Meta-analysis of the heritability of human traits based on fifty years of twin studies.
- Authors
- Polderman, Tinca J C; Benyamin, Beben; de Leeuw, Christiaan A; Sullivan, Patrick F; van Bochoven, Arjen; Visscher, Peter M; Posthuma, Danielle
- Year
- 2015
- Journal
- Nature genetics
- PMID
- 25985137
- DOI
- 10.1038/ng.3285
Despite a century of research on complex traits in humans, the relative importance and specific nature of the influences of genes and environment on human traits remain controversial. We report a meta-analysis of twin correlations and reported variance components for 17,804 traits from 2,748 publications including 14,558,903 partly dependent twin pairs, virtually all published twin studies of complex traits. Estimates of heritability cluster strongly within functional domains, and across all traits the reported heritability is 49%. For a majority (69%) of traits, the observed twin correlations are consistent with a simple and parsimonious model where twin resemblance is solely due to additive genetic variation. The data are inconsistent with substantial influences from shared environment or non-additive genetic variation. This study provides the most comprehensive analysis of the causes of individual differences in human traits thus far and will guide future gene-mapping efforts. All the results can be visualized using the MaTCH webtool.
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| Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka. | Zavos HMS et al. | — | 2024 | → |
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| Genetic Associations With Acceleration, Change of Direction, Jump Height, and Speed in English Academy Football Players. | McAuley ABT et al. | — | 2024 | → |
| Genetic effects on variability in visual aesthetic evaluations are partially shared across visual domains. | Bignardi G et al. | — | 2024 | → |
| Genetic mechanisms underlying local spontaneous brain activity in episodic migraine. | Gui W et al. | — | 2024 | → |
| Genetic similarity between relatives provides evidence on the presence and history of assortative mating. | Sunde HF et al. | — | 2024 | → |
| Genetics of flight in spongy moths (Lymantria dispar ssp.): functionally integrated profiling of a complex invasive trait. | Blackburn GS et al. | — | 2024 | → |
| Genetics of migraine: complexity, implications, and potential clinical applications. | Sutherland HG et al. | — | 2024 | → |
| Genomic insights into the shared and distinct genetic architecture of cognitive function and schizophrenia. | Wootton O et al. | — | 2024 | → |
| Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs. | Haque MA et al. | — | 2024 | → |
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| High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage. | Lai Y et al. | — | 2024 | → |
| How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry. | Koch E et al. | — | 2024 | → |
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| Increased burden of rare protein-truncating variants in constrained, brain-specific and synaptic genes in extremely impulsively violent males with antisocial personality disorder. | Mušálková D et al. | — | 2024 | → |
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| MC4R Variants Modulate α-MSH and Setmelanotide Induced Cellular Signaling at Multiple Levels. | Rodríguez Rondón AV et al. | — | 2024 | → |
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| Two polygenic mouse models of major depressive disorders identify TMEM161B as a potential biomarker of disease in humans. | El Yacoubi M et al. | — | 2024 | → |
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| Zygosity Effects on Human Voice: Fundamental Frequency Analysis of Brazilian Twins' Speech. | Luchesi LC et al. | — | 2024 | → |
| 25 Years of translational research in the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC). | Bisgaard H et al. | — | 2023 | → |
| ABCD Behavior Genetics: Twin, Family, and Genomic Studies Using the Adolescent Brain Cognitive Development (ABCD) Study Dataset. | Wilson S et al. | — | 2023 | → |
| A comprehensive investigation into the genetic relationship between music engagement and mental health. | Wesseldijk LW et al. | — | 2023 | → |
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| A General Cognitive Ability Factor for the UK Biobank. | Williams CM et al. | — | 2023 | → |
| A genetically informed Registered Report on adverse childhood experiences and mental health. | Baldwin JR et al. | — | 2023 | → |
| A genome-wide cross-cancer meta-analysis highlights the shared genetic links of five solid cancers. | Guo H et al. | — | 2023 | → |
| A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores. | Kang M et al. | — | 2023 | → |
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| Attitudes towards genetic testing: The role of genetic literacy, motivated cognition, and socio-demographic characteristics. | Likhanov M et al. | — | 2023 | → |
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| Bidirectional Causal Associations Between Same-Sex Attraction and Psychological Distress: Testing Moderation and Mediation Effects. | Oginni OA et al. | — | 2023 | → |
