Serotonin transporter gene variants and prediction of stress-induced risk for psychological distress.
- Authors
- Stefanis, N C; Mandelli, L; Hatzimanolis, A; Zaninotto, L; Smyrnis, N; Avramopoulos, D; Evdokimidis, I; Serretti, A
- Year
- 2011
- Journal
- Genes, brain, and behavior
- PMID
- 21429092
- DOI
- 10.1111/j.1601-183X.2011.00690.x
The response to psychosocial stress is influenced by both psychosocial factors and genetic vulnerability. The most investigated gene in gene Γ environment studies in abnormal response to environmental stressors is the one coding for the serotonin transporter (SLC6A4). Variability within this gene has been associated with functional brain differences, personality dimensions, reactivity to stress and risk for various psychopathological conditions. In the present study, we set out to investigate the association of common genetic variants within SLC6A4 with state psychopathology in a community sample homogeneously exposed to stress, thus inquiring about potential genetic differences in stress sensitivity. One thousand eight hundred seventy-five young conscripts were evaluated for psychopathological distress with the 90-item Symptoms Checklist Revised in their first 2 weeks of admission to obligatory military service. Of these, 1594 were genotyped for the biallelic ins/del polymorphism (5-HTTLPR S/L) within the promoter region of SLC6A4, as well as the variation within the 'long' 5-HTTLPR allele (rs25531A/G). Homozygous for the 5-HTTLPR S allele reported significantly higher scores for paranoid ideation as compared with L-allele carriers. Slight effects on other subscales were observed, but were not significant after correction for multiple testing. Despite limitations linked to the evaluation of psychopathology by a single general scale and multiple comparisons, the present study support a role of SLC6A4 in modulating abnormal responses to environmental stress. In particular, variation within this gene may confer risk for paranoid/defensive reactions under conditions of environmental stress associated with military induction.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | 2018 | 28373689 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-Ξ±2a and Oral Ribavirin (PEG-IFN-Ξ±2a/RBV). | Pawlowski T et al. | β | 2023 | β |
| Psychobiological screening among patients affected by prostate cancer: Identification of potential psychobiological markers. | Severo M et al. | β | 2023 | β |
| Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process. | Delli Colli C et al. | β | 2022 | β |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | β | 2018 | β |
| Letter to the Editor: Bias in the measurement of bias. Letter regarding 'Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression'. | Vrshek-Schallhorn S et al. | β | 2017 | β |
| An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings. | Sharpley CF et al. | β | 2014 | β |
| Effect of acute stressor and serotonin transporter genotype on amygdala first wave transcriptome in mice. | Hohoff C et al. | β | 2013 | β |