Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis.
paper
Cited
Public
Unavailable
- Authors
- Cullen, Sean P; Kearney, Conor J; Clancy, Danielle M; Martin, Seamus J
- Year
- 2015
- Journal
- Cell reports
- PMID
- 26027935
- DOI
- 10.1016/j.celrep.2015.05.003
The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing "signal I" and diverse agents such as ATP, Nigericin, streptolysin O, uric acid crystals, and alum salts capable of acting as "signal II." In the absence of signal II, pro-IL-1β is upregulated but typically fails to be processed or released. What unites signal II stimuli has been debated, with the ability to promote K+ efflux suggested as a common factor, but the mechanism of IL-1β release remains unclear. Here, we show that all examined inflammasome signal II agents triggered necrosis, which was highly correlated with their ability to promote IL-1β release. IL-1β secretion occurred in tandem with the release of many additional proteins and was confined to necrotic cells. Thus, signal II agents initiate inflammation by promoting necrosis-driven IL-1β release, suggesting that IL-1β represents an inducible danger signal.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Celastrol-Loaded Zwitterionic Nanogels Trigger Pyroptosis for Potent Antitumor Effects. | Sheng S et al. | — | 2026 | → |
| Endothelial NLRP3 inflammasome activation drives immunothrombosis in Streptococcus pyogenes infection. | Lai YH et al. | — | 2026 | → |
| Targeting COL6A3-C5 with nigericin suppresses endotrophin formation and enhances insulin sensitivity in obesity. | Kim CS et al. | — | 2026 | → |
| Targeting VDAC1 to protect against mitochondria-linked cell death pathways: apoptosis, pyroptosis, ferroptosis, and associated diseases. | Shteinfer-Kuzmine A et al. | — | 2026 | → |
| TET2 loss enhances early response to inflammation in primitive and committed myeloid cells. | Jenkins MT et al. | — | 2026 | → |
| The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage. | Boegli A et al. | — | 2026 | → |
| Trans-Golgi network-associated noncanonical autophagy depends on the V-ATPase-ATG16L1 axis and mediates IL1B secretion. | Long J et al. | — | 2026 | → |
| ALIX mediates reversible gasdermin-D pore formation via the endosomal pathway to limit pyroptosis by active membrane repair. | Otchere S et al. | — | 2025 | → |
| Beyond the mutations: spatiotemporal regulation of CFTR by cAMP and calcium signaling in epithelial physiology and cystic fibrosis. | Varga A et al. | — | 2025 | → |
| Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging. | Potenza DM et al. | — | 2025 | → |
| Enhancing Tyro3 signaling ameliorates IL-1β production through STAT1 in Alzheimer's disease models. | Ravichandran KA et al. | — | 2025 | → |
| Ginsenoside Rg2, a principal effective ingredient of <i>Panax ginseng</i>, attenuates DSS-induced ulcerative colitis through NF-κB/NLRP3 pathway. | Zhang J et al. | — | 2025 | → |
| Immune subversion by Leishmania infantum parasites suppresses NLRP3-driven inflammatory responses in amyloid-β-activated microglia. | Calvo Alvarez E et al. | — | 2025 | → |
| Immunomodulatory effects of Purion processed human amniotic membrane allografts in vitro. | Moreno SE et al. | — | 2025 | → |
| Impact of urea as a protein substitute in growing camel rations on performance, nitrogen balance, blood metabolites, immune status, and rumen fermentation. | Nasr HA et al. | — | 2025 | → |
| Interleukin 1β receptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1. | Piacentini R et al. | — | 2025 | → |
| Mechanism of effect and therapeutic potential of NLRP3 inflammasome in spinal cord injury. | Gu HY et al. | — | 2025 | → |
| MiR-146a engineered extracellular vesicles derived from mesenchymal stromal cells more potently attenuate ischaemia-reperfusion injury in lung transplantation. | Yang X et al. | — | 2025 | → |
| Ornithine lipids from <i>Akkermansia muciniphila</i> are dynamically modulated in colitis and shape macrophage inflammatory responses. | Selmi H et al. | — | 2025 | → |
