Disease Modeling in Stem Cell-Derived 3D Organoid Systems.
paper
Cited
Public
Unavailable
- Authors
- Dutta, Devanjali; Heo, Inha; Clevers, Hans
- Year
- 2017
- Journal
- Trends in molecular medicine
- PMID
- 28341301
- DOI
- 10.1016/j.molmed.2017.02.007
Organoids are 3D in vitro culture systems derived from self-organizing stem cells. They can recapitulate the in vivo architecture, functionality, and genetic signature of original tissues. Thus, organoid technology has been rapidly applied to understanding stem cell biology, organogenesis, and various human pathologies. The recent development of human patient-derived organoids has enabled disease modeling with precision, highlighting their great potential in biomedical applications, translational medicine, and personalized therapy. In light of recent breakthroughs using organoids, it is only apt that we appreciate the advantages and shortcomings of this technology to exploit its full potential. We discuss recent advances in the application of organoids in studying cancer and hereditary diseases, as well as in the examination of host cell-microorganism interactions.
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| Title | Year | PMID |
|---|---|---|
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | 2019 | 30087005 |
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| GDNF drives rapid tubule morphogenesis in a novel 3D <i>in vitro</i> model for ADPKD. | Dixon EE et al. | β | 2020 | β |
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| Grand Challenge in Human/Animal Virology: Unseen, Smallest Replicative Entities Shape the Whole Globe. | Adachi A | β | 2020 | β |
| High-resolution tomographic analysis of in vitro 3D glioblastoma tumor model under long-term drug treatment. | Ozturk MS et al. | β | 2020 | β |
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| IFlowPlate-A Customized 384-Well Plate for the Culture of Perfusable Vascularized Colon Organoids. | Rajasekar S et al. | β | 2020 | β |
| Improving natural product research translation: From source to clinical trial. | Sorkin BC et al. | β | 2020 | β |
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| In Vitro and Ex Vivo ModelsΒ - The Tumor Microenvironment in a Flask. | Pinto C et al. | β | 2020 | β |
| In vitro models for investigation of the host-parasite interface - possible applications in acute Chagas disease. | Breyner NM et al. | β | 2020 | β |
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| Midbrain Organoids: A New Tool to Investigate Parkinson's Disease. | Smits LM et al. | β | 2020 | β |
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| Murine Endometrial Organoids to Model <i>Chlamydia</i> Infection. | Bishop RC et al. | β | 2020 | β |
| New Insights and Current Approaches in Cardiac Hypertrophy Cell Culture, Tissue Engineering Models, and Novel Pathways Involving Non-Coding RNA. | Kastner N et al. | β | 2020 | β |
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| Organoids - New Models for Host-Helminth Interactions. | Duque-Correa MA et al. | β | 2020 | β |
| Organotypic Modeling of the Tumor Landscape. | Haykal MM et al. | β | 2020 | β |
| Organs-on-a-Chip. | Low LA et al. | β | 2020 | β |
| Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision. | Kochanek PM et al. | β | 2020 | β |
| Patient-derived cell line, xenograft and organoid models in lung cancer therapy. | Huo KG et al. | β | 2020 | β |
| Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma. | Ramzy GM et al. | β | 2020 | β |
| Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing. | Nanki Y et al. | β | 2020 | β |
| Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids. | Nowrouzi A et al. | β | 2020 | β |
| Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation. | Zhang Y et al. | β | 2020 | β |
| Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature. | Lai Benjamin FL et al. | β | 2020 | β |
| Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures. | Qiu W et al. | β | 2020 | β |
| Spheres of Influence: Insights into <i>Salmonella</i> Pathogenesis from Intestinal Organoids. | Verma S et al. | β | 2020 | β |
| Technical Feasibility and Physiological Relevance of Hypoxic Cell Culture Models. | Pavlacky J et al. | β | 2020 | β |
| The Changing Face of <i>in vitro</i> Culture Models for Thyroid Cancer Research: A Systematic Literature Review. | Chew D et al. | β | 2020 | β |
| Trends in the development of human stem cell-based non-animal drug testing models. | Lee SJ et al. | β | 2020 | β |
