Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference.
paper
Cited
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- Authors
- Hwang, B H; Zhang, J K; Ehlers, C L; Lumeng, L; Li, T K
- Year
- 1999
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 10397286
BACKGROUND: Neuropeptide Y (NPY) is a neuropeptide that has been demonstrated to produce anxiolytic effects when administered centrally. To examine the hypothesis that NPY might play a role in alcohol-seeking behavior, this study took advantage of the genetic differences of the alcohol-preferring (P) rats and alcohol-nonpreferring (NP) rats, as well as the high alcohol-drinking (HAD) rats and low alcohol-drinking (LAD) rats, in voluntary alcohol consumption to examine if NPY neurons in the brains differ between these selected lines. METHODS: The NPY immunoreactivity (NPY-I) was measured using an established radioimmunohistochemical assay in discrete brain structures including the paraventricular hypothalamic nucleus (PVN), arcuate nucleus (ARC), and central nucleus of the amygdala (CeA). RESULTS: The quantitative data indicated that there was more NPY-I in the PVN and ARC of P rats than NP rats, whereas there was less NPY-I in the PVN and ARC of HAD rats than LAD rats. However, the NPY-I in the CeA was less in both the P and HAD rats than in the NP and LAD rats, respectively. Therefore, the data indicate that there are innate differences in the NPY-I in the brain between selectively bred rats with high and low alcohol preference. CONCLUSION: Because both P rats and HAD rats have high alcohol preference, the disparate finding between these two lines of rats suggests that the hypothalamic NPY neurons are probably not associated with alcohol preference. In contrast, consistent findings in the CeA of both P rats and HAD rats suggest that NPY in the CeA of P and HAD rats may contribute to the regulation of alcohol consumption. This is substantiated by a recent report showing that NPY-knockout mice drink significantly more ethanol, and transgenic mice that overexpress the NPY gene drink less alcohol, than wild-type mice. Together, the findings support the notion that NPY agonists that would enhance NPY function in the amygdala might be useful for the treatment of anxiety and alcoholism.
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|---|---|---|---|---|
| Synaptic Effects Induced by Alcohol. | Lovinger DM et al. | — | 2025 | → |
| Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption. | Robinson SL et al. | — | 2024 | → |
| Artificial Intelligence Identified Resilient and Vulnerable Female Rats After Traumatic Stress and Ethanol Exposure: Investigation of Neuropeptide Y Pathway Regulation. | Denny RR et al. | — | 2021 | → |
| Time Course of Blood and Brain Cytokine/Chemokine Levels Following Adolescent Alcohol Exposure and Withdrawal in Rats. | Sanchez-Alavez M et al. | — | 2019 | → |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | — | 2018 | → |
| The intersection of stress and reward: BNST modulation of aversive and appetitive states. | Ch'ng S et al. | — | 2018 | → |
| Neuropeptide Y in Alcohol Addiction and Affective Disorders. | Thorsell A et al. | — | 2017 | → |
| The Role of Neuropeptide Y (NPY) in Alcohol and Drug Abuse Disorders. | Robinson SL et al. | — | 2017 | → |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | — | 2016 | → |
| Hypothalamic neuropeptide signaling in alcohol addiction. | Barson JR et al. | — | 2016 | → |
| Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication. | Barkley-Levenson AM et al. | — | 2016 | → |
| Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. | Sakharkar AJ et al. | — | 2014 | → |
| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | — | 2014 | → |
| Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. | Vadnie CA et al. | — | 2014 | → |
| Involvement of amygdaloid neuropeptide Y in the anxiolytic effects of acupuncture during ethanol withdrawal in rats. | Zhao Z et al. | — | 2014 | → |
| Comparative distribution of central neuropeptide Y (NPY) in the prairie (Microtus ochrogaster) and meadow (M. pennsylvanicus) vole. | Hostetler CM et al. | — | 2013 | → |
| Synaptic effects induced by alcohol. | Lovinger DM et al. | — | 2013 | → |
| Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. | Bell RL et al. | — | 2012 | → |
| Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use. | Barson JR et al. | — | 2012 | → |
| Neuropeptide Y (NPY) in the extended amygdala is recruited during the transition to alcohol dependence. | Gilpin NW | — | 2012 | → |
| Treatment of alcohol dependence with drug antagonists of the stress response. | Higley AE et al. | — | 2012 | → |
| Neuropeptide Y (NPY)-induced reductions in alcohol intake during continuous access and following alcohol deprivation are not altered by restraint stress in alcohol-preferring (P) rats. | Bertholomey ML et al. | — | 2011 | → |
| Regulation of drug and palatable food overconsumption by similar peptide systems. | Morganstern I et al. | — | 2011 | → |
| Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin. | Leggio L et al. | — | 2011 | → |
| Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats. | Zhang H et al. | — | 2010 | → |
| Neuroscience of alcoholism: molecular and cellular mechanisms. | Moonat S et al. | — | 2010 | → |
| Predictors of ethanol consumption in adult Sprague-Dawley rats: relation to hypothalamic peptides that stimulate ethanol intake. | Karatayev O et al. | — | 2010 | → |
| From QTL to candidate gene: a genetic approach to alcoholism research. | Spence JP et al. | — | 2009 | → |
| Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample. | Zill P et al. | — | 2008 | → |
| Approach to the genetics of alcoholism: a review based on pathophysiology. | Köhnke MD | — | 2008 | → |
| Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intake. | Thorsell A | — | 2008 | → |
| Innate differences in the expression of brain-derived neurotrophic factor in the regions within the extended amygdala between alcohol preferring and nonpreferring rats. | Prakash A et al. | — | 2008 | → |
| Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice. | Eva C et al. | — | 2008 | → |
| Neurobiology of addiction. An integrative review. | Goodman A | — | 2008 | → |
| Neuropeptide Y administration into the amygdala suppresses ethanol drinking in alcohol-preferring (P) rats following multiple deprivations. | Gilpin NW et al. | — | 2008 | → |
| Neuropeptide Y modulation of ethanol intake: effects of ethanol drinking history and genetic background. | Badia-Elder NE et al. | — | 2007 | → |
| Neuropeptide Y (NPY) in alcohol intake and dependence. | Thorsell A | — | 2007 | → |
| Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. | Thorsell A et al. | — | 2007 | → |
| Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self-administration in "anxious" rats. | Primeaux SD et al. | — | 2006 | → |
| Physiology and gene regulation of the brain NPY Y1 receptor. | Eva C et al. | — | 2006 | → |
| The alcohol-preferring P rat and animal models of excessive alcohol drinking. | Bell RL et al. | — | 2006 | → |
| The decreased cyclic-AMP dependent-protein kinase A function in the nucleus accumbens: a role in alcohol drinking but not in anxiety-like behaviors in rats. | Misra K et al. | — | 2006 | → |
| Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains. | Hayes DM et al. | — | 2005 | → |
| CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction. | Pandey SC et al. | — | 2005 | → |
| Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. | Pandey SC et al. | — | 2005 | → |
| Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. | Spence JP et al. | — | 2005 | → |
| Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: interaction with chronic ethanol exposure. | Thorsell A et al. | — | 2005 | → |
| Effects of neuropeptide Y on appetitive and consummatory behaviors associated with alcohol drinking in wistar rats with a history of ethanol exposure. | Thorsell A et al. | — | 2005 | → |
| Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. | Rimondini R et al. | — | 2005 | → |
| The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. | Schroeder JP et al. | — | 2005 | → |
| A role for neuropeptide Y in neurobiological responses to ethanol and drugs of abuse. | Thiele TE et al. | — | 2004 | → |
| Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout mice. | Thiele TE et al. | — | 2004 | → |
| Corticotropin-releasing factor gene expression is down-regulated in the central nucleus of the amygdala of alcohol-preferring rats which exhibit high anxiety: a comparison between rat lines selectively bred for high and low alcohol preference. | Hwang BH et al. | — | 2004 | → |
| Effect of neuropeptide Y microinjected into the hypothalamus on ethanol consumption. | Lucas LA et al. | — | 2004 | → |
| Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence. | Heilig M et al. | — | 2004 | → |
| High alcohol preferring (HAP) and low alcohol preferring (LAP) rats show altered proopiomelanocortin (POMC) messenger RNA expression in the arcuate nucleus. | Kinoshita H et al. | — | 2004 | → |
| Innate differences in neuropeptide Y (NPY) mRNA expression in discrete brain regions between alcohol-preferring (P) and -nonpreferring (NP) rats: a significantly low level of NPY mRNA in dentate gyrus of the hippocampus and absence of NPY mRNA in the medial habenular nucleus of P rats. | Hwang BH et al. | — | 2004 | → |
| Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. | Davies AG et al. | — | 2004 | → |
| Neuropeptides: implications for alcoholism. | Cowen MS et al. | — | 2004 | → |
| Neuropeptide Y in the paraventricular nucleus of the hypothalamus increases ethanol intake in high- and low-alcohol-drinking rats. | Gilpin NW et al. | — | 2004 | → |
| Overlapping and interactive pathways regulating appetite and craving. | Kalra SP et al. | — | 2004 | → |
| Overlapping peptide control of alcohol self-administration and feeding. | Thiele TE et al. | — | 2004 | → |
| Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors. | Pandey SC et al. | — | 2004 | → |
| Peripheral and central administration of a selective neuropeptide Y Y1 receptor antagonist suppresses ethanol intake by C57BL/6J mice. | Sparta DR et al. | — | 2004 | → |
| Reduced neuropeptide Y mRNA expression in the central nucleus of amygdala of alcohol preferring (P) rats: its potential involvement in alcohol preference and anxiety. | Suzuki R et al. | — | 2004 | → |
| The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. | Pandey SC | — | 2004 | → |
| Alcoholism: allostasis and beyond. | Koob GF | — | 2003 | → |
| Alcoholism and obesity: overlapping neuropeptide pathways? | Thiele TE et al. | — | 2003 | → |
| Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene. | Pandey SC | — | 2003 | → |
| A role for neuropeptide Y in alcohol intake control: evidence from human and animal research. | Thiele TE et al. | — | 2003 | → |
| Candidate genes for alcohol dependence: animal studies. | Schumann G et al. | — | 2003 | → |
| Central neuropeptide Y alters ethanol-induced sedation, but not ethanol intake, in C57BL/6 mice. | Thiele TE et al. | — | 2003 | → |
| Effects of neuropeptide Y on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. | Badia-Elder NE et al. | — | 2003 | → |
| Effects of PKA modulation on the expression of neuropeptide Y in rat amygdaloid structures during ethanol withdrawal. | Zhang H et al. | — | 2003 | → |
| Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. | Leibowitz SF et al. | — | 2003 | → |
| Genetics of behaviour: phenotypic and molecular study of rats derived from high- and low-alcohol consuming lines. | Terenina-Rigaldie E et al. | — | 2003 | → |
| Moderate doses of ethanol partially reverse avoidance learning deficits in high-alcohol-drinking rats. | Rorick LM et al. | — | 2003 | → |
| Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. | Pandey SC et al. | — | 2003 | → |
| Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence. | Gilpin NW et al. | — | 2003 | → |
| Neuropeptide-Y Y5 receptors modulate the onset and maintenance of operant ethanol self-administration. | Schroeder JP et al. | — | 2003 | → |
| Peptides: their role in excess alcohol drinking and their promise as a therapeutic tool. | Egli M | — | 2003 | → |
| The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in rats. | Pandey SC et al. | — | 2003 | → |
| Acute effect of ethanol on anxiety and 5-HT in the prefrontal cortex of rats. | Langen B et al. | — | 2002 | → |
| Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. | Thorsell A et al. | — | 2002 | → |
| Central nucleus of the amygdala and the effects of alcohol and alcohol-drinking behavior in rodents. | McBride WJ | — | 2002 | → |
| Chronic ingestion of ethanol or glucose solutions affects hypothalamic and limbic TRH metabolism in dams and their pups. | de Gortari P et al. | — | 2002 | → |
| Neuropeptide Y administration into the amygdala does not affect ethanol consumption. | Katner SN et al. | — | 2002 | → |
| Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. | Murphy JM et al. | — | 2002 | → |
| The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposure. | Roy A et al. | — | 2002 | → |
| The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. | Kask A et al. | — | 2002 | → |
| Ultrastructural localization of neuropeptide Y Y1 receptors in the rat medial nucleus tractus solitarius: relationships with neuropeptide Y or catecholamine neurons. | Glass MJ et al. | — | 2002 | → |
| Approaches to understanding the neurobiological regulation of ethanol self-administration: a young investigators forum. | Czachowski CL et al. | — | 2001 | → |
| Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. | Caberlotto L et al. | — | 2001 | → |
| Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. | Badia-Elder NE et al. | — | 2001 | → |
| Neuropeptide-Y in the paraventricular nucleus increases ethanol self-administration. | Kelley SP et al. | — | 2001 | → |
| No leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y in Japanese population or Japanese with alcoholism. | Drube J et al. | — | 2001 | → |
| Acoustic startle and fear-potentiated startle in alcohol-preferring (P) and -nonpreferring (NP) lines of rats. | Mckinzie DL et al. | — | 2000 | → |
| Acute ethanol administration induces changes in TRH and proenkephalin expression in hypothalamic and limbic regions of rat brain. | de Gortari P et al. | — | 2000 | → |
| Ethanol-induced c-fos expression in catecholamine- and neuropeptide Y-producing neurons in rat brainstem. | Thiele TE et al. | — | 2000 | → |
| Increases in sucrose consumption, but not ethanol consumption, following ICV NPY administration. | Slawecki CJ et al. | — | 2000 | → |
| Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor. | Thiele TE et al. | — | 2000 | → |
| Neurophysiological findings and drinking levels in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. | Slawecki CJ et al. | — | 2000 | → |