The neurobiology of oppositional defiant disorder and conduct disorder: altered functioning in three mental domains.
paper
Cited
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- Authors
- Matthys, Walter; Vanderschuren, Louk J M J; Schutter, Dennis J L G
- Year
- 2013
- Journal
- Development and psychopathology
- PMID
- 22800761
- DOI
- 10.1017/S0954579412000272
This review discusses neurobiological studies of oppositional defiant disorder and conduct disorder within the conceptual framework of three interrelated mental domains: punishment processing, reward processing, and cognitive control. First, impaired fear conditioning, reduced cortisol reactivity to stress, amygdala hyporeactivity to negative stimuli, and altered serotonin and noradrenaline neurotransmission suggest low punishment sensitivity, which may compromise the ability of children and adolescents to make associations between inappropriate behaviors and forthcoming punishments. Second, sympathetic nervous system hyporeactivity to incentives, low basal heart rate associated with sensation seeking, orbitofrontal cortex hyporeactiviy to reward, and altered dopamine functioning suggest a hyposensitivity to reward. The associated unpleasant emotional state may make children and adolescents prone to sensation-seeking behavior such as rule breaking, delinquency, and substance abuse. Third, impairments in executive functions, especially when motivational factors are involved, as well as structural deficits and impaired functioning of the paralimbic system encompassing the orbitofrontal and cingulate cortex, suggest impaired cognitive control over emotional behavior. In the discussion we argue that more insight into the neurobiology of oppositional defiance disorder and conduct disorder may be obtained by studying these disorders separately and by paying attention to the heterogeneity of symptoms within each disorder.
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| Title | Year | PMID |
|---|---|---|
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | 2018 | 29063614 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Differentiating ADHD and oppositional defiant disorder through Synapsin III gene polymorphisms and neurocognitive profiles. | TahΔ±llΔ±oΔlu A et al. | β | 2026 | β |
| Linking Genetics to Behavior: From Glutamatergic Genetic Variation Via Amygdala Morphology and Fear Recognition to Youths' Callous-Unemotional Traits and Reactive-Proactive Aggression. | Kleine Deters R et al. | β | 2026 | β |
| The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model. | Camacho MC et al. | β | 2026 | β |
| Callous-unemotional traits moderate the association between inhibitory control and disruptive behavior problems. | Castagna PJ et al. | β | 2025 | β |
| Emotional dysregulation, executive functions and callous-unemotional traits in children and adolescents with Oppositional Defiant Disorder/Conduct Disorder and Autism Spectrum Disorder: a direct comparison. | Narducci C et al. | β | 2025 | β |
| Emotion process deficits in children with ODD and their associations with different dimensions of ODD symptoms: a fNIRS study. | Wang P et al. | β | 2025 | β |
| Executive, behavioural and emotional functioning in Spanish children with dyslexia. | LΓ³pez-Zamora M et al. | β | 2025 | β |
| Measuring Children's Reward and Punishment Sensitivity: An Initial Psychometric Evaluation of the Contingency Response Rating Scale. | Waschbusch DA et al. | β | 2025 | β |
| A critical review of hot executive functioning in youth attention-deficit/hyperactivity disorder: Methodological limitations, conceptual considerations, and future directions. | Smith JN et al. | β | 2024 | β |
| Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm. | Hosoki M et al. | β | 2024 | β |
| Caffeinated Soda Intake in Children Is Associated with Neurobehavioral Risk Factors for Substance Misuse. | Kwon M et al. | β | 2024 | β |
| Involving Parents in Cognitive Behavioral Therapy for Children and Adolescents with Conduct Problems: Goals, Outcome Expectations, and Normative Beliefs About Aggression are Targeted in Sessions with Parents and Their Child. | Matthys W et al. | β | 2024 | β |
| Predictors and Correlates of Positive Urine Drug Screening in a Retrospective Cohort Analysis of Child and Adolescent Psychiatry Inpatients Throughout the COVID-19 Pandemic. | Lynch S et al. | β | 2024 | β |
