Structure, pharmacology, and function of GABAA receptor subtypes.
paper
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- Authors
- Sieghart, Werner
- Year
- 2006
- Journal
- Advances in pharmacology (San Diego, Calif.)
- PMID
- 17175817
- DOI
- 10.1016/s1054-3589(06)54010-4
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| Title | Year | PMID |
|---|---|---|
| Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. | 2009 | 19382902 |
External
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| Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. | MΓΈller HA et al. | β | 2010 | β |
| Preclinical and clinical pharmacology of the GABAA receptor alpha5 subtype-selective inverse agonist alpha5IA. | Atack JR | β | 2010 | β |
| Reduced effect of propofol at human {alpha}1{beta}2(N289M){gamma}2 and {alpha}2{beta}3(N290M){gamma}2 mutant GABA(A) receptors. | Jonsson Fagerlund M et al. | β | 2010 | β |
| Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics. | Nutt DJ et al. | β | 2010 | β |
| Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. | Khom S et al. | β | 2010 | β |
| A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients. | Hajak G et al. | β | 2009 | β |
| Activation of GABAA receptor/Cl- channel and capacitation in rat spermatozoa: HCO3- and Cl- are essential. | Jin JY et al. | β | 2009 | β |
| A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures. | Schofield CM et al. | β | 2009 | β |
| Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. | Hurley JH et al. | β | 2009 | β |
| Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam. | Kaminski RM et al. | β | 2009 | β |
| Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA. | Muroi Y et al. | β | 2009 | β |
| Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. | Desai R et al. | β | 2009 | β |
| In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist. | Atack JR et al. | β | 2009 | β |
| Modulation of the Cys-loop ligand-gated ion channels by fatty acid and cannabinoids. | Zhang L et al. | β | 2009 | β |
| Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. | Long P et al. | β | 2009 | β |
| Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem. | Farkas D et al. | β | 2009 | β |
| Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation. | Khatri A et al. | β | 2009 | β |
| Subtype-selective GABA(A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023. | Atack JR | β | 2009 | β |
| The anxiolytic etifoxine protects against convulsant and anxiogenic aspects of the alcohol withdrawal syndrome in mice. | Verleye M et al. | β | 2009 | β |
| The complexity of the GABAA receptor shapes unique pharmacological profiles. | D'Hulst C et al. | β | 2009 | β |
| The optimization of TaqMan real-time RT-PCR assay for transcriptional profiling of GABA-A receptor subunit plasticity. | Gangisetty O et al. | β | 2009 | β |
| Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status. | Majdi M et al. | β | 2009 | β |
| Axonal GABAA receptors. | Trigo FF et al. | β | 2008 | β |
| Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. | Nilsson J et al. | β | 2008 | β |
| BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway. | Lund IV et al. | β | 2008 | β |
| Comparison of short- and long-acting benzodiazepine-receptor agonists with different receptor selectivity on motor coordination and muscle relaxation following thiopental-induced anesthesia in mice. | Tanaka M et al. | β | 2008 | β |
| Expression of GABA A receptor alpha1 subunit mRNA and protein in rat neocortex following photothrombotic infarction. | Kharlamov EA et al. | β | 2008 | β |
| Expression of the GABA(A) receptor gamma4-subunit gene in discrete nuclei within the zebra finch song system. | Thode C et al. | β | 2008 | β |
| Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors. | Kueny-Stotz M et al. | β | 2008 | β |
| GABAA receptors, anesthetics and anticonvulsants in brain development. | Henschel O et al. | β | 2008 | β |
| GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer. | Atack JR | β | 2008 | β |
| Individually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces. | Sharkey LM et al. | β | 2008 | β |
| Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. | Verleye M et al. | β | 2008 | β |
| Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease. | Mitchell EA et al. | β | 2008 | β |
| Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies. | Guerrini G et al. | β | 2008 | β |
| Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol. | Volgin DV | β | 2008 | β |
| Structural answers and persistent questions about how nicotinic receptors work. | Wells GB | β | 2008 | β |
| The goldfish (Carassius auratus) as a model for neuroendocrine signaling. | Popesku JT et al. | β | 2008 | β |
| Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation. | Stewart D et al. | β | 2008 | β |
| Does neurotransmission impairment accompany aluminium neurotoxicity? | GonΓ§alves PP et al. | β | 2007 | β |
| Elicited hippocampal theta rhythm: a screen for anxiolytic and procognitive drugs through changes in hippocampal function? | McNaughton N et al. | β | 2007 | β |
| Thalamic synchrony and dynamic regulation of global forebrain oscillations. | Huguenard JR et al. | β | 2007 | β |
| The neurotransmitter GABA is a potent inhibitor of the stromal cell-derived factor-1alpha induced migration of adult CD133+ hematopoietic stem and progenitor cells. | Seidel J et al. | β | 2007 | β |