Incorporating genetics into your studies: a guide for social scientists.
- Authors
- Dick, Danielle M; Latendresse, Shawn J; Riley, Brien
- Year
- 2011
- Journal
- Frontiers in psychiatry
- PMID
- 21629842
- DOI
- 10.3389/fpsyt.2011.00017
- PMCID
- PMC3098715
There has been a surge of interest in recent years in incorporating genetic components into on-going longitudinal, developmental studies and related psychological studies. While this represents an exciting new direction in developmental science, much of the research on genetic topics in developmental science does not reflect the most current practice in genetics. This is likely due, in part, to the rapidly changing landscape of the field of genetics, and the difficulty this presents for developmental scientists who are trying to learn this new area. In this review, we present an overview of the paradigm shifts that have occurred in genetics and we introduce the reader to basic genetic methodologies. We present our view of the current stage of research ongoing at the intersection of genetics and social science, and we provide recommendations for how we could do better. We also address a number of issues that social scientists face as they integrate genetics into their projects, including choice of a study design (candidate gene versus genome-wide association versus sequencing), different methods of DNA collection, and special considerations involved in the analysis of genotypic data. Through this review, we hope to equip social scientists with a deeper understanding of the many considerations that go into genetics research, in an effort to foster more meaningful cross-disciplinary initiatives.
Allele frequency differences between cases and controls as defined by the liability threshold model. The white circles refer to the null allele, and the red circles refer to the risk (‘B’) allele. The cases are above the threshold for disease on the liability distribution and are more likely to carry the risk allele than the controls.
LLM interpretation
This diagram illustrates the liability threshold model for disease, featuring a red normal distribution curve plotted against a "Disease liability" x-axis. A vertical threshold line separates "unaffected" controls from "affected" cases, with the cases showing a higher frequency of the risk 'B' allele (50%) compared to the controls (20%). The alleles are visually represented by red circles for the risk allele and white circles for the null allele.
The preservation of linkage disequilibrium (LD) through mutation and subsequent recombination in the human genome. At the time the mutation occurs it is in LD with the genetic background of the chromosome. Recombination changes the genetic background as variation is introduced until only the DNA sequence very near the mutation remains in LD.
LLM interpretation
This diagram illustrates the process of linkage disequilibrium (LD) decay over time in a hypothetical human chromosome. It shows a mutation occurring on a red ancestral chromosome, followed by successive rounds of recombination over 20 and 50 generations. The visualization demonstrates that as recombination introduces genetic material from other ancestral chromosomes (represented by different colors), the region of LD surrounding the mutation progressively shrinks.
Screenshot from Haploview (Barrett et al., 2005) showing the linkage disequilibrium structure surrounding the DRD2 gene.
LLM interpretation
This figure is a Haploview linkage disequilibrium (LD) plot showing the genetic structure surrounding the *DRD2* gene. The top panel displays the genomic coordinates, genotyped SNPs, and associated Entrez genes, including *DRD2* and *NCAM1*. The bottom triangular heat map uses a red-to-white color scale to represent the strength of LD between pairs of SNPs, with dense red blocks indicating high LD regions.
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| 60 | An Example of Research at the Intersection of Genetics and Social Science | gene and behavior problems would be moderated by parental monitoring, based on our work in the… |
| 61 | An Example of Research at the Intersection of Genetics and Social Science | behavior. Further, we tested whether this association was moderated by peer group antisocial… |
| 62 | An Example of Research at the Intersection of Genetics and Social Science | highly selected, affected populations, and characterizing their risk in community-based samples,… |
| 63 | Conclusions | The integration of genetics into developmental projects and other studies conducted by social… |
| 64 | Conflict of Interest Statement | The authors declare that the research was conducted in the absence of any commercial or financial… |
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