ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.
paper
Cited
Public
Unavailable
- Authors
- Luo, Xingguang; Kranzler, Henry R; Zuo, Lingjun; Lappalainen, Jaakko; Yang, Bao-zhu; Gelernter, Joel
- Year
- 2006
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 16237392
- DOI
- 10.1038/sj.npp.1300925
The alcohol dehydrogenase (ADH) family constitutes one of the key sets of enzymes responsible for the oxidation of alcohol. The ADH4 gene, an important member of this family, is a functional and positional candidate for alcohol dependence. The present study aimed to investigate the relationship between ADH4 gene variation and alcohol dependence and drug dependence in European-Americans (EAs) and African-Americans (AAs). Seven single nucleotide polymorphisms (SNPs) spanning the ADH4 gene were genotyped in 365 healthy controls (317 EAs and 48 AAs) and 561 subjects (400 EAs and 161 AAs) affected with alcohol dependence and/or drug dependence (436 with alcohol dependence; 356 with drug dependence). Hardy-Weinberg equilibrium (HWE) for the genotype frequency distributions of these markers was tested in all phenotype groups to evaluate association between ADH4 gene variation and phenotypes and to fine-map the disease risk locus. The allele, genotype, and haplotype frequency distributions of these markers were compared between cases and controls to confirm the associations. The genotype frequency distributions of ADH4 markers were in HWE in EA controls, but were in Hardy-Weinberg disequilibrium (HWD) (ie, deviation from HWE) in EA cases. Among all markers, SNP2 (rs1042363) at exon 9 or SNP6 (rs1800759) at the promoter showed the greatest degree of HWD, among patients with either alcohol dependence or drug dependence. Significant differences between EA cases and controls were seen for genotype (10(-6)<global p<0.044), but not any allele or haplotype, frequency distributions for all seven ADH4 markers. These findings suggest that ADH4 genotypes predispose to alcohol dependence and drug dependence in a recessive manner, a predisposition that is population specific. SNP2 or SNP6 was the marker genetically closest to the functional risk loci for both alcohol dependence and drug dependence.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| SNP rs1801260 at the 3'UTR miRNA binding region of <i>Clock</i> gene is a risk factor of alcohol addiction: A case-control study in East Indian population. | Maji D et al. | β | 2026 | β |
| Gene-based Hardy-Weinberg equilibrium test using genotype count data: application to six types of cancers. | Nishino J et al. | β | 2025 | β |
| Investigation of mitochondrial DNA methylation-related prognostic biomarkers in hepatocellular carcinoma using The Cancer Genome Atlas (TCGA) database. | Shi S et al. | β | 2025 | β |
| ADH4-a potential prognostic marker for hepatocellular carcinoma with possible immune-related implications. | Li L et al. | β | 2024 | β |
| ADH4βa potential prognostic marker for hepatocellular carcinoma with possible immune-related implications | ζ η² et al. | β | 2024 | β |
| Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis. | Tong A et al. | β | 2024 | β |
| Proteomic and Metabolomic Signatures of Diet Quality in Young Adults. | Costello E et al. | β | 2024 | β |
| No significant association between SNPs in the CLOCK and ADH4 genes and susceptibility to cluster headaches: A systematic review and meta-analysis. | Cui J et al. | β | 2022 | β |
| Whole-Exome Sequencing Reveals Migraine-Associated Novel Functional Variants in Arab Ancestry Females: A Pilot Study. | Khan J et al. | β | 2022 | β |
| Characterization of Hepatitis B Virus Integrations Identified in Hepatocellular Carcinoma Genomes. | Mathkar PP et al. | β | 2021 | β |
| Transcriptional regulation of alcohol induced liver fibrosis in a translational porcine hepatocellular carcinoma model. | Yasmin A et al. | β | 2021 | β |
| Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population. | Papasavva M et al. | β | 2020 | β |
| Association between polygenic risk for tobacco or alcohol consumption and liability to licit and illicit substance use in young Australian adults. | Chang LH et al. | β | 2019 | β |
| Genetics of cluster headache. | Gibson KF et al. | β | 2019 | β |
| Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20Β 328 research participants of European ancestry. | Sanchez-Roige S et al. | β | 2019 | β |
| Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review. | Edenberg HJ et al. | β | 2018 | β |
| Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation Γ Preventive intervention. | Cleveland HH et al. | β | 2018 | β |
| Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues. | Lussier AA et al. | β | 2018 | β |
| Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. | Obed A et al. | β | 2018 | β |
| Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. | Peng Q et al. | β | 2017 | β |
| Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. | Katsarou MS et al. | β | 2017 | β |
| Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. | Chartier KG et al. | β | 2016 | β |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | BΓΌhler KM et al. | β | 2015 | β |
| The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores. | Mbarek H et al. | β | 2015 | β |
| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | β | 2014 | β |
| Genetics of alcoholism. | Edenberg HJ et al. | β | 2014 | β |
