VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression.
paper
Cited
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- Authors
- Han, Seung Hyun; Jeon, Jun Ho; Ju, Hyang Ran; Jung, Uhee; Kim, Kun Young; Yoo, Hyang Sook; Lee, Young Ho; Song, Kyu Sang; Hwang, Ho Myeung; Na, Yoon Sook; Yang, Young; Lee, Kee Nyung; Choi, Inpyo
- Year
- 2003
- Journal
- Oncogene
- PMID
- 12821938
- DOI
- 10.1038/sj.onc.1206610
Vitamin D(3) upregulated protein 1 (VDUP1) is a 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) upregulated protein, and it is induced by various stresses. In human tumor tissues, VDUP1 expression was downregulated. Upon stimulation by growth-inhibitory signals such as TGF-beta1 and 1,25(OH)(2)D(3), its expression was rapidly upregulated as the cell growth was retarded. The transfection of VDUP1 in tumor cells reduced cell growth. The VDUP1 expression was also increased when the cell-cycle progression was arrested. Transfection of VDUP1 induced cell-cycle arrest at the G0/G1 phase, indicating that VDUP1 possesses a tumor-suppressive activity. In addition, it was found that VDUP1 interacted with promyelocytic leukemia zinc-finger, Fanconi anemia zinc-finger, and histone deacetylase 1, which are known to be transcriptional corepressors. VDUP1 itself suppressed IL-3 receptor and cyclin A2 promoter activity. Taken together, these results suggest that VDUP1 is a novel antitumor gene which forms a transcriptional repressor complex.
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| Vitamin D3 upregulated protein 1 (VDUP1) is a regulator for redox signaling and stress-mediated diseases. | Chung JW et al. | β | 2006 | β |
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| A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis. | Tome ME et al. | β | 2005 | β |
| Biology of SNU cell lines. | Ku JL et al. | β | 2005 | β |
| Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia. | Xiang G et al. | β | 2005 | β |
| Cellular retinoic acid binding protein I: expression and functional influence in renal cell carcinoma. | Pfoertner S et al. | β | 2005 | β |
| Ets1 is an effector of protein kinase Calpha in cancer cells. | Vetter M et al. | β | 2005 | β |
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| Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells. | Li Y et al. | β | 2005 | β |
| Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells. | Li Y et al. | β | 2005 | β |
| H-Ras oncogene counteracts the growth-inhibitory effect of genistein in T24 bladder carcinoma cells. | Li C et al. | β | 2005 | β |
| Mechanistic analysis of the role of BLCA-4 in bladder cancer pathobiology. | Myers-Irvin JM et al. | β | 2005 | β |
| Monoacyl lipoteichoic acid from pneumococci stimulates human cells but not mouse cells. | Kim JH et al. | β | 2005 | β |
| The thioredoxin system in retroviral infection and apoptosis. | Masutani H et al. | β | 2005 | β |
| Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1. | Jeon JH et al. | β | 2005 | β |
| Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis. | Dutta KK et al. | β | 2005 | β |
| VDUP1 is required for the development of natural killer cells. | Lee KN et al. | β | 2005 | β |
| Effects of 10alpha,25-dihydroxyvitamin D3 on doxorubicin-induced chromosomal aberrations in rat bone marrow cells. | Kocak N et al. | β | 2004 | β |
| Heat shock factor regulates VDUP1 gene expression. | Kim KY et al. | β | 2004 | β |
| Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1. | Nishinaka Y et al. | β | 2004 | β |
| Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells. | Cheng GC et al. | β | 2004 | β |
| Rat endometrial Vdup1 expression: changes related to sensitization for the decidual cell reaction and hormonal control. | Simmons DG et al. | β | 2004 | β |
| Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity. | Yoshioka J et al. | β | 2004 | β |
| Thioredoxin: a key regulator of cardiovascular homeostasis. | Yamawaki H et al. | β | 2003 | β |