| Protein regulatory network mediated by palmitoylation modifications in the pathological progression of Parkinson's disease: a narrative review. | Liu J et al. | — | 2025 | → |
| Regulation of ZFP36 by lncOlfr29 promotes inflammation through NLRP3. | Cheng W et al. | — | 2025 | → |
| Regulatory effect of miR-142-5p on inflammatory process of sepsis by targeting CXCL8. | Wu L et al. | — | 2025 | → |
| Sodium butyrate alleviates colitis by inhibiting mitochondrial ROS mediated macrophage pyroptosis. | Fan G et al. | — | 2025 | → |
| The Emerging Role of Colchicine to Inhibit NOD-like Receptor Family, Pyrin Domain Containing 3 Inflammasome and Interleukin-1β Expression in In Vitro Models. | Astiawati T et al. | — | 2025 | → |
| The vasoconstrictor adenosine 5'-tetraphosphate is a danger signal that induces IL-1β. | Bockstiegel J et al. | — | 2025 | → |
| Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells. | Huang CY et al. | — | 2025 | → |
| Antioxidant and Anti-Inflammatory Properties of Hydrolyzed Royal Jelly Peptide in Human Dermal Fibroblasts: Implications for Skin Health and Care Applications. | Yan CY et al. | — | 2024 | → |
| Cancer-derived exosomal Alu RNA promotes colorectal cancer progression. | Magliacane Trotta S et al. | — | 2024 | → |
| Emerging role of galectin 3 in neuroinflammation and neurodegeneration. | Lozinski BM et al. | — | 2024 | → |
| Exploring the potential molecular intersection of stroke and major depression disorder. | Zhao Y et al. | — | 2024 | → |
| Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis. | Xu R et al. | — | 2024 | → |
| Inflammasome Activation and IL-1β Release Triggered by Nanosecond Pulsed Electric Fields in Murine Innate Immune Cells and Skin. | Mazzarda F et al. | — | 2024 | → |
| Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression. | Han Q et al. | — | 2024 | → |
| NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment. | Pan W et al. | — | 2024 | → |
| Portulaca Oleracea L. Phenolic Amide Methyl (3,4,5-Trimethoxybenzoyl) Valylprolinate Attenuates Diethylhexyl Phthalate-Induced Human Umbilical Vein Endothelial Cells' Inflammation Through NLRP3 and NF-κB Pathways. | Bu F et al. | — | 2024 | → |
| Potassium ion efflux induces exaggerated mitochondrial damage and non-pyroptotic necrosis when energy metabolism is blocked. | Xu R et al. | — | 2024 | → |
| TNFα modulates PANX1 activation to promote ATP release and enhance P2RX7-mediated antitumor immune responses after chemotherapy in colorectal cancer. | Huang KC et al. | — | 2024 | → |
| Type I IFN drives unconventional IL-1β secretion in lupus monocytes. | Caielli S et al. | — | 2024 | → |
| A detailed molecular network map and model of the NLRP3 inflammasome. | Krantz M et al. | — | 2023 | → |
| BC-1215 inhibits ATP-induced IL-1β secretion via the FBXL2-mediated ubiquitination and degradation of not only NLRP3, but also pro-IL-1β in LPS-primed THP-1 cells. | Jeon S et al. | — | 2023 | → |
| Blocking the Hormone Receptors Modulates NLRP3 in LPS-Primed Breast Cancer Cells. | Hamza S et al. | — | 2023 | → |
| Construction of PANoptosis signature: Novel target discovery for prostate cancer immunotherapy. | Yi X et al. | — | 2023 | → |
| Kurarinone exerts anti-inflammatory effect via reducing ROS production, suppressing NLRP3 inflammasome, and protecting against LPS-induced sepsis. | Yazal T et al. | — | 2023 | → |
| Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism. | Delcroix V et al. | — | 2023 | → |
| NLRP3 Inflammasome-Mediated Neuroinflammation and Related Mitochondrial Impairment in Parkinson's Disease. | Han QQ et al. | — | 2023 | → |
| Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space. | Yu TG et al. | — | 2023 | → |
| Pyroptosis in septic lung injury: Interactions with other types of cell death. | Jiang Y et al. | — | 2023 | → |
| The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD-rat model. | Wikan N et al. | — | 2023 | → |
| ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation. | Bai D et al. | — | 2022 | → |
| Chloride Channel and Inflammation-Mediated Pathogenesis of Osteoarthritis. | Lin Z et al. | — | 2022 | → |
| Combination of immune checkpoint inhibitors with radiation therapy in cancer: A hammer breaking the wall of resistance. | Voronova V et al. | — | 2022 | → |
| Dimethyl Itaconate Attenuates CFA-Induced Inflammatory Pain <i>via</i> the NLRP3/ IL-1β Signaling Pathway. | Lin J et al. | — | 2022 | → |
| Identifying Potential Gene Defect Patterns Related to COVID-19 Based on Pharmacological and Bioinformatics Analysis for Lung Adenocarcinoma. | Lou H et al. | — | 2022 | → |
| IL-1 family cytokines serve as 'activity recognition receptors' for aberrant protease activity indicative of danger. | Martin SJ et al. | — | 2022 | → |
| IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases. | Frezza V et al. | — | 2022 | → |
| Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applications. | Alves AL et al. | — | 2022 | → |
| T cell apoptosis characterizes severe Covid-19 disease. | André S et al. | — | 2022 | → |
| The noncanonical inflammasome in health and disease. | Cahoon J et al. | — | 2022 | → |
| The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation. | Drinkall S et al. | — | 2022 | → |
| Activation mechanisms of inflammasomes by bacterial toxins. | Jing W et al. | — | 2021 | → |
| Decoding Cell Death: From a Veritable Library of Babel to <i>Vade Mecum</i>? | Hughes LD et al. | — | 2021 | → |
| Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability. | Blake S et al. | — | 2021 | → |
| Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. | Bjanes E et al. | — | 2021 | → |
| High pathogenicity island is associated with enhanced autophagy in pathogenic Escherichia coli HPI - infected macrophages. | Zhao W et al. | — | 2021 | → |
| IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D. | Kiss M et al. | — | 2021 | → |
| Interleukin 1 beta-induced chloride currents are important in osteoarthritis onset: an in vitro study. | Deng Z et al. | — | 2021 | → |
| Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death. | Bolívar BE et al. | — | 2021 | → |
| Plasma-borne indicators of inflammasome activity in Parkinson's disease patients. | Anderson FL et al. | — | 2021 | → |
| SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway. | Campbell GR et al. | — | 2021 | → |
| The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense. | Snyder AG et al. | — | 2021 | → |
| Activation of Human Monocytes by Colloidal Aluminum Salts. | Vrieling H et al. | — | 2020 | → |
| A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration. | Zhao Z et al. | — | 2020 | → |
| Cathelicidin-related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation. | Li F et al. | — | 2020 | → |
| Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei. | Amemiya K et al. | — | 2020 | → |
| Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium. | Yang Y et al. | — | 2020 | → |
| Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. | Suzuki T et al. | — | 2020 | → |
| Genetic Variability in Antioxidative and Inflammatory Pathways Modifies the Risk for PCOS and Influences Metabolic Profile of the Syndrome. | Herman R et al. | — | 2020 | → |
| <i>Cryptococcus neoformans</i> Secretes Small Molecules That Inhibit IL-1<i>β</i> Inflammasome-Dependent Secretion. | Bürgel PH et al. | — | 2020 | → |
| Inflammasome expression is higher in ovarian tumors than in normal ovary. | Luborsky J et al. | — | 2020 | → |
| Inflammasome signaling and regulation of interleukin-1 family cytokines. | Chan AH et al. | — | 2020 | → |
| Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation. | Duan X et al. | — | 2020 | → |
| Interleukin-1β and Cancer. | Rébé C et al. | — | 2020 | → |
| Macrolets: Outsized Extracellular Vesicles Released from Lipopolysaccharide-Stimulated Macrophages that Trap and Kill Escherichia coli. | Ding W et al. | — | 2020 | → |