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| Brain volumes, thicknesses, and surface areas as mediators of genetic factors and childhood adversity on intelligence. | Williams CM et al. | — | 2023 | → |
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| Burt uses a fallacious motte-and-bailey argument to dispute the value of genetics for social science. | Zietsch BP et al. | — | 2023 | → |
| Causal associations between COVID-19 and childhood mental disorders. | Chen F et al. | — | 2023 | → |
| Celebrating a Century of Research in Behavioral Genetics. | Plomin R | — | 2023 | → |
| Characterizing Alcohol Expectancies in the ABCD Study: Associations with Sociodemographic Factors, the Immediate Social Environment, and Genetic Propensities. | Johnson EC et al. | — | 2023 | → |
| Cohort profile: Genetic data in the German Socio-Economic Panel Innovation Sample (SOEP-G). | Koellinger PD et al. | — | 2023 | → |
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| Computational Modeling of the n-Back Task in the ABCD Study: Associations of Drift Diffusion Model Parameters to Polygenic Scores of Mental Disorders and Cardiometabolic Diseases. | Pedersen ML et al. | — | 2023 | → |
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| Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. | Axelrud LK et al. | — | 2023 | → |
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| Don't miss the chance to reap the fruits of recent advances in behavioral genetics. | Alexander N et al. | — | 2023 | → |
| Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance. | Lyu X et al. | — | 2023 | → |
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| Environmental susceptibility for all: A data-driven approach suggests individual differences in domain-general and domain-specific patterns of environmental susceptibility. | Markovitch N et al. | — | 2023 | → |
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| Evolutionary Psychology and Normal Science: in Search of a Unifying Research Program. | Egeland J | — | 2023 | → |
| Examining the shared etiology of psychopathology with genome-wide association studies. | Mallard TT et al. | — | 2023 | → |
| Exploring opportunities for drug repurposing and precision medicine in cannabis use disorder using genetics. | Greco LA et al. | — | 2023 | → |
| Exploring the differentiation of behavioural and emotional problems across childhood: A prospective longitudinal cohort study. | Askelund AD et al. | — | 2023 | → |
| Exploring the genetics of rhythmic perception and musical engagement in the Vanderbilt Online Musicality Study. | Gustavson DE et al. | — | 2023 | → |
| Exploring the mechanism of artificial selection signature in Chinese indigenous pigs by leveraging multiple bioinformatics database tools. | Feng X et al. | — | 2023 | → |
| Family study of the startle reflex and event-related potentials in anticipation of predictable and unpredictable threat in adolescents and their parents. | Ferry RA et al. | — | 2023 | → |
| Gender differences in the association of polygenic risk and divergent depression trajectories from mid to late life: a national longitudinal study. | Chen P et al. | — | 2023 | → |
| Gene-environment correlations and genetic confounding underlying the association between media use and mental health. | Ayorech Z et al. | — | 2023 | → |
| Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort. | Asefa NG et al. | — | 2023 | → |
| Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder. | Pan PY et al. | — | 2023 | → |
| Genetic and environmental links between executive functioning and effortful control in middle childhood. | Rea-Sandin G et al. | — | 2023 | → |
| Genetic and environmental sources of familial resemblance in anxiety: a nuclear twin family design. | Ding Q et al. | — | 2023 | → |
| Genetic and Environmental Variation in Continuous Phenotypes in the ABCD Study®. | Maes HHM et al. | — | 2023 | → |
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| Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank. | Peng H et al. | — | 2023 | → |
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| Association of Obsessive-Compulsive Disorder and Obsessive-Compulsive Symptoms With Substance Misuse in 2 Longitudinal Cohorts in Sweden. | Virtanen S et al. | — | 2022 | → |
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| Climate change, human health, and the exposome: Utilizing OMIC technologies to navigate an era of uncertainty. | Abdelzaher H et al. | — | 2022 | → |
| Clinical opportunity awaits at the intersection of genomics and brain imaging. | Makowski C et al. | — | 2022 | → |
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| Commentary: Will genomics revolutionise research on gene-environment interplay? | Plomin R et al. | — | 2022 | → |
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| Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders. | Cabana-Domínguez J et al. | — | 2022 | → |
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| Debate: Are cluster headache and migraine distinct headache disorders? | Al-Karagholi MA et al. | — | 2022 | → |
| Does better education mitigate risky health behavior? A mendelian randomization study. | Viinikainen J et al. | — | 2022 | → |
