Issues in genetic testing for susceptibility to alcoholism: lessons from Alzheimer's disease and Huntington's disease.
- Authors
- Quaid, K A; Dinwiddie, H; Conneally, P M; Nurnberger, J I
- Year
- 1996
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 8947321
- DOI
- 10.1111/j.1530-0277.1996.tb01145.x
Evidence from family, twin, and adoption studies suggest a heritable basis for alcoholism. However, alcoholism is likely to be genetically heterogeneous, and any genetic connection is likely to be in the form of genes conferring an increased risk or susceptibility. In this study, we present the evidence for a genetic component for alcoholism, and examine the precedent for genetic testing and screening for genetic susceptibility using Huntington's disease and Alzheimer's disease as examples. Finally, we discuss the preparations that need to be made before taking any findings about the genetics of alcoholism from the research laboratory into the clinic.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
No papers in this knowledge base cite this source.
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Moderate Alcohol Drinking and the Amygdala Proteome: Identification and Validation of Calcium/Calmodulin Dependent Kinase II and AMPA Receptor Activity as Novel Molecular Mechanisms of the Positive Reinforcing Effects of Alcohol. | Salling MC et al. | — | 2016 | → |
| Perceptions about genetic testing for the susceptibility to alcohol dependence and other multifactorial diseases. | Marshall VJ et al. | — | 2012 | → |
| Perspectives on medical research involving men in schizophrenia and HIV-related protocols. | Roberts LW et al. | — | 2006 | → |
| Ethical issues in the use of genetic information. | Dinwiddie SH et al. | — | 2004 | → |
| Genes and geneticization? The social construction of autosomal dominant polycystic kidney disease. | Cox SM et al. | — | 2004 | → |
| Genetic and environmental contributions to age of onset of alcohol dependence symptoms in male twins. | Liu IC et al. | — | 2004 | → |
| Genetics and drug use as a complex phenotype. | Lessov CN et al. | — | 2004 | → |
| The policy and ethical implications of genetic research on attention deficit hyperactivity disorder. | Yeh M et al. | — | 2004 | → |
| Aggressiveness, family history of alcoholism, and the heart rate response to alcohol intoxication. | Assaad JM et al. | — | 2003 | → |
| Conducting research related to treatment of Alzheimer's disease. Ethical issues. | Sevick MA et al. | — | 2003 | → |
| Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation. | Swan GE et al. | — | 2003 | → |