Leptin as a Potential Regulator of FGF21.
- Authors
- Asrih, Mohamed; Veyrat-Durebex, Christelle; Poher, Anne-Laure; Lyautey, Jacqueline; Rohner-Jeanrenaud, Françoise; Jornayvaz, François R
- Year
- 2016
- Journal
- Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
- PMID
- 26982498
- DOI
- 10.1159/000443070
BACKGROUND/AIMS: Fibroblast growth factor 21 (FGF21), a potent metabolic regulator, has been shown to improve insulin sensitivity in animal models of insulin resistance. Several studies have focused on identifying mediators of FGF21 effects. However, the identification of factors involved in FGF21 regulation is far from complete. As leptin is a potent metabolic modulator as well, we aimed at characterizing whether leptin may regulate FGF21. METHODS: We investigated a potential regulation of FGF21 by leptin in vivo in Wistar rats and in vitro using human derived hepatocarcinoma HepG2 cells. This model was chosen as the liver is considered the main FGF21 expression site. RESULTS: We found that leptin injections increased plasma FGF21 levels in adult Wistar rats. This was confirmed in vitro, as leptin increased FGF21 expression in HepG2 cells. We also showed that the leptin effect on FGF21 expression was mediated by STAT3 activation in HepG2 cells. CONCLUSION: New findings regarding a leptin-STAT3-FGF21 axis were provided in this study, although investigating the exact mechanisms linking leptin and FGF21 are still needed. These results are of great interest in the context of identifying potential new clinical approaches to treat metabolic diseases associated with insulin resistance, such as obesity and type 2 diabetes.
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| FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases. | Shen W et al. | β | 2024 | β |
| Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network. | Li S et al. | β | 2024 | β |
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| Hyperleptinemia results in systemic inflammation and the exacerbation of ischemia-reperfusion myocardial injury. | Polyakova EA et al. | β | 2021 | β |
| Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARΞ²/Ξ΄. | Mazuecos L et al. | β | 2021 | β |
| Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs its Signaling Pathways in Liver and Adipose Tissue in Mice | Liu X et al. | β | 2021 | β |
| Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs Its Signaling Pathways in Liver and Adipose Tissue in Mice. | Liu XH et al. | β | 2021 | β |
| Association of FGF19, FGF21 and FGF23 with carbohydrate metabolism parameters and insulin resistance in patients with chronic kidney disease. | Marchelek-Mysliwiec M et al. | β | 2020 | β |
| Serum FGF-21 and FGF-23 in association with gestational diabetes: a longitudinal case-control study. | Mosavat M et al. | β | 2020 | β |
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | Wang K et al. | β | 2019 | β |
| Fibroblast growth factor 21 in non-alcoholic fatty liver disease. | Tucker B et al. | β | 2019 | β |
| Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer. | Divella R et al. | β | 2019 | β |
| Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21. | Yan K et al. | β | 2018 | β |
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| Diabetes and dyslipidemia: characterizing lipoprotein metabolism. | Tomkin GH et al. | β | 2017 | β |
| FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study. | Li G et al. | β | 2017 | β |
| Leptin/OB-R pathway promotes IL-4 secretion from B lymphocytes and induces salivary gland epithelial cell apoptosis in SjΓΆgren's syndrome. | Xu T et al. | β | 2017 | β |
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