Predicting relapse to alcohol and drug abuse via quantitative electroencephalography.
paper
Cited
Public
Unavailable
- Authors
- Bauer, L O
- Year
- 2001
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 11522462
- DOI
- 10.1016/S0893-133X(01)00236-6
A sensitive and specific screening test that would identify the subset of substance-abusing patients at highest risk for relapse would constitute an important advance for treatment planning. This study examined the relative value of quantitative electroencephalography as a rapid, inexpensive, and noninvasive measure of relapse potential. The subjects were 107 substance-dependent patients enrolled in residential treatment programs. All were unmedicated and free of the complicating effects of major medical and neurological disorders. Structured clinical interview data and a 5-minute recording of the resting, eyes-closed electroencephalogram were obtained after patients had verifiably maintained abstinence for 1-5 months. Patients were then monitored for relapse or successful abstinence by research staff for an ensuing 6-month period. ANCOVAs of EEG power spectral density within pre-defined frequency bands revealed an enhanced amount of high frequency (19.5-39.8 Hz) beta activity among the 48 patients who later relapsed compared to both 59 patients who maintained abstinence and 22 additional subjects with no history of substance dependence. Importantly, in subsequent logistic regression analyses, fast beta power was found to be superior to severity of illness, depression level, and childhood conduct problems in predicting relapse. With fast beta power as the sole predictor, the sensitivity, specificity, and positive and negative predictive value parameters for discriminating outcomes were 0.61, 0.85, 0.75, and 0.74, respectively. Additional ANCOVAs revealed that the EEG difference between relapse-prone and abstinence-prone groups was related to the interaction of two premorbid factors, viz., childhood Conduct Disorder and paternal alcoholism. The enhancement of fast beta electroencephalographic activity in patients who will later relapse most likely originates from a premorbid and subtle dysfunction involving frontal brain regions.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Electrophysiological Correlates of the Clinical Benefit Induced by Transcranial Magnetic Stimulation for Alcohol Use Disorder. | Harel M et al. | — | 2026 | → |
| Quantitative Electroencephalogram in Persons with Alcohol Dependence Syndrome: A Pre- and Post-Treatment Findings. | Sharma S et al. | — | 2026 | → |
| Revisiting drunk driving risk among individuals with alcohol use disorder using unsupervised learning: From clinical characteristics and neuropsychological performance to EEG data. | Su YR et al. | — | 2026 | → |
| An electroencephalography connectome predictive model of craving for methamphetamine. | Zhang HB et al. | — | 2025 | → |
| A pilot randomized clinical trial of biomedical link with mental health in art therapy intervention programs for alcohol use disorder: Changes in NK cells, addiction biomarkers, electroencephalography, and MMPI-2 profiles. | Kang SJ et al. | — | 2023 | → |
| Gender-Specific Interactions in a Visual Object Recognition Task in Persons with Opioid Use Disorder. | Petrie J et al. | — | 2023 | → |
| Problematic social media use is associated with depression and similar to behavioral addictions: Physiological and behavioral evidence. | Tsilosani A et al. | — | 2023 | → |
| Targeting electroencephalography for alcohol dependence: A narrative review. | Zhang H et al. | — | 2023 | → |
| A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment. | Bel-Bahar TS et al. | — | 2022 | → |
| Is the relapse concept in studies of substance use disorders a 'one size fits all' concept? A systematic review of relapse operationalisations. | Moe FD et al. | — | 2022 | → |
| Resting-state EEG, Substance use and Abstinence After Chronic use: A Systematic Review. | Liu Y et al. | — | 2022 | → |
| Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder. | Fish KN et al. | — | 2022 | → |
