Exploring the genetic overlap between twelve psychiatric disorders.
paper
Cited
Public
Unavailable
- Authors
- Romero, Cato; Werme, Josefin; Jansen, Philip R; Gelernter, Joel; Stein, Murray B; Levey, Daniel; Polimanti, Renato; de Leeuw, Christiaan; Posthuma, Danielle; Nagel, Mats; van der Sluis, Sophie
- Year
- 2022
- Journal
- Nature genetics
- PMID
- 36471075
- DOI
- 10.1038/s41588-022-01245-2
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological studies is mirrored by non-zero, positive genetic correlations from large-scale genetic studies. To identify shared biological processes underpinning this observed phenotypic and genetic covariance and enhance molecular characterization of general psychiatric disorder liability, we used several strategies aimed at uncovering pleiotropic, that is, cross-trait-associated, single-nucleotide polymorphisms (SNPs), genes and biological pathways. We conducted cross-trait meta-analysis on 12 psychiatric disorders to identify pleiotropic SNPs. The meta-analytic signal was driven by schizophrenia, hampering interpretation and joint biological characterization of the cross-trait meta-analytic signal. Subsequent pairwise comparisons of psychiatric disorders identified substantial pleiotropic overlap, but mainly among pairs of psychiatric disorders, and mainly at less stringent P-value thresholds. Only annotations related to evolutionarily conserved genomic regions were significant for multiple (9 out of 12) psychiatric disorders. Overall, identification of shared biological mechanisms remains challenging due to variation in power and genetic architecture between psychiatric disorders.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | 2025 | 40360802 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The genetic landscape of human functional brain connectivity. | Maciel BA et al. | — | 2026 | → |
| Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries. | Khan Y et al. | — | 2026 | → |
| A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders. | Smeland OB et al. | — | 2025 | → |
| A Mendelian randomization study of the associations between depression, anxiety and clinical conditions including thyroid nodules, flatulence, and irregular menstruation. | Bi Z et al. | — | 2025 | → |
| Association between the methyl-CpG-binding domain protein 5 gene and depressive symptoms in a Mexican population: results from the MxGDAR/Encodat cohort. | Sanabrais-Jiménez MA et al. | — | 2025 | → |
| Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. | Pujol Gualdo N et al. | — | 2025 | → |
| Blunted cortisol as a biomarker of depression based on the attenuation hypothesis: A Mendelian randomization analysis using depression as exposure. | Chan II | — | 2025 | → |
| Chronic psilocybin administration increases sociability and alters the gut microbiome in male wild-type mice but not in a preclinical model of obsessive-compulsive disorder. | Gattuso JJ et al. | — | 2025 | → |
| Classification of schizophrenia, bipolar disorder and major depressive disorder with comorbid traits and deep learning algorithms. | Chen X et al. | — | 2025 | → |
| Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study. | Sha Z et al. | — | 2025 | → |
| Dysregulated Pathways During Pregnancy Predict Drug Candidates in Neurodevelopmental Disorders. | Yin H et al. | — | 2025 | → |
| Exploring dopamine as the master regulator of brain circuitry and mental health genome. | Blum K et al. | — | 2025 | → |
| Genetic Analysis of Retinal Cell Types in Neuropsychiatric Disorders. | Boudriot E et al. | — | 2025 | → |
| Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank. | Kariis HM et al. | — | 2025 | → |
| Genetic neurodevelopmental clustering and dyslexia. | Ciulkinyte A et al. | — | 2025 | → |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | — | 2025 | → |
| GWAShug: a comprehensive platform for decoding the shared genetic basis between complex traits based on summary statistics. | Cao C et al. | — | 2025 | → |
| High-order network degree revealed shared and distinct features among adult schizophrenia, bipolar disorder and ADHD. | Wu D et al. | — | 2025 | → |
| [Identifying genetic etiology of ischemic stroke based on pleiotropy of obesity related genes: A sibling study]. | Wang K et al. | — | 2025 | → |
| Immune-Developmental Processes Contribute to Schizophrenia Risk: Insights From a Genetic Overlap Study With Height. | Romero C et al. | — | 2025 | → |
