Small molecules enable highly efficient neuronal conversion of human fibroblasts.
paper
Cited
Public
Unavailable
- Authors
- Ladewig, Julia; Mertens, Jerome; Kesavan, Jaideep; Doerr, Jonas; Poppe, Daniel; Glaue, Finnja; Herms, Stefan; Wernet, Peter; KΓΆgler, Gesine; MΓΌller, Franz-Josef; Koch, Philipp; BrΓΌstle, Oliver
- Year
- 2012
- Journal
- Nature methods
- PMID
- 22484851
- DOI
- 10.1038/nmeth.1972
Forced expression of proneural transcription factors has been shown to direct neuronal conversion of fibroblasts. Because neurons are postmitotic, conversion efficiencies are an important parameter for this process. We present a minimalist approach combining two-factor neuronal programming with small molecule-based inhibition of glycogen synthase kinase-3Ξ² and SMAD signaling, which converts postnatal human fibroblasts into functional neuron-like cells with yields up to >200% and neuronal purities up to >80%.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Conversion of intestinal smooth muscle cells in Hirschsprung's disease into enteric neuron-like cells using small molecule compounds. | Wu W et al. | β | 2026 | β |
| Modeling Late-Onset Sporadic Alzheimer's Disease Using Patient-Derived Cells: A Review. | Katbe A et al. | β | 2026 | β |
| Redefining cellular reprogramming with advanced genomic technologies. | Morris SA | β | 2026 | β |
| Chemical reprogramming regulates Tip60 expression to improve cleavage rates in somatic cell nuclear transfer reconstituted embryos of cashmere goats. | Zhe X et al. | β | 2025 | β |
| Nanotherapy for Neural Retinal Regeneration. | Yu C et al. | β | 2025 | β |
| Spatial patterning of the epigenome during vertebrate gastrulation. | Azambuja AP et al. | β | 2025 | β |
| AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data. | Li Z et al. | β | 2024 | β |
| A Perspective on the Characterization of Early Neural Progenitor Cell-Derived Extracellular Vesicles for Targeted Delivery to Neuroblastoma Cells. | KΔ±rbaΕ OK et al. | β | 2024 | β |
| Cell reprogramming therapy for Parkinson's disease. | Dong W et al. | β | 2024 | β |
| Development of precision therapies for rare inborn errors of metabolism: Functional investigations in cell culture models. | Didiasova M et al. | β | 2024 | β |
| Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development. | Hirayama M et al. | β | 2024 | β |
| Next-generation direct reprogramming. | Keshri R et al. | β | 2024 | β |
| Using Small Molecules to Reprogram RPE Cells in Regenerative Medicine for Degenerative Eye Disease. | Rzhanova LA et al. | β | 2024 | β |
| A cutting-edge strategy for spinal cord injury treatment: resident cellular transdifferentiation. | Fang YM et al. | β | 2023 | β |
| Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells? | Rodriguez-Jimenez FJ et al. | β | 2023 | β |
| Chemically induced reprogramming to reverse cellular aging. | Yang JH et al. | β | 2023 | β |
| [Chemical reprogramming of human embryonic fibroblasts into neural progenitor cells <i>in vitro</i>]. | Yang P et al. | β | 2023 | β |
| Direct Conversion of Fibroblast into Neurons for Alzheimer's Disease Research: A Systematic Review. | Sattarov R et al. | β | 2023 | β |
| Gene Therapy Using Efficient Direct Lineage Reprogramming Technology for Neurological Diseases. | Chang Y et al. | β | 2023 | β |
| Innovating spinal muscular atrophy models in the therapeutic era. | Signoria I et al. | β | 2023 | β |
| Patient-Derived Cellular Models for Polytarget Precision Medicine in Pantothenate Kinase-Associated Neurodegeneration. | Γlvarez-CΓ³rdoba M et al. | β | 2023 | β |
| P-hydroxy benzaldehyde facilitates reprogramming of reactive astrocytes into neurons via endogenous transcriptional regulation. | Li X et al. | β | 2023 | β |
| Regulation of Cell Plasticity by Bromodomain and Extraterminal Domain (BET) Proteins: A New Perspective in Glioblastoma Therapy. | Gargano D et al. | β | 2023 | β |
| Stem cell programmingΒ - prospects for perinatal medicine. | Berg LJ et al. | β | 2023 | β |
| Strategies and mechanisms of neuronal reprogramming. | Wan Y et al. | β | 2023 | β |
| Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model. | Kurahashi T et al. | β | 2023 | β |