| Prospective associations between early adolescent reward functioning and later dimensions of psychopathology. | Mattoni M et al. | β | 2024 | β |
| Reinforcement sensitivity theory and externalizing problems across early adolescence: Testing within-person reciprocal associations. | Ramer NE et al. | β | 2024 | β |
| Subjective and Autonomic Arousal toward Emotional Stimuli in Preadolescents with Externalizing Problems and the Role of Explicit and Implicit Emotion Regulation. | Panteli M et al. | β | 2024 | β |
| Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable. | Pauli R et al. | β | 2023 | β |
| Detecting social information processing profiles of boys with aggressive behavior problems: An interactive virtual reality approach. | Verhoef REJ et al. | β | 2023 | β |
| Differential processing ofΒ risk andΒ reward inΒ delinquent andΒ non-delinquent youth. | Duell N et al. | β | 2023 | β |
| Exploring the interplay of dopaminergic genotype and parental behavior in relation to executive function in early childhood. | Vrantsidis DM et al. | β | 2023 | β |
| Oppositional defiant disorder. | Hawes DJ et al. | β | 2023 | β |
| Reciprocal associations between affective decision-making and mental health in adolescence. | Bentivegna F et al. | β | 2023 | β |
| Resting heart rate and antisocial behaviour: a Mendelian randomisation study. | Karwatowska L et al. | β | 2023 | β |
| Systematic Review and Meta-analysis: Psychosocial Treatments for Disruptive Behavior Symptoms and Disorders in Adolescence. | Boldrini T et al. | β | 2023 | β |
| Teachers' Self-Efficacy and Perceptions of School Climate are Uniquely Associated with Students' Externalizing and Internalizing Behavior Problems. | Finch JE et al. | β | 2023 | β |
| The good, the bad, and the ugly: a comprehensive study of temperament and personality traits as correlates of self-reported disruptive behavior problems in male and female adolescents. | Muris P et al. | β | 2023 | β |
| Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability. | Armbruster-GenΓ§ DJN et al. | β | 2022 | β |
| Differential associations of maternal behavior to preschool boys' and girls' executive function. | Vrantsidis DM et al. | β | 2022 | β |
| Improving Our Understanding of Impaired Social Problem-Solving in Children and Adolescents with Conduct Problems: Implications for Cognitive Behavioral Therapy. | Matthys W et al. | β | 2022 | β |
| Influence of maltreatment, bullying, and neurocognitive impairment on recidivism in adolescents with conduct disorder: A 3-Year prospective study. | Miura H et al. | β | 2022 | β |
| Loss and Frontal Striatal Reactivities Characterize Alcohol Use Severity and Rule-Breaking Behavior in Young Adult Drinkers. | Li G et al. | β | 2022 | β |
| Raging Hormones: Why Age-Based Etiological Conceptualizations of the Development of Antisocial Behavior Are Insufficient. | White SF et al. | β | 2022 | β |
| Reciprocal relations between dimensions of Oppositional defiant problems and callous-unemotional traits. | Ezpeleta L et al. | β | 2022 | β |
| The bidirectional relationship between sleep and externalizing behavior: A systematic review. | Liu J et al. | β | 2022 | β |
| Association between child/adolescent overweight/obesity and conduct disorder: A systematic review and meta-analysis. | NujiΔ D et al. | β | 2021 | β |
| Caffeinated soda intake in children is associated with neurobehavioral risk factors for substance misuse | Kwon M et al. | β | 2021 | β |
| Epistemic Trust and the Emergence of Conduct Problems: Aggression in the Service of Communication. | Talia A et al. | β | 2021 | β |
| Increasing Effectiveness of Cognitive Behavioral Therapy for Conduct Problems in Children and Adolescents: What Can We Learn from Neuroimaging Studies? | Matthys W et al. | β | 2021 | β |
| Inhibitory Control Deficits in Children with Oppositional Defiant Disorder and Conduct Disorder Compared to Attention Deficit/Hyperactivity Disorder: A Systematic Review and Meta-analysis. | Bonham MD et al. | β | 2021 | β |
| Neural processes of reward and punishment processing in childhood and adolescence: An event-related potential study on age differences. | Feldmann L et al. | β | 2021 | β |
