The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation.
paper
Cited
Public
Unavailable
- Authors
- Di Marzo, Vincenzo
- Year
- 2009
- Journal
- Pharmacological research
- PMID
- 19559360
- DOI
- 10.1016/j.phrs.2009.02.010
The endocannabinoid signalling system includes: (1) at least two G-protein-coupled receptors, known as the cannabinoid CB(1) and CB(2) receptors and discovered following studies on the mechanism of action of Delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant Cannabis sativa; (2) the endogenous agonists at these receptors, known as endocannabinoids, of which anandamide and 2-arachidonoylglycerol are the best known; and (3) proteins and enzymes for the regulation of endocannabinoid levels and action at receptors. The endocannabinoid system is quite widespread in mammalian tissues and cells and appears to play a pro-homeostatic role by being activated following transient or chronic perturbation of homeostasis, and by regulating in a local way the levels and action of other chemical signals. Compounds that selectively manipulate the action and levels of endocannabinoids at their targets have been and are being developed, and represent templates for potential new therapeutic drugs.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Delta-9-tetrahydrocannabinol and Cannabidiol for Pain: Preclinical and Clinical Models. | Harris HM et al. | β | 2026 | β |
| Light-Controlled Modulation of the Endocannabinoid System: Photoswitchable Ligands for Cannabinoid and TRPV1 Receptors. | Corallo AA et al. | β | 2026 | β |
| Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review. | Fonseca CDF et al. | β | 2025 | β |
| Higher plasma levels of endocannabinoids and analogues are correlated with a worse cardiometabolic profile in middle-aged adults. | RodrΓguez-GarcΓa C et al. | β | 2025 | β |
| Identification of a Possible Endocannabinoid-Mediated Mechanism of Action of Cetylated Fatty Acids. | Bononi G et al. | β | 2025 | β |
| Inhibition of an endocannabinoid catabolizing enzyme is a potential mechanism for the anxiolytic effect of chamomile. | El-Alfy AT et al. | β | 2025 | β |
| The effect of cannabinoid type β ‘ receptor on the excitability of substantia nigra dopaminergic neurons. | Zhao S et al. | β | 2025 | β |
| The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract. | Γckert S et al. | β | 2025 | β |
| A Comprehensive Review and Update on Cannabis Hyperemesis Syndrome. | Loganathan P et al. | β | 2024 | β |
| A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for<i>in vivo</i>studies | Chicca A et al. | β | 2024 | β |
| A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for <i>In Vivo</i> Studies. | Chicca A et al. | β | 2024 | β |
| Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review. | Ryan JE et al. | β | 2024 | β |
| Cannabinoid levels description in a cohort of patients with chronic and neuropathic pain treated with Cannabis decoction: A possible role of TDM. | Manca A et al. | β | 2024 | β |
| Efficacy and mechanisms of cannabis oil for alleviating side effects of breast cancer chemotherapy (CBC2): protocol for randomized controlled trial. | Thu MS et al. | β | 2024 | β |
| Optimizing and characterizing 4-methyl substituted pyrazol-3-carboxamides leading to the peripheral cannabinoid 1 receptor inverse agonist TM38837. | HΓΆgberg T et al. | β | 2024 | β |
| Role of Cannabinoids in Oral Cancer. | Cretu B et al. | β | 2024 | β |
| The current state of cannabinoids in orofacial pain. | Grossmann E et al. | β | 2024 | β |
| The Relationship between Muscarinic and Cannabinoid Receptors in Neuronal Excitability and Epilepsy: A Review. | Hall RR et al. | β | 2024 | β |
| A Cross Talk between the Endocannabinoid System and Different Systems Involved in the Pathogenesis of Hypertensive Retinopathy. | Alswailmi FK | β | 2023 | β |
| Endocannabinoid signaling in synaptic function. | Noriega-Prieto JA et al. | β | 2023 | β |
| Exploring the Therapeutic Potential of Cannabinoid Receptor Antagonists in Inflammation, Diabetes Mellitus, and Obesity. | Vasincu A et al. | β | 2023 | β |