| Use of <i>in vitro</i> derived human neuronal models to study host-parasite interactions of <i>Toxoplasma gondii</i> in neurons and neuropathogenesis of chronic toxoplasmosis. | Halonen SK | β | 2023 | β |
| An Improved Method to Generate Human Induced Astrocytes. | Drouin-Ouellet J | β | 2022 | β |
| Application of Small Molecules in the Central Nervous System Direct Neuronal Reprogramming. | Wang J et al. | β | 2022 | β |
| Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion. | BΓΆhnke L et al. | β | 2022 | β |
| Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches. | Bocchi R et al. | β | 2022 | β |
| Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons. | van den Hurk M et al. | β | 2022 | β |
| Global Transcriptional and Epigenetic Reconfiguration during Chemical Reprogramming of Human Retinal Pigment Epithelial Cells into Photoreceptor-like Cells. | Deng X et al. | β | 2022 | β |
| Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson's Disease Research and Therapeutic Development. | McComish SF et al. | β | 2022 | β |
| Impact of Mitochondrial A3243G Heteroplasmy on Mitochondrial Bioenergetics and Dynamics of Directly Reprogrammed MELAS Neurons. | Lin DS et al. | β | 2022 | β |
| Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. | Herdy JR et al. | β | 2022 | β |
| Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming. | Povea-Cabello S et al. | β | 2022 | β |
| Small compound-based direct cell conversion with combinatorial optimization of pathway regulations. | Nakamura T et al. | β | 2022 | β |
| Small Molecules Enhance Reprogramming of Adult Human Dermal Fibroblasts to Dorsal Forebrain Precursor Cells. | Edwards N et al. | β | 2022 | β |
| The Twofold Role of Osteogenic Small Molecules in Parkinson's Disease Therapeutics: Crosstalk of Osteogenesis and Neurogenesis. | Tavakol S | β | 2022 | β |
| Transcription factor-based direct conversion of human fibroblasts to functional astrocytes. | Quist E et al. | β | 2022 | β |
| Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells. | Kowalski TW et al. | β | 2022 | β |
| Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. | Mertens J et al. | β | 2021 | β |
| Automatic identification of small molecules that promote cell conversion and reprogramming. | Napolitano F et al. | β | 2021 | β |
| Cell Reprogramming to Model Huntington's Disease: A Comprehensive Review. | Monk R et al. | β | 2021 | β |
| Current Approaches and Molecular Mechanisms for Directly Reprogramming Fibroblasts Into Neurons and Dopamine Neurons. | Han F et al. | β | 2021 | β |
| Direct Conversion of Human Fibroblasts to Induced Neurons. | Zhou-Yang L et al. | β | 2021 | β |
| Directly Reprogrammed Human Neurons to Understand Age-Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration. | Gudenschwager C et al. | β | 2021 | β |
| Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application. | Vasan L et al. | β | 2021 | β |
| Direct Reprogramming of Somatic Cells to Neurons: Pros and Cons of Chemical Approach. | Mollinari C et al. | β | 2021 | β |
| Generation of Hepatic Progenitor Cells from the Primary Hepatocytes of Nonhuman Primates Using Small Molecules. | Hee Hong D et al. | β | 2021 | β |
| Generation of Induced Dopaminergic Neurons from Human Fetal Fibroblasts. | Legault EM et al. | β | 2021 | β |
| Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2. | Kempf J et al. | β | 2021 | β |
| Human cell transformation by combined lineage conversion and oncogene expression. | Sahu B et al. | β | 2021 | β |
| Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia. | Bassil R et al. | β | 2021 | β |
| Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex. | Xiang Z et al. | β | 2021 | β |
| Recent Advances in Understandings Towards Pathogenesis and Treatment for Intrauterine Adhesion and Disruptive Insights from Single-Cell Analysis. | Leung RK et al. | β | 2021 | β |
| Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1. | Zhou M et al. | β | 2021 | β |
| Single-Cell Genomics: Catalyst for Cell Fate Engineering. | Li B et al. | β | 2021 | β |
| Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury. | Yang Y et al. | β | 2021 | β |
| Small molecules efficiently reprogram apical papilla stem cells into neuron-like cells. | Chen Q et al. | β | 2021 | β |