| Editorial: Genome-wide Association Studies of Internalizing Symptoms: A Big Step on a Long Road. | Coleman JRI | — | 2022 | → |
| Education as a moderator of middle-age cardiovascular risk factor-old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study. | Iso-Markku P et al. | — | 2022 | → |
| Elucidating the relationship between migraine risk and brain structure using genetic data. | Mitchell BL et al. | — | 2022 | → |
| Estimating heritability of height without zygosity information for twins under five years in low- and middle-income countries: An application of normal finite mixture distribution models. | Karlsson O et al. | — | 2022 | → |
| Estimating SNP heritability in presence of population substructure in biobank-scale datasets. | Lin Z et al. | — | 2022 | → |
| Evaluation of Existing Methods for High-Order Epistasis Detection. | Ponte-Fernandez C et al. | — | 2022 | → |
| Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia. | Palmer DS et al. | — | 2022 | → |
| Exposome and Trans-syndromal Developmental Trajectories Toward Psychosis. | Barzilay R et al. | — | 2022 | → |
| Familial load of psychiatric disorders and overall functioning in patients newly diagnosed with bipolar disorder and their unaffected first-degree relatives. | Sletved KSO et al. | — | 2022 | → |
| Familial resemblance, citizenship, and counterproductive work behavior: A combined twin, adoption, parent-offspring, and spouse approach. | Anderson EL et al. | — | 2022 | → |
| FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors. | Vereczkei A et al. | — | 2022 | → |
| From Genome-Wide to Environment-Wide: Capturing the Environome. | von Stumm S et al. | — | 2022 | → |
| From Genotype to Phenotype: Polygenic Prediction of Complex Human Traits. | Raben TG et al. | — | 2022 | → |
| From goodness to good looks: Changing images of human germline genetic modification. | So D | — | 2022 | → |
| From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill. | Charlesworth B et al. | — | 2022 | → |
| Gattaca as a lens on contemporary genetics: marking 25 years into the film's "not-too-distant" future. | Ogbunugafor CB et al. | — | 2022 | → |
| Gene-environment correlations across geographic regions affect genome-wide association studies. | Abdellaoui A et al. | — | 2022 | → |
| Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits. | Merino J et al. | — | 2022 | → |
| Genetic and Environmental Influences on Biological Essentialism, Heuristic Thinking, Need for Closure, and Conservative Values: Insights From a Survey and Twin Study. | Morosoli JJ et al. | — | 2022 | → |
| Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders. | Reay WR et al. | — | 2022 | → |
| Genetic factors and shared environment contribute equally to objective singing ability. | Yeom D et al. | — | 2022 | → |
| Genetic factors explain a significant part of associations between adolescent well-being and the social environment. | van de Weijer MP et al. | — | 2022 | → |
| Genetic heterogeneity and subtypes of major depression. | Nguyen TD et al. | — | 2022 | → |
| Genetic Relationships between Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Intelligence. | Rao S et al. | — | 2022 | → |
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| Genetics of psychic ability - A pilot case-control exome sequencing study. | Wahbeh H et al. | — | 2022 | → |
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| Genome-wide association analyses of common infections in a large practice-based biobank. | Jiang L et al. | — | 2022 | → |
| Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms. | Jami ES et al. | — | 2022 | → |
| Gut microbial similarity in twins is driven by shared environment and aging. | Vilchez-Vargas R et al. | — | 2022 | → |
| Heritability of Bullying and Victimization in Children and Adolescents: Moderation by the KiVa Antibullying Program. | Johansson A et al. | — | 2022 | → |
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| Integrating the study of personality and psychopathology in the context of gene-environment correlations across development. | Perlstein S et al. | — | 2022 | → |
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| Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome. | Liu X et al. | — | 2022 | → |
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| Molecular Gatekeeper Discovery: Workflow for Linking Multiple Exposure Biomarkers to Metabolomics. | Yu M et al. | — | 2022 | → |
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| No effects of siblings and twin testosterone transfer on autistic traits. | de Wit MM et al. | — | 2022 | → |
| Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity? | Kittel-Schneider S et al. | — | 2022 | → |
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| On the Opportunities and Risks of Examining the Genetics of Entrepreneurship. | Heller B et al. | — | 2022 | → |
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| Overview of CAPICE-Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe-an EU Marie Skłodowska-Curie International Training Network. | Rajula HSR et al. | — | 2022 | → |
| Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance. | Greco LA et al. | — | 2022 | → |
| Parental age and the risk of bipolar disorder in the offspring: A systematic review and meta-analysis. | Polga N et al. | — | 2022 | → |