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| Advancing the understanding of NAFLD to hepatocellular carcinoma development: From experimental models to humans. | Chen K et al. | β | 2019 | β |
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| Allometric Scaling of physiologically-relevant organoids. | Magliaro C et al. | β | 2019 | β |
| A one-stop microfluidic-based lung cancer organoid culture platform for testing drug sensitivity. | Jung DJ et al. | β | 2019 | β |
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| Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids. | Smith RC et al. | β | 2019 | β |
| Copper Transport and Disease: What Can We Learn from Organoids? | Pierson H et al. | β | 2019 | β |
| Craniofacial, orofacial and dental disorders: the role of the RAS/ERK pathway. | Vogiatzi A et al. | β | 2019 | β |
| Derivation of adult canine intestinal organoids for translational research in gastroenterology. | Chandra L et al. | β | 2019 | β |
| Design of synthetic microbial consortia for gut microbiota modulation. | VΓ‘zquez-Castellanos JF et al. | β | 2019 | β |
| Disease modelling in human organoids. | Lancaster MA et al. | β | 2019 | β |
| Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer. | Nowak-Sliwinska P et al. | β | 2019 | β |
| Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance. | Aronchik I et al. | β | 2019 | β |
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| Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors. | Szvicsek Z et al. | β | 2019 | β |
| Gelatin-polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics. | Afewerki S et al. | β | 2019 | β |
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| Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders. | Mofazzal Jahromi MA et al. | β | 2019 | β |
| Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues. | Paek J et al. | β | 2019 | β |
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| Modeling Human Brain Circuitry Using Pluripotent Stem Cell Platforms. | Hartlaub AM et al. | β | 2019 | β |
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| 'Omics Approaches to Explore the Breast Cancer Landscape. | Parsons J et al. | β | 2019 | β |
| Organoids of epithelial ovarian cancer as an emerging preclinical in vitro tool: a review. | Dumont S et al. | β | 2019 | β |
| Organoids of liver diseases: From bench to bedside. | Wu LJ et al. | β | 2019 | β |
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| Remodelling and Improvements in Organoid Technology to Study Liver Carcinogenesis in a Dish. | Tharehalli U et al. | β | 2019 | β |
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| The use of iPSC technology for modeling Autism Spectrum Disorders. | Russo FB et al. | β | 2019 | β |
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| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| What gastroenterologists and hepatologists should know about organoids in 2019. | GΓΌnther C et al. | β | 2019 | β |
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| 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade. | Aref AR et al. | β | 2018 | β |
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| A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology. | Williamson IA et al. | β | 2018 | β |
| Amyloid Fibrils: Versatile Biomaterials for Cell Adhesion and Tissue Engineering Applications. | Das S et al. | β | 2018 | β |
| A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues. | Laternser S et al. | β | 2018 | β |
| Assessing the Role of Teleoperated Robotic Systems in Biomanipulations - A Case Study on Blastocyst Microinjection. | Mattos LS et al. | β | 2018 | β |
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| Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicine. | Praharaj PP et al. | β | 2018 | β |
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| Disease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells. | Ho BX et al. | β | 2018 | β |
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| Effects of the Extracts from Fruit and Stem of <i>Camellia japonica</i> on Induced Pluripotency and Wound Healing. | Jeon H et al. | β | 2018 | β |
| Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. | Blutt SE et al. | β | 2018 | β |
| Engineering a second brain in a dish. | Mahe MM | β | 2018 | β |
| Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant. | van der Sanden SMG et al. | β | 2018 | β |
| Esophageal 3D Culture Systems as Modeling Tools in Esophageal Epithelial Pathobiology and Personalized Medicine. | Whelan KA et al. | β | 2018 | β |
| Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. | Hoang P et al. | β | 2018 | β |
