Metabolic diseases and cancer risk.
paper
Cited
Public
Unavailable
- Authors
- Faulds, Malin H; Dahlman-Wright, Karin
- Year
- 2012
- Journal
- Current opinion in oncology
- PMID
- 22123235
- DOI
- 10.1097/CCO.0b013e32834e0582
PURPOSE OF REVIEW: Metabolic disease and cancer are two of the leading causes of death worldwide. This review focuses on the potential increased relative risk for the development of cancer in a population with a rapidly increasing incidence of metabolic disturbances. RECENT FINDINGS: A large number of recent epidemiological and prospective studies link metabolic syndrome-associated diseases to an increased risk for development of, as well as mortality from, several types of cancer. In patients diagnosed with metabolic disorders, the incidence of gastrointestinal, glandular and reproductive tract cancers is significantly higher compared to the general population. In line with that, hyperglycemia has recently been shown to be an independent risk factor for overall cancer incidence. SUMMARY: Disorders connected to the metabolic syndrome have been shown to have profound impacts on the incidence and progression of cancer. Continued efforts to make lifestyle interventions, such as weight loss and increased physical activity in the general population, are clearly warranted as a contribution to efforts aimed at decreasing the development of and mortality from cancer. Progression in this field requires a better understanding of the underlying mechanisms behind the cancer-promoting effects associated with disturbed energy balance.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis. | 2014 | 24884913 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation. | Li J et al. | β | 2025 | β |
| Correlation of Body Mass Index with Endometrial Pathology in Perimenopausal Women with AUB: A Prospective Study. | Kaur SB et al. | β | 2025 | β |
| Metabolomic Analysis of Breast Cancer in Colombian Patients: Exploring Molecular Signatures in Different Subtypes and Stages. | LeΓ³n-CarreΓ±o L et al. | β | 2025 | β |
| [Overview of the prevalence and features of oncological diseases in type 2 diabetes and possible immunological mechanisms]. | Dvoryanchikov YV et al. | β | 2025 | β |
| Insulin Resistance: The Increased Risk of Cancers. | Szablewski L | β | 2024 | β |
| Endocrine-disrupting compounds and metabolomic reprogramming in breast cancer. | Winz C et al. | β | 2023 | β |
| Untargeted metabolomic and lipidomic analyses reveal lipid dysregulation in the plasma of acute leukemia patients. | ArΓ©valo C et al. | β | 2023 | β |
| Unveiling Disrupted Lipid Metabolism in Benign Prostate Hyperplasia, Prostate Cancer, and Metastatic Patients: Insights from a Colombian Nested Case-Control Study. | Pardo-Rodriguez D et al. | β | 2023 | β |
| Diabetes mellitus and its impact on mortality rate and outcome in pulmonary embolism. | Schmitt VH et al. | β | 2022 | β |
| Intermittent fasting positively modulates human gut microbial diversity and ameliorates blood lipid profile. | Khan MN et al. | β | 2022 | β |
| Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review. | Tozzi R et al. | β | 2022 | β |
| Research trends of cancer metabolism: analysis from a Chinese perspective. | Li Y et al. | β | 2022 | β |
| Clinicopathological and ultrasound features of endometrial cancer in postmenopausal women: a retrospective study in a single institute in South Korea. | Jo HC et al. | β | 2021 | β |
| Galectin-3 for prediction of cardiac function compared to NT-proBNP in individuals with prediabetes and type 2 diabetes mellitus. | Schmitt VH et al. | β | 2021 | β |
| Impact of diabetes mellitus on mortality rates and outcomes in myocardial infarction. | Schmitt VH et al. | β | 2021 | β |
| Metabolomics in cancer research and emerging applications in clinical oncology. | Schmidt DR et al. | β | 2021 | β |
| Single-bulb garlic oil regulates toll-like receptors and Nrf2 cross-talk and IL-17 production in mice fed with high-fat diet. | Lestari SR et al. | β | 2021 | β |
| <i>In Silico</i> Prediction of the Mode of Action of <i>Viola odorata</i> in Diabetes. | Buabeid MA et al. | β | 2020 | β |
| L-Carnitine Is Involved in Hyperbaric Oxygen-Mediated Therapeutic Effects in High Fat Diet-Induced Lipid Metabolism Dysfunction. | Yuan J et al. | β | 2020 | β |
| Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review. | Lee HS et al. | β | 2020 | β |
| Negative Association of Proton Pump Inhibitors With Subsequent Development of Breast Cancer: A Nationwide Population-Based Study. | Chen CH et al. | β | 2019 | β |
| Recipient obesity does not affect survival after deceased donor liver transplantation for hepatocellular carcinoma. A national retrospective cohort study in the United States. | Ata N et al. | β | 2019 | β |
| Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated circulating testosterone. | Adeyanju OA et al. | β | 2019 | β |
| Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy. | Michael OS et al. | β | 2018 | β |
| Carboxylesterases in lipid metabolism: from mouse to human. | Lian J et al. | β | 2018 | β |
| Human carboxylesterases: a comprehensive review. | Wang D et al. | β | 2018 | β |
| Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1. | Wang YQ et al. | β | 2018 | β |
| Oral hormonal therapy with ethinylestradiol-levonorgestrel improves insulin resistance, obesity, and glycogen synthase kinase-3 independent of circulating mineralocorticoid in estrogen-deficient rats. | Adeyanju OA et al. | β | 2018 | β |
| Clinical and Metabolic Response to Vitamin D Supplementation in Endometrial Hyperplasia: a Randomized, Double-Blind, Placebo-Controlled Trial. | Tabassi Z et al. | β | 2017 | β |
| Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4<sup>+</sup> T Cell Differentiation via PI3K p110Ξ΄-Akt-Mediated Signals. | Mauro C et al. | β | 2017 | β |
| Saponins from stems and leaves of Panax ginseng prevent obesity via regulating thermogenesis, lipogenesis and lipolysis in high-fat diet-induced obese C57BL/6 mice. | Chen G et al. | β | 2017 | β |
| Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the <i>Drosophila</i> Ovary. | Ables ET et al. | β | 2017 | β |
| Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD. | Takeuchi M et al. | β | 2017 | β |
| Hypertensive disorders of pregnancy and subsequent risk of solid cancer--A nationwide cohort study. | Behrens I et al. | β | 2016 | β |
| Phytochemicals in regulating fatty acid Ξ²-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss. | Rupasinghe HP et al. | β | 2016 | β |
| Tripping on TRIB3 at the junction of health, metabolic dysfunction and cancer. | Mondal D et al. | β | 2016 | β |
| Association of diabetes and cancer mortality in American Indians: the Strong Heart Study. | Best LG et al. | β | 2015 | β |
| A systematic review and meta-analysis of interventions for weight management using text messaging. | Siopis G et al. | β | 2015 | β |
| Cancer-drug induced insulin resistance: innocent bystander or unusual suspect. | Ariaans G et al. | β | 2015 | β |
| Gut bacteria and cancer. | Erdman SE et al. | β | 2015 | β |
| Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal. | Sandhir R et al. | β | 2015 | β |
| Obesity and female malignancies. | Benedetto C et al. | β | 2015 | β |
| Relation of metabolic syndrome with endometrial pathologies in patients with abnormal uterine bleeding. | Γzdemir S et al. | β | 2015 | β |
| Apple flavonols and n-3 polyunsaturated fatty acid-rich fish oil lowers blood C-reactive protein in rats with hypercholesterolemia and acute inflammation. | Sekhon-Loodu S et al. | β | 2014 | β |
| Brain metabolic dysfunction at the core of Alzheimer's disease. | de la Monte SM et al. | β | 2014 | β |
| Metabolic syndrome and smoking may justify earlier colorectal cancer screening in men. | Chang LC et al. | β | 2014 | β |
| On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis. | Peterson RE et al. | β | 2014 | β |
| Relationships between diabetes and cognitive impairment. | de la Monte SM | β | 2014 | β |
| Up-regulation of Bcl-2 during adipogenesis mediates apoptosis resistance in human adipocytes. | Nagel SA et al. | β | 2014 | β |
| Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet. | Souza CG et al. | β | 2013 | β |
| Endogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease. | Tonack S et al. | β | 2013 | β |
| Metabolism and breast cancer risk: frontiers in research and practice. | Patterson RE et al. | β | 2013 | β |
| Natural killer T cells in adipose tissue are activated in lean mice. | Kondo T et al. | β | 2013 | β |
| Presentation, diagnostic features and glucose handling in a monocentric series of insulinomas. | Toaiari M et al. | β | 2013 | β |
| Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. | Palm W et al. | β | 2013 | β |
| The role of chronic inflammation in obesity-associated cancers. | Ramos-Nino ME | β | 2013 | β |
| Type 2 diabetes: prevalence and relevance of genetic and acquired factors for its prediction. | Rathmann W et al. | β | 2013 | β |
| Chronic exposure to nicotine enhances insulin sensitivity through Ξ±7 nicotinic acetylcholine receptor-STAT3 pathway. | Xu TY et al. | β | 2012 | β |
| High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. | Kim KA et al. | β | 2012 | β |
| Lipids and prostate cancer. | Suburu J et al. | β | 2012 | β |
| Oxidant stress and skeletal muscle microvasculopathy in the metabolic syndrome. | Goodwill AG et al. | β | 2012 | β |
| Phosphorylated AMP-activated protein kinase expression associated with prognosis for patients with gastric cancer treated with cisplatin-based adjuvant chemotherapy. | Kang BW et al. | β | 2012 | β |