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| Physiological Genomics Plays a Crucial Role in Response to Stressful Life Events, the Development of Aggressive Behaviours, and Post-Traumatic Stress Disorder (PTSD). | Magwai T et al. | — | 2022 | → |
| Polygenic resilience scores capture protective genetic effects for Alzheimer's disease. | Hou J et al. | — | 2022 | → |
| Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association. | O'Sullivan JW et al. | — | 2022 | → |
| Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases. | Sillanpää E et al. | — | 2022 | → |
| Polygenic Scores in Psychiatry: On the Road From Discovery to Implementation. | Lewis CM et al. | — | 2022 | → |
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| Predicting Physical Appearance from DNA Data-Towards Genomic Solutions. | Pośpiech E et al. | — | 2022 | → |
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| Rare genetic variants explain missing heritability in smoking. | Jang SK et al. | — | 2022 | → |
| Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation. | Neumann A et al. | — | 2022 | → |
| Reared-Apart and Reunited: Extraordinary Dynamics/Twin Research Reviews: Twin Bereavement and Lifespan Associations; Identifying Novel Mutations in Twins; Parenting Premature Multiples; Conjoined Twins in Cross-Cultural Context/In the News: Madeline Albright, Mother of Twins, Passes Away; Identical Twin Songwriters Compose New Musical; Visually Impaired Twin Skiers; Identical Twin Brothers Undergo Heart Transplants; Naming the Genain Quadruplets. | Segal NL | — | 2022 | → |
| Retrospective Self-Reported Childhood Experiences in Enriched Environments Uniquely Predict Prosocial Behavior and Personality Traits in Adulthood. | McCauley TG et al. | — | 2022 | → |
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| Schooling substantially improves intelligence, but neither lessens nor widens the impacts of socioeconomics and genetics. | Judd N et al. | — | 2022 | → |
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| Special Issue editorial: Leveraging genetically informative study designs to understand the development and familial transmission of psychopathology. | Wilson S et al. | — | 2022 | → |
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| Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders. | Akingbuwa WA et al. | — | 2022 | → |
| Systemic lupus erythematosus as a genetic disease. | Harley ITW et al. | — | 2022 | → |
| The clinical utility of polygenic risk scores in genomic medicine practices: a systematic review. | Kumuthini J et al. | — | 2022 | → |
| The consequences of a year of the COVID-19 pandemic for the mental health of young adult twins in England and Wales. | Rimfeld K et al. | — | 2022 | → |
| The effects of maternal input on language in the absence of genetic confounds: Vocabulary development in internationally adopted children. | Coffey JR et al. | — | 2022 | → |
| "The elephant in the room": social responsibility in the production of sociogenomics research. | Martschenko DO | — | 2022 | → |
| The emergence and development of behavioral individuality in clonal fish. | Laskowski KL et al. | — | 2022 | → |
| The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond. | Verweij KJH et al. | — | 2022 | → |
| The gut microbiome modulates nitroglycerin-induced migraine-related hyperalgesia in mice. | Kang L et al. | — | 2022 | → |
| The Heritability of Kidney Function Using an Older Australian Twin Population. | Jefferis J et al. | — | 2022 | → |
| The impact of educational attainment, intelligence and intellectual disability on schizophrenia: a Swedish population-based register and genetic study. | Song J et al. | — | 2022 | → |
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| The next 10 years of behavioural genomic research. | Plomin R | — | 2022 | → |
| The P-factor and its genomic and neural equivalents: an integrated perspective. | Sprooten E et al. | — | 2022 | → |
| The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores. | Page ML et al. | — | 2022 | → |
| The role of gene-ambient air pollution interactions in paediatric asthma. | Kelchtermans J et al. | — | 2022 | → |
| The social learning of threat and safety in the family: Parent-to-child transmission of social fears via verbal information. | Aktar E et al. | — | 2022 | → |
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| Why twin studies are important for health span science research: the case of maltreatment of aging adults. | Boutwell BB et al. | — | 2022 | → |
| A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics. | Lu H et al. | — | 2021 | → |
| A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine. | Ebahimzadeh K et al. | — | 2021 | → |
| Agonistic experience during development establishes inter-individual differences in approach-avoidance behaviour of crickets. | Balsam JS et al. | — | 2021 | → |
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| An examination of genetic and environmental factors related to negative personality traits, educational attainment, and economic success. | Stallings MC et al. | — | 2021 | → |