| The application of in vitro-derived human neurons in neurodegenerative disease modeling. | D'Souza GX et al. | β | 2021 | β |
| Advances in mt-tRNA Mutation-Caused Mitochondrial Disease Modeling: Patients' Brain in a Dish. | Povea-Cabello S et al. | β | 2020 | β |
| Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer's disease. | Ma S et al. | β | 2020 | β |
| Automatic identification of small molecules that promote cell conversion and reprogramming | Napolitano F et al. | β | 2020 | β |
| Cell Reprogramming Preserving Epigenetic Age: Advantages and Limitations. | Samoylova EM et al. | β | 2020 | β |
| Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells. | Varderidou-Minasian S et al. | β | 2020 | β |
| Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors. | Qin H et al. | β | 2020 | β |
| From in vitro to in vivo reprogramming for neural transdifferentiation: An approach for CNS tissue remodeling using stem cell technology. | Egawa N et al. | β | 2020 | β |
| How to reprogram human fibroblasts to neurons. | Xu Z et al. | β | 2020 | β |
| Human in vitro models for understanding mechanisms of autism spectrum disorder. | Gordon A et al. | β | 2020 | β |
| MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons. | Habekost M et al. | β | 2020 | β |
| Modeling Alzheimer's disease with iPSC-derived brain cells. | Penney J et al. | β | 2020 | β |
| Precision Medicine in Rare Diseases. | VillalΓ³n-GarcΓa I et al. | β | 2020 | β |
| Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells. | Chen M et al. | β | 2020 | β |
| Small molecular compounds efficiently convert human fibroblasts directly into neurons. | Yang J et al. | β | 2020 | β |
| Sweat gland regeneration: Current strategies and future opportunities. | Chen R et al. | β | 2020 | β |
| Acquisition of functional neurons by direct conversion: Switching the developmental clock directly. | Chen S et al. | β | 2019 | β |
| A Revolution in Reprogramming: Small Molecules. | Zhou J et al. | β | 2019 | β |
| Cell Reprogramming: The Many Roads to Success. | Aydin B et al. | β | 2019 | β |
| Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons. | Herdy J et al. | β | 2019 | β |
| Deconstructing age reprogramming. | Singh PB et al. | β | 2019 | β |
| Direct Conversion of Human Urine Cells to Neurons by Small Molecules. | Xu G et al. | β | 2019 | β |
| Direct neuronal reprogramming of olfactory ensheathing cells for CNS repair. | Sun X et al. | β | 2019 | β |
| Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors. | Colasante G et al. | β | 2019 | β |
| Dual modulation of neuron-specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons. | Birtele M et al. | β | 2019 | β |
| Epigenetic Analysis in Human Neurons: Considerations for Disease Modeling in PD. | de Boni L et al. | β | 2019 | β |
| Evolving principles underlying neural lineage conversion and their relevance for biomedical translation. | Flitsch LJ et al. | β | 2019 | β |
| Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes. | Ge JY et al. | β | 2019 | β |
| Modeling Cell-Cell Interactions in Parkinson's Disease Using Human Stem Cell-Based Models. | Simmnacher K et al. | β | 2019 | β |
| Next-generation disease modeling with direct conversion: a new path to old neurons. | Traxler L et al. | β | 2019 | β |
| Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains. | Lei W et al. | β | 2019 | β |
| ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility. | van der Raadt J et al. | β | 2019 | β |
| Precision medicine in pantothenate kinase-associated neurodegeneration. | Alvarez-Cordoba M et al. | β | 2019 | β |
| Proteomics in the World of Induced Pluripotent Stem Cells. | Lindoso RS et al. | β | 2019 | β |
| Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons by Small Molecules. | Yang Y et al. | β | 2019 | β |
| Small molecules enhance neurogenic differentiation of dental-derived adult stem cells. | Heng BC et al. | β | 2019 | β |
| Small molecules re-establish neural cell fate of human fibroblasts via autophagy activation. | Rujanapun N et al. | β | 2019 | β |
| Transcriptome Analysis of Small Molecule-Mediated Astrocyte-to-Neuron Reprogramming. | Ma NX et al. | β | 2019 | β |
