Rapid single-step induction of functional neurons from human pluripotent stem cells.

paper Cited Public

Authors: Zhang, Yingsha; Pak, Changhui; Han, Yan; Ahlenius, Henrik; Zhang, Zhenjie; Chanda, Soham; Marro, Samuele; Patzke, Christopher; Acuna, Claudio; Covy, Jason; Xu, Wei; Yang, Nan; Danko, Tamas; Chen, Lu; Wernig, Marius; Südhof, Thomas C
Year: 2013
Journal: Neuron
PMID: 23764284
DOI: 10.1016/j.neuron.2013.05.029
PMCID: PMC3751803

Figure 1

Rapid single-step generation of human iN cellsA, Design of lentiviral vectors for Ngn2-mediated conversion of ES and iPS cells to iN cells. Cells are transduced with (i) a virus expressing rtTA and (ii) either a single additional virus expressing an Ngn2/EGFP/puromycin resistance gene as a fusion protein linked by P2A and T2A sequences, or with two viruses that separately express Ngn2/puromycin resistance gene and EGFP.B, Flow diagram of iN cell generation.C, Representative images illustrating the time course of the conversion of H1 ES cells into iN cells. Corresponding differential interference contrast (DIC) and GFP fluorescence pictures are shown on top and bottom.D, Representative images of converted iN cells from two different iPS cells lines at day 6 and day 14. Note that iN cells are clearly identifiable already on day 6. For iN cells generated with NeuroD1 expression, see Fig. S1.

LLM interpretation

This figure illustrates the methodology and results of converting human ES and iPS cells into induced neurons (iN cells). Panel A shows the lentiviral vector designs for Ngn2 expression, and Panel B provides a timeline of the conversion process from cell plating to functional analysis. Panels C and D present DIC and EGFP fluorescence microscopy images showing the morphological transition of H1 ES cells and two iPS cell lines into neuron-like cells over a period of 14 days.

Figure 2

Characterization of the properties and yield of Ngn2-generated iN cellsA, Immunofluorescence images of H1 ES cells and H1 ES cell-derived iN cells (3 weeks after induction). H1 ES but not iN cells are positive for the ES cell markers Nanog, Sox2 and Oct4, while GFAP is only present in co-cultured astrocytes but not iN or ES cells.B, Quantification of selected mRNA levels in H1 ES cells and in H1 ES-cell derived iN cells after 2 and 3 weeks of lentiviral infection. Levels are normalized for GAPDH mRNA levels as an internal control, and are shown on a logarithmic scale. Note that endogenous Ngn2 is induced ~20-fold, and endogenous Brain-2 and FOXG1 expression is induced >1,000-fold. Data are means ± SEM (n=3 independent experiments).C, Immunoblot analyses of proteins extracted from human postmortem cortex (hu Brain), mouse brain (m Brain), and cultured mouse glia cells (m Glia), and of proteins solubilized from iN cells that were derived from H1 ES and two different iPS cell lines (3 weeks after induction) and from the starting ES and iPS cells as indicated. Proteins are identified on the left (Cpx1/2, complexin-1 and −2; Syb2, synaptobrevin-2; Syt1, synaptotagmin-1; Syn1, synapsin-1; Synt1A/B, syntaxin-1A and -1B).D, Representative images of H1 ES-cell derived iN cells visualized via their EGFP fluorescence and immunolabelled for MAP2 or NeuN as indicated.E, Yield of iN cell conversion of H1 ES cells and two different iPS cell lines. The percentage of EGFP-positive cells that also express the neuronal marker MAP2 after 2 or 3 weeks of conversion is shown on the left, and the yield of NeuN-positive cells at the right. NeuN-positive cell yields are calculated both in terms of the percentage of EGFP-positive cells (dark bars) or in terms of starting cell numbers (light bars). For the latter, the yield exceeds 100% for H1-derived but not iPS-derived iN cells because H1 cells still proliferate after lentiviral infection, while iPS cells do not because they are more sensitive to lentivirally induced cell death. Data are means ± SEMs (n=3 independent experiments). For additional data, see Fig. S2.

LLM interpretation

This figure characterizes Ngn2-generated induced neurons (iN cells) through five panels. Panel A shows immunofluorescence images where iN cells lose ES markers (Nanog, Sox2, Oct4) and lack GFAP, while Panel B uses a bar chart to show a significant logarithmic increase in mRNA levels for Ngn2, NeuN, MAP2, BRN2, and FOXG1 in iN cells compared to H1 ES cells. Panel C presents an immunoblot comparing protein expression across human/mouse brain controls, iN cells, and ES/iPS cells, showing iN cells express several synaptic proteins (e.g., Syb2, Syt1, Syn1). Panel D provides representative EGFP/MAP2 and EGFP/NeuN co-localization images, and Panel E uses bar charts to quantify the conversion yield, showing high percentages of MAP2+ and NeuN+ cells across H1 and iPS lines.

Figure 3

iN cell generation involves reproducible changes in gene expressionA, Single-cell quantitative RT-PCR analysis (Fluidigm) of the expression levels of the genes indicated on the right. Expression levels (expressed as Ct values) are color coded as shown on the bottom. mRNA levels were quantified in cytoplasm aspirated from individual iN cells using patch pipettes after 3 weeks of induction.B, Comparison of gene expression profiles in iN cells differentiated from H1 ES and two different lines of iPS cells. The plot depicts average Ct values of the genes indicated at the bottom, with a cutoff of 27 cycles (on top of the 18 cycle pre-amplification).For more extensive analyses of further marker genes, see Fig. S3.

LLM interpretation

Figure A is a heatmap showing single-cell quantitative RT-PCR expression levels (Ct values) for various marker genes across iN cells derived from H1 ES, iPS#1, and iPS#2 lines, with colors ranging from red (low Ct/high expression) to blue (high Ct/low expression). Figure B is a line plot comparing the average Ct values of these same genes across the three cell lines, using a dashed cutoff line at 27 cycles. Both panels demonstrate consistent expression patterns of neuronal markers and the absence of ES and NPC markers across the different cell sources.

Figure 4

iN cells derived from ES and iPS cells form functional synapsesA, Representative traces of membrane currents (upper panel) recorded following a ramp depolarization protocol (lower panel). Na+-currents were blocked by QX-314 (10 mM).B, Representative traces of whole-cell voltage-clamp Na+- and K+-currents recorded in iN cells. iN cells were subjected to 10 mV step depolarizations from −90 mV to +50 mV at a −70 mV holding potential (pipette solution (in mM): 123 K-gluconate, 10 KCl, 1 MgCl2, 10 HEPES-KOH pH 7.2, 1 EGTA, 0.1 CaCl2, 1 K2ATP, 0.2 Na4GTP and 4 glucose).C, Quantification of I/V curves of Na+- and K+-currents in iN cells derived from H1 ES cells and from two different iPS cell lines. Data are means ± SEMs; numbers of cells/cultures analyzed are shown on the right lower corner.D, Representative traces of spontaneous EPSCs (likely mEPSCs based on size); middle panels depict expansions of selected events. The lower traces display block of spontaneous EPSCs by 50 μM CNQX.E & F, Representative traces of evoked EPSCs monitored at −70 mV (E) and at +40 mV (F); lower panels show that CNQX completely blocks all EPSCs. Two superimposed traces are shown.G, Quantification of the frequency (left panel) and amplitude of spontaneous EPSCs (middle panel) and of the amplitude of evoked EPSCs (right panel). Data are means ± SEM; numbers in the left bars indicate the number of cells/independent experiments performed, and apply to all panels. Note that iN cells derived from different ES/iPS cell lines exhibit quantitatively similar synaptic properties.H, Representative traces of EPSCs evoked by a 10 Hz stimulus train applied for 1 s and monitored at −70 mV (top traces) and +40 mV (bottom traces).I, Quantification of the rate of successful observations of voltage-gated Na+-currents, spontaneous EPSCs (sEPSCs), and evoked EPSCs (eEPSCs) in iN cells. Numbers in top bars indicate the number of cells/independent experiments performed.

LLM interpretation

This figure consists of electrophysiological traces and quantitative bar/line graphs comparing iN cells derived from H1 ES cells and two iPS cell lines (iPS#1, iPS#2). Panels A-C show voltage-gated $\text{Na}^+$ and $\text{K}^+$ currents, with I/V curves in C demonstrating similar current-voltage relationships across all three cell types. Panels D-H present spontaneous and evoked EPSCs, showing that these currents are blocked by CNQX and exhibit similar frequencies and amplitudes across the groups, as quantified in panel G. Panel I uses bar charts to show the percentage of neurons exhibiting $\text{Na}^+$-currents, sEPSCs, and eEPSCs, indicating high success rates across all three cell lines.