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| Association of public explanations of why children struggle and support for policy solutions using a national sample. | Klevens J et al. | — | 2021 | → |
| Associations between maternal depressive symptoms and risk for offspring early-life psychopathology: the role of genetic and non-genetic mechanisms. | Gjerde LC et al. | — | 2021 | → |
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| Difference in Rupture Risk Between Familial and Sporadic Intracranial Aneurysms: An Individual Patient Data Meta-analysis. | Zuurbier CCM et al. | — | 2021 | → |
| Diffusion properties of the fornix assessed by deterministic tractography shows age, sex, volume, cognitive, hemispheric, and twin relationships in young adults from the Human Connectome Project. | Cahn AJ et al. | — | 2021 | → |
| Direct and Indirect Effects of Maternal, Paternal, and Offspring Genotypes: Trio-GCTA. | Eilertsen EM et al. | — | 2021 | → |
| Distinct Origins of Two-order Hierarchical Cognitive Abilities in Human Adults | Jiang S et al. | — | 2021 | — |
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| Effects of developmental exposure to pesticides in wax and pollen on honey bee (Apis mellifera) queen reproductive phenotypes. | Milone JP et al. | — | 2021 | → |
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| Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits. | Martin J et al. | — | 2021 | → |
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| Familial Aggregation of CKD and Heritability of Kidney Biomarkers in the General Population: The Lifelines Cohort Study. | Zhang J et al. | — | 2021 | → |
| Fisher's principle remains a plausible explanation for human sex ratio evolution. A Comment on: Zietsch <i>et al</i>. 2020. | Lehtonen J | — | 2021 | → |
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| Genetic Correlates of Psychological Responses to the COVID-19 Crisis in Young Adult Twins in Great Britain. | Rimfeld K et al. | — | 2021 | → |
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| Genetic Influences on the Covariance and Genetic Correlations in a Bivariate Twin Model: An Application to Well-Being. | de Vries LP et al. | — | 2021 | → |
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| Using the Theory of Reasoned Action to examine grandparent and maternal substance use on the cannabis use of children of teen mothers. | Cederbaum JA et al. | — | 2021 | → |
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| Analyzing Metabolomics Data for Environmental Health and Exposome Research. | Cai Y et al. | — | 2020 | → |
| An Array of Studies Addressing Cognition and Cognitively Defined Neuropsychiatric Conditions: Many More Connections Than You Might Think. | Harvey PD | — | 2020 | → |
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| CRISPR/Cas9-mediated Knockout of the Neuropsychiatric Risk Gene KCTD13 Causes Developmental Deficits in Human Cortical Neurons Derived from Induced Pluripotent Stem Cells. | Kizner V et al. | — | 2020 | → |
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| Exploring human trainability: Design and rationale of Studies of Twin Responses to Understand Exercise as a Therapy (STRUETH) study. | Marsh CE et al. | — | 2020 | → |
| Exploring the Genomic Architectures of Health, Physical Traits and Antisocial Behavioral Outcomes: A Brief Report. | Tielbeek JJ et al. | — | 2020 | → |
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| Female Reproductive Performance and Maternal Birth Month: A Comprehensive Meta-Analysis Exploring Multiple Seasonal Mechanisms. | Boland MR et al. | — | 2020 | → |
| Fitness and strength responses to distinct exercise modes in twins: Studies of Twin Responses to Understand Exercise as a THerapy (STRUETH) study. | Marsh CE et al. | — | 2020 | → |
| Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review. | Bourdon JL et al. | — | 2020 | → |
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| Genetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice. | Goudriaan A et al. | — | 2020 | → |
| Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. | Smeland OB et al. | — | 2020 | → |
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| Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study. | Matsumoto D et al. | — | 2020 | → |
| Higher burden of rare frameshift indels in genes related to synaptic transmission separate familial hemiplegic migraine from common types of migraine. | Rasmussen AH et al. | — | 2020 | → |
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| Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges. | Domingue BW et al. | — | 2020 | → |
| Introduction to the Special Issue on 'The Genetic Architecture of Neurodevelopmental Disorders'. | Taylor MJ et al. | — | 2020 | → |
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| ISSLS Prize in Clinical Science 2020. Examining causal effects of body mass index on back pain: a Mendelian randomization study. | Elgaeva EE et al. | — | 2020 | → |
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| Maternal and paternal effects on offspring internalizing problems: Results from genetic and family-based analyses. | Jami ES et al. | — | 2020 | → |