| Characteristic changes in EEG spectral powers of patients with opioid-use disorder as compared with those with methamphetamine- and alcohol-use disorders | Minnerly C et al. | — | 2021 | — |
| Characteristic changes in EEG spectral powers of patients with opioid-use disorder as compared with those with methamphetamine- and alcohol-use disorders. | Minnerly C et al. | — | 2021 | → |
| Effectiveness of an Integrated Intervention Program for Alcoholism: Electrophysiological Findings. | Kumar R et al. | — | 2021 | → |
| Neurophysiological correlate of incubation of craving in individuals with methamphetamine use disorder. | Zhao D et al. | — | 2021 | → |
| Prospective Prediction of Lapses in Opioid Use Disorder: Protocol for a Personal Sensing Study. | Moshontz H et al. | — | 2021 | → |
| Quantitative EEG (QEEG) Analysis of Emotional Interaction between Abusers and Victims in Intimate Partner Violence: A Pilot Study. | Weon HW et al. | — | 2021 | → |
| Induced pluripotent stem cell reprogramming-associated methylation at the GABRA2 promoter and chr4p12 GABA<sub>A</sub> subunit gene expression in the context of alcohol use disorder. | Goetjen A et al. | — | 2020 | → |
| Neuropsychophysiological Measures of Alcohol Dependence: Can We Use EEG in the Clinical Assessment? | Jurado-Barba R et al. | — | 2020 | → |
| Resting-state connectivity and network parameter analysis in alcohol-dependent males. A simultaneous EEG-MEG study. | Sion A et al. | — | 2020 | → |
| Alcohol use disorder relapse factors: A systematic review. | Sliedrecht W et al. | — | 2019 | → |
| Computer-aided classifying and characterizing of methamphetamine use disorder using resting-state EEG. | Khajehpour H et al. | — | 2019 | → |
| CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms. | Ehlers CL et al. | — | 2019 | → |
| Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol-Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort. | Meda SA et al. | — | 2019 | → |
| Reliability and validity of an internalizing symptom scale based on the adolescent and adult Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). | Acion L et al. | — | 2019 | → |
| A review on EEG-based methods for screening and diagnosing alcohol use disorder. | Mumtaz W et al. | — | 2018 | → |
| Cannabis users exhibit increased cortical activation during resting state compared to non-users. | Prashad S et al. | — | 2018 | → |
| EEG Frequency Bands in Psychiatric Disorders: A Review of Resting State Studies. | Newson JJ et al. | — | 2018 | → |
| Effect of Gabapentin on Sleep and Event-Related Oscillations (EROs) in Rats Exposed to Chronic Intermittent Ethanol Vapor and Protracted Withdrawal. | Sanchez-Alavez M et al. | — | 2018 | → |
| Effects of quantitative electroencephalography based neurofeedback training on autonomous regulations in patients with alcohol use disorder. | Ko S et al. | — | 2018 | → |
| Event-Related Potentials as Biomarkers of Behavior Change Mechanisms in Substance Use Disorder Treatment. | Houston RJ et al. | — | 2018 | → |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | — | 2018 | → |
| Nature and Nurture: Brain Region-Specific Inheritance of Sleep Neurophysiology in Adolescence. | Rusterholz T et al. | — | 2018 | → |
| Toward biomarkers of the addicted human brain: Using neuroimaging to predict relapse and sustained abstinence in substance use disorder. | Moeller SJ et al. | — | 2018 | → |
| A genome wide association study of fast beta EEG in families of European ancestry. | Meyers JL et al. | — | 2017 | → |
| An EEG-based machine learning method to screen alcohol use disorder. | Mumtaz W et al. | — | 2017 | → |
| An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. | Meyers JL et al. | — | 2017 | → |
| An ERP Study of Response Inhibition in the Auditory Domain in Children with Fetal Alcohol Spectrum Disorders. | Gerhold MM et al. | — | 2017 | → |
| Resting-state EEG activity related to impulsivity in gambling disorder. | Lee JY et al. | — | 2017 | → |
| The Brain of Binge Drinkers at Rest: Alterations in Theta and Beta Oscillations in First-Year College Students with a Binge Drinking Pattern. | López-Caneda E et al. | — | 2017 | → |
