Neuroprotective effect of Bougainvillea glabra Choisy. | Soares JJ et al. | β | 2017 | β |
| Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice. | Runegaard AH et al. | β | 2017 | β |
| Probing the Allosteric Role of the Ξ±5 Subunit of Ξ±3Ξ²4Ξ±5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands. | Ray C et al. | β | 2017 | β |
| Recombinant Adeno-Associated Virus-mediated rescue of function in a mouse model of Dopamine Transporter Deficiency Syndrome. | Illiano P et al. | β | 2017 | β |
| Reduced levels of Cacna1c attenuate mesolimbic dopamine system function. | Terrillion CE et al. | β | 2017 | β |
| Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem. | Gerth AI et al. | β | 2017 | β |
| Research Domain Criteria versus DSM V: How does this debate affect attempts to model corticostriatal dysfunction in animals? | Young JW et al. | β | 2017 | β |
| Striatal dopamine in Parkinson disease: A meta-analysis of imaging studies. | Kaasinen V et al. | β | 2017 | β |
| Striatal GΞ±<sub>olf</sub>/cAMP Signal-Dependent Mechanism to Generate Levodopa-Induced Dyskinesia in Parkinson's Disease. | Goto S | β | 2017 | β |
| Structure-Activity Relationship Studies on a Series of 3Ξ±-[Bis(4-fluorophenyl)methoxy]tropanes and 3Ξ±-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders. | Zou MF et al. | β | 2017 | β |
| Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter. | Ma S et al. | β | 2017 | β |
| The antipsychotic-like effects in rodents of YQA31 involve dopamine D3 and 5-HT1A receptor. | Gou HY et al. | β | 2017 | β |
| The Case for TAAR1 as a Modulator of Central Nervous System Function. | Rutigliano G et al. | β | 2017 | β |
| The relationship between the striatal dopamine transporter and novelty seeking and cognitive flexibility in opioid dependence. | Liang CS et al. | β | 2017 | β |
| The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission. | Sambo DO et al. | β | 2017 | β |
| Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene. | Vengeliene V et al. | β | 2017 | β |
| Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. | Shimohata A et al. | β | 2017 | β |
| Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. | Speca DJ et al. | β | 2017 | β |
| Ξ±6Ξ²2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. | Siciliano CA et al. | β | 2017 | β |
| Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids. | Appiah-Kusi E et al. | β | 2016 | β |
| Association between the 5-HTTLPR Genotype and Childhood Characteristics in Mood Disorders. | Eun TK et al. | β | 2016 | β |
| Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density. | Berkowicz SR et al. | β | 2016 | β |
| British Society for Gene and Cell Therapy Annual Conference University College London Institute of Child Health Friday 15(th) April 2016 Conference Abstracts. | β | β | 2016 | β |
| CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. | Miyake K et al. | β | 2016 | β |
| Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice. | Moreno Γvila CL et al. | β | 2016 | β |
| Cyclin-Dependent Kinase Inhibitor 1a (p21) Modulates Response to Cocaine and Motivated Behaviors. | Scholpa NE et al. | β | 2016 | β |
| Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure. | Juarez B et al. | β | 2016 | β |
| Dopamine transporter mutant animals: a translational perspective. | Efimova EV et al. | β | 2016 | β |
| Effects of the ΞΊ-opioid receptor on the inhibition of 100 Hz electroacupuncture on cocaine-induced conditioned place preference. | Hou B | β | 2016 | β |
| Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum. | Pereira DB et al. | β | 2016 | β |
| Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. | Reddy IA et al. | β | 2016 | β |
| Identification of rare high-risk copy number variants affecting the dopamine transporter gene in mental disorders. | Hoeffding LK et al. | β | 2016 | β |
| Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function. | Singer BF et al. | β | 2016 | β |
| Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system. | Barroso-Chinea P et al. | β | 2016 | β |
| Modeling mania in preclinical settings: A comprehensive review. | Sharma AN et al. | β | 2016 | β |
| Modelling ADHD: A review of ADHD theories through their predictions for computational models of decision-making and reinforcement learning. | Ziegler S et al. | β | 2016 | β |
| Moving towards causality in attention-deficit hyperactivity disorder: overview of neural and genetic mechanisms. | Gallo EF et al. | β | 2016 | β |
| N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data. | Monti DA et al. | β | 2016 | β |
| Nicotine-dopamine-transporter interactions during reward-based decision making. | Kambeitz J et al. | β | 2016 | β |
| Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice. | FranΓ§a AS et al. | β | 2016 | β |
| Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells. | Beerepoot P et al. | β | 2016 | β |
| PKCΞ² Inhibitors Attenuate Amphetamine-Stimulated Dopamine Efflux. | Zestos AG et al. | β | 2016 | β |
| Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior. | Ferenczi EA et al. | β | 2016 | β |
| Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice. | Salvatore MF et al. | β | 2016 | β |
| Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour. | Isingrini E et al. | β | 2016 | β |
| Striatal dopamine neurotransmission: regulation of release and uptake. | Sulzer D et al. | β | 2016 | β |
| "TAARgeting Addiction"--The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference. | Grandy DK et al. | β | 2016 | β |
| The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia. | Griebel G et al. | β | 2016 | β |
| The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms. | Landgraf D et al. | β | 2016 | β |
| The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction. | Lutfy K et al. | β | 2016 | β |
| Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. | Homberg JR et al. | β | 2016 | β |
| What Mechanisms Are Responsible for the Reuptake of Levodopa-Derived Dopamine in Parkinsonian Striatum? | Nishijima H et al. | β | 2016 | β |
| Y-QA31, a novel dopamine D3 receptor antagonist, exhibits antipsychotic-like properties in preclinical animal models of schizophrenia. | Sun X et al. | β | 2016 | β |
| 5p deletions: Current knowledge and future directions. | Nguyen JM et al. | β | 2015 | β |
| A behavioral defect of temporal association memory in mice that partly lack dopamine reuptake transporter. | Deng S et al. | β | 2015 | β |
| Activity in descending dopaminergic neurons represents but is not required for leg movements in the fruit fly Drosophila. | Tschida K et al. | β | 2015 | β |
| Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. | Siciliano CA et al. | β | 2015 | β |
| Amphetamine activates calcium channels through dopamine transporter-mediated depolarization. | Cameron KN et al. | β | 2015 | β |
| A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. | Apuschkin M et al. | β | 2015 | β |
| Association of COMT and SLC6A3 polymorphisms with impulsivity, response inhibition and brain function. | Kasparbauer AM et al. | β | 2015 | β |
| Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics. | Zimmermann AM et al. | β | 2015 | β |
| Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. | Igari M et al. | β | 2015 | β |
| Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter. | Andersen J et al. | β | 2015 | β |
| Can the dopaminergic-related effects of general anesthetics be linked to mechanisms involved in drug abuse and addiction? | Melo A et al. | β | 2015 | β |
| Chronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity. | Eells JB et al. | β | 2015 | β |
| Classic Studies on the Interaction of Cocaine and the Dopamine Transporter. | Verma V | β | 2015 | β |
| Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice. | Nakao A et al. | β | 2015 | β |
| Ctr9, a Protein in the Transcription Complex Paf1, Regulates Dopamine Transporter Activity at the Plasma Membrane. | De Gois S et al. | β | 2015 | β |
| Developmental Deltamethrin Exposure Causes Persistent Changes in Dopaminergic Gene Expression, Neurochemistry, and Locomotor Activity in Zebrafish. | Kung TS et al. | β | 2015 | β |
| Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. | Richardson JR et al. | β | 2015 | β |
| Differential effects of dopamine-directed treatments on cognition. | Ashby FG et al. | β | 2015 | β |
| Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys. | John WS et al. | β | 2015 | β |
| Dopamine transporter gene may be associated with bipolar disorder and its personality traits. | Huang CC et al. | β | 2015 | β |
| Eating high fat chow decreases dopamine clearance in adolescent and adult male rats but selectively enhances the locomotor stimulating effects of cocaine in adolescents. | Baladi MG et al. | β | 2015 | β |
| Effectiveness of Ξ³-oryzanol in reducing neuromotor deficits, dopamine depletion and oxidative stress in a Drosophila melanogaster model of Parkinson's disease induced by rotenone. | Araujo SM et al. | β | 2015 | β |
| Effect of insulin deficiency on the rewarding properties of methamphetamine in streptozotocin-induced diabetic rats. | Bayat AH et al. | β | 2015 | β |
| Elevated dopamine alters consummatory pattern generation and increases behavioral variability during learning. | Rossi MA et al. | β | 2015 | β |
| Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma Cells. | Green AL et al. | β | 2015 | β |
| Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine. | Sutton LP et al. | β | 2015 | β |
| Fabrication of High-Performance Ultrathin In2O3 Film Field-Effect Transistors and Biosensors Using Chemical Lift-Off Lithography. | Kim J et al. | β | 2015 | β |
| Genes of the dopaminergic system selectively modulate top-down but not bottom-up attention. | Schneider KK et al. | β | 2015 | β |
| Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. | Brewer AJ et al. | β | 2015 | β |
| Gold-nanoparticle-based colorimetric array for detection of dopamine in urine and serum. | Leng Y et al. | β | 2015 | β |
| Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. | Masoud ST et al. | β | 2015 | β |
| IRBIT regulates CaMKIIΞ± activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. | Kawaai K et al. | β | 2015 | β |
| Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons. | Ehrich JM et al. | β | 2015 | β |
| Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways. | Barr JL et al. | β | 2015 | β |
| Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. | Piao YS et al. | β | 2015 | β |
| Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors. | Suri D et al. | β | 2015 | β |
| Monoamine transporters: insights from molecular dynamics simulations. | Grouleff J et al. | β | 2015 | β |
| Neurotransmitter and psychostimulant recognition by the dopamine transporter. | Wang KH et al. | β | 2015 | β |
| Ni(2+) affects dopamine uptake which limits suitability as inhibitor of T-type voltage-gated Ca(2+) channels. | Brimblecombe KR et al. | β | 2015 | β |
| Occupational exposures and parkinsonism. | Caudle WM | β | 2015 | β |
| Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. | Bastide MF et al. | β | 2015 | β |
| Phasic dopamine signals: from subjective reward value to formal economic utility. | Schultz W et al. | β | 2015 | β |
| Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3Ξ² pathway. | Wong P et al. | β | 2015 | β |
| Presynaptic D2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus. | Rocchetti J et al. | β | 2015 | β |
| Protein kinase C beta regulates the Dβ-like dopamine autoreceptor. | Luderman KD et al. | β | 2015 | β |
| Psychiatric disorders as vulnerability factors for nicotine addiction: what have we learned from animal models? | Le Foll B et al. | β | 2015 | β |
| Psychostimulants affect dopamine transmission through both dopamine transporter-dependent and independent mechanisms. | Dela PeΓ±a I et al. | β | 2015 | β |
| Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics. | Moritz AE et al. | β | 2015 | β |
| Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease. | German CL et al. | β | 2015 | β |
| Reward modulation of cognitive function in adult attention-deficit/hyperactivity disorder: a pilot study on the role of striatal dopamine. | Aarts E et al. | β | 2015 | β |
| Single-quantum-dot tracking reveals altered membrane dynamics of an attention-deficit/hyperactivity-disorder-derived dopamine transporter coding variant. | Kovtun O et al. | β | 2015 | β |
| SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis. | Larhammar M et al. | β | 2015 | β |
| Stress and Drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function. | Fox ME et al. | β | 2015 | β |
| Targeting Ξ²-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease. | Urs NM et al. | β | 2015 | β |
| The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited. | van Enkhuizen J et al. | β | 2015 | β |
| The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. | Mediouni S et al. | β | 2015 | β |
| The impact of nandrolone decanoate on the central nervous system. | BusardΓ² FP et al. | β | 2015 | β |
| The molecular genetic architecture of attention deficit hyperactivity disorder. | Hawi Z et al. | β | 2015 | β |