| Metal nanoparticles-induced activation of NLRP3 inflammasome in human oral keratinocytes is a possible mechanism of oral lichenoid lesions. | Sasabe E et al. | — | 2020 | → |
| MiR-223-3p in Cardiovascular Diseases: A Biomarker and Potential Therapeutic Target. | Zhang MW et al. | — | 2020 | → |
| Recent insights into the regulatory networks of NLRP3 inflammasome activation. | Weber ANR et al. | — | 2020 | → |
| Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis. | de Vasconcelos NM et al. | — | 2020 | → |
| Sodium Butyrate Alleviates Lipopolysaccharide-Induced Inflammatory Responses by Down-Regulation of NF-κB, NLRP3 Signaling Pathway, and Activating Histone Acetylation in Bovine Macrophages. | Jiang L et al. | — | 2020 | → |
| The c-Met inhibitor capmatinib alleviates acetaminophen-induced hepatotoxicity. | Saad KM et al. | — | 2020 | → |
| The Impact of Acute Ingestion of a Ketone Monoester Drink on LPS-Stimulated NLRP3 Activation in Humans with Obesity. | Neudorf H et al. | — | 2020 | → |
| Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. | Ipseiz N et al. | — | 2020 | → |
| Total Absence of Dystrophin Expression Exacerbates Ectopic Myofiber Calcification and Fibrosis and Alters Macrophage Infiltration Patterns. | Young CNJ et al. | — | 2020 | → |
| Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen-host interactions. | Sanchez-Garrido J et al. | — | 2020 | → |
| A Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo. | Talley S et al. | — | 2019 | → |
| An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS). | Lin L et al. | — | 2019 | → |
| Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM. | Carty M et al. | — | 2019 | → |
| Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization. | Baroja-Mazo A et al. | — | 2019 | → |
| Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism. | Li H et al. | — | 2019 | → |
| Exogenous hydrogen sulfide mitigates LPS + ATP-induced inflammation by inhibiting NLRP3 inflammasome activation and promoting autophagy in L02 cells. | Wu D et al. | — | 2019 | → |
| Extract From <i>Plectranthus amboinicus</i> Inhibit Maturation and Release of Interleukin 1β Through Inhibition of NF-κB Nuclear Translocation and NLRP3 Inflammasome Activation. | Leu WJ et al. | — | 2019 | → |
| Frontline Science: Escherichia coli use LPS as decoy to impair neutrophil chemotaxis and defeat antimicrobial host defense. | Kondo Y et al. | — | 2019 | → |
| Host Cell Death Responses to Non-typhoidal <i>Salmonella</i> Infection. | Wemyss MA et al. | — | 2019 | → |
| <i>Cryptococcus neoformans</i>secretes small molecules that inhibit IL-1β inflammasome-dependent secretion | Bürgel PH et al. | — | 2019 | — |
| Inflammasome Activation Induced by a Snake Venom Lys49-Phospholipase A<sub>2</sub> Homologue. | Boeno CN et al. | — | 2019 | → |
| Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease. | Bolívar BE et al. | — | 2019 | → |
| Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β. | Talty A et al. | — | 2019 | → |
| lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. | Xue Z et al. | — | 2019 | → |
| LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses. | Pfalzgraff A et al. | — | 2019 | → |
| Neutrophil pyroptosis: new perspectives on sepsis. | Liu L et al. | — | 2019 | → |
| Optimized protocols for studying the NLRP3 inflammasome and assessment of potential targets of CP-453,773 in undifferentiated THP1 cells. | Guzova JA et al. | — | 2019 | → |
| Pleiotropic Roles of P2X7 in the Central Nervous System. | Kanellopoulos JM et al. | — | 2019 | → |
| Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. | Akula MK et al. | — | 2019 | → |
| Pyroptosis versus necroptosis: similarities, differences, and crosstalk. | Frank D et al. | — | 2019 | → |
| Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis. | Tudrej KB et al. | — | 2019 | → |
| The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome. | Baljon JJ et al. | — | 2019 | → |
| The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release. | Rashidi M et al. | — | 2019 | → |