| Genetics and biology of prostate cancer. | Wang G et al. | β | 2018 | β |
| Human Microphysiological Systems and Organoids as <i>in Vitro</i> Models for Toxicological Studies. | Truskey GA | β | 2018 | β |
| Human organoid cultures: transformative new tools for human virus studies. | Ramani S et al. | β | 2018 | β |
| Hydrogel-incorporating unit in a well: 3D cell culture for high-throughput analysis. | Yu YJ et al. | β | 2018 | β |
| Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment. | Kyffin JA et al. | β | 2018 | β |
| Kras in Organoids. | Cheng D et al. | β | 2018 | β |
| Many Cells Make Life Work-Multicellularity in Stem Cell-Based Cardiac Disease Modelling. | Wang BX et al. | β | 2018 | β |
| Mechanisms of Ξ±-Synuclein Induced Synaptopathy in Parkinson's Disease. | Bridi JC et al. | β | 2018 | β |
| Microglia innately develop within cerebral organoids. | Ormel PR et al. | β | 2018 | β |
| Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age. | Barrila J et al. | β | 2018 | β |
| Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. | Liu C et al. | β | 2018 | β |
| Modeling Tissue Polarity in Context. | Tharp KM et al. | β | 2018 | β |
| Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids. | Liu X et al. | β | 2018 | β |
| Modelling Cryptosporidium infection in human small intestinal and lung organoids. | Heo I et al. | β | 2018 | β |
| Organoid and Enteroid Modeling of <i>Salmonella</i> Infection. | Yin Y et al. | β | 2018 | β |
| Organoid as a culture system for viral vaccine strains. | Hong KJ et al. | β | 2018 | β |
| Organoids: An intermediate modeling platform in precision oncology. | Jin MZ et al. | β | 2018 | β |
| Organoids for Modeling Genetic Diseases. | Perez-Lanzon M et al. | β | 2018 | β |
| Organoids Provide an Important Window on Inflammation in Cancer. | Baker K | β | 2018 | β |
| Patient-derived tumor organoids for prediction of cancer treatment response. | Nagle PW et al. | β | 2018 | β |
| Pluripotent Stem Cell Platforms for Drug Discovery. | Chen KG et al. | β | 2018 | β |
| Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. | Hill SJ et al. | β | 2018 | β |
| Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta. | Haider S et al. | β | 2018 | β |
| Single-cell genomics to guide human stem cell and tissue engineering. | Camp JG et al. | β | 2018 | β |
| Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems. | Modena MM et al. | β | 2018 | β |
| Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine. | Takata N et al. | β | 2018 | β |
| Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology. | Sasaki N et al. | β | 2018 | β |
| Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells. | Cvetkovic C et al. | β | 2018 | β |
| The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy. | Vincan E et al. | β | 2018 | β |
| The development of an in vitro cerebral organoid model for investigating the pathomolecular mechanisms associated with the central nervous system involvement in Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE). | Pacitti D et al. | β | 2018 | β |
| The truth about in vitro culture of Cryptosporidium species. | Karanis P | β | 2018 | β |
| Three-dimensional cell culture: from evolution to revolution. | Alhaque S et al. | β | 2018 | β |
| Three-Dimensional <i>in Vitro</i> Cell Culture Models in Drug Discovery and Drug Repositioning. | Langhans SA | β | 2018 | β |
| Three-dimensional in vitro models answer the right questions in ADPKD cystogenesis. | Dixon EE et al. | β | 2018 | β |
| Three-Dimensional Organoids in Cancer Research: The Search for the Holy Grail of Preclinical Cancer Modeling. | Dzobo K et al. | β | 2018 | β |
| Use and application of 3D-organoid technology. | Artegiani B et al. | β | 2018 | β |
| Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures. | Finnberg NK et al. | β | 2017 | β |
| Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells. | Regan JL et al. | β | 2017 | β |
| Optic neuropathies: the tip of the neurodegeneration iceberg. | Carelli V et al. | β | 2017 | β |
| Organoid culture systems to study host-pathogen interactions. | Dutta D et al. | β | 2017 | β |
| Patient-derived xenografts, a multi-faceted <i>in vivo</i> model enlightening research on rare liver cancer biology. | Moro M et al. | β | 2017 | β |
| Recent advances in modelling of cerebellar ataxia using induced pluripotent stem cells. | Wong MMK et al. | β | 2017 | β |
| The impact of cellular metabolism on chromatin dynamics and epigenetics. | Reid MA et al. | β | 2017 | β |
| Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology. | Conway JRW et al. | β | 2017 | β |