Cocaine- and amphetamine-regulated transcript (CART) is colocalized with the orexigenic neuropeptide Y and agouti-related protein and absent from the anorexigenic alpha-melanocyte-stimulating hormone neurons in the infundibular nucleus of the human hypothalamus.
paper
Cited
Public
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- Authors
- MenyhΓ©rt, Judit; Wittmann, GΓ‘bor; Lechan, Ronald M; Keller, Eva; Liposits, Zsolt; Fekete, Csaba
- Year
- 2007
- Journal
- Endocrinology
- PMID
- 17525122
- DOI
- 10.1210/en.2007-0390
Cocaine- and amphetamine-regulated transcript (CART) is a recently discovered anorexigenic peptide. In rodents, CART inhibits food intake and is expressed in the anorexigenic alpha-MSH- but not in the orexigenic neuropeptide Y (NPY)- and agouti-related protein (AGRP)-synthesizing neurons of the arcuate nucleus. To understand whether CART is similarly expressed in feeding-related neuronal groups of the human hypothalamus as observed in rodents, colocalization of CART with alpha-MSH, NPY, AGRP, and melanin-concentrating hormone was studied using double-labeling immunofluorescence and confocal microscopy on human hypothalamic tissues obtained at autopsy. Unlike in rodents, we observed that CART is absent from the perikarya and axons of alpha-MSH-synthesizing neurons, but expressed in approximately one third of NPY/AGRP neurons in the human infundibular nucleus. In the lateral hypothalamus of the humans, colocalization of CART and melanin-concentrating hormone was observed, similar to that described in rodents. The anatomy of CART-containing neurons in the human infundibular nucleus differs markedly from that observed in the rodent brain, raising the question whether the colocalization of CART with orexigenic NPY and AGRP neurons is associated with an orexigenic role of CART in the human brain.
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| CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis. | Lau J et al. | β | 2018 | β |
| Cocaine- and amphetamine-regulated transcript (CART): A multifaceted neuropeptide. | Ahmadian-Moghadam H et al. | β | 2018 | β |
| Neuropeptides in Obesity and Metabolic Disease. | van der Klaauw AA | β | 2018 | β |
| Arcuate nucleus neuropeptide coexpression and connections to gonadotrophin-releasing hormone neurones in the female rhesus macaque. | True C et al. | β | 2017 | β |
| Altered Gene Expression Profiles of the Hypothalamic Arcuate Nucleus of Male Mice Suggest Profound Developmental Changes in Peptidergic Signaling. | MolnΓ‘r CS et al. | β | 2016 | β |
| Hypothalamus-Pituitary-Thyroid Axis. | Ortiga-Carvalho TM et al. | β | 2016 | β |
| Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. | Nasif S et al. | β | 2015 | β |
| Molecular and neuroendocrine mechanisms of cancer cachexia. | Mendes MC et al. | β | 2015 | β |
| CART in the brain of vertebrates: circuits, functions and evolution. | Subhedar NK et al. | β | 2014 | β |
| CART in the regulation of appetite and energy homeostasis. | Lau J et al. | β | 2014 | β |
| Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions. | Fekete C et al. | β | 2014 | β |
| Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region. | Skrapits K et al. | β | 2014 | β |
| Comparing label-free quantitative peptidomics approaches to characterize diurnal variation of peptides in the rat suprachiasmatic nucleus. | Southey BR et al. | β | 2014 | β |
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| Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice. | Lee SJ et al. | β | 2013 | β |
| Neuropeptide alterations in the infundibular nucleus of Huntington's disease patients. | van Wamelen DJ et al. | β | 2013 | β |
| Recent advances in obesity: genetics and beyond. | Cheung WW et al. | β | 2012 | β |
| Comparative distribution of cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus of the capuchin monkey (Cebus apella) and the common marmoset (Callithrix jacchus). | Cavalcante JC et al. | β | 2011 | β |
| Developmental programming of energy balance and its hypothalamic regulation. | Remmers F et al. | β | 2011 | β |
| Critical determinants of hypothalamic appetitive neuropeptide development and expression: species considerations. | Grayson BE et al. | β | 2010 | β |
| Phentermine, topiramate and their combination for the treatment of adiposopathy ('sick fat') and metabolic disease. | Bays H | β | 2010 | β |
| Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs. | Nillni EA | β | 2010 | β |
| Hormonal regulators of appetite. | Austin J et al. | β | 2009 | β |
| Integrative role of brain and hypothalamus in the control of energy balance. | Majdic G | β | 2009 | β |
| MCH and feeding behavior-interaction with peptidic network. | Griffond B et al. | β | 2009 | β |
| Nonselective innervation of lamina I projection neurons by cocaine- and amphetamine-regulated transcript peptide (CART)-immunoreactive fibres in the rat spinal dorsal horn. | Kozsurek M et al. | β | 2009 | β |
| Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice. | Kim SJ et al. | β | 2009 | β |
| Association of cocaine- and amphetamine-regulated transcript and neuropeptide Y in the forebrain and pituitary of the catfish, Clarias batrachus: a double immunofluorescent labeling study. | Singru PS et al. | β | 2008 | β |
| Differential expression of hypothalamic CART mRNA in response to body weight change following different dietary interventions. | Yu Y et al. | β | 2008 | β |
| Expression of cocaine- and amphetamine-regulated transcript (CART) peptides at climbing fibre-Purkinje cell synapses in the rat vestibular cerebellum. | Press DA et al. | β | 2008 | β |
| Neural control of the anorexia-cachexia syndrome. | Laviano A et al. | β | 2008 | β |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | β | 2008 | β |
| Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction. | Wikberg JE et al. | β | 2008 | β |