Multipoint interval mapping of quantitative trait loci, using sib pairs.
paper
Cited
Public
Unavailable
- Authors
- Fulker, D W; Cherny, S S; Cardon, L R
- Year
- 1995
- Journal
- American journal of human genetics
- PMID
- 7726180
- PMCID
- PMC1801470
The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.
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| Title | Year | PMID |
|---|---|---|
| A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. | 2008 | 18454434 |
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