| Brain potentials predict substance abuse treatment completion in a prison sample. | Fink BC et al. | — | 2016 | → |
| Electroencephalogram variability in patients with cirrhosis associates with the presence and severity of hepatic encephalopathy. | Olesen SS et al. | — | 2016 | → |
| Functional Connectivity and Quantitative EEG in Women with Alcohol Use Disorders: A Resting-State Study. | Herrera-Díaz A et al. | — | 2016 | → |
| Occipital event-related potentials to addiction-related stimuli in detoxified patients with alcohol dependence, and their association with three-month relapse. | Matheus-Roth C et al. | — | 2016 | → |
| Reductions in physical pain predict lower risk of relapse following alcohol treatment. | Jakubczyk A et al. | — | 2016 | → |
| The Effectiveness of Visual Short-Time Neurofeedback on Brain Activity and Clinical Characteristics in Alcohol Use Disorders: Practical Issues and Results. | Lackner N et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Neuroplasticity and Predictors of Alcohol Recovery. | Seo D et al. | — | 2015 | → |
| Reduced processing of alcohol cues predicts abstinence in recently detoxified alcoholic patients in a three-month follow up period: an ERP study. | Petit G et al. | — | 2015 | → |
| Alcohol and the sleeping brain. | Colrain IM et al. | — | 2014 | → |
| Alcohol reduces cross-frequency theta-phase gamma-amplitude coupling in resting electroencephalography. | Lee J et al. | — | 2014 | → |
| Computer-aided diagnosis of alcoholism-related EEG signals. | Acharya UR et al. | — | 2014 | → |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Mechanisms underlying sleep-wake disturbances in alcoholism: focus on the cholinergic pedunculopontine tegmentum. | Knapp CM et al. | — | 2014 | → |
| Quantitative EEG and neurofeedback in children and adolescents: anxiety disorders, depressive disorders, comorbid addiction and attention-deficit/hyperactivity disorder, and brain injury. | Simkin DR et al. | — | 2014 | → |
| Quantitative Electroencephalography Analysis (qEEG) of Neuro-Electro-Adaptive Therapy 12™ [NEAT12] Up-Regulates Cortical Potentials in an Alcoholic during Protracted Abstinence: Putative Anti-Craving Implications. | Waite RL et al. | — | 2014 | → |
| Sex differences in alcohol-related neurobehavioral consequences. | Nixon SJ et al. | — | 2014 | → |
| The neurobiology of alcohol craving and relapse. | Seo D et al. | — | 2014 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Disrupted ventromedial prefrontal function, alcohol craving, and subsequent relapse risk. | Seo D et al. | — | 2013 | → |
| Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. | Wiggins WF et al. | — | 2013 | → |
| Neurofeedback: an integrative treatment of substance use disorders. | Ross SM | — | 2013 | → |
| The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment. | Jakubczyk A et al. | — | 2013 | → |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | — | 2012 | → |
| GABRA2 and KIBRA genotypes predict early relapse to substance use. | Bauer LO et al. | — | 2012 | → |
| GABRA2 genotype, impulsivity, and body mass. | Bauer LO et al. | — | 2012 | → |
| Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. | Villafuerte S et al. | — | 2012 | → |
| Non-invasive brain stimulation in the functional evaluation of alcohol effects and in the treatment of alcohol craving: a review. | Nardone R et al. | — | 2012 | → |
| Oscillatory power and synchrony in the rat forebrain are altered by a sensitizing regime of D-amphetamine. | Lapish CC et al. | — | 2012 | → |
| Disrupted thalamic T-type Ca2+ channel expression and function during ethanol exposure and withdrawal. | Graef JD et al. | — | 2011 | → |
| Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence. | Lydall GJ et al. | — | 2011 | → |
| Neuroimaging for drug addiction and related behaviors. | Parvaz MA et al. | — | 2011 | → |
| P3a amplitude predicts successful treatment program completion in substance-dependent individuals. | Anderson NE et al. | — | 2011 | → |
| Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: part 1, pilot study with 2 case reports. | Miller DK et al. | — | 2010 | → |
