Requirement of central ghrelin signaling for alcohol reward.
paper
Cited
Public
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- Authors
- Jerlhag, Elisabet; Egecioglu, Emil; Landgren, Sara; SalomΓ©, Nicolas; Heilig, Markus; Moechars, Diederik; Datta, Rakesh; Perrissoud, Daniel; Dickson, Suzanne L; Engel, JΓΆrgen A
- Year
- 2009
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 19564604
- DOI
- 10.1073/pnas.0812809106
- PMCID
- PMC2703665
The stomach-derived hormone ghrelin interacts with key CNS circuits regulating energy balance and body weight. Here we provide evidence that the central ghrelin signaling system is required for alcohol reward. Central ghrelin administration (to brain ventricles or to tegmental areas involved in reward) increased alcohol intake in a 2-bottle (alcohol/water) free choice limited access paradigm in mice. By contrast, central or peripheral administration of ghrelin receptor (GHS-R1A) antagonists suppressed alcohol intake in this model. Alcohol-induced locomotor stimulation, accumbal dopamine release and conditioned place preference were abolished in models of suppressed central ghrelin signaling: GHS-R1A knockout mice and mice treated with 2 different GHS-R1A antagonists. Thus, central ghrelin signaling, via GHS-R1A, not only stimulates the reward system, but is also required for stimulation of that system by alcohol. Our data suggest that central ghrelin signaling constitutes a potential target for treatment of alcohol-related disorders.
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| Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents. | Dickson SL et al. | β | 2010 | β |
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| Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. | Perello M et al. | β | 2010 | β |
| Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference. | Jerlhag E et al. | β | 2010 | β |
| Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons. | Kaur S et al. | β | 2010 | β |
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