| The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster. | Tomita J et al. | β | 2015 | β |
| The structure and function of the dopamine transporter and its role in CNS diseases. | McHugh PC et al. | β | 2015 | β |
| The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters. | Loland CJ | β | 2015 | β |
| ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence. | Kollins SH et al. | β | 2014 | β |
| A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal. | Blum ID et al. | β | 2014 | β |
| Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene. | Nakai T et al. | β | 2014 | β |
| Amphetamine potentiates the effects of Ξ²-phenylethylamine through activation of an amine-gated chloride channel. | Safratowich BD et al. | β | 2014 | β |
| Animal models of tic disorders: a translational perspective. | Godar SC et al. | β | 2014 | β |
| Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridge. | Gaffaney JD et al. | β | 2014 | β |
| A short review on the relation between the dopamine transporter 10/10-repeat allele and ADHD: implications for HIV infection. | Koutsilieri E et al. | β | 2014 | β |
| Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbΞ±. | Jager J et al. | β | 2014 | β |
| Biphasic mechanisms of amphetamine action at the dopamine terminal. | Siciliano CA et al. | β | 2014 | β |
| Characterization of A11 neurons projecting to the spinal cord of mice. | Koblinger K et al. | β | 2014 | β |
| Chlorogenic and caftaric acids in liver toxicity and oxidative stress induced by methamphetamine. | Koriem KM et al. | β | 2014 | β |
| Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site. | Dahal RA et al. | β | 2014 | β |
| Coping with unpredictability: dopaminergic and neurotrophic responses to omission of expected reward in Atlantic salmon (Salmo salar L.). | Vindas MA et al. | β | 2014 | β |
| Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems. | Hall FS et al. | β | 2014 | β |
| Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. | Toriumi K et al. | β | 2014 | β |
| Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. | Speca DJ et al. | β | 2014 | β |
| Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of Parkinson's disease. | Sahin G et al. | β | 2014 | β |
| Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice. | Del'Guidice T et al. | β | 2014 | β |
| Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine. | Heal DJ et al. | β | 2014 | β |
| Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. | Holst SC et al. | β | 2014 | β |
| Entacapone augmentation of antipsychotic treatment in schizophrenic patients with negative symptoms; a double-blind placebo-controlled study. | Kaphzan H et al. | β | 2014 | β |
| Epigenetics, microRNA, and addiction. | Kenny PJ | β | 2014 | β |
| Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice. | Clough SJ et al. | β | 2014 | β |
| Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults. | Valomon A et al. | β | 2014 | β |
| Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load. | Smith CT et al. | β | 2014 | β |
| Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder. | Mergy MA et al. | β | 2014 | β |
| Good riddance to dopamine: roles for the dopamine transporter in synaptic function and dopamine-associated brain disorders. | Gowrishankar R et al. | β | 2014 | β |
| Habit formation: implications for alcoholism research. | O'Tousa D et al. | β | 2014 | β |
| Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: effects on locomotor behavior and seizure susceptibility. | Tripathi PP et al. | β | 2014 | β |
| Integrated approaches to understanding antipsychotic drug action at GPCRs. | Urs NM et al. | β | 2014 | β |
| Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing. | Saha K et al. | β | 2014 | β |
| In vivo amphetamine action is contingent on Ξ±CaMKII. | Steinkellner T et al. | β | 2014 | β |
| Localized drug application and sub-second voltammetric dopamine release measurements in a brain slice perfusion device. | Sun M et al. | β | 2014 | β |
| Meta-analysis of the association between dopamine transporter genotype and response to methylphenidate treatment in ADHD. | Kambeitz J et al. | β | 2014 | β |
| Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. | Tritsch NX et al. | β | 2014 | β |
| Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system. | Cristino AS et al. | β | 2014 | β |
| NMDA receptor-deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities. | Milenkovic M et al. | β | 2014 | β |
| N-terminal tagging of the dopamine transporter impairs protein expression and trafficking in vivo. | Vecchio LM et al. | β | 2014 | β |
| Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice. | Miyamoto Y et al. | β | 2014 | β |
| Pharmacological assessment of methamphetamine-induced behavioral hyperactivity mediated by dopaminergic transmission in planarian Dugesia japonica. | Tashiro N et al. | β | 2014 | β |
| PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. | Hamilton PJ et al. | β | 2014 | β |
| Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders. | Chen CK et al. | β | 2014 | β |
| Protective and toxic roles of dopamine in Parkinson's disease. | Segura-Aguilar J et al. | β | 2014 | β |
| Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. | Wang N et al. | β | 2014 | β |
| Reduced dopamine transporter expression in the amygdala of subjects diagnosed with schizophrenia. | Markota M et al. | β | 2014 | β |
| Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P Ξ±-synuclein BAC transgenic mouse. | Taylor TN et al. | β | 2014 | β |
| Repeated exposure of adult rats to transient oxidative stress induces various long-lasting alterations in cognitive and behavioral functions. | Iguchi Y et al. | β | 2014 | β |
| Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter. | Wu H et al. | β | 2014 | β |
| Role of COMT in ADHD: a systematic meta-analysis. | Sun H et al. | β | 2014 | β |
| Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. | Daigle TL et al. | β | 2014 | β |
| Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout. | Hall FS et al. | β | 2014 | β |
| Sex differences in the effects of estradiol in the nucleus accumbens and striatum on the response to cocaine: neurochemistry and behavior. | Cummings JA et al. | β | 2014 | β |
| Six weeks of voluntary exercise don't protect C57BL/6 mice against neurotoxicity of MPTP and MPP(+). | Aguiar AS et al. | β | 2014 | β |
| SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. | Bowton E et al. | β | 2014 | β |
| Striatal firing rate reflects head movement velocity. | Kim N et al. | β | 2014 | β |
| Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans. | Masoudi N et al. | β | 2014 | β |
| The clathrin-dependent localization of dopamine transporter to surface membranes is affected by Ξ±-synuclein. | Kisos H et al. | β | 2014 | β |
| The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. | Cagniard B et al. | β | 2014 | β |
| The effects of benzofury (5-APB) on the dopamine transporter and 5-HT2-dependent vasoconstriction in the rat. | Dawson P et al. | β | 2014 | β |
| The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders. | Lavoie J et al. | β | 2014 | β |
| The endocannabinoid system: an emotional buffer in the modulation of memory function. | Morena M et al. | β | 2014 | β |
| The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants. | Mergy MA et al. | β | 2014 | β |
| Ventral midbrain correlation between genetic variation and expression of the dopamine transporter gene in cocaine-abusing versus non-abusing subjects. | Zhou Y et al. | β | 2014 | β |
| A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. | Rickhag M et al. | β | 2013 | β |
| Advanced transgenic approaches to understand alcohol-related phenotypes in animals. | Bilbao A | β | 2013 | β |
| Advances in studying phasic dopamine signaling in brain reward mechanisms. | Wickham RJ et al. | β | 2013 | β |
| A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD. | Hawi Z et al. | β | 2013 | β |
| An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice. | Fox MA et al. | β | 2013 | β |
| A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. | Riemensperger T et al. | β | 2013 | β |
| Association between the GRM7 rs3792452 polymorphism and attention deficit hyperacitiveity disorder in a Korean sample. | Park S et al. | β | 2013 | β |
| Association of dopamine transporter gene variants with childhood ADHD features in bipolar disorder. | Greenwood TA et al. | β | 2013 | β |
| B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments. | Nagy PM et al. | β | 2013 | β |
| Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice. | Havrda MC et al. | β | 2013 | β |
| Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia. | UrigΓΌen L et al. | β | 2013 | β |
| Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans. | Peden AS et al. | β | 2013 | β |
| Caffeic acid protects tissue antioxidants and DNA content in methamphetamine induced tissue toxicity in Sprague Dawley rats. | Koriem KM et al. | β | 2013 | β |
| Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers. | Navarro G et al. | β | 2013 | β |
| D1 dopamine receptor coupling to PLCΞ² regulates forward locomotion in mice. | Medvedev IO et al. | β | 2013 | β |
| Dances with black widow spiders: dysregulation of glutamate signalling enters centre stage in ADHD. | Lesch KP et al. | β | 2013 | β |
| Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex. | Carson RP et al. | β | 2013 | β |
| De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. | Hamilton PJ et al. | β | 2013 | β |
| Distribution of dopamine transporter immunoreactive fibers in the human amygdaloid complex. | GarcΓa-Amado M et al. | β | 2013 | β |
| Dopamine and training-related working-memory improvement. | BΓ€ckman L et al. | β | 2013 | β |
| Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. | Golden JP et al. | β | 2013 | β |
| Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility. | Chen JY et al. | β | 2013 | β |
| Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. | Γlvaro-BartolomΓ© M et al. | β | 2013 | β |
| Ephrin-A5 deficiency alters sensorimotor and monoaminergic development. | Sheleg M et al. | β | 2013 | β |
| Exposure to chronic mild stress prevents kappa opioid-mediated reinstatement of cocaine and nicotine place preference. | Al-Hasani R et al. | β | 2013 | β |
| Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. | Rodriguez PC et al. | β | 2013 | β |
| Functional genomics of attention-deficit/hyperactivity disorder (ADHD) risk alleles on dopamine transporter binding in ADHD and healthy control subjects. | Spencer TJ et al. | β | 2013 | β |
| GABA transporter-1 deficiency confers schizophrenia-like behavioral phenotypes. | Yu Z et al. | β | 2013 | β |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | β | 2013 | β |
| Interaction of dopamine transporter gene and observed parenting behaviors on attention-deficit/hyperactivity disorder: a structural equation modeling approach. | Li JJ et al. | β | 2013 | β |
| In vivo occupancy of dopamine D3 receptors by antagonists produces neurochemical and behavioral effects of potential relevance to attention-deficit-hyperactivity disorder. | Barth V et al. | β | 2013 | β |
| Is the treatment with psychostimulants in children and adolescents with attention deficit hyperactivity disorder harmful for the dopaminergic system? | Gerlach M et al. | β | 2013 | β |
| Kinetics of the dopamine transporter in Drosophila larva. | Vickrey TL et al. | β | 2013 | β |
| Locomotor hyperactivity in 14-3-3ΞΆ KO mice is associated with dopamine transporter dysfunction. | Ramshaw H et al. | β | 2013 | β |
| Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. | Wu TH et al. | β | 2013 | β |
| Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. | Rickhag M et al. | β | 2013 | β |
| Mice expressing markedly reduced striatal dopamine transporters exhibit increased locomotor activity, dopamine uptake turnover rate, and cocaine responsiveness. | Rao A et al. | β | 2013 | β |
| Molecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs. | Jonkman S et al. | β | 2013 | β |
| Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. | Vereczkei A et al. | β | 2013 | β |
| Neurobehavioral alterations in HIV-1 transgenic rats: evidence for dopaminergic dysfunction. | Moran LM et al. | β | 2013 | β |
| Oral administration of methylphenidate blocks the effect of cocaine on uptake at the Drosophila dopamine transporter. | Berglund EC et al. | β | 2013 | β |
| Parallel processing of environmental recognition and locomotion in the mouse striatum. | Yamin HG et al. | β | 2013 | β |
| Pharmacogenetic activation of midbrain dopaminergic neurons induces hyperactivity. | Wang S et al. | β | 2013 | β |
| Rats classified as low or high cocaine locomotor responders: a unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors. | Yamamoto DJ et al. | β | 2013 | β |
| Rit subfamily small GTPases: regulators in neuronal differentiation and survival. | Shi GX et al. | β | 2013 | β |
| Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine. | Uchiumi O et al. | β | 2013 | β |
| Sexually dimorphic, developmental, and chronobiological behavioral profiles of a mouse mania model. | Saul MC et al. | β | 2013 | β |