| Neuropsychological Characterization of Aggressive Behavior in Children and Adolescents with CD/ODD and Effects of Single Doses of Medications: The Protocol of the Matrics_WP6-1 Study. | Balia C et al. | β | 2021 | β |
| Which Child Will Benefit From a Behavioral Intervention for ADHD? A Pilot Study to Predict Intervention Efficacy From Individual Reward Sensitivity. | van Langen MJM et al. | β | 2021 | β |
| Effects of Behavioral Treatment Modified to Fit Children with Conduct Problems and Callous-Unemotional (CU) Traits. | Waschbusch DA et al. | β | 2020 | β |
| Executive functioning and emotion recognition in youth with oppositional defiant disorder and/or conduct disorder. | Kleine Deters R et al. | β | 2020 | β |
| Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder. | Gao Y et al. | β | 2020 | β |
| Maternal Elaborative Language in Shared Emotion Talk with ODD Children: Relationship to Child Emotion Competencies. | Pate A et al. | β | 2020 | β |
| Neurocognitive Deficits in Attention-Deficit/Hyperactivity Disorder With and Without Comorbid Oppositional Defiant Disorder. | Noordermeer SDS et al. | β | 2020 | β |
| Neurofunctional abnormalities in antisocial spectrum: A meta-analysis of fMRI studies on Five distinct neurocognitive research domains. | DugrΓ© JR et al. | β | 2020 | β |
| Parental Problem Recognition and Help-Seeking for Disruptive Behavior Disorders. | Johnston OG et al. | β | 2020 | β |
| Trajectories of internalising and externalising symptoms and inflammation in the general child population. | Flouri E et al. | β | 2020 | β |
| Transdiagnostic trajectories of irritability and oppositional, depression and anxiety problems from preschool to early adolescence. | Ezpeleta L et al. | β | 2020 | β |
| Development of the frontal lobe. | Rosch KS et al. | β | 2019 | β |
| Irritability and parenting practices as mediational variables between temperament and affective, anxiety, and oppositional defiant problems. | Ezpeleta L et al. | β | 2019 | β |
| Neuropsychological Predictors of ODD Symptom Dimensions in Young Children. | Griffith SF et al. | β | 2019 | β |
| Psychophysiological activity and reactivity in children and adolescents with conduct problems: A systematic review and meta-analysis. | Fanti KA et al. | β | 2019 | β |
| Relation Between Oppositional/Conduct Behaviors and Executive Function Among Youth with Histories of Heavy Prenatal Alcohol Exposure. | Doyle LR et al. | β | 2019 | β |
| Risk-Taking Behavior in Attention Deficit/Hyperactivity Disorder (ADHD): a Review of Potential Underlying Mechanisms and of Interventions. | Pollak Y et al. | β | 2019 | β |
| Toward Tailored Interventions: Sympathetic and Parasympathetic Functioning Predicts Responses to an Intervention for Conduct Problems Delivered in Two Formats. | Glenn AL et al. | β | 2019 | β |
| Valence, arousal or both? Shared emotional deficits associated with Attention Deficit and Hyperactivity Disorder and Oppositional/Defiant-Conduct Disorder symptoms in school-aged youth. | Souroulla AV et al. | β | 2019 | β |
| Associations of ADHD Symptoms With Smoking and Alternative Tobacco Product Use Initiation During Adolescence. | Goldenson NI et al. | β | 2018 | β |
| Can laboratory animals violate behavioural norms? Towards a preclinical model of conduct disorder. | MacrΓ¬ S et al. | β | 2018 | β |
| Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium. | Freitag CM et al. | β | 2018 | β |
| Conduct problems in youth and the RDoC approach: A developmental, evolutionary-based view. | Fonagy P et al. | β | 2018 | β |
| Development and validation of the Canine Reward Responsiveness Scale -Examining individual differences in reward responsiveness of the domestic dog. | GerencsΓ©r L et al. | β | 2018 | β |
| Dopamine D2 receptor gene polymorphisms and externalizing behaviors in children and adolescents. | Della Torre OH et al. | β | 2018 | β |
| Executive Function Variation in Children With Conduct Problems: Influences of Coexisting Reading Difficulties. | Kallitsoglou A | β | 2018 | β |
| Maternal smoking during pregnancy and offspring executive function: What do we know and what are the next steps? | Micalizzi L et al. | β | 2018 | β |
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | Wetherill L et al. | β | 2018 | β |