Figure 5

Use of rapidly induced human iN cells for characterizing human synapses and modeling human diseasesA–C, Optogenetic mapping of functional presynaptic specializations formed by iN cells onto co-cultured cortical mouse neurons. A, Strategy for the generation of channelrhodopsin-expressing iN cells (top), and combined tdTomato fluorescence and DIC images (overview) or DIC images only (images of patched mouse neurons and iN cells) to illustrate the selectively patching human iN cells or mouse neurons (bottom). ES cells were co-infected with lentivirus expressing the channelrhodopsin variant CHIEF as a td-Tomato fusion protein at the time of Ngn2 transduction. B, Synaptic responses triggered by presynaptic optogenetic stimulation of iN cells and monitored in postsynaptic mouse neurons (top, representative traces; bottom, summary graph of the evoked EPSC amplitudes). Responses were triggered by 3 ms blue light pulses without or with 0.5 μM TTX (to block presynaptic action potentials induced by channelrhodopsin). C, Channelrhodopsin-mediated presynaptic depolarizations monitored in human iN cells (top, representative traces; bottom, summary graph of the light-evoked EPSC). As in B, responses were triggered by light pulses in the absence or presence of 0.5 μM TTX, but TTX has no effect because the recorded current is directly induced by channelrhodopsin activation which is not inhibited by TTX.D & E, Ca2+-imaging of human iN cells. D, Representative images of GCaMP6M-expressing iN cells cultured alone (top) or E, of co-cultured with cortical primary neurons (top) in the absence (left panels) or presence of a Ca2+-signal (right panels). Traces of Ca2+-signals induced by field stimulation (D; indicated action potential (AP) inducing pulses were delivered at 50 Hz) or by network activity triggered by 0.1 mM picrotoxin (E) monitored in these iN cells are shown on the bottom.F, iN cells derived from H1 ES cells or two different iPS cell lines exhibit retinoic acid (RA) dependent increases in synaptic strength as a model of homeostatic plasticity. iN cells were incubated with 1 μM RA for 45 min, and the amplitude of spontaneous miniature EPSCs (mEPSCs) was recorded in TTX (T-test,). Data shown are means ± SEMs (n = 12 cells/3 independent experiments for DMSO, and 14/3 for RA treatments; statistical significance was assessed by Student’s t-test; **P<0.01; ***P<0.001).G–I, Effect of a Munc18-1 loss-of-function on synaptic transmission in human iN cells. G, quantification of the Munc18-1 knockdown (KD) efficiency in iN cells. Munc18-1 mRNA levels were measured by quantitative RT-PCR in conrol iN cells and iN cells infected with Munc18-1 KD lentivirus, and normalized to MAP2 as an endogenous control (n=3 independent experiments). H, Representative traces of spontaneous EPSCs monitored in control and Munc18-1 KD iN cells from H1 ES cells (left), and quantifications of the frequency (center) and amplitudes of spontaneous EPSCs (right). Numbers of cells/ independent experiments performed are indicated; I, Representative traces of evoked EPSCs of control and Munc18-1 KD iN cells derived from H1 cells (left), and quantification of spontaneous EPSCs amplitudes (right). Numbers of cells/independent experiments performed are shown in the bars. Data are means ± SEMs; statistical significance was assessed by Student’s t-test (*P<0.05; ***P<0.001).

LLM interpretation

This multi-panel figure uses a combination of microscopy images, electrophysiological traces, and bar/scatter plots to characterize human iN cells. Panels A–C use optogenetics and patch-clamp recordings to demonstrate functional synapses between human iN cells and mouse neurons, showing that light-evoked EPSCs are blocked by TTX in postsynaptic mouse neurons (B) but not in presynaptic human iN cells (C). Panels D–E show $\text{Ca}^{2+}$-imaging of iN cells responding to field stimulation and picrotoxin-induced network activity, while panel F uses bar charts to show a significant increase in mEPSC amplitude following retinoic acid (RA) treatment across three cell lines ($P<0.01$ or $P<0.001$). Panels G–I quantify the effect of Munc18-1 knockdown, showing reduced mRNA levels (G) and a significant decrease in the frequency and amplitude of both spontaneous and evoked EPSCs (H, I; $P<0.05$ to $P<0.001$).

Figure 6

Functional integration of transplanted H1-derived iN cells into mouse brainA, Representative image of EGFP-expressing iN cells in mouse striatum. Note dispersion of the iN cells into the parenchyma (CC, corpus callosum; CTX, cortex; LV, lateral ventricle; STR, striatum; scale bar: 200 μm).B, Labeling of the area in A. with antibodies to the marker protein HuNu specific for human neurons (scale bar: 200 μm).C, Morphology of a single EGFP- and human NCAM- positive iN cells after transplantation (scale bars: 20 μm and 10 μm (inset)).D, Example of an EGFP-positive human iN cell (left panel) that is co-labeled with NeuN (right panel; scale bar: 20 μm).E, Example traces showing action-potential generation (upper traces) in response to current pulses (lower traces) applied with 10 pA step sizes. For the recording configuration from transplanted iN cells, see Fig. S6.F, Average resting membrane potential (Vrest), action-potential threshold (Threshold), and action-potential height (Height) measured in transplanted iN cells (n = 4, left panel). Number of action-potentials (AP #) plotted against current pulse values (n = 4, right panel).G, Representative traces of spontaneous postsynaptic inhibitory currents (IPSCs) monitored in transplanted iN cells; currents are blocked by picrotoxin.I, Evoked IPSCs elicited by extracellular stimulation (arrowhead) and blocked by addition of picrotoxin in transplanted iN cells.

LLM interpretation

This figure demonstrates the integration of transplanted H1-derived iN cells into the mouse striatum through imaging and electrophysiology. Panels A-D show microscopy images of EGFP-expressing cells co-labeled with human-specific markers (HuNu, HuNCAM) and the neuronal marker NeuN, illustrating cell dispersion and morphology. Panels E-H provide electrophysiological data, including action-potential traces, a summary plot of membrane properties and AP frequency versus current (Panel F), and traces of spontaneous and evoked IPSCs that are blocked by picrotoxin.

#	Section	Preview
0	INTRODUCTION	The generation of human embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS…
1	INTRODUCTION	Brennand et al., 2012; Marchetto and Gage 2012). Moreover, elegant studies have described…
2	INTRODUCTION	The first limitation is based on characteristic differences between particular pluripotent cell…
3	INTRODUCTION	The second limitation is related to the cumbersome, variable, and slow procedures needed for…
4	INTRODUCTION	The two major limitations of current technologies for generating human neurons outlined above…
5	INTRODUCTION	2011; Son et al., 2011) found that the same three transcription factors that convert mouse…
6	INTRODUCTION	To address these problems, we here developed approaches that allow rapid and reproducible production…
7	RESULTS — A single transcription factor efficiently converts human ES and iPS cells into neurons	Following our initial observation that the combined expression of Brn2, Ascl1, and Myt1l induces…
8	RESULTS — A single transcription factor efficiently converts human ES and iPS cells into neurons	Because the effects of NeuroD1 and Ngn2 were similar, we decided to focus only on one factor and…
9	RESULTS — A single transcription factor efficiently converts human ES and iPS cells into neurons	We stained H1 ES cells and H1-derived iN cells at 21 days after induction for EGFP (to identify…
10	RESULTS — A single transcription factor efficiently converts human ES and iPS cells into neurons	Immunoblotting experiments showed that the neuronal precursor cell (NPC) markers nestin and Sox2…
11	RESULTS — A single transcription factor efficiently converts human ES and iPS cells into neurons	Measurements of the yield of iN cell conversion in three stem cell lines, H1 ES cells and two…
12	RESULTS — ES- and iPS-cell derived iN cells exhibit reproducible gene expression patterns	We next aimed to gain insight into the nature of the neurons generated and more importantly, to…
13	RESULTS — ES- and iPS-cell derived iN cells exhibit reproducible gene expression patterns	expressed AMPA-type glutamate receptors GluA1, A2, and A4, but lacked NMDA-type glutamate receptors…
14	RESULTS — ES- and iPS-cell derived iN cells exhibit reproducible gene expression patterns	Arguably the most important question in the production of iN cells – in fact, in the in vitro…
15	RESULTS — Human ES- and iPS-cell derived iN cells form synapses	We next probed the ability of Ngn2-induced iN cells to differentiate into electrophysiologically…
16	RESULTS — Human ES- and iPS-cell derived iN cells form synapses	to activation of AMPA-type and not of NMDA-type glutamate receptors, although we did observe small…
17	RESULTS — Human ES- and iPS-cell derived iN cells form synapses	Stimulus trains of 10 Hz revealed fast synaptic depression, showing that iN cell synapses exhibit…
18	RESULTS — Application of human iN cells to study normal and diseased human neurons	To explore the potential use of ES- or iPS-cell derived iN cells for monitoring drug activities,…
19	RESULTS — Application of human iN cells to study normal and diseased human neurons	We then examined the possibility of monitoring activity-dependent Ca2+-transients in entire…

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Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.	2016	26626326