| Somatodendritic targeting of M5 muscarinic receptor in the rat ventral tegmental area: implications for mesolimbic dopamine transmission. | GarzΓ³n M et al. | β | 2013 | β |
| SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRΞ±1 and RET. | Glerup S et al. | β | 2013 | β |
| The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. | Ignatowska-Jankowska BM et al. | β | 2013 | β |
| The ClockΞ19 mutation in mice fails to alter the primary and secondary reinforcing properties of nicotine. | Bernardi RE et al. | β | 2013 | β |
| The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells. | Roth JA et al. | β | 2013 | β |
| The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice. | Seminerio MJ et al. | β | 2013 | β |
| The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila. | Pizzo AB et al. | β | 2013 | β |
| The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in humans. | Taylor SB et al. | β | 2013 | β |
| The role of Homer 1a in increasing locomotor activity and non-selective attention, and impairing learning and memory abilities. | Yang L et al. | β | 2013 | β |
| The synaptic adhesion molecule SynCAM 1 contributes to cocaine effects on synapse structure and psychostimulant behavior. | Giza JI et al. | β | 2013 | β |
| Transgenic mouse models for ADHD. | Leo D et al. | β | 2013 | β |
| Translating the evidence for gene association with depression into mouse models of depression-relevant behaviour: current limitations and future potential. | Pryce CR et al. | β | 2013 | β |
| Using rodents to model schizophrenia and substance use comorbidity. | Ng E et al. | β | 2013 | β |
| Ξ±-Lipoic acid interaction with dopamine D2 receptor-dependent activation of the Akt/GSK-3Ξ² signaling pathway induced by antipsychotics: potential relevance for the treatment of schizophrenia. | Deslauriers J et al. | β | 2013 | β |
| Advancing addiction treatment: what can we learn from animal studies? | Wu PH et al. | β | 2012 | β |
| A flow cytometry-based dopamine transporter binding assay using antagonist-conjugated quantum dots. | Kovtun O et al. | β | 2012 | β |
| A new mouse model for mania shares genetic correlates with human bipolar disorder. | Saul MC et al. | β | 2012 | β |
| Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation. | Sakrikar D et al. | β | 2012 | β |
| Behavioral animal models of antipsychotic drug actions. | Peleg-Raibstein D et al. | β | 2012 | β |
| Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation. | Li D et al. | β | 2012 | β |
| Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters. | Severinsen K et al. | β | 2012 | β |
| Candidate system analysis in ADHD: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1. | RibasΓ©s M et al. | β | 2012 | β |
| Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis. | TammimΓ€ki A et al. | β | 2012 | β |
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| Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, DeltaFosB expression, and conditioned place preference to amphetamine and cocaine. | Marazziti D et al. | β | 2011 | β |
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| Ξ±-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. | Swant J et al. | β | 2011 | β |
| Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression. | Speed NK et al. | β | 2010 | β |
| A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia. | Vuillermot S et al. | β | 2010 | β |
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| Effect of rhynchophylline on central neurotransmitter levels in amphetamine-induced conditioned place preference rat brain. | Zhou JY et al. | β | 2010 | β |
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| Functional analysis of intron 8 and 3' UTR variable number of tandem repeats of SLC6A3: differential activity of intron 8 variants. | Hill M et al. | β | 2010 | β |
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| Low novelty seeking and high self directedness scores in alcohol-dependent patients without comorbid psychiatric disorders homozygous for the A10 allele of the dopamine transporter gene. | Anghelescu I et al. | β | 2010 | β |
| Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS. | Ariyannur PS et al. | β | 2010 | β |
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| Molecular structure-function relations of the optical properties and dimensions of gold nanoparticle assemblies. | Kaminker R et al. | β | 2010 | β |
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| N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. | Xi ZX et al. | β | 2010 | β |
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| Protein interacting with C alpha kinase 1 (PICK1) is involved in promoting tumor growth and correlates with poor prognosis of human breast cancer. | Zhang B et al. | β | 2010 | β |
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| Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. | Makos MA et al. | β | 2010 | β |
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| Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study. | Akahoshi E et al. | β | 2009 | β |
| Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain. | Schuh RA et al. | β | 2009 | β |
| Effects on prolactin secretion and binding to dopaminergic receptors in sleep-deprived lupus-prone mice. | Palma BD et al. | β | 2009 | β |
| Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice. | Zhou W et al. | β | 2009 | β |
| Exploratory activity and motor coordination in old versus middle-aged C57BL/6J mice. | Lalonde R et al. | β | 2009 | β |
| Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems. | Ji J et al. | β | 2009 | β |
| Genetic analysis of daily physical activity using a mouse chromosome substitution strain. | Yang HS et al. | β | 2009 | β |
| [Genetic factors of alcohol-dependence]. | Pinto E et al. | β | 2009 | β |
| Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. | Kurian MA et al. | β | 2009 | β |
| Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. | Dzirasa K et al. | β | 2009 | β |
| Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate. | Xu TX et al. | β | 2009 | β |
| Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. | Jacobs FM et al. | β | 2009 | β |
| Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters. | Liang YJ et al. | β | 2009 | β |
| In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex. | Meyers B et al. | β | 2009 | β |
| In vivo electrochemical measurements of exogenously applied dopamine in Drosophila melanogaster. | Makos MA et al. | β | 2009 | β |
| Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. | Thomsen M et al. | β | 2009 | β |
| Mice lacking adenylyl cyclase-5 cope badly with repeated restraint stress. | Kim KS et al. | β | 2009 | β |
| Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep. | Dzirasa K et al. | β | 2009 | β |
| Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. | Haile CN et al. | β | 2009 | β |
| Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. | EgaΓ±a LA et al. | β | 2009 | β |
| Prepulse inhibition and genetic mouse models of schizophrenia. | Powell SB et al. | β | 2009 | β |
| Proline-directed phosphorylation of the dopamine transporter N-terminal domain. | Gorentla BK et al. | β | 2009 | β |
| Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. | Andersen J et al. | β | 2009 | β |
| Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. | Ghisi V et al. | β | 2009 | β |
| Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats. | Aragona BJ et al. | β | 2009 | β |
| Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function. | WallΓ©n-Mackenzie A et al. | β | 2009 | β |
| Short-term erythrosine B-induced inhibition of the brain regional serotonergic activity suppresses motor activity (exploratory behavior) of young adult mammals. | Dalal A et al. | β | 2009 | β |
| Stimulation of movement in a quiescent, hibernation-like form of Caenorhabditis elegans by dopamine signaling. | Gaglia MM et al. | β | 2009 | β |
| Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters. | Kharkar PS et al. | β | 2009 | β |
| The genetic basis of individual differences in reward processing and the link to addictive behavior and social cognition. | Yacubian J et al. | β | 2009 | β |
| The genetics of deliria. | Adamis D et al. | β | 2009 | β |
| Trace amine-associated receptors as emerging therapeutic targets. | Sotnikova TD et al. | β | 2009 | β |
| Trafficking of dopamine transporters in psychostimulant actions. | Zahniser NR et al. | β | 2009 | β |
| Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents. | Uchida N et al. | β | 2009 | β |
| A catechol-O-methyltransferase that is essential for auditory function in mice and humans. | Du X et al. | β | 2008 | β |
| A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder. | Genro JP et al. | β | 2008 | β |
| Activity-dependent regulation of the dopamine transporter is mediated by Ca(2+)/calmodulin-dependent protein kinase signaling. | Padmanabhan S et al. | β | 2008 | β |
| Alteration of dopamine uptake into rat striatal vesicles and synaptosomes caused by an in vitro exposure to atrazine and some of its metabolites. | Hossain MM et al. | β | 2008 | β |
| Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. | Perona MT et al. | β | 2008 | β |
| An (n-3) polyunsaturated fatty acid-deficient diet disturbs daily locomotor activity, melatonin rhythm, and striatal dopamine in Syrian hamsters. | Lavialle M et al. | β | 2008 | β |
| Anomalous dopamine release associated with a human dopamine transporter coding variant. | Mazei-Robison MS et al. | β | 2008 | β |
| Antioxidant enzyme activities following acute or chronic methylphenidate treatment in young rats. | Gomes KM et al. | β | 2008 | β |
| Approach to the genetics of alcoholism: a review based on pathophysiology. | KΓΆhnke MD | β | 2008 | β |
| A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD. | Rommelse NN et al. | β | 2008 | β |
| Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice. | Powell SB et al. | β | 2008 | β |
| Behavioral effects of amphetamine in streptozotocin-treated rats. | Sevak RJ et al. | β | 2008 | β |
| Behavioral genetic contributions to the study of addiction-related amphetamine effects. | Phillips TJ et al. | β | 2008 | β |
| Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. | Xie Z et al. | β | 2008 | β |
| Blockade of group II metabotropic glutamate receptors produces hyper-locomotion in cocaine pre-exposed rats by interactions with dopamine receptors. | Yoon HS et al. | β | 2008 | β |
| Bupropion hydrochloride versus placebo, in combination with cognitive behavioral therapy, for the treatment of cocaine abuse/dependence. | Shoptaw S et al. | β | 2008 | β |
| Case-control and within-family tests for an association between conduct disorder and DAT1. | Schulz-Heik RJ et al. | β | 2008 | β |
| Clinical utility of monoamine neurotransmitter metabolite analysis in cerebrospinal fluid. | Hyland K | β | 2008 | β |
| Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association. | Xie Z et al. | β | 2008 | β |
| Contributions of dopamine D1, D2, and D3 receptor subtypes to the disruptive effects of cocaine on prepulse inhibition in mice. | Doherty JM et al. | β | 2008 | β |
| Correlation of axon size and myelin occupancy in rats prenatally exposed to methamphetamine. | Melo P et al. | β | 2008 | β |
| DARPP-32 and NCS-1 expression is not altered in brains of rats treated with typical or atypical antipsychotics. | Souza BR et al. | β | 2008 | β |
| Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule. | Gelegen C et al. | β | 2008 | β |
| Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome. | Marques Pereira P et al. | β | 2008 | β |
| Dopamine spillover after quantal release: rethinking dopamine transmission in the nigrostriatal pathway. | Rice ME et al. | β | 2008 | β |
| Dopamine transporter comparative molecular modeling and binding site prediction using the LeuT(Aa) leucine transporter as a template. | Indarte M et al. | β | 2008 | β |
| Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization. | Boudanova E et al. | β | 2008 | β |
| Dopamine transporter mutant mice in experimental neuropharmacology. | Gainetdinov RR | β | 2008 | β |
| Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. | Carvelli L et al. | β | 2008 | β |
| Drugs of abuse and the aging brain. | Dowling GJ et al. | β | 2008 | β |
| Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats. | Sevak RJ et al. | β | 2008 | β |
| Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. | Mishra M et al. | β | 2008 | β |
| Gene by social context interactions for number of sexual partners among white male youths: genetics-informed sociology. | Guo G et al. | β | 2008 | β |
| Genetics of attention deficit hyperactivity disorder. | Mick E et al. | β | 2008 | β |
| Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. | Engblom D et al. | β | 2008 | β |
| Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. | Salahpour A et al. | β | 2008 | β |
| Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. | Senior SL et al. | β | 2008 | β |