| Preschool Oppositional Defiant Disorder: A Disorder of Negative Affect, Surgency, and Disagreeableness. | Zastrow BL et al. | β | 2018 | β |
| Rat behavior and dopamine release are modulated by conspecific distress. | Lichtenberg NT et al. | β | 2018 | β |
| The Neurodevelopmental Basis of Early Childhood Disruptive Behavior: Irritable and Callous Phenotypes as Exemplars. | Wakschlag LS et al. | β | 2018 | β |
| The pharmacological treatment of aggression in children and adolescents with conduct disorder. Do callous-unemotional traits modulate the efficacy of medication? | Balia C et al. | β | 2018 | β |
| Understanding heterogeneity in conduct disorder: A review of psychophysiological studies. | Fanti KA | β | 2018 | β |
| Adolescent externalizing behaviour, psychological control, and peer rejection: Transactional links and dopaminergic moderation. | Janssens A et al. | β | 2017 | β |
| Attentional control of emotional interference in children with ADHD and typically developing children: An emotional N-back study. | Villemonteix T et al. | β | 2017 | β |
| Differential neuropsychological functioning between adolescents with attention-deficit/hyperactivity disorder with and without conduct disorder. | Lin YJ et al. | β | 2017 | β |
| Disruptive Behavior Disorders in Children 0 to 6Β Years Old. | Tandon M et al. | β | 2017 | β |
| Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, TheΒ Incredible Years, and Externalizing Behavior in Children. | Chhangur RR et al. | β | 2017 | β |
| Impaired executive function in 14- to 16-year-old boys with conduct disorder is related to recidivism: A prospective longitudinal study. | Miura H et al. | β | 2017 | β |
| Influence of Dopamine-Related Genes on Neurobehavioral Recovery after Traumatic Brain Injury during Early Childhood. | Treble-Barna A et al. | β | 2017 | β |
| Investigation of the Changes in the Power Distribution in Resting-State Brain Networks Associated with Pure Conduct Disorder. | Zhang J et al. | β | 2017 | β |
| Neurocognitive characteristics of youth with noncomorbid and comorbid forms of conduct disorder and attention deficit hyperactivity disorder. | Glenn AL et al. | β | 2017 | β |
| The Epidemiology of Antisocial Behavioral Syndromes in Adulthood: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III. | Goldstein RB et al. | β | 2017 | β |
| The Mutual Effect of Marital Quality and Parenting Stress on Child and Parent Depressive Symptoms in Families of Children with Oppositional Defiant Disorder. | Lin X et al. | β | 2017 | β |
| A Systematic Review and Meta-analysis of Neuroimaging in Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) Taking Attention-Deficit Hyperactivity Disorder (ADHD) Into Account. | Noordermeer SD et al. | β | 2016 | β |
| Cool Decision-Making in Adolescents with Behavior Disorder and/or Mild-to-Borderline Intellectual Disability. | Bexkens A et al. | β | 2016 | β |
| Guanfacine Use in Children With Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) With Disruptive Behaviors. | Capone GT et al. | β | 2016 | β |
| Mechanisms of comorbidity, continuity, and discontinuity in anxiety-related disorders. | McNaughton N et al. | β | 2016 | β |
| Meta-Analysis of fMRI Studies of Disruptive Behavior Disorders. | Alegria AA et al. | β | 2016 | β |
| Monoamine oxidase and agitation in psychiatric patients. | Nikolac Perkovic M et al. | β | 2016 | β |
| Neural correlates of reactive aggression in children with attention-deficit/hyperactivity disorder and comorbid disruptive behaviour disorders. | Bubenzer-Busch S et al. | β | 2016 | β |
| Permissive Parenting, Deviant Peer Affiliations, and Delinquent Behavior in Adolescence: the Moderating Role of Sympathetic Nervous System Reactivity. | Hinnant JB et al. | β | 2016 | β |
| Reduced Default Mode Connectivity in Adolescents With Conduct Disorder. | Broulidakis MJ et al. | β | 2016 | β |
| Regulatory Control and Depression in Adolescents: Findings from Neuroimaging and Neuropsychological Research. | Klimes-Dougan B et al. | β | 2016 | β |
| Teacher-student relationships and adolescent behavioral engagement and rule-breaking behavior: The moderating role of dopaminergic genes. | De Laet S et al. | β | 2016 | β |
| The influence of comorbid oppositional defiant disorder on white matter microstructure in attention-deficit/hyperactivity disorder. | van Ewijk H et al. | β | 2016 | β |