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Forward programming of human pluripotent stem cells to generate glutamatergic and GABAergic neurons in a tri-culture model with astrocytes.	Gu J et al.	—	2026	→
Functional implications of polygenic risk for schizophrenia in human neurons.	Michael Deans PJ et al.	—	2026	→
Generation of two tetracycline-inducible NGN2 iN iPSC lines carrying a heterozygous floating-Harbor syndrome SRCAP truncating mutation.	Kantor I et al.	—	2026	→
GluN2A-mediated currents and calcium signal in human iPSC-derived neurons.	Escamilla S et al.	—	2026	→
Human neuronal networks on micro-electrode arrays as a tool to assess genotype-phenotype correlation in CACNA1A-related disorders.	Hommersom MP et al.	—	2026	→
Interplay between DYRK1A dosage and aneuploidy-induced neuropathology in Down syndrome.	Nambara T et al.	—	2026	→
Kinetochore proteins control microtubule dynamics in postmitotic neurons to regulate the formation of dendritic spines.	Zhao G et al.	—	2026	→
Lipid membrane remodeling by myristic acid treatment reverses Parkinson's disease α-synuclein phenotypes in patient neurons.	Pacheco JA et al.	—	2026	→
Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans.	Zarodniuk M et al.	—	2026	→
Modeling neurovascular dysfunction in Alzheimer's disease using an isogenic brain-chip model.	Shen AN et al.	—	2026	→
Modulating alternative splicing of <i>MECP2</i> is a potential therapeutic strategy for Rett syndrome.	Tirumala HP et al.	—	2026	→
Multidimensional profiling of heterogeneity in supratentorial ependymomas.	Jeong D et al.	—	2026	→
Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric disorders.	He B et al.	—	2026	→
Optimization of lytic herpes simplex virus infection in human induced pluripotent stem cell-derived cortical neurones.	Nash DA et al.	—	2026	→
Pharmacological manipulation of nested oscillations in human iPSC-derived 2D neuronal networks.	Pré D et al.	—	2026	→
Presynaptic Trafficking of Glutamate Decarboxylase Isoforms Is Dispensable for Basal GABAergic Neurotransmission.	Benner O et al.	—	2026	→
Prevention of transgene silencing during human pluripotent stem cell differentiation.	Uenaka T et al.	—	2026	→
Protective ApoE variants support neuronal function by effluxing oxidized phospholipids.	Ralhan I et al.	—	2026	→
Redefining cellular reprogramming with advanced genomic technologies.	Morris SA	—	2026	→
STRAIGHT-IN Dual: a platform for dual single-copy integrations of DNA payloads and gene circuits into human induced pluripotent stem cells.	Blanch-Asensio A et al.	—	2026	→
Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation in the reference iPSC line KOLF2.1J.	Hao Y et al.	—	2026	→
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming.	Zhu L et al.	—	2026	→
The application of directly induced neurons into neurodegenerative disease modeling.	Matsumoto K et al.	—	2026	→
The insertion of an ATTTC repeat in an Alu element hyperactivates a neurodevelopmental enhancer in spinocerebellar ataxia type 37.	Loureiro JR et al.	—	2026	→
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.	Fernandez Garcia M et al.	—	2026	→
TYK2 mediates neuroinflammation in Alzheimer's disease brains with TDP-43 pathology.	König LE et al.	—	2026	→
Uncovering NMDA receptor-mediated high firing activity in excitatory human neurons.	Gameiro-Ros I et al.	—	2026	→
Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs-Derived Neuronal Model.	Tian Y et al.	—	2026	→
Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease.	Matusova Z et al.	—	2025	→
A Blueprint for Translational Precision Medicine in Autism Spectrum Disorder and Related Neurogenetic Syndromes.	Thom RP et al.	—	2025	→
Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing.	Rohm D et al.	—	2025	→
Aggregation shifts amyloid-β peptides from synaptogenic to synaptotoxic.	Siddu A et al.	—	2025	→
Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication.	Zhao X et al.	—	2025	→
An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome.	Thakur P et al.	—	2025	→
An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels.	Yang T et al.	—	2025	→
Antisense oligonucleotides modulate aberrant inclusion of poison exons in SCN1A-related Dravet syndrome.	Tang S et al.	—	2025	→
A potential role for NADPH oxidase (NOX1/2) in mutant huntingtin-induced anomalous neurite outgrowth.	Villegas LD et al.	—	2025	→
A proper excitatory/inhibitory ratio is required to develop synchronized network activity in mouse cortical cultures.	Crocco E et al.	—	2025	→
A scoping review of stem cell models of leukodystrophies: advances in understanding pathophysiological mechanisms.	Chapleau A et al.	—	2025	→
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures.	Lish AM et al.	—	2025	→
A subcellular map of translational machinery composition and regulation at the single-molecule level.	Zhang Z et al.	—	2025	→
Biochemical Properties of Synaptic Proteins Are Dependent on Tissue Preparation: NMDA Receptor Solubility Is Regulated by the C-Terminal Tail.	Won S et al.	—	2025	→
BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning.	Habich C et al.	—	2025	→
C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7.	Wang KS et al.	—	2025	→
CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability.	Hommersom MP et al.	—	2025	→
Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars.	Kshirsagar S et al.	—	2025	→
Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1.	Lundie-Brown J et al.	—	2025	→
Cell type-specific 3D-genome organization and transcription regulation in the brain.	Liu S et al.	—	2025	→
Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs.	Ward TR et al.	—	2025	→
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing.	Tetzlaff SK et al.	—	2025	→
CHIP protects lysosomes from CLN4 mutant-induced membrane damage.	Lee J et al.	—	2025	→
CLU alleviates Alzheimer's disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density.	Lish AM et al.	—	2025	→
Co-cultures of Human-Induced Pluripotent Stem Cell-Derived Neurons, Astrocytes, and Microglia for Modeling Neurodegenerative Diseases.	Roewe J et al.	—	2025	→
Commander complex regulates lysosomal function and is implicated in Parkinson's disease risk.	Minakaki G et al.	—	2025	→
Compact transcription factor cassettes generate functional, engraftable motor neurons by direct conversion.	Wang NB et al.	—	2025	→
Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late-Onset Alzheimer's Disease.	Lee H et al.	—	2025	→
Coordination of autophagosome closure and release by the Alzheimer's disease-associated protein BIN1.	Palmer JE et al.	—	2025	→
CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models.	Khan H et al.	—	2025	→
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.	Li E et al.	—	2025	→
Current Applications of Human Pluripotent Stem Cells in Neuroscience Research and Cell Transplantation Therapy for Neurological Disorders.	Verma I et al.	—	2025	→
Current Development of iPSC-Based Modeling in Neurodegenerative Diseases.	Guo X et al.	—	2025	→
Customizable virus-like particles deliver CRISPR-Cas9 ribonucleoprotein for effective ocular neovascular and Huntington's disease gene therapy.	Ling S et al.	—	2025	→
Decoding microglial functions in Alzheimer's disease: insights from human models.	Rao C et al.	—	2025	→
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.	Guo JL et al.	—	2025	→
Detecting MUNC18-1 related presynaptic dysfunction and rescue in human iPSC-derived neurons.	Long M et al.	—	2025	→
Development and characterization of a scalable calcium imaging assay using human iPSC-derived neurons.	Haustein MD et al.	—	2025	→
Development of Cellular Energy Metabolism During Differentiation of Human iPSCs into Cortical Neurons.	Danačíková Š et al.	—	2025	→
Development of Neural Cells and Spontaneous Neural Activities in Engineered Brain-Like Constructs for Transplantation.	Gai K et al.	—	2025	→
Dissection of Neurochemical Pathways Across Complexity and Scale.	Abbondanza A et al.	—	2025	→
Dynamic properties of transcriptional condensates modulate CRISPRa-mediated gene activation.	Fu Y et al.	—	2025	→
Electrical stimulation of stem cell-derived human neural networks for evaluating anti-seizure medications.	Nicholls J et al.	—	2025	→
Engineered 3D immuno-glial-neurovascular human miBrain model.	Stanton AE et al.	—	2025	→
Engineering Gene and Protein Switches for Regulation of Lineage-Specifying Transcription Factors.	Teixeira AP et al.	—	2025	→
Environmental costs in healthcare system: the case studies of Greece health care.	Sepetis A et al.	—	2025	→
Excitatory cortical neurons from CDKL5 deficiency disorder patient-derived organoids show early hyperexcitability not identified in neurogenin2 induced neurons.	Glass MR et al.	—	2025	→
Experimental evidence that readily diffusible forms of Aβ from Alzheimer's disease brain have seeding activity.	Song S et al.	—	2025	→
Exploring the complexity of MECP2 function in Rett syndrome.	Liu Y et al.	—	2025	→
Extracellular microRNAs modulate human microglial function through TLR8.	Weidling H et al.	—	2025	→
Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.	Juul-Madsen K et al.	—	2025	→
From Organoids to Assembloids: Experimental Approaches to Study Human Neuropsychiatric Disorders.	Levy RJ et al.	—	2025	→
Functional Neurogenomics to Dissect Disease Mechanisms Across Models.	Zheng X et al.	—	2025	→
Functional Validation of Alcohol Dependence-Associated <i>FYN</i> Variants Using Gene Editing and Stem Cell Study Approaches.	Cakir B et al.	—	2025	→
Generation of Glutamatergic Human Neurons from Induced Pluripotent Stem Cells.	Rizalar FS et al.	—	2025	→
Generation of human induced pluripotent stem cell-derived cortical neurons expressing the six tau isoforms.	Jiang H et al.	—	2025	→
Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders.	Zetterdahl OG et al.	—	2025	→
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis.	Augur ZM et al.	—	2025	→
Growth factor supplementation modulates survival, morphology, and network activity of neurogenin-2 induced human neurons.	Abramian A et al.	—	2025	→
High-resolution dynamic imaging of chromatin DNA communication using Oligo-LiveFISH.	Zhu Y et al.	—	2025	→
High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.	Luteijn MJ et al.	—	2025	→