| Increase in free choice oral ethanol self-administration in catechol-o-methyltransferase gene-disrupted male mice. | TammimΓ€ki A et al. | β | 2008 | β |
| Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties. | Schmitt KC et al. | β | 2008 | β |
| Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites. | Parnas ML et al. | β | 2008 | β |
| Methylphenidate and nicotine focus responding to an informative discrete CS over successive sessions of appetitive conditioning. | Cassaday HJ et al. | β | 2008 | β |
| Microdialysis of GABA and glutamate: analysis, interpretation and comparison with microsensors. | van der Zeyden M et al. | β | 2008 | β |
| Microtubule-associated STOP protein deletion triggers restricted changes in dopaminergic neurotransmission. | Bouvrais-Veret C et al. | β | 2008 | β |
| Molecular genetics of monoamine transporters: relevance to brain disorders. | Haddley K et al. | β | 2008 | β |
| Monitoring rapid chemical communication in the brain. | Robinson DL et al. | β | 2008 | β |
| Motor alterations are reduced in mice lacking the PARK2 gene in the presence of a human FTDP-17 mutant form of four-repeat tau. | Navarro P et al. | β | 2008 | β |
| Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. | Volkow ND et al. | β | 2008 | β |
| [Pathophysiology of Huntington's disease: an update]. | Roze E et al. | β | 2008 | β |
| Phorbol ester induced trafficking-independent regulation and enhanced phosphorylation of the dopamine transporter associated with membrane rafts and cholesterol. | Foster JD et al. | β | 2008 | β |
| PI3K signaling supports amphetamine-induced dopamine efflux. | Lute BJ et al. | β | 2008 | β |
| Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders. | Lafuente A et al. | β | 2008 | β |
| Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events. | Aragona BJ et al. | β | 2008 | β |
| Reduced tumor growth in a mouse model of schizophrenia, lacking the dopamine transporter. | Asada M et al. | β | 2008 | β |
| Regional adaptations in PSD-95, NGFI-A and secretogranin gene transcripts related to vulnerability to behavioral sensitization to amphetamine in the Roman rat strains. | Guitart-Masip M et al. | β | 2008 | β |
| Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy. | GarcΓa Navia JT et al. | β | 2008 | β |
| Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. | Loland CJ et al. | β | 2008 | β |
| Review: Genetics of attention deficit/hyperactivity disorder. | Wallis D et al. | β | 2008 | β |
| Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. | Zhu J et al. | β | 2008 | β |
| Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. | Fukakusa A et al. | β | 2008 | β |
| Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice. | Ji J et al. | β | 2008 | β |
| Sodium-coupled neurotransmitter transporters. | Kanner BI et al. | β | 2008 | β |
| The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence. | Le Strat Y et al. | β | 2008 | β |
| The binding sites for cocaine and dopamine in the dopamine transporter overlap. | Beuming T et al. | β | 2008 | β |
| The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice. | Thanos PK et al. | β | 2008 | β |
| The effects of methylphenidate on knockin mice with a methylphenidate-resistant dopamine transporter. | Tilley MR et al. | β | 2008 | β |
| Trace amine associated receptor 1 and movement control. | Sotnikova TD et al. | β | 2008 | β |
| Truncation of human dopamine transporter by protease calpain. | Franekova V et al. | β | 2008 | β |
| Adderall produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers. | Joyce BM et al. | β | 2007 | β |
| Adult mice with reduced Nurr1 expression: an animal model for schizophrenia. | Rojas P et al. | β | 2007 | β |
| Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice. | Wu N et al. | β | 2007 | β |
| A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder. | Yang B et al. | β | 2007 | β |
| A murine model of hyperdopaminergic state displays altered respiratory control. | Vincent SG et al. | β | 2007 | β |
| Animal models concerning the role of dopamine in attention-deficit hyperactivity disorder. | van der Kooij MA et al. | β | 2007 | β |
| An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha protects against methamphetamine-induced rewarding effects and sensitization. | Niwa M et al. | β | 2007 | β |
| An open-label pilot study of risperidone in the treatment of methamphetamine dependence. | Meredith CW et al. | β | 2007 | β |
| A novel molecule "shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference. | Niwa M et al. | β | 2007 | β |
| A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. | Fox MA et al. | β | 2007 | β |
| A preliminary study of dopamine transporter binding in bipolar and unipolar depressed patients and healthy controls. | Amsterdam JD et al. | β | 2007 | β |
| Association and linkage of allelic variants of the dopamine transporter gene in ADHD. | Friedel S et al. | β | 2007 | β |
| Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder. | Dorval KM et al. | β | 2007 | β |
| Brain metabolic changes following 4-week citalopram infusion: increased 18FDG uptake and gamma-amino butyric acid levels. | Marsteller DA et al. | β | 2007 | β |
| Canadian Association of Neurosciences Review: the role of dopamine receptor function in neurodegenerative diseases. | Lebel M et al. | β | 2007 | β |
| CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum. | Price DA et al. | β | 2007 | β |
| Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat. | LΓ³pez-Gil X et al. | β | 2007 | β |
| Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression. | Tilley MR et al. | β | 2007 | β |
| Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults. | Guo G et al. | β | 2007 | β |
| D2-like dopamine receptors mediate the response to amphetamine in a mouse model of ADHD. | Fan X et al. | β | 2007 | β |
| DAT1 3'-UTR 9R allele: preferential transmission in Indian children with attention deficit hyperactivity disorder. | Das M et al. | β | 2007 | β |
| Dopaminergic modulation of short-term synaptic plasticity at striatal inhibitory synapses. | Tecuapetla F et al. | β | 2007 | β |
| Dopamine transporter binding in smokers and nonsmokers. | Newberg A et al. | β | 2007 | β |
| Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor. | Lee FJ et al. | β | 2007 | β |
| Dopamine transporter density may be associated with the depressed affect in healthy subjects. | Newberg A et al. | β | 2007 | β |
| Dopamine transporter, gender, and number of sexual partners among young adults. | Guo G et al. | β | 2007 | β |
| Drosophila ebony activity is required in glia for the circadian regulation of locomotor activity. | Suh J et al. | β | 2007 | β |