| Transactional Links Between Teacher-Student Relationships and Adolescent Rule-Breaking Behavior and Behavioral School Engagement: Moderating Role of a Dopaminergic Genetic Profile Score. | De Laet S et al. | β | 2016 | β |
| Transactional relations between caregiving stress, executive functioning, and problem behavior from early childhood to early adolescence. | Lagasse LL et al. | β | 2016 | β |
| Adolescent Substance Use and Comorbid Psychopathology: Emotion Regulation Deficits as a Transdiagnostic Risk Factor. | Shadur JM et al. | β | 2015 | β |
| A Hierarchical Factor Model of Executive Functions in Adolescents: Evidence of Gene-Environment Interplay. | Li JJ et al. | β | 2015 | β |
| Brain morphology of childhood aggressive behavior: A multi-informant study in school-age children. | Thijssen S et al. | β | 2015 | β |
| Emergence of sex differences in the development of substance use and abuse during adolescence. | Kuhn C | β | 2015 | β |
| Externalizing Problem Behavior in Adolescence: Dopaminergic Genes in Interaction with Peer Acceptance and Rejection. | Janssens A et al. | β | 2015 | β |
| How does reactivity to frustrative non-reward increase risk for externalizing symptoms? | Gatzke-Kopp LM et al. | β | 2015 | β |
| Impaired Frontal-Basal Ganglia Connectivity in Male Adolescents with Conduct Disorder. | Zhang J et al. | β | 2015 | β |
| Instrumental learning in ADHD in a context of reward: intact learning curves and performance improvement with methylphenidate. | Luman M et al. | β | 2015 | β |
| Neural reactivity to monetary rewards and losses differentiates social from generalized anxiety in children. | Kessel EM et al. | β | 2015 | β |
| Pathophysiology of ADHD and associated problems-starting points for NF interventions? | Albrecht B et al. | β | 2015 | β |
| Prenatal tobacco exposure and self-regulation in early childhood: Implications for developmental psychopathology. | Wiebe SA et al. | β | 2015 | β |
| Punishment Insensitivity in Early Childhood: A Developmental, Dimensional Approach. | Nichols SR et al. | β | 2015 | β |
| Reward Anticipation in Ventral Striatum and Individual Sensitivity to Reward: A Pilot Study of a Child-Friendly fMRI Task. | van Hulst BM et al. | β | 2015 | β |
| Short fused? associations between white matter connections, sex steroids, and aggression across adolescence. | Peper JS et al. | β | 2015 | β |
| Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms. | Weeland J et al. | β | 2015 | β |
| Antisocial behavior, psychopathic features and abnormalities in reward and punishment processing in youth. | Byrd AL et al. | β | 2014 | β |
| A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework. | Badcock JC et al. | β | 2014 | β |
| Facial mimicry in 6-7 year old children with disruptive behavior disorder and ADHD. | Deschamps P et al. | β | 2014 | β |
| On the interaction between drugs of abuse and adolescent social behavior. | Trezza V et al. | β | 2014 | β |
| Parsing dimensional vs diagnostic category-related patterns of reward circuitry function in behaviorally and emotionally dysregulated youth in the Longitudinal Assessment of Manic Symptoms study. | Bebko G et al. | β | 2014 | β |
| The attention deficit hyperactivity disorder phenotype as a summation of deficits in executive functioning and reward sensitivity: does this explain its relationship with oppositional defiant disorder? | Poulton A et al. | β | 2014 | β |
| Blunted responses to stress and reward: reflections on biological disengagement? | Ginty AT | β | 2013 | β |
| Comorbidities and continuities as ontogenic processes: toward a developmental spectrum model of externalizing psychopathology. | Beauchaine TP et al. | β | 2013 | β |
| Gene variants associated with antisocial behaviour: a latent variable approach. | Bentley MJ et al. | β | 2013 | β |
| Internalizing and externalizing behaviors predict elevated inflammatory markers in childhood. | Slopen N et al. | β | 2013 | β |
| Impaired neurocognitive functions affect social learning processes in oppositional defiant disorder and conduct disorder: implications for interventions. | Matthys W et al. | β | 2012 | β |
| ORCHIDS: an observational randomized controlled trial on childhood differential susceptibility. | Chhangur RR et al. | β | 2012 | β |