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| Mental Health Disease or Preventable Problem? Australian Dog Trainers' Opinions about Canine Separation Anxiety Differ with Training Style. | Hunter T et al. | — | 2020 | → |
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| Modeling the Comorbidity of Cannabis Abuse and Conduct Disorder/Conduct Problems from a Cognitive Neuroscience Perspective. | Blair RJ | — | 2020 | → |
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| Partitioning heritability analyses unveil the genetic architecture of human brain multidimensional functional connectivity patterns. | Feng J et al. | — | 2020 | → |
| Pattern Similarity Analyses of FrontoParietal Task Coding: Individual Variation and Genetic Influences. | Etzel JA et al. | — | 2020 | → |
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| Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies. | Hammerschlag AR et al. | — | 2020 | → |
| Resemblance and clustering of mother's and father's psychopathology levels among Chinese parents of schoolchildren with psychiatric disorders. | Gao Y et al. | — | 2020 | → |
| Risk of Depression in the Adolescent and Adult Offspring of Mothers With Perinatal Depression: A Systematic Review and Meta-analysis. | Tirumalaraju V et al. | — | 2020 | → |
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| Synaptic and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders. | Hammerschlag AR et al. | — | 2020 | → |
| The Association Between Genetic Predisposition and Parental Socialization: An Examination of Gene-Environment Correlations Using an Adoption-Based Design. | Knoblach RA et al. | — | 2020 | → |
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| The E Is in the G: Gene-Environment-Trait Correlations and Findings From Genome-Wide Association Studies. | Avinun R | — | 2020 | → |
| The Epigenetic Drug Discovery Landscape for Metabolic-associated Fatty Liver Disease. | Bayoumi A et al. | — | 2020 | → |
| The genetic and environmental origins of emotional and cognitive empathy: Review and meta-analyses of twin studies. | Abramson L et al. | — | 2020 | → |
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| The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. | Coleman JRI et al. | — | 2020 | → |
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| The intersection of individual differences, personality variation, & military service: A twin comparison design. | Nedelec JL et al. | — | 2020 | → |
| The Mitochondrial Theory of <i>g</i> Is Incompatible with Genetic Evidence and Does Not Explain Statistical Phenomena. | Ujma PP et al. | — | 2020 | → |
| The Role of the Environment in Overweight and Eating Behavior Variability: Insights from a Multivariate Twin Study. | Herle M et al. | — | 2020 | → |
| Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychoses. | Hess JL et al. | — | 2020 | → |
| Twins Assessing Their Own and Parental Intelligence: Examining the Raters' Agreement and the Effect of Raters' and Targets' Gender. | Bratko D et al. | — | 2020 | → |
| Twin studies of subjective sleep quality and sleep duration, and their behavioral correlates: Systematic review and meta-analysis of heritability estimates. | Madrid-Valero JJ et al. | — | 2020 | → |
| Twin study designs as a tool to identify new candidate genes for depression: A systematic review of DNA methylation studies. | Palma-Gudiel H et al. | — | 2020 | → |
| Using DNA From Mothers and Children to Study Parental Investment in Children's Educational Attainment. | Wertz J et al. | — | 2020 | → |
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| Association of Genetic Risk Factors for Psychiatric Disorders and Traits of These Disorders in a Swedish Population Twin Sample. | Taylor MJ et al. | — | 2019 | → |
| Associations of mental health and family background with opioid analgesic therapy: a nationwide Swedish register-based study. | Quinn PD et al. | — | 2019 | → |
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| Chronic diseases and objectively monitored physical activity profile among aged individuals - a cross-sectional twin cohort study. | Kujala UM et al. | — | 2019 | → |
| Comparing Within- and Between-Family Polygenic Score Prediction. | Selzam S et al. | — | 2019 | → |
| Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies. | Joiret M et al. | — | 2019 | → |
| Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour: results from a prospective cohort assessed in adolescence and early adulthood. | Langevin S et al. | — | 2019 | → |
| Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders. | Sullivan PF et al. | — | 2019 | → |
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| Epigenomics and Transcriptomics in the Prediction and Diagnosis of Childhood Asthma: Are We There Yet? | Forno E et al. | — | 2019 | → |
| Establishing a generalized polyepigenetic biomarker for tobacco smoking. | Sugden K et al. | — | 2019 | → |
| Examining the Association Between Personal Victimization in Adolescence and Intimate Partner Victimization in Adulthood. | Rima D et al. | — | 2019 | → |
| Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use. | Brazel DM et al. | — | 2019 | → |
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| Genetic Analysis of a Large Family with Migraine, Vertigo, and Motion Sickness. | Peddareddygari LR et al. | — | 2019 | → |