Human brain organoids: an innovative model for neurological disorder research and therapy.	Li H et al.	—	2025	→
Human CLOCK enhances neocortical function.	Liu Y et al.	—	2025	→
Human cortical neurons rapidly generated by embryonic stem cell programming integrate into the stroke-injured rat cortex.	Martinez-Curiel R et al.	—	2025	→
Human Induced Pluripotent Stem Cells: Directed Differentiation Methods and Applications in Brain Diseases.	Wang Y et al.	—	2025	→
Human iPSC-derived glutamatergic neurons with pathogenic KCNQ2 variants display hyperactive bursting phenotypes.	Sundberg M et al.	—	2025	→
Human neuron subtype programming via single-cell transcriptome-coupled patterning screens.	Lin HC et al.	—	2025	→
Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism.	McCready FP et al.	—	2025	→
Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment.	Seah C et al.	—	2025	→
Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease.	Yi LX et al.	—	2025	→
Inhibition of Bone Morphogenetic Protein Signaling Prevents Tau Pathology in iPSC Derived Neurons and PS19 Mice.	Affaneh A et al.	—	2025	→
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders.	Mei Y et al.	—	2025	→
Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel.	Greda AK et al.	—	2025	→
Investigating the ageing-Parkinson's disease nexus: standardisation of in vitro models and techniques by the PD-AGE network.	Bury AG et al.	—	2025	→
iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau.	Imamura K et al.	—	2025	→
K<sub>V</sub>7.2 channel dysfunction delays neuronal maturation and undermines early network development in a hiPSC model of KCNQ2-DEE.	Rosa F et al.	—	2025	→
Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons.	Guillaud L et al.	—	2025	→
Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions.	Samaddar M et al.	—	2025	→
Microglia-to-neuron signaling links <i>APOE4</i> and inflammation to enhanced neuronal lipid metabolism and network activity.	Verduzco Espinoza AP et al.	—	2025	→
Mitochondrial dysfunction mediated by ER-calcium dysregulation in neurons derived from Alzheimer's disease patients.	Mustaly-Kalimi S et al.	—	2025	→
Modeling and correction of protein conformational disease in iPSC-derived neurons through personalized base editing.	Konishi CT et al.	—	2025	→
mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons.	Buttermore ED et al.	—	2025	→
Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons.	Su X et al.	—	2025	→
Nanometer-resolution tracking of single cargo reveals dynein motor mechanisms.	Peng CS et al.	—	2025	→
Neocortical neurogenesis: a proneural gene perspective.	Vasan L et al.	—	2025	→
Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability.	Kumbol V et al.	—	2025	→
Neurogenin 2-induced central neurons generated from NPC patient-derived iPSC display attenuated neurite outgrowth while accumulating cholesterol.	Igarashi M et al.	—	2025	→
Neuronal branching in stem cell models of mitochondrial and neurological diseases.	Lickfett S et al.	—	2025	→
Neuronal constitutive endolysosomal perforations enable α-synuclein aggregation by internalized PFFs.	Sanyal A et al.	—	2025	→
Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation.	Kobayashi H et al.	—	2025	→
Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease models.	Afshar-Saber W et al.	—	2025	→
Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation.	Meli M et al.	—	2025	→
Optimization of Transcription Factor-Driven Neuronal Differentiation from Human Induced Pluripotent Stem Cells for Disease Modelling and Drug Screening.	Servetti M et al.	—	2025	→
Optimized AAV capsids for basal ganglia diseases show robust potency and distribution.	Leib DE et al.	—	2025	→
Optimizing the in vitro neuronal microenvironment to mitigate phototoxicity in live-cell imaging.	Hoffmann CR et al.	—	2025	→
Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons.	Augur ZM et al.	—	2025	→
Optogenetic-induced α-synuclein accumulation reveals early synaptic dysfunction in experimental models of Parkinson's disease.	Rodriguez-Aller R et al.	—	2025	→
Parkinson disease-associated toxic exposures selectively up-regulate vesicular glutamate transporter vGlut2 in a model of human cortical neurons.	Clark KA et al.	—	2025	→
Pathogenic PPP2R5D variants disrupt neuronal development and neurite outgrowth in patient-derived neurons that are reversed by allele-specific knockdown.	Young RE et al.	—	2025	→
Patient-Derived Variants Define Constraints for Ligand Binding at the PDZ Domain of CASK.	Tibbe D et al.	—	2025	→
Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model.	Huie EZ et al.	—	2025	→
Phenotypic complexities of rare heterozygous neurexin-1 deletions.	Fernando MB et al.	—	2025	→
Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks.	Smeyers J et al.	—	2025	→
PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia.	Kozlova A et al.	—	2025	→
Polyunsaturated fatty acids in lipid membranes regulate human neuronal function and amyloid-β production.	Morita S et al.	—	2025	→
POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population.	Benoit CR et al.	—	2025	→
Precision medicine approach for in vitro modeling and computational screening of anti-epileptic drugs in pediatric epilepsy patients with SCN2A (R1629L) mutation.	Kim J et al.	—	2025	→
Proteomics-based receptor-ligand matching enhances differentiation maturity of human-stem-cell-derived neurons.	Dimitrov D et al.	—	2025	→
Protocol for generating a human iPSC-derived tri-culture model to study interactions between neurons, astrocytes, and microglia.	Lish AM et al.	—	2025	→
Protocol for live imaging of axonal transport in iPSC-derived iNeurons.	Dou D et al.	—	2025	→
Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis.	Chen P et al.	—	2025	→
Reducing education inequalities through cloud-enabled live-cell biotechnology.	Vera-Choqqueccota S et al.	—	2025	→
Research on Alzheimer's Disease (AD) Involving the Use of <i>In vivo</i> and <i>In vitro</i> Models and Mechanisms.	Sinha S et al.	—	2025	→
Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome.	Giona F et al.	—	2025	→
SIMPATHIC: Accelerating drug repurposing for rare diseases by exploiting SIMilarities in clinical and molecular PATHology.	van Karnebeek CDM et al.	—	2025	→
Small cell lung cancer induces synaptic scaling to alter neuronal excitability.	Houcek AJ et al.	—	2025	→
Starting a synthetic biological intelligence lab from scratch.	Tanveer MS et al.	—	2025	→
Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice.	Nuber S et al.	—	2025	→
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease.	Cai Y et al.	—	2025	→
Tackling ciliary specialization to understand phenotypic variability in human primary ciliopathies.	Bachmann-Gagescu R et al.	—	2025	→
Targeting STAU1 prevents p53 apoptotic signaling in neurodegeneration.	Gandelman M et al.	—	2025	→
Tau Axonal Sorting and Interaction With Synaptic Plasticity Modulators Is Domain- and Isoform-Dependent in Human iPSC-Derived Neurons.	Bell-Simons M et al.	—	2025	→
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.	Joseph BJ et al.	—	2025	→
The ADCY1-mediated cAMP signaling pathway mediates functional effects of montelukast treatment in brain organoids.	Xu Z et al.	—	2025	→
The Evolving Landscape of Functional Models of Autism Spectrum Disorder.	Ranjan J et al.	—	2025	→
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation.	Jin G et al.	—	2025	→
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.	Feringa FM et al.	—	2025	→
The potential of brain organoids in addressing the heterogeneity of synucleinopathies.	Diao XJ et al.	—	2025	→
The Shab family potassium channels are highly enriched at the presynaptic terminals of human neurons.	Benner O et al.	—	2025	→
Transcription Factor-Based Differentiation of Pluripotent Stem Cells: Overcoming the Traps of Random Neuronal Fate.	McDaid G et al.	—	2025	→
Transcriptomic profiling of neural cultures from the KYOU iPSC line via alternative differentiation protocols.	Galiakberova A et al.	—	2025	→
UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome.	Yang X et al.	—	2025	→
Use of polyadenosine tail mimetics to enhance mRNA expression from genes associated with haploinsufficiency disorders.	Torkzaban B et al.	—	2025	→
Validation of human sensory neurons derived from inducible pluripotent stem cells as a model for latent infection and reactivation by herpes simplex virus 1.	Oh HS et al.	—	2025	→
VCP regulates early tau seed amplification via specific cofactors.	Batra S et al.	—	2025	→
Vesicle-associated membrane protein 5 is an intrinsic defense factor for embryonic stem cells against coronaviruses.	Dong H et al.	—	2025	→
VPS13B recruits lipid vesicles to promote mitochondrial fission and quality control.	Lee SK et al.	—	2025	→
YY1 mutations disrupt corticogenesis through a cell type specific rewiring of cell-autonomous and non-cell-autonomous transcriptional programs.	Pereira MF et al.	—	2025	→
ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development.	Yang G et al.	—	2025	→
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation.	Sitron CS et al.	—	2025	→
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.	Trambauer J et al.	—	2025	→
AAV-mediated Stambp gene replacement therapy rescues neurological defects in a mouse model of microcephaly-capillary malformation syndrome.	Hu M et al.	—	2024	→
Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease.	Gojanovich AD et al.	—	2024	→
Activity-Dependent Transcriptional Program in NGN2+ Neurons Enriched for Genetic Risk for Brain-Related Disorders.	Ma Y et al.	—	2024	→
A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events.	Hao YA et al.	—	2024	→
A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy.	Nebuloni F et al.	—	2024	→
ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations.	Afshar-Saber W et al.	—	2024	→
An activity-specificity trade-off encoded in human transcription factors.	Naderi J et al.	—	2024	→
Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism.	Wang L et al.	—	2024	→
An epigenetic barrier sets the timing of human neuronal maturation.	Ciceri G et al.	—	2024	→
An induced pluripotent stem cell line carrying a silencing-resistant calcium reporter allele.	Durens M et al.	—	2024	→