| Binge drinking effects on EEG in young adult humans. | Courtney KE et al. | — | 2010 | → |
| Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. | Gilmore CS et al. | — | 2010 | → |
| Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances. | Brower KJ et al. | — | 2010 | → |
| Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. | Wojnar M et al. | — | 2009 | → |
| Chronic alcoholism: insights from neurophysiology. | Campanella S et al. | — | 2009 | → |
| Deficits in behavioral inhibition predict treatment engagement in prison inmates. | Fishbein D et al. | — | 2009 | → |
| EEG and cerebral blood flow velocity abnormalities in chronic cocaine users. | Copersino ML et al. | — | 2009 | → |
| Impact of alcoholism on sleep architecture and EEG power spectra in men and women. | Colrain IM et al. | — | 2009 | → |
| Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. | Enoch MA et al. | — | 2008 | → |
| EEG biofeedback as a treatment for substance use disorders: review, rating of efficacy, and recommendations for further research. | Sokhadze TM et al. | — | 2008 | → |
| The role of self-reported impulsivity and reward sensitivity versus neurocognitive measures of disinhibition and decision-making in the prediction of relapse in pathological gamblers. | Goudriaan AE et al. | — | 2008 | → |
| Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. | Rangaswamy M et al. | — | 2008 | → |
| EEG absolute power during extended cocaine abstinence. | Levin KH et al. | — | 2007 | → |
| Opioid withdrawal results in an increased local and remote functional connectivity at EEG alpha and beta frequency bands. | Fingelkurts AA et al. | — | 2007 | → |
| Sleep electroencephalographic spectral power after withdrawal from alcohol in alcohol-dependent patients. | Feige B et al. | — | 2007 | → |
| Variation in GABRA2 predicts drinking behavior in project MATCH subjects. | Bauer LO et al. | — | 2007 | → |
| Clinical correlates of quantitative EEG alterations in alcoholic patients. | Coutin-Churchman P et al. | — | 2006 | → |
| Genetics of human brain oscillations. | Begleiter H et al. | — | 2006 | → |
| Moderate-to-heavy alcohol intake is associated with differences in synchronization of brain activity during rest and mental rehearsal. | de Bruin EA et al. | — | 2006 | → |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | — | 2006 | → |
| Cognitive performance and autonomic reactivity in abstinent drug abusers and nonusers. | Fishbein D et al. | — | 2005 | → |
| Quantitative electroencephalographic measures in homicidal men with antisocial personality disorder. | Lindberg N et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Electroencephalographic power and coherence analyses suggest altered brain function in abstinent male heroin-dependent patients. | Franken IH et al. | — | 2004 | → |
| Relapse prevention for alcohol and drug problems: that was Zen, this is Tao. | Witkiewitz K et al. | — | 2004 | → |
| Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. | Edenberg HJ et al. | — | 2004 | → |
| Alcoholism and human electrophysiology. | Porjesz B et al. | — | 2003 | → |
| [ERPs (N200, P300 and CNV) in alcoholics: relapse risk assessment]. | Cristini P et al. | — | 2003 | → |
| Outcome predictors in substance use disorders. | Ciraulo DA et al. | — | 2003 | → |
| Pharmacogenomics of alcohol response and addiction. | Enoch MA | — | 2003 | → |
| Quantitative spectral analysis of EEG in psychiatry revisited: drawing signs out of numbers in a clinical setting. | Coutin-Churchman P et al. | — | 2003 | → |
| Beta power in the EEG of alcoholics. | Rangaswamy M et al. | — | 2002 | → |
| Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. | Bauer LO | — | 2002 | → |
| Lateral asymmetries in the frontal brain: effects of depression and a family history of alcoholism in female adolescents. | Bauer LO et al. | — | 2002 | → |
| Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics. | Irwin M et al. | — | 2002 | → |
| CNS recovery from cocaine, cocaine and alcohol, or opioid dependence: a P300 study. | Bauer LO | — | 2001 | → |