| Lipids in major depressive disorder: new kids on the block or old friends revisited? | van der Heijden AR et al. | β | 2023 | β |
| Neuro-Gastro-Cannabinology: A Novel Paradigm for Regulating Mood and Digestive Health. | Turco F et al. | β | 2023 | β |
| Neuronal and astrocytic CB1R signaling differentially modulates goal-directed behavior and working memory by distinct temporal mechanisms. | Shang H et al. | β | 2023 | β |
| Sex-dimorphism in human serum endocannabinoid and n-acyl ethanolamine concentrations across the lifespan. | Amir Hamzah K et al. | β | 2023 | β |
| The Role of Neuro-Inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors. | Casili G et al. | β | 2023 | β |
| Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection. | Janecki M et al. | β | 2022 | β |
| Cannabidiol and periodontal inflammatory disease: A critical assessment. | Jirasek P et al. | β | 2022 | β |
| Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases. | Ramer R et al. | β | 2022 | β |
| Cannabinoids as anticancer drugs: current status of preclinical research. | Hinz B et al. | β | 2022 | β |
| Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB<sub>2</sub>R). | Ferrisi R et al. | β | 2022 | β |
| Endocannabinoid and Nitric Oxide-Dependent IGF-I-Mediated Synaptic Plasticity at Mice Barrel Cortex. | Noriega-Prieto JA et al. | β | 2022 | β |
| Endocannabinoid system and cannabis hyperemesis syndrome: a narrative update. | Perisetti A et al. | β | 2022 | β |
| Expression of type 1 cannabinoid receptor gene in bipolar disorder. | Escelsior A et al. | β | 2022 | β |
| Impact of Cannabinoid Compounds on Skin Cancer. | Ramer R et al. | β | 2022 | β |
| Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review. | de Camargo RW et al. | β | 2022 | β |
| Interactions between the Nicotinic and Endocannabinoid Receptors at the Plasma Membrane. | VallΓ©s AS et al. | β | 2022 | β |
| Preclinical Studies of Posttraumatic Headache and the Potential Therapeutics. | Tanaka M et al. | β | 2022 | β |
| Recent Advances in Endocannabinoid System Targeting for Improved Specificity: Strategic Approaches to Targeted Drug Delivery. | Dasram MH et al. | β | 2022 | β |
| Role of cannabinoids and the endocannabinoid system in modulation of diabetic cardiomyopathy. | El-Azab MF et al. | β | 2022 | β |
| The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism. | Srivastava RK et al. | β | 2022 | β |
| The neuropharmacology of cannabinoid receptor ligands in central signaling pathways. | Brunt TM et al. | β | 2022 | β |
| The synaptic lipidome in health and disease. | VallΓ©s AS et al. | β | 2022 | β |
| Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells. | Capozzi A et al. | β | 2021 | β |
| Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder. | Alexander C et al. | β | 2021 | β |
| Cannabidiol modulation of oxidative stress and signalling. | Pereira SR et al. | β | 2021 | β |
| Cannabinoid use and self-injurious behaviours: A systematic review and meta-analysis. | Escelsior A et al. | β | 2021 | β |
| Chloroform-based liquid-liquid extraction and LC-MS/MS quantification of endocannabinoids, cortisol and progesterone in human hair. | Ney LJ et al. | β | 2021 | β |
| From an Alternative Medicine to a New Treatment for Refractory Epilepsies: Can Cannabidiol Follow the Same Path to Treat Neuropsychiatric Disorders? | Bitencourt RM et al. | β | 2021 | β |
| Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic Ξ²-cells. | Tobias JM et al. | β | 2021 | β |
| <i>Cannabis sativa</i>: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC. | Oultram JMJ et al. | β | 2021 | β |
| Integrating Endocannabinoid Signalling In Depression. | Rana T et al. | β | 2021 | β |
| Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment. | VallΓ©s AS et al. | β | 2021 | β |
| The Current and Potential Application of Medicinal Cannabis Products in Dentistry. | Lowe H et al. | β | 2021 | β |
| The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases. | Lowe H et al. | β | 2021 | β |