An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds.	Zhao C et al.	—	2024	→
ApoE maintains neuronal integrity via microRNA and H3K27me3-mediated repression.	Tan J et al.	—	2024	→
Applications of multiphoton microscopy in imaging cerebral and retinal organoids.	Lacin ME et al.	—	2024	→
A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons.	White AJ et al.	—	2024	→
ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia.	Lai J et al.	—	2024	→
Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders.	Vivi E et al.	—	2024	→
Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder.	Tokatly Latzer I et al.	—	2024	→
Combinatorial selective ER-phagy remodels the ER during neurogenesis.	Hoyer MJ et al.	—	2024	→
CRISPR-Cas9 editing of synaptic genes in human embryonic stem cells for functional analysis in induced human neurons.	Houcek A et al.	—	2024	→
CRISPRi: a way to integrate iPSC-derived neuronal models.	Franks SNJ et al.	—	2024	→
Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau.	Buchholz S et al.	—	2024	→
Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer's disease and aging.	Paudel B et al.	—	2024	→
Deciphering the Pathophysiological Mechanisms Underpinning Myoclonus Dystonia Using Pluripotent Stem Cell-Derived Cellular Models.	Li Z et al.	—	2024	→
Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype.	Fink JJ et al.	—	2024	→
Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons.	Heider J et al.	—	2024	→
Degree of differentiation impacts neurobiological signature and resistance to hypoxia of SH-SY5Y cells.	Voogd EJHF et al.	—	2024	→
Differential susceptibility of human motor neurons to infection with Usutu and West Nile virus.	Marshall EM et al.	—	2024	→
Directed Differentiation of Neurons from Human iPSCs for Modeling Neurological Disorders.	Wang C et al.	—	2024	→
Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function <i>SCN2A</i> Developmental and Epileptic Encephalopathy.	Mao M et al.	—	2024	→
DLK-dependent axonal mitochondrial fission drives degeneration after axotomy.	Gómez-Deza J et al.	—	2024	→
Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis.	Shi X et al.	—	2024	→
Dynein and dynactin move long-range but are delivered separately to the axon tip.	Fellows AD et al.	—	2024	→
Emerging Models to Study Human Microglia In vitro.	Jäntti H et al.	—	2024	→
Endo-IP and lyso-IP toolkit for endolysosomal profiling of human-induced neurons.	Hundley FV et al.	—	2024	→
Epigenome editing technologies for discovery and medicine.	McCutcheon SR et al.	—	2024	→
Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations.	Bahnassawy L et al.	—	2024	→
Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation.	Shan X et al.	—	2024	→
Functional properties of measles virus proteins derived from a subacute sclerosing panencephalitis patient who received repeated remdesivir treatments.	Schmitz KS et al.	—	2024	→
Generation of a stably transfected mouse embryonic stem cell line for inducible differentiation to excitatory neurons.	Gu J et al.	—	2024	→
Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1.	Ang CE et al.	—	2024	→
Genome access is transcription factor-specific and defined by nucleosome position.	Grand RS et al.	—	2024	→
Gephyrin promotes autonomous assembly and synaptic localization of GABAergic postsynaptic components without presynaptic GABA release.	Carricaburu E et al.	—	2024	→
Harnessing the potential of human induced pluripotent stem cells, functional assays and machine learning for neurodevelopmental disorders.	Yang Z et al.	—	2024	→
High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia.	Saffari A et al.	—	2024	→
High-throughput assay for regulated secretion of neuropeptides in mouse and human neurons.	Baginska U et al.	—	2024	→
Histone acetylation in an Alzheimer's disease cell model promotes homeostatic amyloid-reducing pathways.	Xu DC et al.	—	2024	→
Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials.	Bullmann T et al.	—	2024	→
Human neuronal maturation comes of age: cellular mechanisms and species differences.	Wallace JL et al.	—	2024	→
Human Pluripotent Stem Cell-Derived Astrocyte Functionality Compares Favorably with Primary Rat Astrocytes.	Lendemeijer B et al.	—	2024	→
Human pluripotent stem cell (hPSC)-derived microglia for the study of brain disorders. A comprehensive review of existing protocols.	Teo F et al.	—	2024	→
Human stem cell-specific epigenetic signatures control transgene expression.	Kwak CS et al.	—	2024	→
Human stem cell transplantation models of Alzheimer's disease.	Ifediora N et al.	—	2024	→
Hypothermia improves neuronal network recovery in a human-derived in vitro model of oxygen-deprivation.	Voogd EJHF et al.	—	2024	→
In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline.	Pereira MF et al.	—	2024	→
Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani.	Baert L et al.	—	2024	→
Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture.	Das D et al.	—	2024	→
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons.	Hees JT et al.	—	2024	→
Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons.	Zhou X et al.	—	2024	→
In vitro electrophysiological drug testing on neuronal networks derived from human induced pluripotent stem cells.	Parodi G et al.	—	2024	→
In vitro human cell culture models in a bench-to-bedside approach to epilepsy.	Danačíková Š et al.	—	2024	→
iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.	Rylaarsdam L et al.	—	2024	→
iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.	Theofilas P et al.	—	2024	→
<i>REST</i> and <i>RCOR</i> genes display distinct expression profiles in neurons and astrocytes using 2D and 3D human pluripotent stem cell models.	Maksour S et al.	—	2024	→
KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons.	Yheskel M et al.	—	2024	→
Liprin-α proteins are master regulators of human presynapse assembly.	Marcó de la Cruz B et al.	—	2024	→
Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cell cortex.	Ghisleni A et al.	—	2024	→
MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	Liu Y et al.	—	2024	→
Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels.	Bajikar SS et al.	—	2024	→
Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells.	Muhtaseb AW et al.	—	2024	→
Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming.	Sun Z et al.	—	2024	→
Modeling Parkinson's disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines.	Bayati A et al.	—	2024	→
Models of Herpes Simplex Virus Latency.	Canova PN et al.	—	2024	→
Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes.	Lemieux MR et al.	—	2024	→
Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements.	Chardon FM et al.	—	2024	→
Multiscale modeling uncovers 7q11.23 copy number variation-dependent changes in ribosomal biogenesis and neuronal maturation and excitability.	Mihailovich M et al.	—	2024	→
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.	Lisowski P et al.	—	2024	→
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation.	Suzuki H et al.	—	2024	→
Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders.	Jiang J et al.	—	2024	→
Neural and metabolic dysregulation in PMM2-deficient human in vitro neural models.	Radenkovic S et al.	—	2024	→
Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression.	Giansante G et al.	—	2024	→
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.	Marques C et al.	—	2024	→
NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease Models.	Tumdam R et al.	—	2024	→
Novel Approaches to Studying SLC13A5 Disease.	Beltran AS	—	2024	→
Phospho-regulation of ASCL1-mediated chromatin opening during cellular reprogramming.	Azzarelli R et al.	—	2024	→
Pluripotent Stem Cells as a Preclinical Cellular Model for Studying Hereditary Spastic Paraplegias.	Damiani D et al.	—	2024	→
Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.	Li X et al.	—	2024	→
Probing the molecular and cellular pathological mechanisms of schizophrenia using human induced pluripotent stem cell models.	Sebastian R et al.	—	2024	→
Protocol for generation of PD modeling induced neurons and detection of α-synuclein forms.	Nardi FV et al.	—	2024	→
Protocol for the efficient and inducible generation of CRISPR-Cas9-edited human cortical neurons from the iCas9-iNgn2 hPSCs.	Dhaliwal NK et al.	—	2024	→
Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington's disease.	Wu J et al.	—	2024	→
RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages.	Susanto TT et al.	—	2024	→
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.	Lam I et al.	—	2024	→
Reduced MUNC18-1 Levels, Synaptic Proteome Changes, and Altered Network Activity in <i>STXBP</i><i>1</i>-Related Disorder Patient Neurons.	van Berkel AA et al.	—	2024	→
Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F.	Öttl M et al.	—	2024	→
Regulation potential of transcribed simple repeated sequences in developing neurons.	Chung TH et al.	—	2024	→
Reprogramming Stars #14: Fast-Forwarding Cellular Reprogramming- An Interview with Dr. Mark Kotter.	Kotter MR et al.	—	2024	→
RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy.	Tripathi A et al.	—	2024	→
Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs.	Zhang H et al.	—	2024	→
Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons.	Yoshida F et al.	—	2024	→
Spliceosome malfunction causes neurodevelopmental disorders with overlapping features.	Li D et al.	—	2024	→
STAMBP is Required for Long-Term Maintenance of Neural Progenitor Cells Derived from hESCs.	Zhang J et al.	—	2024	→
Strategies for dissecting the complexity of neurodevelopmental disorders.	Sun J et al.	—	2024	→
Structural and functional alterations of neurons derived from sporadic Alzheimer's disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis.	Sollazzo R et al.	—	2024	→
Supra- and sub-threshold intracellular-like recording of 2D and 3D neuronal networks using nanopillar electrode arrays.	Shukla S et al.	—	2024	→
Synergistic Effect of Electrical and Biochemical Stimulation on Human iPSC-Derived Neural Differentiation in a Microfluidic Electrode Array Chip.	Kim NY et al.	—	2024	→
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.	Dhaliwal NK et al.	—	2024	→
