Understanding the time variant connectivity of the language network in developmental dyslexia: new insights using Granger causality.
- Authors
- Ligges, Carolin; Ungureanu, M; Ligges, M; Blanz, B; Witte, H
- Year
- 2010
- Journal
- Journal of neural transmission (Vienna, Austria : 1996)
- PMID
- 20101420
- DOI
- 10.1007/s00702-010-0367-x
The reading process takes place in a neuronal network comprising the inferior frontal, posterior dorsal and posterior ventral brain areas. It is suggested that developmental dyslexia is caused by a disruption of the two posterior network areas. What remains debatable is whether these areas are affected in their functionality or whether the neuronal networking (connectivity) of these areas suffer from a disturbed information transfer. Thus, it is of major interest to investigate the time flow of the directed information transfer (time variant connectivity) within the neuronal reading network of dyslexic subjects. We investigated adolescents with dyslexia and normal-reading controls with functional magnetic resonance imaging and electroencephalography (EEG) with a paradigm addressing basic visual, orthographic and phonological processing. EEG data were analyzed with the time variant Granger causality index (tvGCI) to investigate the temporal order of the directed information transfer (time variant causal connectivity: which network node passes when information to which network node) during reading in dyslexic readers. Results show that the reading network of dyslexic readers comprises the same brain areas as identified in normal-reading subjects. The tvGCI analysis of the network profiles of dyslexic readers indicates that dyslexics show a difference in timing and localization of connectivity within this reading network compared to normal readers. Dyslexic readers use right hemisphere language areas to counterbalance posterior left hemisphere processing deficits. The compensatory involvement of homologue right hemisphere brain areas for the reading process may be the neurobiological background for the significantly longer reading times by dyslexics.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Altered brain network topology during speech tracking in developmental dyslexia. | Zhang M et al. | β | 2022 | β |
| Empirical Analysis of Apnea Syndrome Using an Artificial Intelligence-Based Granger Panel Model Approach. | Onyema EM et al. | β | 2022 | β |
| An Evolutionary Perspective of Dyslexia, Stress, and Brain Network Homeostasis. | Kershner JR | β | 2020 | β |
| Altered patterns of directed connectivity within the reading network of dyslexic children and their relation to reading dysfluency. | Ε½ariΔ G et al. | β | 2017 | β |
| Graph theoretical analysis of EEG effective connectivity in vascular dementia patients during a visual oddball task. | Wang C et al. | β | 2016 | β |
| Letter-sound processing deficits in children with developmental dyslexia: An ERP study. | Moll K et al. | β | 2016 | β |
| Tackling the 'dyslexia paradox': reading brain and behavior for early markers of developmental dyslexia. | Ozernov-Palchik O et al. | β | 2016 | β |
| Advances in Electrophysiological Research. | Kamarajan C et al. | β | 2015 | β |
| Dyslexic children lack word selectivity gradients in occipito-temporal and inferior frontal cortex. | Olulade OA et al. | β | 2015 | β |
| Sound localization and word discrimination in reverberant environment in children with developmental dyslexia. | Castro-Camacho W et al. | β | 2015 | β |
| Resting-state functional connectivity and reading abilities in first and second languages. | Zhang M et al. | β | 2014 | β |
| Age, sex, and verbal abilities affect location of linguistic connectivity in ventral visual pathway. | Burman DD et al. | β | 2013 | β |
| Monitoring the fetal heart rate variations by means of time-variant multivariate analysis. | Ungureanu GM et al. | β | 2013 | β |
| Neurobiological underpinnings of math and reading learning disabilities. | Ashkenazi S et al. | β | 2013 | β |
| An analytical approach to network motif detection in samples of networks with pairwise different vertex labels. | Schmidt C et al. | β | 2012 | β |
| N300 indexes deficient integration of orthographic and phonological representations in children with dyslexia. | Hasko S et al. | β | 2012 | β |