| The Endocannabinoid System as a Pharmacological Target for New Cancer Therapies. | Ramer R et al. | β | 2021 | β |
| The Novel Monoacylglycerol Lipase Inhibitor MJN110 Suppresses Neuroinflammation, Normalizes Synaptic Composition and Improves Behavioral Performance in the Repetitive Traumatic Brain Injury Mouse Model. | Selvaraj P et al. | β | 2021 | β |
| Ξ²-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly <i>via</i> CB2 and Non-CB2 Receptor Mechanisms. | He XH et al. | β | 2021 | β |
| Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant Crypt Foci (ACF) and Tumor Volume: A Systematic Review. | Orrego-GonzΓ‘lez E et al. | β | 2020 | β |
| Cannabinoid Receptors: An Update on Cell Signaling, Pathophysiological Roles and Therapeutic Opportunities in Neurological, Cardiovascular, and Inflammatory Diseases. | Haspula D et al. | β | 2020 | β |
| Cannabis hyperemesis syndrome: an update on the pathophysiology and management. | Perisetti A et al. | β | 2020 | β |
| Distinctive Evidence Involved in the Role of Endocannabinoid Signalling in Parkinson's Disease: A Perspective on Associated Therapeutic Interventions. | Behl T et al. | β | 2020 | β |
| Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling. | Bartoll A et al. | β | 2020 | β |
| Possible therapeutic applications of cannabis in the neuropsychopharmacology field. | FernΓ‘ndez-Ruiz J et al. | β | 2020 | β |
| Red-hot chili receptors: A systematic review of TRPV1 antagonism in animal models of psychiatric disorders and addiction. | Escelsior A et al. | β | 2020 | β |
| Simultaneous quantification of endocannabinoids, oleoylethanolamide and steroid hormones in human plasma and saliva. | Ney LJ et al. | β | 2020 | β |
| Ξ²-Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents. | He Y et al. | β | 2020 | β |
| A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics. | Cox EJ et al. | β | 2019 | β |
| Anti-tumour actions of cannabinoids. | Hinz B et al. | β | 2019 | β |
| Cannabinoid interventions for PTSD: Where to next? | Ney LJ et al. | β | 2019 | β |
| Cannabinoids in Pain Treatment: An Overview. | Mallick-Searle T et al. | β | 2019 | β |
| Comparative studies of endocannabinoid modulation of pain. | Paulsen RT et al. | β | 2019 | β |
| Kynurenines and the Endocannabinoid System in Schizophrenia: Common Points and Potential Interactions. | ZΓ‘dor F et al. | β | 2019 | β |
| Modulation of the Endocannabinoid System as a Potential Anticancer Strategy. | Ramer R et al. | β | 2019 | β |
| Molecular Interaction between Distal C-Terminal Domain of the CB<sub>1</sub> Cannabinoid Receptor and Cannabinoid Receptor Interacting Proteins (CRIP1a/CRIP1b). | Singh P et al. | β | 2019 | β |
| Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities. | Bisi A et al. | β | 2019 | β |
| The Potential of Cannabinoid-Based Treatments in Tourette Syndrome. | Artukoglu BB et al. | β | 2019 | β |
| Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion. | Poddighe L et al. | β | 2018 | β |
| Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats. | Jee Kim M et al. | β | 2018 | β |
| Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials. | Bitencourt RM et al. | β | 2018 | β |
| Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. | Forner-Piquer I et al. | β | 2018 | β |
| Endocannabinoid-related compounds in gastrointestinal diseases. | Pesce M et al. | β | 2018 | β |
| Endocannabinoids in the treatment of gasytrointestinal inflammation and symptoms. | Pesce M et al. | β | 2018 | β |
| Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression. | Stampanoni Bassi M et al. | β | 2018 | β |
| First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [<sup>11</sup>C]SAR127303. | Yamasaki T et al. | β | 2018 | β |
| Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy. | Iannotti FA et al. | β | 2018 | β |
| Limited Access to a High Fat Diet Alters Endocannabinoid Tone in Female Rats. | Satta V et al. | β | 2018 | β |
| Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues. | Gallelli CA et al. | β | 2018 | β |
| Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation. | Paloczi J et al. | β | 2018 | β |
| Optimization of a preclinical therapy of cannabinoids in combination with temozolomide against glioma. | LΓ³pez-Valero I et al. | β | 2018 | β |
| Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB<sub>2</sub>) ligand designed for PET studies. | Heimann D et al. | β | 2018 | β |
| Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage. | Heinitz S et al. | β | 2018 | β |
| Role of palmitoylation of cysteine 415 in functional coupling CB<sub>1</sub> receptor to GΞ±<sub>i2</sub> protein. | Oddi S et al. | β | 2018 | β |
| Structure-kinetic relationship studies of cannabinoid CB<sub>2</sub> receptor agonists reveal substituent-specific lipophilic effects on residence time. | Soethoudt M et al. | β | 2018 | β |
| Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide. | LΓ³pez-Valero I et al. | β | 2018 | β |
| Targeting the endocannabinoid system as a potential anticancer approach. | Schwarz R et al. | β | 2018 | β |
| Therapeutic Effect of the Substrate-Selective COX-2 Inhibitor IMMA in the Animal Model of Chronic Constriction Injury. | Jones M et al. | β | 2018 | β |
| Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to cannabinoid receptors activation in mice. | Veloso CC et al. | β | 2018 | β |
| A Novel Selective Inverse Agonist of the CB<sub>2</sub> Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies. | Martella A et al. | β | 2017 | β |
| Cannabinoid CB<sub>1</sub> /CB<sub>2</sub> receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-based anorexia. | Scherma M et al. | β | 2017 | β |
| Cannabinoids in Parkinson's Disease. | Stampanoni Bassi M et al. | β | 2017 | β |
| Comparative biology of pain: What invertebrates can tell us about how nociception works. | Burrell BD | β | 2017 | β |
| Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice. | Zhao X et al. | β | 2017 | β |
| Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion. | Quartu M et al. | β | 2017 | β |
| Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism. | Medeiros D et al. | β | 2017 | β |
| Synaptic functions of endocannabinoid signaling in health and disease. | Araque A et al. | β | 2017 | β |
| The Odyssey of Dental Anxiety: From Prehistory to the Present. A Narrative Review. | Facco E et al. | β | 2017 | β |
| Tumor-promoting effects of cannabinoid receptor type 1 in human melanoma cells. | Carpi S et al. | β | 2017 | β |
| 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors. | Granchi C et al. | β | 2016 | β |
| A Comparative Analysis of the Endocannabinoid System in the Retina of Mice, Tree Shrews, and Monkeys. | Bouskila J et al. | β | 2016 | β |
| Cannabinoid receptors in the kidney. | Hryciw DH et al. | β | 2016 | β |
| CB<sub>1</sub> allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling. | Gamage TF et al. | β | 2016 | β |
| Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2. | Slavik R et al. | β | 2016 | β |
| Dissecting the Signaling Pathways Involved in the Crosstalk between Metabotropic Glutamate 5 and Cannabinoid Type 1 Receptors. | Olmo IG et al. | β | 2016 | β |
| Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. | Iannotti FA et al. | β | 2016 | β |
| Endocannabinoids in the gastrointestinal tract. | Lee Y et al. | β | 2016 | β |
| Expression and Function of the Endocannabinoid System in the Retina and the Visual Brain. | Bouchard JF et al. | β | 2016 | β |
| GPR55 - a putative "type 3" cannabinoid receptor in inflammation. | Yang H et al. | β | 2016 | β |
| Interactions between the endocannabinoid and nicotinic cholinergic systems: preclinical evidence and therapeutic perspectives. | Scherma M et al. | β | 2016 | β |
| Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility. | Mugnaini C et al. | β | 2016 | β |
| Marijuana, the Endocannabinoid System and the Female Reproductive System. | Brents LK | β | 2016 | β |
| New insights on the role of the endocannabinoid system in the regulation of energy balance. | Gatta-Cherifi B et al. | β | 2016 | β |