| Transplantation of neural scaffolds consisting of dermal fibroblast-reprogrammed neurons and 3D silk fibrous materials promotes the repair of spinal cord injury. | Hu Y et al. | β | 2019 | β |
| Understanding and Modulating Immunity With Cell Reprogramming. | Pires CF et al. | β | 2019 | β |
| Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. | Mertens J et al. | β | 2018 | β |
| A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. | Sheng C et al. | β | 2018 | β |
| Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. | HΓ©bert JM et al. | β | 2018 | β |
| Chemical conversion of human and mouse fibroblasts into motor neurons. | Qin H et al. | β | 2018 | β |
| Chemical conversion of human lung fibroblasts into neuronal cells. | Wan XY et al. | β | 2018 | β |
| Common Gene Expression Patterns in the Generation of Induced Neurons From Fibroblasts. | Mohammadnia A et al. | β | 2018 | β |
| Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program. | Karow M et al. | β | 2018 | β |
| Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using <i>Sox2, Ascl1</i>, and <i>Neurog2</i>. | AraΓΊjo JAM et al. | β | 2018 | β |
| Dynamic Changes of the Mitochondria in Psychiatric Illnesses: New Mechanistic Insights From Human Neuronal Models. | Srivastava R et al. | β | 2018 | β |
| Epigenetics and cerebral organoids: promising directions in autism spectrum disorders. | Forsberg SL et al. | β | 2018 | β |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | β | 2018 | β |
| Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions. | Chanoumidou K et al. | β | 2018 | β |
| Human neurons to model aging: A dish best served old. | BΓΆhnke L et al. | β | 2018 | β |
| Materials for Neural Differentiation, Trans-Differentiation, and Modeling of Neurological Disease. | Gong L et al. | β | 2018 | β |
| Mechanistic Insights Into MicroRNA-Induced Neuronal Reprogramming of Human Adult Fibroblasts. | Lu YL et al. | β | 2018 | β |
| Parkinson's disease: what the model systems have taught us so far. | Ghatak S et al. | β | 2018 | β |
| Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration. | Fang L et al. | β | 2018 | β |
| Representing Diversity in the Dish: Using Patient-Derived <i>in Vitro</i> Models to Recreate the Heterogeneity of Neurological Disease. | Ghaffari LT et al. | β | 2018 | β |
| Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene Regulation. | Packer J et al. | β | 2018 | β |
| Tensor Decomposition-Based Unsupervised Feature Extraction Can Identify the Universal Nature of Sequence-Nonspecific Off-Target Regulation of mRNA Mediated by MicroRNA Transfection. | Taguchi YH | β | 2018 | β |
| Transdifferentiation: a new promise for neurodegenerative diseases. | Mollinari C et al. | β | 2018 | β |
| Transdifferentiation of human adult peripheral blood T cells into neurons. | Tanabe K et al. | β | 2018 | β |
| Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming. | Meng S et al. | β | 2018 | β |
| Brain repair from intrinsic cell sources: Turning reactive glia into neurons. | Torper O et al. | β | 2017 | β |
| C9ORF135 encodes a membrane protein whose expression is related to pluripotency in human embryonic stem cells. | Zhou S et al. | β | 2017 | β |
| Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development? | Zheng F et al. | β | 2017 | β |
| Direct conversion of human fibroblasts to functional excitatory cortical neurons integrating into human neural networks. | Miskinyte G et al. | β | 2017 | β |
| Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules. | Gao L et al. | β | 2017 | β |
| Direct induction of functional neuronal cells from fibroblast-like cells derived from adult human retina. | Hao L et al. | β | 2017 | β |
| Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success. | GascΓ³n S et al. | β | 2017 | β |
| Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. | Li X et al. | β | 2017 | β |
| Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons. | Tang Y et al. | β | 2017 | β |
| Discovery and progress of direct cardiac reprogramming. | Kojima H et al. | β | 2017 | β |
| Induced dopaminergic neurons: A new promise for Parkinson's disease. | Xu Z et al. | β | 2017 | β |
| Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response. | Bernhardt M et al. | β | 2017 | β |
| New approaches for direct conversion of patient fibroblasts into neural cells. | Gopalakrishnan S et al. | β | 2017 | β |
| New neurons in adult brain: distribution, molecular mechanisms and therapies. | Pino A et al. | β | 2017 | β |
| Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma. | Oh J et al. | β | 2017 | β |
| Reprogramming of somatic cells: iPS and iN cells. | Broccoli V | β | 2017 | β |
| Small molecules for reprogramming and transdifferentiation. | Qin H et al. | β | 2017 | β |
| The zinc finger E-box-binding homeobox 1 (<i>Zeb1</i>) promotes the conversion of mouse fibroblasts into functional neurons. | Yan L et al. | β | 2017 | β |
| Transflammation: Innate immune signaling in nuclear reprogramming. | Meng S et al. | β | 2017 | β |
| Understanding neurodevelopmental disorders using human pluripotent stem cell-derived neurons. | Tamburini C et al. | β | 2017 | β |
| Use of Human Neurons Derived via Cellular Reprogramming Methods to Study Host-Parasite Interactions of Toxoplasma gondii in Neurons. | Halonen SK | β | 2017 | β |
| Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models. | Haggarty SJ et al. | β | 2016 | β |
| An Overview of Direct Somatic Reprogramming: The Ins and Outs of iPSCs. | Menon S et al. | β | 2016 | β |
| Brain repair and reprogramming: the route to clinical translation. | Grealish S et al. | β | 2016 | β |
| Chemically Induced Reprogramming of Somatic Cells to Pluripotent Stem Cells and Neural Cells. | Biswas D et al. | β | 2016 | β |
| Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. | Liu K et al. | β | 2016 | β |
| Chemical transdifferentiation: closer to regenerative medicine. | Xu A et al. | β | 2016 | β |
| Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders. | Panchision DM | β | 2016 | β |
| Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor. | Shahbazi E et al. | β | 2016 | β |
| Deterministic transfection drives efficient nonviral reprogramming and uncovers reprogramming barriers. | Gallego-Perez D et al. | β | 2016 | β |
| Direct conversion of human fibroblasts to induced serotonergic neurons. | Xu Z et al. | β | 2016 | β |
| Direct neuronal reprogramming: learning from and for development. | Masserdotti G et al. | β | 2016 | β |
| Efficient induction of neural precursor cells from fibroblasts using stromal cell-derived inducing activity. | Lim MS et al. | β | 2016 | β |
| Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders. | Mlody B et al. | β | 2016 | β |
| Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. | Mertens J et al. | β | 2016 | β |
| Functional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Different Oxygen and Medium Conditions. | Yamazaki K et al. | β | 2016 | β |
| Generating human serotonergic neurons in vitro: Methodological advances. | Vadodaria KC et al. | β | 2016 | β |
| Generation of diverse neural cell types through direct conversion. | Petersen GF et al. | β | 2016 | β |
| Generation of functional human serotonergic neurons from fibroblasts. | Vadodaria KC et al. | β | 2016 | β |
| Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls. | Passeri E et al. | β | 2016 | β |
| InΒ Vivo Cellular Reprogramming: The Next Generation. | Srivastava D et al. | β | 2016 | β |
| Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. | Zheng X et al. | β | 2016 | β |
| Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. | Xue Y et al. | β | 2016 | β |
| Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. | Kang H et al. | β | 2016 | β |
| Small molecules increase direct neural conversion of human fibroblasts. | Pfisterer U et al. | β | 2016 | β |
| Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. | Black JB et al. | β | 2016 | β |
| Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron. | Zhang J et al. | β | 2016 | β |
| Therapeutical Strategies for Spinal Cord Injury and a Promising Autologous Astrocyte-Based Therapy Using Efficient Reprogramming Techniques. | Yang H et al. | β | 2016 | β |
| Advances in reprogramming-based study of neurologic disorders. | Nityanandam A et al. | β | 2015 | β |
| Cell divisions are not essential for the direct conversion of fibroblasts into neuronal cells. | Fishman VS et al. | β | 2015 | β |
| Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells. | Meyer S et al. | β | 2015 | β |
| Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. | Sadahiro T et al. | β | 2015 | β |
| Direct Conversion of Equine Adipose-Derived Stem Cells into Induced Neuronal Cells Is Enhanced in Three-Dimensional Culture. | Petersen GF et al. | β | 2015 | β |
| Direct conversion of human fibroblasts into dopaminergic neural progenitor-like cells using TAT-mediated protein transduction of recombinant factors. | Mirakhori F et al. | β | 2015 | β |
| Direct conversion of mouse fibroblasts to GABAergic neurons with combined medium without the introduction of transcription factors or miRNAs. | Xu H et al. | β | 2015 | β |
| Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules. | Hu W et al. | β | 2015 | β |
| Direct Conversion Provides Old Neurons from Aged Donor's Skin. | Koch P | β | 2015 | β |
| Direct lineage reprogramming: strategies, mechanisms, and applications. | Xu J et al. | β | 2015 | β |
| Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. | Mertens J et al. | β | 2015 | β |
| Direct somatic lineage conversion. | Tanabe K et al. | β | 2015 | β |
| Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. | Passeri E et al. | β | 2015 | β |
| Forward engineering neuronal diversity using direct reprogramming. | Tsunemoto RK et al. | β | 2015 | β |
| Generation of induced pluripotent stem cells without genetic defects by small molecules. | Park HS et al. | β | 2015 | β |
| High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. | Zhao Y et al. | β | 2015 | β |
| Highly efficient direct conversion of human fibroblasts to neuronal cells by chemical compounds. | Dai P et al. | β | 2015 | β |
| How to make a midbrain dopaminergic neuron. | Arenas E et al. | β | 2015 | β |
| Human induced pluripotent stem cell and nanotechnology-based therapeutics. | Liu WH et al. | β | 2015 | β |
| Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons. | Bradford AB et al. | β | 2015 | β |
| Induction of Neural Progenitor-Like Cells from Human Fibroblasts via a Genetic Material-Free Approach. | Mirakhori F et al. | β | 2015 | β |
| In Vivo Reprogramming for Brain and Spinal Cord Repair. | Chen G et al. | β | 2015 | β |
| Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. | JoviΔiΔ A et al. | β | 2015 | β |
| Neurogenin 2 enhances the generation of patient-specific induced neuronal cells. | Zhao P et al. | β | 2015 | β |
| Overcoming the hurdles for a reproducible generation of human functionally mature reprogrammed neurons. | Broccoli V et al. | β | 2015 | β |
| Probing disorders of the nervous system using reprogramming approaches. | Ichida JK et al. | β | 2015 | β |
| Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. | Li X et al. | β | 2015 | β |
| Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. | Zhang L et al. | β | 2015 | β |
| Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells. | Halder D et al. | β | 2015 | β |
| Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients. | Lim CS et al. | β | 2015 | β |
| bHLH factors in self-renewal, multipotency, and fate choice of neural progenitor cells. | Imayoshi I et al. | β | 2014 | β |
| Chemical conversion of human fibroblasts into functional Schwann cells. | Thoma EC et al. | β | 2014 | β |
| Development-inspired reprogramming of the mammalian central nervous system. | Amamoto R et al. | β | 2014 | β |
| Direct neural conversion from human fibroblasts using self-regulating and nonintegrating viral vectors. | Lau S et al. | β | 2014 | β |
| Fast and efficient neural conversion of human hematopoietic cells. | CastaΓ±o J et al. | β | 2014 | β |
| Generation of induced neuronal cells by the single reprogramming factor ASCL1. | Chanda S et al. | β | 2014 | β |
| Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain. | Pereira M et al. | β | 2014 | β |
| Imidazole-based small molecules that promote neurogenesis in pluripotent cells. | Kim GH et al. | β | 2014 | β |
| Induced neural lineage cells as repair kits: so close, yet so far away. | Mirakhori F et al. | β | 2014 | β |
| Inhibition of TGFΞ² signaling increases direct conversion of fibroblasts to induced cardiomyocytes. | Ifkovits JL et al. | β | 2014 | β |