| The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes. | Tapia VS et al. | — | 2019 | → |
| Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes. | Mambwe B et al. | — | 2019 | → |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | — | 2019 | → |
| Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge. | Tomar J et al. | — | 2018 | → |
| Assessing NLRP3 Inflammasome Activation by Nanoparticles. | Sharma B et al. | — | 2018 | → |
| Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release. | Dautova Y et al. | — | 2018 | → |
| Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing. | Clancy DM et al. | — | 2018 | → |
| From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response? | Cypryk W et al. | — | 2018 | → |
| How Inflammasomes Inform Adaptive Immunity. | Evavold CL et al. | — | 2018 | → |
| Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both <i>in vitro</i> and in a mouse model of inflammation. | Castelblanco M et al. | — | 2018 | → |
| Inflammasome, Inflammation, and Tissue Homeostasis. | Rathinam VAK et al. | — | 2018 | → |
| Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis. | Montgomery ST et al. | — | 2018 | → |
| Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion. | Monteleone M et al. | — | 2018 | → |
| Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders. | Lu J et al. | — | 2018 | → |
| Ky-2, a hybrid compound histone deacetylase inhibitor, regulated inflammatory response in LPS-driven human macrophages. | Kaneko J et al. | — | 2018 | → |
| Novel identified aluminum hydroxide-induced pathways prove monocyte activation and pro-inflammatory preparedness. | Kooijman S et al. | — | 2018 | → |
| P2RX7 Purinoceptor as a Therapeutic Target-The Second Coming? | Young CNJ et al. | — | 2018 | → |
| Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. | Mouton-Liger F et al. | — | 2018 | → |
| PGE2 Augments Inflammasome Activation and M1 Polarization in Macrophages Infected With <i>Salmonella</i> Typhimurium and <i>Yersinia enterocolitica</i>. | Sheppe AEF et al. | — | 2018 | → |
| Placenta Specific 8 Suppresses IL-18 Production through Regulation of Autophagy and Is Associated with Adult Still Disease. | Segawa S et al. | — | 2018 | → |
| Redefining the ancestral origins of the interleukin-1 superfamily. | Rivers-Auty J et al. | — | 2018 | → |
| Regulation of alveolar macrophage death in acute lung inflammation. | Fan EKY et al. | — | 2018 | → |
| Role of receptor-interacting protein 1/receptor-interacting protein 3 in inflammation and necrosis following chronic constriction injury of the sciatic nerve. | Pu S et al. | — | 2018 | → |
| Sex influences in behavior and brain inflammatory and oxidative alterations in mice submitted to lipopolysaccharide-induced inflammatory model of depression. | Mello BSF et al. | — | 2018 | → |
| Simultaneous Detection of Cellular Viability and Interleukin-1β Secretion from Single Cells by ELISpot. | Conos SA et al. | — | 2018 | → |
| SOD2 is upregulated in periodontitis to reduce further inflammation progression. | Yoon Y et al. | — | 2018 | → |
| Structural Moieties Required for Cinnamaldehyde-Related Compounds to Inhibit Canonical IL-1β Secretion. | Ho SC et al. | — | 2018 | → |
| The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. | Kasper L et al. | — | 2018 | → |
| The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory. | Gaidt MM et al. | — | 2018 | → |
| Withaferin A Associated Differential Regulation of Inflammatory Cytokines. | Dubey S et al. | — | 2018 | → |
| Zoledronic acid exacerbates inflammation through M1 macrophage polarization. | Kaneko J et al. | — | 2018 | → |
| A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells. | O'Brien M et al. | — | 2017 | → |
| Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. | Conos SA et al. | — | 2017 | → |
| Allergy-Inducing Chromium Compounds Trigger Potent Innate Immune Stimulation Via ROS-Dependent Inflammasome Activation. | Adam C et al. | — | 2017 | → |