| Leveraging pleiotropy for the improved treatment of psychiatric disorders. | Woodward DJ et al. | — | 2025 | → |
| Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset. | van der Meer D et al. | — | 2025 | → |
| Multitrait Genetic Analysis Identifies Novel Pleiotropic Loci for Depression and Schizophrenia in East Asians. | Song Y et al. | — | 2025 | → |
| NDD-ECHO: A standardised digital assessment tool to capture early life environmental and inflammatory factors for children with neurodevelopmental disorders. | Patel S et al. | — | 2025 | → |
| Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders. | Cilleros-Portet A et al. | — | 2025 | → |
| Predominant Polarity for Enhanced Phenotyping and Personalized Treatment of Bipolar Disorder: A Narrative Review on Recent Findings. | Fico G et al. | — | 2025 | → |
| Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein-Protein Interaction. | Guillen-Burgos HF et al. | — | 2025 | → |
| Shared genetic architecture contributes to risk of major cardiovascular diseases. | Qiao J et al. | — | 2025 | → |
| Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases. | Ma Y et al. | — | 2025 | → |
| The genetic landscape of heterogeneity in human functional brain connectivity | Maciel BdA et al. | — | 2025 | — |
| The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder. | Christiansen GB et al. | — | 2025 | → |
| The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry. | Chopra S et al. | — | 2025 | → |
| Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma. | Zhang Y et al. | — | 2025 | → |
| Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders. | Xu H et al. | — | 2025 | → |
| Aberrant brain dynamics of large-scale functional networks across schizophrenia and mood disorder. | Ishida T et al. | — | 2024 | → |
| An atlas of the shared genetic architecture between atopic and gastrointestinal diseases. | Qi C et al. | — | 2024 | → |
| Challenges in multi-task learning for fMRI-based diagnosis: Benefits for psychiatric conditions and CNVs would likely require thousands of patients. | Harvey A et al. | — | 2024 | → |
| Convergence of the dysregulated regulome in schizophrenia with polygenic risk and evolutionarily constrained enhancers. | Dong P et al. | — | 2024 | → |
| Genetic network structure of 13 psychiatric disorders in the general population. | Ihm HK et al. | — | 2024 | → |
| Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. | Nievergelt CM et al. | — | 2024 | → |
| Integrating genetic and proteomic data to elucidate the association between immune system and blood-brain barrier dysfunction with multiple sclerosis risk and severity. | Sun D et al. | — | 2024 | → |
| Is There a Natural, Non-addictive, and Non-anti-reward, Safe, Gene-based Solution to Treat Reward Deficiency Syndrome? KB220 Variants vs GLP-1 Analogs. | Modestino EJ et al. | — | 2024 | → |
| Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults. | Deng YT et al. | — | 2024 | → |
| Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models. | Antón-Galindo E et al. | — | 2024 | → |
| Post-transcriptional dysregulation in autism, schizophrenia, and bipolar disorder. | Wang Y et al. | — | 2024 | → |
| Precision psychiatry: predicting predictability. | van Dellen E | — | 2024 | → |
| Shared genetic architecture of cortical thickness alterations in major depressive disorder and schizophrenia. | Wang H et al. | — | 2024 | → |
| Using Genetics to Investigate Relationships between Phenotypes: Application to Endometrial Cancer. | Bouttle K et al. | — | 2024 | → |
| Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses. | Huang Y et al. | — | 2023 | → |
| Dimensional clinical phenotyping using <i>post-mortem</i> brain donor medical records: <i>post-mortem</i> RDoC profiling is associated with Alzheimer's disease neuropathology. | Vogelgsang J et al. | — | 2023 | → |
| Examining the shared etiology of psychopathology with genome-wide association studies. | Mallard TT et al. | — | 2023 | → |
| Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data. | Quintero Reis A et al. | — | 2023 | → |
| Genome-wide association study of cerebellar white matter microstructure and genetic overlap with common brain disorders. | Wu BS et al. | — | 2023 | → |
| Revealing the impact of psychiatric comorbidities on treatment outcome in early psychosis using counterfactual model explanation. | van Dee V et al. | — | 2023 | → |