| Genetic and Environmental Influences on Different Forms of Bullying Perpetration, Bullying Victimization, and Their Co-occurrence. | Veldkamp SAM et al. | — | 2019 | → |
| Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. | Walker RL et al. | — | 2019 | → |
| Genetic correlations of polygenic disease traits: from theory to practice. | van Rheenen W et al. | — | 2019 | → |
| Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. | Hübel C et al. | — | 2019 | → |
| Genetic Epidemiology of Liability for Alcohol-Induced Blacking and Passing Out. | Davis CN et al. | — | 2019 | → |
| Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. | Pettersson E et al. | — | 2019 | → |
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| Genetic risk for schizophrenia is associated with substance use in emerging adulthood: an event-level polygenic prediction model. | Mallard TT et al. | — | 2019 | → |
| Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma. | Morales E et al. | — | 2019 | → |
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| Identification of common genetic risk variants for autism spectrum disorder. | Grove J et al. | — | 2019 | → |
| IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL mapping and allele-specific analysis. | Fan Y et al. | — | 2019 | → |
| Inferring the Nature of Missing Heritability in Human Traits Using Data from the GWAS Catalog. | López-Cortegano E et al. | — | 2019 | → |
| Insight from focus group interviews: adolescent girls' well-being in relation to experiences of winter, nature and seasonal changes in Northern Finland. | Wiens V et al. | — | 2019 | → |
| Interpreting Behavior Genetic Models: Seven Developmental Processes to Understand. | Briley DA et al. | — | 2019 | → |
| Introduction: Preconceptional care: do we have to care? | Simon C | — | 2019 | → |
| Joint factorial structure of psychopathology and personality. | Rosenström T et al. | — | 2019 | → |
| Lifespans of Twins: Does Zygosity Matter? | Hjelmborg J et al. | — | 2019 | → |
| Making Sense of the Epigenome Using Data Integration Approaches. | Cazaly E et al. | — | 2019 | → |
| Mapping causal pathways from genetics to neuropsychiatric disorders using genome-wide imaging genetics: Current status and future directions. | Le BD et al. | — | 2019 | → |
| Mendelian randomization: the challenge of unobserved environmental confounds. | Koellinger PD et al. | — | 2019 | → |
| Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation. | Haertle L et al. | — | 2019 | → |
| Myopia: is the nature-nurture debate finally over? | Morgan IG et al. | — | 2019 | → |
| Neuroticism as a Predictor of Frailty in Old Age: A Genetically Informative Approach. | Daníelsdóttir HB et al. | — | 2019 | → |
| Parent-offspring transmission of drug abuse and alcohol use disorder: Application of the multiple parenting relationships design. | Kendler KS et al. | — | 2019 | → |
| Performing group-level functional image analyses based on homologous functional regions mapped in individuals. | Li M et al. | — | 2019 | → |
| Phenotypic Annotation: Using Polygenic Scores to Translate Discoveries From Genome-Wide Association Studies From the Top Down. | Belsky DW et al. | — | 2019 | → |
| Polygenic risk for neuropsychiatric disease and vulnerability to abnormal deep grey matter development. | Cullen H et al. | — | 2019 | → |
| Polygenic score for educational attainment captures DNA variants shared between personality traits and educational achievement. | Smith-Woolley E et al. | — | 2019 | → |
| Population-based genome-wide association study of cognitive decline in older adults free of dementia: identification of a novel locus for the attention domain. | Kamboh MI et al. | — | 2019 | → |
| Post-Modern Epidemiology: When Methods Meet Matter. | Davey Smith G | — | 2019 | → |
| Post-traumatic Stress Disorder Symptoms are Associated With Incident Chronic Back Pain: A Longitudinal Twin Study of Older Male Veterans. | Suri P et al. | — | 2019 | → |
| Potential Causal Influence of Neighborhood Disadvantage on Disordered Gambling: Evidence From a Multilevel Discordant Twin Design. | Slutske WS et al. | — | 2019 | → |
| Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach. | Vivian-Griffiths T et al. | — | 2019 | → |
| Primers on nutrigenetics and nutri(epi)genomics: Origins and development of precision nutrition. | Bordoni L et al. | — | 2019 | → |
| Protocol for establishing a child and adolescent twin register for mental health research and capacity building in Sri Lanka and other low and middle-income countries in South Asia. | Jayaweera K et al. | — | 2019 | → |
| Psychiatric Genetics Begins to Find Its Footing. | Smoller JW | — | 2019 | → |
| Remitted affective disorders and high familial risk of affective disorders associate with aberrant intestinal microbiota. | Vinberg M et al. | — | 2019 | → |
| Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes. | Lakhani CM et al. | — | 2019 | → |
| Research Weaving: Visualizing the Future of Research Synthesis. | Nakagawa S et al. | — | 2019 | → |
| Shared heritability and functional enrichment across six solid cancers. | Jiang X et al. | — | 2019 | → |