| Use of diplotypes - matched haplotype pairs from homologous chromosomes - in gene-disease association studies. | Zuo L et al. | β | 2014 | β |
| Case-control association testing of common variants from sequencing of DNA pools. | McRae AF et al. | β | 2013 | β |
| Genetic instrumental variable studies of effects of prenatal risk factors. | Wehby GL et al. | β | 2013 | β |
| NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. | Zuo L et al. | β | 2013 | β |
| ADH4 intronic variations are associated with alcohol dependence: results from an Italian case-control association study. | Turchi C et al. | β | 2012 | β |
| Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances. | Yang BZ et al. | β | 2012 | β |
| HTR2A gene polymorphisms and Inward and Outward Personal Meaning Organisations. | Nardi B et al. | β | 2012 | β |
| Identification of ADH4 as a novel and potential prognostic marker in hepatocellular carcinoma. | Wei RR et al. | β | 2012 | β |
| Identifying genetic variation for alcohol dependence. | Agrawal A et al. | β | 2012 | β |
| Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood. | van Beek JH et al. | β | 2012 | β |
| Zebrafish: a model for the study of addiction genetics. | Klee EW et al. | β | 2012 | β |
| A candidate gene association study of alcohol consumption in young women. | Agrawal A et al. | β | 2011 | β |
| An overview of the genetic susceptibility to alcoholism. | Buscemi L et al. | β | 2011 | β |
| Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. | Preuss UW et al. | β | 2011 | β |
| Fine mapping quantitative trait loci that influence alcohol preference behavior in the High and Low Alcohol Preferring (HAP and LAP) mice. | Bice PJ et al. | β | 2011 | β |
| Genetics of alcohol dependence. | Kimura M et al. | β | 2011 | β |
| Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. | Liu J et al. | β | 2011 | β |
| Associations between ADH gene variants and alcohol phenotypes in Dutch adults. | van Beek JH et al. | β | 2010 | β |
| Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene. | Rainero I et al. | β | 2010 | β |
| GABRA2 and alcohol use disorders: no evidence of an association in an Italian case-control study. | Onori N et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | β | 2010 | β |
| H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. | Nelson EC et al. | β | 2010 | β |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | β | 2010 | β |
| A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women. | Zuccolo L et al. | β | 2009 | β |
| Association of a polymorphism in the intron 7 of the SREBF1 gene with osteonecrosis of the femoral head in Koreans. | Lee HJ et al. | β | 2009 | β |
| Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. | Sherva R et al. | β | 2009 | β |
| Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S et al. | β | 2009 | β |
| Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. | Gelernter J et al. | β | 2009 | β |
| Genetics of alcohol dependence. | Gelernter J et al. | β | 2009 | β |
| Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study. | Anand SS et al. | β | 2009 | β |
| Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice. | Bice P et al. | β | 2009 | β |
| Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. | Zuo L et al. | β | 2009 | β |
| Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects. | Kimura Y et al. | β | 2009 | β |
| ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. | Luo X et al. | β | 2008 | β |
| Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. | Kuo PH et al. | β | 2008 | β |
| Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response. | Souza RP et al. | β | 2008 | β |
| Hardy-Weinberg analysis of a large set of published association studies reveals genotyping error and a deficit of heterozygotes across multiple loci. | Sen S et al. | β | 2008 | β |
| Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test. | Luo X et al. | β | 2008 | β |
| Regulatory polymorphisms and their contribution to interindividual differences in the expression of enzymes influencing drug and toxicant disposition. | Hines RN et al. | β | 2008 | β |
| Substance dependence low-density whole genome association study in two distinct American populations. | Yu Y et al. | β | 2008 | β |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | β | 2008 | β |
| A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin. | Kapur S et al. | β | 2007 | β |
| CNR1 variation modulates risk for drug and alcohol dependence. | Zuo L et al. | β | 2007 | β |
| Common polymorphisms in the CACNA1H gene associated with childhood absence epilepsy in Chinese Han population. | Liang J et al. | β | 2007 | β |
| Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. | Luo X et al. | β | 2007 | β |
| Personality traits of agreeableness and extraversion are associated with ADH4 variation. | Luo X et al. | β | 2007 | β |
| The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. | Edenberg HJ | β | 2007 | β |
| Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. | Zhang H et al. | β | 2006 | β |
| Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. | Luo X et al. | β | 2006 | β |
| Genomewide linkage scan for opioid dependence and related traits. | Gelernter J et al. | β | 2006 | β |
| Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. | Drgon T et al. | β | 2006 | β |
| The genetics of alcohol dependence. | Dick DM et al. | β | 2006 | β |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | β | 2006 | β |