Regional cerebral blood flow-SPECT in chronic alcoholism: relation to neuropsychological testing.
paper
Cited
Public
Unavailable
- Authors
- NicolΓ‘s, J M; Catafau, A M; Estruch, R; LomeΓ±a, F J; Salamero, M; Herranz, R; Monforte, R; Cardenal, C; Urbano-Marquez, A
- Year
- 1993
- Journal
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- PMID
- 8355063
To determine the prevalence of central nervous system damage due to ethanol, we evaluated 40 asymptomatic chronic alcoholics and 20 age-matched controls. Studies included neuropsychological testing, brain 99mTc-HMPAO SPECT, and morphometric analysis by CT scan. In the qualitative analysis, 30 of the 40 alcoholics showed hypoperfused areas on SPECT scan. In the semiquantitative analysis, alcoholics exhibited significant reduction in regional cerebral blood flow (rCBF) ratio of all brain lobes compared to controls (p < 0.001). The rCBF ratio was mainly reduced in frontal lobes (65%). Only 11 alcoholics showed significant frontal lobe atrophy in the morphometric analysis; most also had abnormalities on SPECT scan. Alcoholics exhibited significant impairment of frontal tasks and visuospatial skills. Frontal test impairment was independently related to both frontal atrophy and hypoperfusion. In a group of ten alcoholics in whom another SPECT scan was performed after 2 mo of ethanol abstinence, rCBF ratio of the frontal lobes normalized in eight, without frontal atrophy. In patients without frontal atrophy, reduced rCBF ratio of the anterior portion of the frontal lobes correlated negatively with frontal test results (r = -0.6535, p < 0.001). A significant negative correlation between cerebral perfusion and the amount of ethanol consumed in the month prior to study was observed (r = -0.6289, p < 0.001). In conclusion, asymptomatic chronic alcoholics frequently showed reversible frontal lobe hypoperfusion, which is related to recent ethanol intake, reflects brain function impairment and is independent of brain atrophy.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Early abstinence in severe alcohol use disorder: MCP-1 decline, choroid plexus shrinkage, and region-specific grey-matter volume changes. | Petit G et al. | β | 2026 | β |
| SPECT Cerebral Perfusion Patterns in Isolated Cervical Dystonia. | Kim B et al. | β | 2025 | β |
| Characterization of cerebrovascular changes in mice treated with alcohol by photoacoustic imaging. | Sun W et al. | β | 2023 | β |
| Artificial intelligence in single photon emission computed tomography (SPECT) imaging: a narrative review. | Shao W et al. | β | 2021 | β |
| Attenuated cerebral blood flow in frontolimbic and insular cortices in Alcohol Use Disorder: Relation to working memory. | Sullivan EV et al. | β | 2021 | β |
| The Legacy of the TTASAAN Report-Premature Conclusions and Forgotten Promises: A Review of Policy and Practice Part I. | Pavel DG et al. | β | 2021 | β |
| Chemogenetic Inactivation of Orbitofrontal Cortex Decreases Cue-induced Reinstatement of Ethanol and Sucrose Seeking in Male and Female Wistar Rats. | Hernandez JS et al. | β | 2020 | β |
| Follow-Up of Brain Single-Photon Emission Computed Tomography (SPECT) and Magnetic Resonance Imaging (MRI) in a Case of Seizure Caused by Osmotic Demyelination Syndrome. | Chong A et al. | β | 2020 | β |
| Selective impact of lateral orbitofrontal cortex inactivation on reinstatement of alcohol seeking in male Long-Evans rats. | Arinze I et al. | β | 2020 | β |
| Towards a Dynamic Exploration of Vision, Cognition and Emotion in Alcohol-Use Disorders. | Creupelandt C et al. | β | 2019 | β |
| Regional cerebral blood flow in opiate dependence relates to substance use and neuropsychological performance. | Murray DE et al. | β | 2018 | β |
| The role of the orbitofrontal cortex in alcohol use, abuse, and dependence. | Moorman DE | β | 2018 | β |
| Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers. | Shokri-Kojori E et al. | β | 2017 | β |
| Frontal lobe executive dysfunction and cerebral perfusion study in alcohol dependence syndrome. | Khanna P et al. | β | 2017 | β |
| Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques. | Chandler CM et al. | β | 2017 | β |
| Up-Regulation of PKR Signaling Pathway by Ethanol Displays an Age of Onset-Dependent Relationship. | Duncan JW et al. | β | 2016 | β |
| Brain perfusion in polysubstance users: relationship to substance and tobacco use, cognition, and self-regulation. | Murray DE et al. | β | 2015 | β |
| Central pontine myelinolysis in a case of alcohol dependence syndrome. | Chatterjee K et al. | β | 2015 | β |
| Chronic Social Stress and Ethanol Increase Expression of KLF11, a Cell Death Mediator, in Rat Brain. | Duncan J et al. | β | 2015 | β |