| Systematic review and meta-analysis approach on vitamin A fortified foods and its effect on retinol concentration in under 10 year children. | Mendu VVR et al. | — | 2019 | → |
| The association between emotional eating and depressive symptoms: a population-based twin study in Sri Lanka. | Herle MP et al. | — | 2019 | → |
| The complex genetic and psychosocial influences on polysubstance misuse. | Vaughn MG et al. | — | 2019 | → |
| The Dynamic Associations Between Cortical Thickness and General Intelligence are Genetically Mediated. | Schmitt JE et al. | — | 2019 | → |
| The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. | Middeldorp CM et al. | — | 2019 | → |
| The effects of playing music on mental health outcomes. | Wesseldijk LW et al. | — | 2019 | → |
| The epigenome of twins as a perfect laboratory for studying behavioural traits. | Tan Q | — | 2019 | → |
| The genetics of depression: successful genome-wide association studies introduce new challenges. | Ormel J et al. | — | 2019 | → |
| The genetic underpinnings of callous-unemotional traits: A systematic research review. | Moore AA et al. | — | 2019 | → |
| The Genome-Wide Study of Human Social Behavior and Its Application in Sociology. | Tanksley PT et al. | — | 2019 | → |
| The Problem of Non-Shared Environment in Behavioral Genetics. | Tikhodeyev ON et al. | — | 2019 | → |
| The role of sex in the genomics of human complex traits. | Khramtsova EA et al. | — | 2019 | → |
| The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology. | Ge T et al. | — | 2019 | → |
| Thinking About the Evolution of Complex Traits in the Era of Genome-Wide Association Studies. | Sella G et al. | — | 2019 | → |
| Toddler risk and protective characteristics: Common and unique genetic and environmental influences. | Rea-Sandin G et al. | — | 2019 | → |
| To Use or Not to Use: No Consensus on Whether and How to Apply Genetic Information in the Justice System. | Selita F et al. | — | 2019 | → |
| Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions. | Xue J et al. | — | 2019 | → |
| Twin Family Registries Worldwide: An Important Resource for Scientific Research. | Hur YM et al. | — | 2019 | → |
| Uncontrolled eating: a unifying heritable trait linked with obesity, overeating, personality and the brain. | Vainik U et al. | — | 2019 | → |
| Uncovering the Genetic Architecture of Major Depression. | McIntosh AM et al. | — | 2019 | → |
| Using DNA to predict educational trajectories in early adulthood. | Ayorech Z et al. | — | 2019 | → |
| What next for adolescent forensic mental health research? | Hales H et al. | — | 2019 | → |
| Association of Maternal Roux-en-Y Gastric Bypass with Obstetric Outcomes and Fluid Intelligence in Offspring. | Blume CA et al. | — | 2018 | → |
| Child temperament predicts the adiposity rebound. A 9-year prospective sibling control study. | Vollrath ME et al. | — | 2018 | → |
| Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance. | Handelsman DJ et al. | — | 2018 | → |
| Developing SENSES: Student experience of non-shared environment scales. | Yerdelen S et al. | — | 2018 | → |
| Differential Genetic Effect of the Norepinephrine Transporter Promoter Polymorphisms on Attention Problems in Clinical and Non-clinical Samples. | Nemoda Z et al. | — | 2018 | → |
| Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? | Kaminski JA et al. | — | 2018 | → |
| Exploring the genetic correlations of antisocial behaviour and life history traits. | Tielbeek JJ et al. | — | 2018 | → |
| Feasibility of Linking Molecular Genetic Markers to Real-World Social Network Size Tracked on Smartphones. | Sariyska R et al. | — | 2018 | → |
| Genetic architecture and selective sweeps after polygenic adaptation to distant trait optima. | Stetter MG et al. | — | 2018 | → |
| Genetic moderation of the effects of the Family Check-Up intervention on children's internalizing symptoms: A longitudinal study with a racially/ethnically diverse sample. | Lemery-Chalfant K et al. | — | 2018 | → |
| Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs. | Ohi K et al. | — | 2018 | → |
| Genetics, personality and wellbeing. A twin study of traits, facets and life satisfaction. | Røysamb E et al. | — | 2018 | → |
| Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. | Arnau-Soler A et al. | — | 2018 | → |
| Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. | Suri P et al. | — | 2018 | → |
| Nature and Nurture: Brain Region-Specific Inheritance of Sleep Neurophysiology in Adolescence. | Rusterholz T et al. | — | 2018 | → |
| Network Neuroscience and Personality. | Markett S et al. | — | 2018 | → |
| On variability & human consciousness. | Boutwell BB | — | 2018 | → |
| Pairs of Genetically Unrelated Look-Alikes : Further Tests of Personality Similarity and Social Affiliation. | Segal NL et al. | — | 2018 | → |
| Relatedness disequilibrium regression estimates heritability without environmental bias. | Young AI et al. | — | 2018 | → |
| Socioeconomic Status and Adolescent Alcohol Involvement: Evidence for a Gene-Environment Interaction. | Davis CN et al. | — | 2018 | → |
| Sociogenomics in the 21<sup>st</sup> Century: An Introduction to the History and Potential of Genetically-informed Social Science. | Braudt DB | — | 2018 | → |