| Ameloblastin Upregulates Inflammatory Response Through Induction of IL-1β in Human Macrophages. | Otsuka M et al. | — | 2017 | → |
| Baicalin Inhibits NOD-Like Receptor Family, Pyrin Containing Domain 3 Inflammasome Activation in Murine Macrophages by Augmenting Protein Kinase A Signaling. | Li CG et al. | — | 2017 | → |
| Berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling. | Li CG et al. | — | 2017 | → |
| Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory "FADDosome" Complex upon TRAIL Stimulation. | Henry CM et al. | — | 2017 | → |
| Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses. | Mayer-Barber KD et al. | — | 2017 | → |
| Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions. | Wang J et al. | — | 2017 | → |
| Helicobacter pylori-Induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease. | Smolka AJ et al. | — | 2017 | → |
| Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP-1-derived macrophages. | Huang Y et al. | — | 2017 | → |
| Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies. | Montgomery ST et al. | — | 2017 | → |
| MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D. | Gutierrez KD et al. | — | 2017 | → |
| Necroptosis: Mechanisms and Relevance to Disease. | Galluzzi L et al. | — | 2017 | → |
| Potent NLRP3 Inflammasome Activation by the HIV Reverse Transcriptase Inhibitor Abacavir. | Toksoy A et al. | — | 2017 | → |
| Programmed Cell Death and Inflammation: Winter Is Coming. | Kolb JP et al. | — | 2017 | → |
| RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. | Downey J et al. | — | 2017 | → |
| Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure. | Woolbright BL et al. | — | 2017 | → |
| The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. | Schneider KS et al. | — | 2017 | → |
| Unconventional Pathways of Secretion Contribute to Inflammation. | Daniels MJ et al. | — | 2017 | → |
| WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3. | Honda S et al. | — | 2017 | → |
| ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages. | Zha QB et al. | — | 2016 | → |
| Bactericidal antibiotics promote reactive oxygen species formation and inflammation in human sinonasal epithelial cells. | Kohanski MA et al. | — | 2016 | → |
| Beyond the grave: When is cell death critical for immunity to infection? | Stephenson HN et al. | — | 2016 | → |
| Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages. | Välimäki E et al. | — | 2016 | → |
| Caspases Connect Cell-Death Signaling to Organismal Homeostasis. | Galluzzi L et al. | — | 2016 | → |
| Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system. | Martin SJ | — | 2016 | → |
| Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion. | Conos SA et al. | — | 2016 | → |
| Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. | Pietras EM et al. | — | 2016 | → |
| Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. | Cadwell K | — | 2016 | → |
| Crystallopathies. | Mulay SR et al. | — | 2016 | → |
| Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. | De Filippis L et al. | — | 2016 | → |
| IL-1 Contributes to the Anti-Cancer Efficacy of Ingenol Mebutate. | Le TT et al. | — | 2016 | → |
| Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells. | Eichholz K et al. | — | 2016 | → |
| Inflammasome-dependent IL-1β release depends upon membrane permeabilisation. | Martín-Sánchez F et al. | — | 2016 | → |
| MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts. | Qin D et al. | — | 2016 | → |
| Piperine Suppresses Pyroptosis and Interleukin-1β Release upon ATP Triggering and Bacterial Infection. | Liang YD et al. | — | 2016 | → |
| Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs. | Clancy DM et al. | — | 2016 | → |
| The intersection of cell death and inflammasome activation. | Vince JE et al. | — | 2016 | → |
| Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety. | Petrovsky N et al. | — | 2015 | → |
| Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. | Galluzzi L et al. | — | 2015 | → |