| In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model. | Guo Z et al. | β | 2014 | β |
| Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. | Wang JL et al. | β | 2014 | β |
| Lineage-reprogramming of pericyte-derived cells of the adult human brain into induced neurons. | Karow M et al. | β | 2014 | β |
| Mash1 efficiently reprograms rat astrocytes into neurons. | Ding D et al. | β | 2014 | β |
| Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD. | Kim DS et al. | β | 2014 | β |
| Rapid neurogenesis through transcriptional activation in human stem cells. | Busskamp V et al. | β | 2014 | β |
| Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors. | Zhou Z et al. | β | 2014 | β |
| Reprogram or reboot: small molecule approaches for the production of induced pluripotent stem cells and direct cell reprogramming. | Jung DW et al. | β | 2014 | β |
| Retinoic acid receptor Ξ³ (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons. | Shi Z et al. | β | 2014 | β |
| Senescence impairs direct conversion of human somatic cells to neurons. | Sun CK et al. | β | 2014 | β |
| Small molecules facilitate rapid and synchronous iPSC generation. | Bar-Nur O et al. | β | 2014 | β |
| Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. | Heinrich C et al. | β | 2014 | β |
| The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons. | Kulangara K et al. | β | 2014 | β |
| The genome in three dimensions: a new frontier in human brain research. | Mitchell AC et al. | β | 2014 | β |
| The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. | Ali FR et al. | β | 2014 | β |
| The potential of alternate sources of cells for neural grafting in Parkinson's and Huntington's disease. | Drouin-Ouellet J | β | 2014 | β |
| The Power and the Promise of Cell Reprogramming: Personalized Autologous Body Organ and Cell Transplantation. | Palomo AB et al. | β | 2014 | β |
| Tuning cell fate: from insights to vertebrate regeneration. | Kami D et al. | β | 2014 | β |
| Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways. | Tsai HL et al. | β | 2014 | β |
| Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. | Arenas E | β | 2014 | β |
| Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts. | Davila J et al. | β | 2013 | β |
| Cell therapy: the final frontier for treatment of neurological diseases. | Dutta S et al. | β | 2013 | β |
| Chemical approaches to stem cell biology and therapeutics. | Li W et al. | β | 2013 | β |
| Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors. | Xu T et al. | β | 2013 | β |
| Differential L1 regulation in pluripotent stem cells of humans and apes. | Marchetto MCN et al. | β | 2013 | β |
| Induced neural stem cells (iNSCs) in neurodegenerative diseases. | Hermann A et al. | β | 2013 | β |
| Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. | Ladewig J et al. | β | 2013 | β |
| Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. | Ladewig J et al. | β | 2013 | β |
| Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. | Chanda S et al. | β | 2013 | β |
| [Possible applications of new stem cell sources in neurology]. | Hermann A et al. | β | 2013 | β |
| Proneural genes in neocortical development. | Wilkinson G et al. | β | 2013 | β |
| Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders. | Qiang L et al. | β | 2013 | β |
| Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes. | Raciti M et al. | β | 2013 | β |
| Reshaping the brain: direct lineage conversion in the nervous system. | Amamoto R et al. | β | 2013 | β |
| Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. | Liu ML et al. | β | 2013 | β |
| Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy. | Aguila JC et al. | β | 2012 | β |
| Cellular reprogramming: a small molecule perspective. | Nie B et al. | β | 2012 | β |
| Direct lineage conversion: induced neuronal cells and induced neural stem cells. | Shi Z et al. | β | 2012 | β |
| Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells. | Adler AF et al. | β | 2012 | β |
| Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming. | Zhang Y et al. | β | 2012 | β |
| The author file: Oliver BrΓΌstle. | Baker M | β | 2012 | β |