| Thalamic abnormalities are a cardinal feature of alcohol-related brain dysfunction. | Pitel AL et al. | β | 2015 | β |
| Alcohol-induced psychotic disorder: a review. | Jordaan GP et al. | β | 2014 | β |
| Cognitive control in alcohol use disorder: deficits and clinical relevance. | Wilcox CE et al. | β | 2014 | β |
| Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy. | Li H et al. | β | 2014 | β |
| Alcohol-induced changes in cerebral blood flow and cerebral blood volume in social drinkers. | Gundersen H et al. | β | 2013 | β |
| A selective insular perfusion deficit contributes to compromised salience network connectivity in recovering alcoholic men. | Sullivan EV et al. | β | 2013 | β |
| Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. | Umhau JC et al. | β | 2013 | β |
| Psychosocial predictors of impulsivity in alcohol-dependent patients. | Jakubczyk A et al. | β | 2013 | β |
| Alcohol-induced psychotic disorder: brain perfusion and psychopathology--before and after anti-psychotic treatment. | Jordaan GP et al. | β | 2012 | β |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | β | 2012 | β |
| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | Pandey AK et al. | β | 2012 | β |
| Neuropsychological functions in bipolar disorders I and II with and without comorbid alcohol dependence. | Chang YH et al. | β | 2012 | β |
| Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease. | Daulatzai MA | β | 2012 | β |
| Structural Changes in the Insular Cortex in Alcohol Dependence: A cross sectional study. | Chattopadhyay S et al. | β | 2011 | β |
| Brain hypoperfusion in adolescents dependent of multiple drugs. | Etchebehere EC et al. | β | 2010 | β |
| Recruitment of additional brain regions to accomplish simple motor tasks in chronic alcohol-dependent patients. | Parks MH et al. | β | 2010 | β |
| Resting brain perfusion in alcohol-induced psychotic disorder: a comparison in patients with alcohol dependence, schizophrenia and healthy controls. | Jordaan GP et al. | β | 2010 | β |
| The impact of chronic cigarette smoking on recovery from cortical gray matter perfusion deficits in alcohol dependence: longitudinal arterial spin labeling MRI. | Mon A et al. | β | 2009 | β |
| Alcohol consumption and cerebral blood flow among older adults. | Christie IC et al. | β | 2008 | β |
| Executive dysfunction as a risk marker for substance abuse: the role of impulsive personality traits. | Dolan SL et al. | β | 2008 | β |
| Social cognition in alcoholism: a link to prefrontal cortex dysfunction? | Uekermann J et al. | β | 2008 | β |
| Alcohol: effects on neurobehavioral functions and the brain. | Oscar-Berman M et al. | β | 2007 | β |
| A comparison of neurocognitive function in nonsmoking and chronically smoking short-term abstinent alcoholics. | Durazzo TC et al. | β | 2006 | β |
| Effects of chronic alcohol dependence and chronic cigarette smoking on cerebral perfusion: a preliminary magnetic resonance study. | Gazdzinski S et al. | β | 2006 | β |
| Relation of left ventricular hypertrophy to regional cerebral blood flow: single photon emission computed tomography abnormalities in essential hypertension. | Sierra C et al. | β | 2006 | β |
| Suppression of early evoked gamma band response in male alcoholics during a visual oddball task. | Padmanabhapillai A et al. | β | 2006 | β |
| Evaluation of cingulate gyrus blood flow in patients with liver cirrhosis. | Iwasa M et al. | β | 2005 | β |
| GABA-benzodiazepine receptor function in alcohol dependence: a combined 11C-flumazenil PET and pharmacodynamic study. | Lingford-Hughes AR et al. | β | 2005 | β |
| Genetic influences in emotional dysfunction and alcoholism-related brain damage. | Oscar-Berman M et al. | β | 2005 | β |
| Comparisons of Korsakoff and non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioning. | Oscar-Berman M et al. | β | 2004 | β |
| Does liver-disease aetiology have a role in cerebral blood-flow alterations in liver cirrhosis? | Burra P et al. | β | 2004 | β |
| Single photon emission computed tomography and statistical parametric mapping analysis in cirrhotic patients with and without minimal hepatic encephalopathy. | Nakagawa Y et al. | β | 2004 | β |
| The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism. | Kamarajan C et al. | β | 2004 | β |
| Cerebral blood flow in alcohol withdrawal: relation to severity of dependence and cognitive impairment. | Hamdi E et al. | β | 2003 | β |
| Comparison of prefrontal cell pathology between depression and alcohol dependence. | Miguel-Hidalgo JJ et al. | β | 2003 | β |