| Preclinical studies on the reinforcing effects of cannabinoids. A tribute to the scientific research of Dr. Steve Goldberg. | Tanda G | β | 2016 | β |
| Prenatal cannabis exposure - The "first hit" to the endocannabinoid system. | Richardson KA et al. | β | 2016 | β |
| Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase. | Chupak LS et al. | β | 2016 | β |
| The endocannabinoid system and Post Traumatic Stress Disorder (PTSD): From preclinical findings to innovative therapeutic approaches in clinical settings. | Berardi A et al. | β | 2016 | β |
| Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. | Pisanti S et al. | β | 2015 | β |
| Endocannabinoid Signaling in the Stress Response of Male and Female Songbirds. | Dickens MJ et al. | β | 2015 | β |
| Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity. | Douglass JD et al. | β | 2015 | β |
| HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FAStβ’ Column Extraction. | Poklis JL et al. | β | 2015 | β |
| Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets. | Palermo G et al. | β | 2015 | β |
| Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor. | Janero DR et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |
| Quantitative profiling of endocannabinoids in lipoproteins by LC-MS/MS. | Bilgin M et al. | β | 2015 | β |
| Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators. | Nguyen T et al. | β | 2015 | β |
| The therapeutic potential of cannabinoids for movement disorders. | Kluger B et al. | β | 2015 | β |
| Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats. | Zamberletti E et al. | β | 2014 | β |
| Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis. | Toguri JT et al. | β | 2014 | β |
| A role for the endocannabinoid system in exercise-induced spatial memory enhancement in mice. | Ferreira-Vieira TH et al. | β | 2014 | β |
| Astrocytes in endocannabinoid signalling. | Navarrete M et al. | β | 2014 | β |
| Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature. | MacIntyre J et al. | β | 2014 | β |
| Cannabinoids, eating behaviour, and energy homeostasis. | Romero-Zerbo SY et al. | β | 2014 | β |
| Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level. | Bovolin P et al. | β | 2014 | β |
| Endogenous cannabinoid signaling at inhibitory interneurons. | Younts TJ et al. | β | 2014 | β |
| Interplay between synaptic endocannabinoid signaling and metaplasticity in neuronal circuit function and dysfunction. | Melis M et al. | β | 2014 | β |
| In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. | Ignatowska-Jankowska BM et al. | β | 2014 | β |
| Medical marijuana: A panacea or scourge. | Kashyap S et al. | β | 2014 | β |
| MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure. | MΓΆhnle P et al. | β | 2014 | β |
| Prostaglandins and n-3 polyunsaturated fatty acids in the regulation of the hypothalamic-pituitary axis. | Shewchuk BM | β | 2014 | β |
| Strain- and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats. | Manduca A et al. | β | 2014 | β |
| Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems. | Janero DR et al. | β | 2014 | β |
| The endocannabinoid anandamide regulates the peristaltic reflex by reducing neuro-neuronal and neuro-muscular neurotransmission in ascending myenteric reflex pathways in rats. | Sibaev A et al. | β | 2014 | β |
| The endocannabinoid system and the neuroendocrine control of hydromineral balance. | Ruginsk SG et al. | β | 2014 | β |
| Towards a personalized treatment in depression: endocannabinoids, inflammation and stress response. | Zajkowska ZE et al. | β | 2014 | β |
| Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: role of NADPH oxidase. | Wang M et al. | β | 2014 | β |
| 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling. | KΓ€snΓ€nen H et al. | β | 2013 | β |
| Anticancer activity of anandamide in human cutaneous melanoma cells. | Adinolfi B et al. | β | 2013 | β |
| Biochemistry and pathophysiology of intravascular and intracellular lipolysis. | Young SG et al. | β | 2013 | β |
| Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far. | Flores A et al. | β | 2013 | β |