Systematic Evaluation of Extracellular Coating Matrix on the Differentiation of Human-Induced Pluripotent Stem Cells to Cortical Neurons.	Li S et al.	—	2024	→
Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy.	Qu G et al.	—	2024	→
The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons.	Mamais A et al.	—	2024	→
Tracking induced pluripotent stem cell differentiation with a fluorescent genetically encoded epigenetic probe.	Stepanov AI et al.	—	2024	→
Transcription-coupled DNA-protein crosslink repair by CSB and CRL4<sup>CSA</sup>-mediated degradation.	van Sluis M et al.	—	2024	→
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.	Singh PNP et al.	—	2024	→
Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs-A Comparison of Methods.	McDonald KO et al.	—	2024	→
Uncovering the dynamics and consequences of RNA isoform changes during neuronal differentiation.	Ulicevic J et al.	—	2024	→
USP14 inhibition enhances Parkin-independent mitophagy in iNeurons.	Bernardo G et al.	—	2024	→
β-Amyloid species production and tau phosphorylation in iPSC-neurons with reference to neuropathologically characterized matched donor brains.	Oakley DH et al.	—	2024	→
3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease.	Lomoio S et al.	—	2023	→
A 3D human co-culture to model neuron-astrocyte interactions in tauopathies.	Batenburg KL et al.	—	2023	→
Acoustofluidic Engineering of Functional Vessel-on-a-Chip.	Wu Y et al.	—	2023	→
A fully automated FAIMS-DIA mass spectrometry-based proteomic pipeline.	Reilly L et al.	—	2023	→
A Human Neuron/Astrocyte Co-culture to Model Seeded and Spontaneous Intraneuronal Tau Aggregation.	Batenburg KL et al.	—	2023	→
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.	Popova D et al.	—	2023	→
Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice.	Zhang L et al.	—	2023	→
A Missense Variant in CASKIN1's Proline-Rich Region Segregates with Psychosis in a Three-Generation Family.	Wahbeh MH et al.	—	2023	→
Aneuploidy effects on human gene expression across three cell types.	Liu S et al.	—	2023	→
ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.	Teunissen MWA et al.	—	2023	→
An Optogenetic-Controlled Cell Reprogramming System for Driving Cell Fate and Light-Responsive Chimeric Mice.	Wang M et al.	—	2023	→
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels.	Zhou J et al.	—	2023	→
APOE expression and secretion are modulated by mitochondrial dysfunction.	Wynne ME et al.	—	2023	→
A robust and reliable methodology to perform GECI-based multi-time point neuronal calcium imaging within mixed cultures of human iPSC-derived cortical neurons.	Patel N et al.	—	2023	→
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons.	Álvarez Z et al.	—	2023	→
Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.	Vainorius G et al.	—	2023	→
A Simple Ca<sup>2+</sup>-Imaging Approach of Network-Activity Analyses for Human Neurons.	Sun Z	—	2023	→
Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia.	Canals I et al.	—	2023	→
Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons.	Pietiläinen O et al.	—	2023	→
ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids.	You Y et al.	—	2023	→
A transcription factor atlas of directed differentiation.	Joung J et al.	—	2023	→
A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases.	Beaver D et al.	—	2023	→
Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition.	Zaghi M et al.	—	2023	→
Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12.	Zhou C et al.	—	2023	→
Brain organoids are new tool for drug screening of neurological diseases.	Zhou JQ et al.	—	2023	→
Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs	Zhang X et al.	—	2023	—
Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1.	Lee H et al.	—	2023	→
Characterization of a Human Neuronal Culture System for the Study of Cofilin-Actin Rod Pathology.	Tahtamouni LH et al.	—	2023	→
Characterizing the Neuron-Glial Interactions by the Co-cultures of Human iPSC-Derived Oligodendroglia and Neurons.	Vulakh G et al.	—	2023	→
Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation.	Meng L	—	2023	→
Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons.	Lin W et al.	—	2023	→
Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome.	Geng J et al.	—	2023	→
Differentiation of astrocytes with characteristics of ventral midbrain from human embryonic stem cells.	Yeon GB et al.	—	2023	→
Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.	Chen SW et al.	—	2023	→
Disruption of DDX53 coding sequence has limited impact on iPSC-derived human NGN2 neurons.	Faheem M et al.	—	2023	→
Disruption of the autism-associated gene <i>SCN2A</i> alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons.	Brown CO et al.	—	2023	→
DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders.	Feuer KL et al.	—	2023	→
Early Alzheimer's disease pathology in human cortex involves transient cell states.	Gazestani V et al.	—	2023	→
Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression.	Liu Y et al.	—	2023	→
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues.	Limone F et al.	—	2023	→
Engineering circuits of human iPSC-derived neurons and rat primary glia.	Girardin S et al.	—	2023	→
Essential transcription factors for induced neuron differentiation.	Lu C et al.	—	2023	→
Excitatory Dysfunction Drives Network and Calcium Handling Deficits in 16p11.2 Duplication Schizophrenia Induced Pluripotent Stem Cell-Derived Neurons.	Parnell E et al.	—	2023	→
Excitatory Neurons Derived from Human-Induced Pluripotent Stem Cells Show Transcriptomic Differences in Alzheimer's Patients from Controls.	Sagar R et al.	—	2023	→
Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	Griffin TA et al.	—	2023	→
Field-dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging.	Fu S et al.	—	2023	→
FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.	Park SHE et al.	—	2023	→
From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome.	Watson LA et al.	—	2023	→
Functional characterization of a single nucleotide polymorphism associated with Alzheimer's disease in a hiPSC-based neuron model.	Stolzenburg LR et al.	—	2023	→
Functional genomics in stem cell models: considerations and applications.	Shevade K et al.	—	2023	→
GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.	Senkevich K et al.	—	2023	→
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.	Neel DV et al.	—	2023	→
Generation and Co-culture of Cortical Glutamatergic and GABAergic-Induced Neuronal Cells.	English J et al.	—	2023	→
Generation of Oligodendrocytes from Human Pluripotent and Embryonic Stem Cells.	Mattingly Z et al.	—	2023	→
Haplotype-specific MAPK3 expression in 16p11.2 deletion contributes to variable neurodevelopment.	Liu F et al.	—	2023	→
Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction.	Shi X et al.	—	2023	→
High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly.	Berryer MH et al.	—	2023	→
hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal Cord Injury.	Du X et al.	—	2023	→
Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation.	Nadler MJS et al.	—	2023	→
Human-Derived Cortical Neurospheroids Coupled to Passive, High-Density and 3D MEAs: A Valid Platform for Functional Tests.	Muzzi L et al.	—	2023	→
Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease.	Young JE et al.	—	2023	→
Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations.	Kilpatrick S et al.	—	2023	→
<i>Bcl</i>-<i>xL</i> Promotes the Survival of Motor Neurons Derived from Neural Stem Cells.	Wu Y et al.	—	2023	→
Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease.	Liu L et al.	—	2023	→
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	Unda BK et al.	—	2023	→
Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex.	Winden KD et al.	—	2023	→
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk.	Powell SK et al.	—	2023	→
INPP5D regulates inflammasome activation in human microglia.	Chou V et al.	—	2023	→
Insights and applications of direct neuronal reprogramming.	Schaukowitch K et al.	—	2023	→
Instructional materials that control cellular activity through synthetic Notch receptors.	Lee JC et al.	—	2023	→
Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.	Hicks EM et al.	—	2023	→
Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases.	Guo MG et al.	—	2023	→
Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging.	Nithianandam V et al.	—	2023	→
Intraneuronal tau aggregation induces the integrated stress response in astrocytes.	Batenburg KL et al.	—	2023	→
iPSC-derived reactive astrocytes from patients with multiple sclerosis protect cocultured neurons in inflammatory conditions.	Kerkering J et al.	—	2023	→
iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons.	Held A et al.	—	2023	→
Iron drives anabolic metabolism through active histone demethylation and mTORC1.	Shapiro JS et al.	—	2023	→
Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics.	Wang Z et al.	—	2023	→
Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders.	Michalski C et al.	—	2023	→
Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity.	Wen J et al.	—	2023	→
LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size.	Serra-Vinardell J et al.	—	2023	→
MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD.	Korn L et al.	—	2023	→
Massively parallel functional dissection of schizophrenia-associated noncoding genetic variants.	Rummel CK et al.	—	2023	→
Measuring Neuronal Network Activity Using Human Induced Neuronal Cells.	McSweeney D et al.	—	2023	→
Mechanisms and biotechnological applications of transcription factors.	He H et al.	—	2023	→
Methods for the isolation and analysis of Aβ from postmortem brain.	Hong W et al.	—	2023	→
Molecular Insights into Cell Type-specific Roles in Alzheimer's Disease: Human Induced Pluripotent Stem Cell-based Disease Modelling.	Qu W et al.	—	2023	→
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.	Hasan S et al.	—	2023	→
Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons.	Zhang S et al.	—	2023	→
Mutations in human DNA methyltransferase DNMT1 induce specific genome-wide epigenomic and transcriptomic changes in neurodevelopment.	Davis KN et al.	—	2023	→
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.	Sampognaro PJ et al.	—	2023	→
MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention.	Weigel B et al.	—	2023	→
