Auditory brainstem potentials in sons of alcoholic fathers.
- Authors
- Begleiter, H; Porjesz, B; Bihari, B
- Year
- 1987
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 3314564
- DOI
- 10.1111/j.1530-0277.1987.tb01927.x
With the use of event-related brain potentials we have observed sensory as well as cognitive deficits in abstinent alcoholics. By recording auditory brainstem potentials (BSP) from abstinent alcoholics we demonstrated significant delays in brainstem transmission time. We have also reported that P3 amplitudes are significantly reduced in abstinent alcoholics compared to control subjects. Although the neurophysiological deficits observed in abstinent alcoholics are presumed to be alcohol-related effects, it is possible that some of these deficits may exist prior to alcohol exposure, and may be present in subjects at high risk for alcoholism. We have recently observed significantly reduced P3 components in young sons of alcoholics similar to those observed in abstinent alcoholics. In the present study, we examined auditory BSPs in young boys at high risk for alcoholism and matched controls. We found no statistically significant difference in brainstem transmission time between high risk individuals and matched control subjects. These findings suggest that while some brain deficits observed in abstinent alcoholics may antecede the development of alcoholism (P3) and may represent a predisposing factor, other deficits (BSP) appear to be the consequence of alcohol and/or nutritional-related effects.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| The human adolescent brain and alcohol use disorders. | Tapert SF et al. | — | 2005 | → |
| Middle-latency auditory evoked potentials in children at high risk for alcoholism. | Rodríguez Holguín S et al. | — | 2001 | → |
| Event-related potentials during visual selective attention in children of alcoholics. | van der Stelt O et al. | — | 1998 | → |
| Mismatch negativity in young children of alcoholics from high-density families. | Rodríguez Holguín S et al. | — | 1998 | → |
| Alcohol, auditory functioning and deafness. | Crawford A | — | 1997 | → |
| Multi-center N400 ERP consistency using a primed and unprimed word paradigm. | Kuperman S et al. | — | 1995 | → |
| Patterns of alcoholism inheritance. | Dinwiddie SH | — | 1992 | → |
| Event-related potentials in populations at risk for alcoholism. | Begleiter H et al. | — | 1990 | → |
| Information processing, neuropsychological function, and the inherited predisposition to alcoholism. | Peterson JB et al. | — | 1990 | → |
| Potential biological markers in individuals at high risk for developing alcoholism. | Begleiter H et al. | — | 1988 | → |