| Cannabinoid receptors are widely expressed in goldfish: molecular cloning of a CB2-like receptor and evaluation of CB1 and CB2 mRNA expression profiles in different organs. | Cottone E et al. | β | 2013 | β |
| CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. | Citraro R et al. | β | 2013 | β |
| Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia. | Geurts L et al. | β | 2013 | β |
| Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids. | Higgins A et al. | β | 2013 | β |
| Does Cannabidiol Protect Against Adverse Psychological Effects of THC? | Niesink RJ et al. | β | 2013 | β |
| Emerging targets in lipid-based therapy. | Tucker SC et al. | β | 2013 | β |
| Emotional, endocrine and brain anandamide response to social challenge in infant male rats. | Marco EM et al. | β | 2013 | β |
| Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. | Niphakis MJ et al. | β | 2013 | β |
| Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. | Wang R et al. | β | 2013 | β |
| Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme. | HernΓ‘n PΓ©rez de la Ossa D et al. | β | 2013 | β |
| Peripherally restricted CB1 receptor blockers. | Chorvat RJ | β | 2013 | β |
| Role of the endocannabinoid system in the central regulation of nonmammalian vertebrate reproduction. | Cottone E et al. | β | 2013 | β |
| Selfish brain and neuroprogression in bipolar disorder. | Mansur RB et al. | β | 2013 | β |
| Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. | Hermanson DJ et al. | β | 2013 | β |
| Temporal changes of CB1 cannabinoid receptor in the basal ganglia as a possible structure-specific plasticity process in 6-OHDA lesioned rats. | Chaves-Kirsten GP et al. | β | 2013 | β |
| The administration of endocannabinoid uptake inhibitors OMDM-2 or VDM-11 promotes sleep and decreases extracellular levels of dopamine in rats. | Murillo-RodrΓguez E et al. | β | 2013 | β |
| The argument for medical marijuana for the treatment of chronic pain. | Carter GT | β | 2013 | β |
| The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. | Ignatowska-Jankowska BM et al. | β | 2013 | β |
| The cannabis conundrum. | Miller RJ | β | 2013 | β |
| Use of cannabis among 139 cluster headache sufferers. | Leroux E et al. | β | 2013 | β |
| Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance. | Trezza V et al. | β | 2012 | β |
| At the heart of the matter: the endocannabinoid system in cardiovascular function and dysfunction. | Montecucco F et al. | β | 2012 | β |
| Cannabinoid-1 receptor (CB1R) blockers as medicines: beyond obesity and cardiometabolic disorders to substance abuse/drug addiction with CB1R neutral antagonists. | Janero DR | β | 2012 | β |
| Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis. | Cao MH et al. | β | 2012 | β |
| Cannabinoid receptor CB2 protects against balloon-induced neointima formation. | Molica F et al. | β | 2012 | β |
| Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. | Wiskerke J et al. | β | 2012 | β |
| Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). | Karageorgos I et al. | β | 2012 | β |
| Endocannabinoids and the cardiovascular response to stress. | O'Sullivan SE et al. | β | 2012 | β |
| Endocannabinoid signaling and synaptic function. | Castillo PE et al. | β | 2012 | β |
| Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis. | Hilliard A et al. | β | 2012 | β |
| FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. | Zechner R et al. | β | 2012 | β |
| Functional diversity on synaptic plasticity mediated by endocannabinoids. | Cachope R | β | 2012 | β |
| Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. | Chang JW et al. | β | 2012 | β |
| Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice. | Bashashati M et al. | β | 2012 | β |
| JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. | Chorvat RJ et al. | β | 2012 | β |
| Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CBβ receptor ligand. | Ligresti A et al. | β | 2012 | β |
| N-Acylated phospholipid metabolism and seedling growth: insights from lipidomics studies in Arabidopsis. | Kilaru A et al. | β | 2012 | β |
| Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues. | Oleson EB et al. | β | 2012 | β |
| Phytocannabinoids as novel therapeutic agents in CNS disorders. | Hill AJ et al. | β | 2012 | β |
| Phytoestrogens enhance the vascular actions of the endocannabinoid anandamide in mesenteric beds of female rats. | Peroni RN et al. | β | 2012 | β |
| Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. | Ferreira SG et al. | β | 2012 | β |
| Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNA ameliorates hepatic fibrosis in rats. | Chen SW et al. | β | 2012 | β |
| The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior. | FogaΓ§a MV et al. | β | 2012 | β |
| The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1. | Grimaldi P et al. | β | 2012 | β |
| The gastrointestinal pharmacology of cannabinoids: focus on motility. | Abalo R et al. | β | 2012 | β |
| The role of the endocannabinoid system in the neuroendocrine regulation of energy balance. | Bermudez-Silva FJ et al. | β | 2012 | β |
| Unique effects of compounds active at both cannabinoid and serotonin receptors during stroke. | Zhang M et al. | β | 2012 | β |
| A combined preclinical therapy of cannabinoids and temozolomide against glioma. | Torres S et al. | β | 2011 | β |
| A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents. | Lin XH et al. | β | 2011 | β |
| A randomized, double-blind, placebo-controlled, crossover study to evaluate the subjective abuse potential and cognitive effects of nabiximols oromucosal spray in subjects with a history of recreational cannabis use. | Schoedel KA et al. | β | 2011 | β |
| Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors. | Comba A et al. | β | 2011 | β |
| Bioactivation pathways of the cannabinoid receptor 1 antagonist rimonabant. | BergstrΓΆm MA et al. | β | 2011 | β |
| Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk. | Janero DR et al. | β | 2011 | β |
| Cannabinoid-induced delayed gastric emptying is selectively increased upon intermittent administration in the rat: role of CB1 receptors. | Abalo R et al. | β | 2011 | β |
| Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance. | Maccarrone M et al. | β | 2011 | β |
| Effects of opioids, cannabinoids, and vanilloids on body temperature. | Rawls SM et al. | β | 2011 | β |
| Endocannabinoids and diacylglycerol kinase activity. | Gantayet A et al. | β | 2011 | β |
| Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease. | Johnston TH et al. | β | 2011 | β |
| Human cannabinoid 1 GPCR C-terminal domain interacts with bilayer phospholipids to modulate the structure of its membrane environment. | Tiburu EK et al. | β | 2011 | β |
| Lipoxygenase-mediated oxidation of polyunsaturated N-acylethanolamines in Arabidopsis. | Kilaru A et al. | β | 2011 | β |
| Marijuana-based drugs: innovative therapeutics or designer drugs of abuse? | Seely KA et al. | β | 2011 | β |
| Mass spectrometry-based proteomics of human cannabinoid receptor 2: covalent cysteine 6.47(257)-ligand interaction affording megagonist receptor activation. | Szymanski DW et al. | β | 2011 | β |
| Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists. | Schuehly W et al. | β | 2011 | β |
| Modulation of peripheral sensory neurons by the immune system: implications for pain therapy. | Stein C et al. | β | 2011 | β |
| Molecular characterization and identification of surrogate substrates for diacylglycerol lipase Ξ±. | Pedicord DL et al. | β | 2011 | β |
| Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. | Taschler U et al. | β | 2011 | β |
| Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure. | Szczesniak AM et al. | β | 2011 | β |
| Novel selective cannabinoid CB(1) receptor antagonist MJ08 with potent in vivo bioactivity and inverse agonistic effects. | Chen W et al. | β | 2011 | β |
| Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia. | Pan C et al. | β | 2011 | β |
| Prospects for cannabinoid therapies in basal ganglia disorders. | FernΓ‘ndez-Ruiz J et al. | β | 2011 | β |