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages.	Wells MF et al.	—	2023	→
Neural differentiation protocols: how to choose the correct approach.	Telias M	—	2023	→
Neuronal differentiation and functional maturation of neurons from neural stem cells induced by bFGF-chitosan controlled release system.	Bai T et al.	—	2023	→
Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease.	Essayan-Perez S et al.	—	2023	→
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.	Kapell H et al.	—	2023	→
Neurons require glucose uptake and glycolysis in vivo.	Li H et al.	—	2023	→
Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging.	Uzay B et al.	—	2023	→
NGLY1 mutations cause protein aggregation in human neurons.	Manole A et al.	—	2023	→
NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies.	Steinke S et al.	—	2023	→
Opportunities and limitations for studying neuropsychiatric disorders using patient-derived induced pluripotent stem cells.	Hong Y et al.	—	2023	→
Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons.	Sheta R et al.	—	2023	→
Palmitoylation of the Parkinson's disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis.	Ho GPH et al.	—	2023	→
PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems.	Kraus F et al.	—	2023	→
Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the <i>RBFOX1</i> Gene.	Kostic M et al.	—	2023	→
Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.	Rizalar FS et al.	—	2023	→
Pooled analysis of frontal lobe transcriptomic data identifies key mitophagy gene changes in Alzheimer's disease brain.	Mei T et al.	—	2023	→
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer's disease.	Marei HE et al.	—	2023	→
Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease.	Merchant JP et al.	—	2023	→
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.	Pintacuda G et al.	—	2023	→
Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes.	Kondo T et al.	—	2023	→
Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke.	Ninomiya I et al.	—	2023	→
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.	Breitmeyer R et al.	—	2023	→
Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success.	Waxman EA et al.	—	2023	→
Reverse electron transfer is activated during aging and contributes to aging and age-related disease.	Rimal S et al.	—	2023	→
RNA-based translation activators for targeted gene upregulation.	Cao Y et al.	—	2023	→
Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells.	Berryer MH et al.	—	2023	→
SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes.	van Hugte EJH et al.	—	2023	→
Shedding light on latent pathogenesis and pathophysiology of mental disorders: The potential of iPS cell technology.	Arioka Y et al.	—	2023	→
Sialic acid biosynthesis pathway blockade disturbs neuronal network formation in human iPSC-derived excitatory neurons.	Mijdam R et al.	—	2023	→
Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders.	Seah C et al.	—	2023	→
Stem cell programming - prospects for perinatal medicine.	Berg LJ et al.	—	2023	→
The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment.	Ma F et al.	—	2023	→
The Breakthroughs and Caveats of Using Human Pluripotent Stem Cells in Modeling Alzheimer's Disease.	Sahlgren Bendtsen KM et al.	—	2023	→
The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies.	Liou RH et al.	—	2023	→
The Multifaceted Role of WNT Signaling in Alzheimer's Disease Onset and Age-Related Progression.	Kostes WW et al.	—	2023	→
The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells.	Koch J et al.	—	2023	→
Transcription factor combinations that define human astrocyte identity encode significant variation of maturity and function.	Baranes K et al.	—	2023	→
Transcription Factor-Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells.	Ng YH et al.	—	2023	→
Transcription Factor-Mediated Differentiation of Motor Neurons from Human Pluripotent Stem Cells.	Wu J et al.	—	2023	→
Transition from Animal-Based to Human Induced Pluripotent Stem Cells (iPSCs)-Based Models of Neurodevelopmental Disorders: Opportunities and Challenges.	Guerreiro S et al.	—	2023	→
Understanding neural development and diseases using CRISPR screens in human pluripotent stem cell-derived cultures.	Ahmed M et al.	—	2023	→
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	Hsu YH et al.	—	2023	→
USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the <i>Drosophila</i> Brain and in Human Neurons.	Mauri S et al.	—	2023	→
Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects.	Ayers KL et al.	—	2023	→
What connects splicing of transfer RNA precursor molecules with pontocerebellar hypoplasia?	Sekulovski S et al.	—	2023	→
Whole Cell Patch Clamp Electrophysiology in Human Neuronal Cells.	Gabriel R et al.	—	2023	→
16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons.	Buttermore ED et al.	—	2022	→
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.	Bérard M et al.	—	2022	→
An Optimized Direct Lysis Gene Expression Microplate Assay and Applications for Disease, Differentiation, and Pharmacological Cell-Based Studies.	Ng NS et al.	—	2022	→
AP-4-mediated axonal transport controls endocannabinoid production in neurons.	Davies AK et al.	—	2022	→
APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons.	Wu CI et al.	—	2022	→
Application and prospects of high-throughput screening for <i>in vitro</i> neurogenesis.	Zhang SY et al.	—	2022	→
Applications of 3D Bioprinting Technology in Induced Pluripotent Stem Cells-Based Tissue Engineering.	Shukla AK et al.	—	2022	→
A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development.	Benedetti V et al.	—	2022	→
Assessing the neurotoxicity of airborne nano-scale particulate matter in human iPSC-derived neurons using a transcriptomics benchmark dose model.	Zhang Z et al.	—	2022	→
Association of AK4 Protein From Stem Cell-Derived Neurons With Cognitive Reserve: An Autopsy Study.	Yu L et al.	—	2022	→
A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis.	Deneault E et al.	—	2022	→
A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility.	Voloudakis G et al.	—	2022	→
Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.	Lee A et al.	—	2022	→
Biomaterial and tissue-engineering strategies for the treatment of brain neurodegeneration.	Martinez B et al.	—	2022	→
Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings.	Alich TC et al.	—	2022	→
Building in vitro models of the brain to understand the role of <i>APOE</i> in Alzheimer's disease.	Pinals RL et al.	—	2022	→
Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks.	Mossink B et al.	—	2022	→
Cell models for Down syndrome-Alzheimer's disease research.	Wu Y et al.	—	2022	→
Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy.	Jang A et al.	—	2022	→
Combinatorial Approach of Binary Colloidal Crystals and CRISPR Activation to Improve Induced Pluripotent Stem Cell Differentiation into Neurons.	Urrutia-Cabrera D et al.	—	2022	→
Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons.	Sheta R et al.	—	2022	→
Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks.	Kapucu FE et al.	—	2022	→
Culture of Human iPSC-Derived Motoneurons in Compartmentalized Microfluidic Devices and Quantitative Assays for Studying Axonal Phenotypes.	Garone MG et al.	—	2022	→
Developing antisense oligonucleotides for a <i>TECPR2</i> mutation-induced, ultra-rare neurological disorder using patient-derived cellular models.	Williams LA et al.	—	2022	→
Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine.	Silva MC et al.	—	2022	→
Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo.	Luo Z et al.	—	2022	→
Diseased, differentiated and difficult: Strategies for improved engineering of <i>in vitro</i> neurological systems.	Elder N et al.	—	2022	→
Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.	Blanchard JW et al.	—	2022	→
Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G<sub>4</sub>C<sub>2</sub>)<sub>n</sub> expression in C9orf72 ALS/FTD.	Czuppa M et al.	—	2022	→
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery.	Li J et al.	—	2022	→
Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells.	Li Q et al.	—	2022	→
Efficient Generation of Stable Cell Lines with Inducible Neuronal Transgene Expression Using the piggyBac Transposon System.	Gu J et al.	—	2022	→
Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity.	Hsieh YC et al.	—	2022	→
Endocytosis in the axon initial segment maintains neuronal polarity.	Eichel K et al.	—	2022	→
Endoplasmic reticulum stress induces Alzheimer disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein.	Devina T et al.	—	2022	→
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation.	Kaluscha S et al.	—	2022	→
Following Excitation/Inhibition Ratio Homeostasis from Synapse to EEG in Monogenetic Neurodevelopmental Disorders.	Geertjens L et al.	—	2022	→
Gene Expression Analysis in Stem Cell-derived Cortical Neuronal Cultures Using Multi-well SYBR Green Quantitative PCR Arrays.	Srinivasaraghavan VN et al.	—	2022	→
Gene-independent therapeutic interventions to maintain and restore light sensitivity in degenerating photoreceptors.	Zuzic M et al.	—	2022	→
Genome Sequencing Variations in the <i>Octodon degus</i>, an Unconventional Natural Model of Aging and Alzheimer's Disease.	Hurley MJ et al.	—	2022	→
Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders.	Chang X et al.	—	2022	→
High-content analysis of neuronal morphology in human iPSC-derived neurons.	Lickfett S et al.	—	2022	→
Human brain organogenesis: Toward a cellular understanding of development and disease.	Kelley KW et al.	—	2022	→
Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells.	Javaid MS et al.	—	2022	→
Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids.	Barak M et al.	—	2022	→
Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.	You Y et al.	—	2022	→
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation.	Giacomelli E et al.	—	2022	→
<i>CASK</i> loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons.	McSweeney D et al.	—	2022	→
Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening.	Flitsch LJ et al.	—	2022	→
Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.	Linda K et al.	—	2022	→
Impaired Functional Connectivity Underlies Fragile X Syndrome.	Gildin L et al.	—	2022	→