| Emerging use of non-viral RNA interference in the brain. | Cryan JF et al. | β | 2007 | β |
| Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population. | Qian Q et al. | β | 2007 | β |
| Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample. | Heiser P et al. | β | 2007 | β |
| Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter. | Ukairo OT et al. | β | 2007 | β |
| Functional alterations of nicotinic neurotransmission in dopamine transporter knock-out mice. | Weiss S et al. | β | 2007 | β |
| Gene-environment interactions in addictive disorders: epidemiological and methodological aspects. | Gorwood P et al. | β | 2007 | β |
| Genetic deletion of vesicular monoamine transporter-2 (VMAT2) reduces dopamine transporter activity in mesencephalic neurons in primary culture. | Yamamoto H et al. | β | 2007 | β |
| Genetics of dopamine and its contribution to cocaine addiction. | Haile CN et al. | β | 2007 | β |
| Hyperactivity and alteration of the midbrain dopaminergic system in maternally stressed male mice offspring. | Son GH et al. | β | 2007 | β |
| Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. | Williams JM et al. | β | 2007 | β |
| Increased dopamine D2High receptors in knockouts of the dopamine transporter and the vesicular monoamine transporter may contribute to spontaneous hyperactivity and dopamine supersensitivity. | Seeman P et al. | β | 2007 | β |
| Intake of fermented soybean (natto) increased locomotor activity in mice. | Mamiya T et al. | β | 2007 | β |
| Lesions of the medial prefrontal cortex prevent the induction but not expression of morphine-induced behavioral sensitization in mice. | Hao Y et al. | β | 2007 | β |
| Lesions of the nucleus accumbens shell can reduce activity in the elevated plus-maze. | Horsley RR et al. | β | 2007 | β |
| Mechanism of chloride interaction with neurotransmitter:sodium symporters. | Zomot E et al. | β | 2007 | β |
| Mesencephalic neurodegeneration in the orally administered bisphenol A-caused hyperactive rats. | Ishido M et al. | β | 2007 | β |
| Methamphetamine-induced locomotor activity and sensitization in dopamine transporter and vesicular monoamine transporter 2 double mutant mice. | Fukushima S et al. | β | 2007 | β |
| Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression. | Kishida I et al. | β | 2007 | β |
| Neurocognitive effects of methamphetamine: a critical review and meta-analysis. | Scott JC et al. | β | 2007 | β |
| New 2alpha-tropane amides as potential PET ligands for the dopamine transporter. | Drewes B et al. | β | 2007 | β |
| Nicotine improves cognitive deficits of dopamine transporter knockout mice without long-term tolerance. | Weiss S et al. | β | 2007 | β |
| Parallel loss of hippocampal LTD and cognitive flexibility in a genetic model of hyperdopaminergia. | Morice E et al. | β | 2007 | β |
| Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum. | Kitaoka S et al. | β | 2007 | β |
| Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice. | Hao Y et al. | β | 2007 | β |
| Quantitative changes in Galphaolf protein levels, but not D1 receptor, alter specifically acute responses to psychostimulants. | Corvol JC et al. | β | 2007 | β |
| Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. | Beaulieu JM et al. | β | 2007 | β |
| Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post-mortem midbrain tissue. | Brookes KJ et al. | β | 2007 | β |
| Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol. | Nagai T et al. | β | 2007 | β |
| Rodent models: utility for candidate gene studies in human attention-deficit hyperactivity disorder (ADHD). | Mill J | β | 2007 | β |
| Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury. | Wagner AK et al. | β | 2007 | β |
| Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice. | Barbier E et al. | β | 2007 | β |
| Sustained increase of alpha7 nicotinic receptors and choline-induced improvement of learning deficit in STOP knock-out mice. | Bouvrais-Veret C et al. | β | 2007 | β |
| The involvement of dopamine in the modulation of sleep and waking. | Monti JM et al. | β | 2007 | β |
| The neurotransmitter cycle and quantal size. | Edwards RH | β | 2007 | β |
| Trace amine-associated receptor 1-Family archetype or iconoclast? | Grandy DK | β | 2007 | β |
| Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors. | Apud JA et al. | β | 2007 | β |
| Tumor necrosis factor-alpha and its inducer inhibit morphine-induced rewarding effects and sensitization. | Niwa M et al. | β | 2007 | β |
| Vigorous motor activity in Caenorhabditis elegans requires efficient clearance of dopamine mediated by synaptic localization of the dopamine transporter DAT-1. | McDonald PW et al. | β | 2007 | β |
| Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. | John CE et al. | β | 2007 | β |
| What do we know about the serotonergic genetic heterogeneity in attention-deficit/hyperactivity and autistic disorders? | Sinzig J et al. | β | 2007 | β |
| Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains. | Yang PB et al. | β | 2006 | β |
| A genetic association study of dopamine metabolism-related genes and chronic headache with drug abuse. | Cevoli S et al. | β | 2006 | β |
| Alcohol, neurotransmitter systems, and behavior. | Chastain G | β | 2006 | β |
| DDD mice, a novel acute mouse model of Parkinson's disease. | Sotnikova TD et al. | β | 2006 | β |
| Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin. | Cyr M et al. | β | 2006 | β |
| Dopamine: from pharmacology to molecular biology and back. | Caron MG et al. | β | 2006 | β |
| [Genetic findings in Attention-Deficit and Hyperactivity Disorder (ADHD)]. | Schimmelmann BG et al. | β | 2006 | β |
| Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system. | Fuke S et al. | β | 2006 | β |
| Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission. | Kobayashi K et al. | β | 2006 | β |
| Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation. | Kaga Y et al. | β | 2006 | β |
| Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions. | Kitanaka J et al. | β | 2006 | β |
| Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. | Beaulieu JM et al. | β | 2006 | β |
| Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice. | Ehrman LA et al. | β | 2006 | β |
| Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. | Costa RM et al. | β | 2006 | β |
| RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. | Jain S et al. | β | 2006 | β |
| The endocannabinoid system as an emerging target of pharmacotherapy. | Pacher P et al. | β | 2006 | β |