| Electrophysiological evidence of abnormal activation of the cerebral network of involuntary attention in alcoholism. | Polo MD et al. | β | 2003 | β |
| Value of regional cerebral blood flow in the evaluation of chronic liver disease and subclinical hepatic encephalopathy. | Yazgan Y et al. | β | 2003 | β |
| Cerebral perfusion defects in combined cocaine and alcohol dependence. | Gottschalk PC et al. | β | 2002 | β |
| Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms. | Miguel-Hidalgo JJ et al. | β | 2002 | β |
| Neurocognitive impairment associated with alcohol use disorders: implications for treatment. | Bates ME et al. | β | 2002 | β |
| Regional cerebral blood flow measured by the resting and vascular reserve (RVR) method in chronic alcoholics. | Suzuki Y et al. | β | 2002 | β |
| Correlations between P300 components and regional cerebral blood flows. | Mochizuki Y et al. | β | 2001 | β |
| Temporal effect of alcohol consumption on reactivity of pial arterioles: role of oxygen radicals. | Sun H et al. | β | 2001 | β |
| Frontal P300 decrements, alcohol dependence, and antisocial personality disorder. | Costa L et al. | β | 2000 | β |
| Increased distractibility by task-irrelevant sound changes in abstinent alcoholics. | Ahveninen J et al. | β | 2000 | β |
| Linear CT-scan measurements in alcohol-dependent patients with and without delirium tremens. | Maes M et al. | β | 2000 | β |
| Neurocognitive functioning of adolescents: effects of protracted alcohol use. | Brown SA et al. | β | 2000 | β |
| Corpus callosum atrophy and cerebral blood flow in chronic alcoholics. | Oishi M et al. | β | 1999 | β |
| Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging. | Meyerhoff DJ et al. | β | 1999 | β |
| Hypoperfusion of the cerebellum and aging effects on cerebral cortex blood flow in abstinent alcoholics: a SPECT study. | Harris GJ et al. | β | 1999 | β |
| Structural and functional neuroimaging findings in substance-related disorders. | Netrakom P et al. | β | 1999 | β |
| Suppression of mismatch negativity by backward masking predicts impaired working-memory performance in alcoholics. | Ahveninen J et al. | β | 1999 | β |
| Visual P3a in male alcoholics and controls. | Rodriguez Holguin S et al. | β | 1999 | β |
| Brain imaging. Functional consequences of ethanol in the central nervous system. | Lyons D et al. | β | 1998 | β |
| Brain imaging in alcoholism. | Estruch R et al. | β | 1998 | β |
| Executive cognitive functioning in alcohol use disorders. | Giancola PR et al. | β | 1998 | β |
| Natural history of alcoholic myopathy: a 5-year study. | Estruch R et al. | β | 1998 | β |
| Quantitative EEG (QEEG) predicts relapse in patients with chronic alcoholism and points to a frontally pronounced cerebral disturbance. | Winterer G et al. | β | 1998 | β |
| Regional cerebral blood flow during acute and chronic abstinence from combined cocaine-alcohol abuse. | Kosten TR et al. | β | 1998 | β |
| Transient frontal hypoperfusion in Tc-99m hexamethylpropyleneamineoxime single photon emission computed tomography imaging during alcohol withdrawal. | Tutus A et al. | β | 1998 | β |
| Brain impairment in well-nourished chronic alcoholics is related to ethanol intake. | NicolΓ‘s JM et al. | β | 1997 | β |
| Effects of abstinence and relapse upon neuropsychological function and cerebral glucose metabolism in severe chronic alcoholism. | Johnson-Greene D et al. | β | 1997 | β |
| Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. | Pfefferbaum A et al. | β | 1997 | β |
| Reduction in cortical IMP-SPET tracer uptake with recent cigarette consumption in a young group of healthy males. San Diego HIV Neurobehavioral Research Center. | Rourke SB et al. | β | 1997 | β |
| 99m-Tc-HMPAO-SPECT in diagnosis of early cerebral vasculitis. | Meusser S et al. | β | 1996 | β |
| Regional cerebral blood flow pattern in normal young and aged volunteers: a 99mTc-HMPAO SPET study. | Catafau AM et al. | β | 1996 | β |
| Single photon emission computed tomography with iodoamphetamine-123 and neuropsychological studies in long-term abstinent alcoholics. | Dupont RM et al. | β | 1996 | β |
| Single photon emission computerised tomography in chronic alcoholism. Antisocial personality disorder may be associated with decreased frontal perfusion. | KuruoΔlu AC et al. | β | 1996 | β |
| Delayed P3A in abstinent elderly male chronic alcoholics. | Biggins CA et al. | β | 1995 | β |
| Drug-induced disorders of the central nervous system. | Lexa FJ | β | 1995 | β |
| Acute ethanol-induced changes in cerebral blood flow. | Tiihonen J et al. | β | 1994 | β |
| An analytical approach to quantitative reconstruction of non-uniform attenuated brain SPECT. | Liang Z et al. | β | 1994 | β |