| Regulation and functions of diacylglycerol kinases. | Shulga YV et al. | β | 2011 | β |
| Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas. | Li C et al. | β | 2011 | β |
| (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. | Duggan KC et al. | β | 2011 | β |
| SAR and LC/MS studies of Ξ²-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process. | Feledziak M et al. | β | 2011 | β |
| Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala. | Kamprath K et al. | β | 2011 | β |
| The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro. | Bisset KM et al. | β | 2011 | β |
| The major central endocannabinoid directly acts at GABA(A) receptors. | Sigel E et al. | β | 2011 | β |
| A covering method for detecting genetic associations between rare variants and common phenotypes. | Bhatia G et al. | β | 2010 | β |
| Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Delta(9)-THC. | Castaldo P et al. | β | 2010 | β |
| Cannabinoid-Induced Hyperemesis: A Conundrum-From Clinical Recognition to Basic Science Mechanisms. | Darmani NA | β | 2010 | β |
| Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA and histone displacement. | Chioccarelli T et al. | β | 2010 | β |
| Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. | Tedesco L et al. | β | 2010 | β |
| Cannabinoids and experimental models of multiple sclerosis. | Kubajewska I et al. | β | 2010 | β |
| Cannabinoids and the gut: new developments and emerging concepts. | Izzo AA et al. | β | 2010 | β |
| Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant. | MartΓn-GarcΓa E et al. | β | 2010 | β |
| Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood-brain-barrier. | Receveur JM et al. | β | 2010 | β |
| Design and synthesis of (13S)-methyl-substituted arachidonic acid analogues: templates for novel endocannabinoids. | Papahatjis DP et al. | β | 2010 | β |
| Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice. | Storr MA et al. | β | 2010 | β |
| Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. | Reggio PH | β | 2010 | β |
| Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems. | Micale V et al. | β | 2010 | β |
| Exploring SAR features in diverse library of 4-cyanomethyl-pyrazole-3-carboxamides suitable for further elaborations as CB1 antagonists. | Cooper M et al. | β | 2010 | β |
| Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. | Evanson NK et al. | β | 2010 | β |
| hCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation. | Mercier RW et al. | β | 2010 | β |
| Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae. | Heier C et al. | β | 2010 | β |
| In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists. | Cascio MG et al. | β | 2010 | β |
| Involvement of central beta2-adrenergic, NMDA and thromboxane A2 receptors in the pressor effect of anandamide in rats. | Malinowska B et al. | β | 2010 | β |
| Mass spectrometry-based GPCR proteomics: comprehensive characterization of the human cannabinoid 1 receptor. | Zvonok N et al. | β | 2010 | β |
| Membrane environment and endocannabinoid signaling. | Maccarrone M | β | 2010 | β |
| Molecular mechanisms involved in the antitumor activity of cannabinoids on gliomas: role for oxidative stress. | Massi P et al. | β | 2010 | β |
| New approaches to the pharmacological treatment of obesity: can they break through the efficacy barrier? | Kennett GA et al. | β | 2010 | β |
| Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways. | Gallotta D et al. | β | 2010 | β |
| Targeting the endocannabinoid system for gastrointestinal diseases: future therapeutic strategies. | Schicho R et al. | β | 2010 | β |
| The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice. | Costa B et al. | β | 2010 | β |
| The endocannabinoid system in gp120-mediated insults and HIV-associated dementia. | Bari M et al. | β | 2010 | β |
| New approaches to the pharmacological management of major depressive disorder. | Witkin JM et al. | β | 2009 | β |
| NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: candidate electrostatic interactions and microdomain formation. | Tyukhtenko S et al. | β | 2009 | β |