Indirect Mechanisms of Transcription Factor-Mediated Gene Regulation during Cell Fate Changes.	Larcombe MR et al.	—	2022	→
Induction of synapse formation by de novo neurotransmitter synthesis.	Burlingham SR et al.	—	2022	→
Interferon-γ exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression.	Pavlinek A et al.	—	2022	→
Investigating the feasibility and ethical implications of phenotypic screening using stem cell-derived tissue models to detect and manage disease.	Harris AR et al.	—	2022	→
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants.	Bauer L et al.	—	2022	→
In vitro neurons learn and exhibit sentience when embodied in a simulated game-world.	Kagan BJ et al.	—	2022	→
IPSC-Derived Human Neurons with GCaMP6s Expression Allow In Vitro Study of Neurophysiological Responses to Neurochemicals.	Galiakberova AA et al.	—	2022	→
iPSC toolbox for understanding and repairing disrupted brain circuits in autism.	Chiola S et al.	—	2022	→
Leveraging the Genetic Diversity of Human Stem Cells in Therapeutic Approaches.	Tegtmeyer M et al.	—	2022	→
Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy.	Fanning S et al.	—	2022	→
Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays.	Habibey R et al.	—	2022	→
Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons.	Fernandez MA et al.	—	2022	→
Loss of function of OTUD7A in the schizophrenia- associated 15q13.3 deletion impairs synapse development and function in human neurons.	Kozlova A et al.	—	2022	→
Loss of mouse Stmn2 function causes motor neuropathy.	Guerra San Juan I et al.	—	2022	→
Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation.	Hulme AJ et al.	—	2022	→
Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs.	Sanchez-Priego C et al.	—	2022	→
Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation.	Kreimer A et al.	—	2022	→
Modeling Developmental Brain Diseases Using Human Pluripotent Stem Cells-Derived Brain Organoids - Progress and Perspective.	Bhattacharya A et al.	—	2022	→
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression.	Seah C et al.	—	2022	→
Modeling PTSD neuronal stress responses in a dish.	Zhang S et al.	—	2022	→
Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models.	Susco SG et al.	—	2022	→
mRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development.	Salamon I et al.	—	2022	→
Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders.	McCready FP et al.	—	2022	→
Multi-omics study reveals associations among neurotransmitter, extracellular vesicle-derived microRNA and psychiatric comorbidities during heroin and methamphetamine withdrawal.	Chen F et al.	—	2022	→
Neurodevelopmental copy-number variants: A roadmap to improving outcomes by uniting patient advocates, researchers, and clinicians for collective impact.	Commission on Novel Technologies for Neurodevelopmental Copy Number Variants	—	2022	→
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.	Ng B et al.	—	2022	→
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	Murtaza N et al.	—	2022	→
New Players in Neuronal Iron Homeostasis: Insights from CRISPRi Studies.	Bórquez DA et al.	—	2022	→
Nuclear Transporter <i>IPO13</i> Is Central to Efficient Neuronal Differentiation.	Gajewska KA et al.	—	2022	→
Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.	Lim ET et al.	—	2022	→
Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons.	Fonseca-Ornelas L et al.	—	2022	→
Past, Present, and Future of Direct Cell Reprogramming.	Ahlenius H	—	2022	→
Patient-Derived In Vitro Models of Microglial Function and Synaptic Engulfment in Schizophrenia.	Sheridan SD et al.	—	2022	→
Pluripotent stem cell strategies for rebuilding the human brain.	Limone F et al.	—	2022	→
Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease.	Jun GR et al.	—	2022	→
Rapid Conversion of Human Induced Pluripotent Stem Cells into Dopaminergic Neurons by Inducible Expression of Two Transcription Factors.	Nishimura K et al.	—	2022	→
Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons.	Soloperto A et al.	—	2022	→
Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity.	Thapliyal S et al.	—	2022	→
Revealing the Impact of Mitochondrial Fitness During Early Neural Development Using Human Brain Organoids.	Romero-Morales AI et al.	—	2022	→
RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.	van der Linden RJ et al.	—	2022	→
Screening for modulators of autism spectrum disorder using induced human neurons.	Rao SR et al.	—	2022	→
Selected Histone Deacetylase Inhibitors Reverse the Frataxin Transcriptional Defect in a Novel Friedreich's Ataxia Induced Pluripotent Stem Cell-Derived Neuronal Reporter System.	Schreiber AM et al.	—	2022	→
Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex.	Lei Y et al.	—	2022	→
Spinal motor neuron transplantation to enhance nerve reconstruction strategies: Towards a cell therapy.	Bazarek S et al.	—	2022	→
Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p.	Weiner DJ et al.	—	2022	→
Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins.	Birke R et al.	—	2022	→
Synaptogenic effect of <i>APP</i>-Swedish mutation in familial Alzheimer's disease.	Zhou B et al.	—	2022	→
Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms.	Tian S et al.	—	2022	→
Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells.	Zhang W et al.	—	2022	→
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	Tracy TE et al.	—	2022	→
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.	Nehme R et al.	—	2022	→
The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.	Haddad Derafshi B et al.	—	2022	→
The bHLH Transcription Factors in Neural Development and Therapeutic Applications for Neurodegenerative Diseases.	Lee DG et al.	—	2022	→
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.	Gerosa L et al.	—	2022	→
The mitochondrial RNA granule modulates manganese-dependent cell toxicity.	Werner E et al.	—	2022	→
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.	Hallacli E et al.	—	2022	→
The Role of Aldose Reductase in Beta-Amyloid-Induced Microglia Activation.	Huang YK et al.	—	2022	→
Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation.	Janas JA et al.	—	2022	→
Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models.	Tai DJC et al.	—	2022	→
Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings.	Girardin S et al.	—	2022	→
Tracking connectivity maps in human stem cell-derived neuronal networks by holographic optogenetics.	Schmieder F et al.	—	2022	→
Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models.	Mohajeri K et al.	—	2022	→
Transgene and Chemical Transdifferentiation of Somatic Cells for Rapid and Efficient Neurological Disease Cell Models.	Ng N et al.	—	2022	→
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1.	Mabe NW et al.	—	2022	→
Two engineered AAV capsid variants for efficient transduction of human cortical neurons directly converted from iPSC.	Fischer S et al.	—	2022	→
Ultrasensitive Single Extracellular Vesicle Detection Using High Throughput Droplet Digital Enzyme-Linked Immunosorbent Assay.	Yang Z et al.	—	2022	→
Using 2D and 3D pluripotent stem cell models to study neurotropic viruses.	LaNoce E et al.	—	2022	→
VLDLR and ApoER2 are receptors for multiple alphaviruses.	Clark LE et al.	—	2022	→
Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations.	Mok RSF et al.	—	2022	→
WNT signaling at the intersection between neurogenesis and brain tumorigenesis.	Alkailani MI et al.	—	2022	→
5'-UTR SNP of <i>FGF13</i> causes translational defect and intellectual disability.	Pan X et al.	—	2021	→
A Closer Look to the Evolution of Neurons in Humans and Apes Using Stem-Cell-Derived Model Systems.	Schörnig M et al.	—	2021	→
A comprehensive library of human transcription factors for cell fate engineering.	Ng AHM et al.	—	2021	→
An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons.	Cast TP et al.	—	2021	→
Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia.	Michael Deans PJ et al.	—	2021	→
A simple Ca<sup>2+</sup>-imaging approach to neural network analyses in cultured neurons.	Sun Z et al.	—	2021	→
Association of Mitochondrial Biogenesis With Variable Penetrance of Schizophrenia.	Li J et al.	—	2021	→
A Step-by-Step Refined Strategy for Highly Efficient Generation of Neural Progenitors and Motor Neurons from Human Pluripotent Stem Cells.	Ren J et al.	—	2021	→
A synaptic temperature sensor for body cooling.	Kamm GB et al.	—	2021	→
BANP opens chromatin and activates CpG-island-regulated genes.	Grand RS et al.	—	2021	→
Bioengineered optogenetic model of human neuromuscular junction.	Vila OF et al.	—	2021	→
Building on a Solid Foundation: Adding Relevance and Reproducibility to Neurological Modeling Using Human Pluripotent Stem Cells.	Knock E et al.	—	2021	→
Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses.	Patzke C et al.	—	2021	→
Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors.	Lonfat N et al.	—	2021	→
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection.	Dobrindt K et al.	—	2021	→
Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures.	Saavedra L et al.	—	2021	→
Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes.	Schörnig M et al.	—	2021	→
Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons.	Oakley DH et al.	—	2021	→
Contribution of Human Pluripotent Stem Cell-Based Models to Drug Discovery for Neurological Disorders.	Benchoua A et al.	—	2021	→
Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived <i>NRXN1</i>-mutant neurons.	Pak C et al.	—	2021	→
Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders.	de Rus Jacquet A et al.	—	2021	→
DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.	Deshimaru M et al.	—	2021	→
Deciphering the Role of Fluctuation Dependent Intercellular Communication in Neural Stem Cell Development.	Giri A et al.	—	2021	→
Developing nociceptor-selective treatments for acute and chronic pain.	Jayakar S et al.	—	2021	→
Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages.	Chang CY et al.	—	2021	→
Direct Cell Reprogramming of Mouse Fibroblasts into Functional Astrocytes Using Lentiviral Overexpression of the Transcription Factors NFIA, NFIB, and SOX9.	Qiu B et al.	—	2021	→
Direct Differentiation of Functional Neurons from Human Pluripotent Stem Cells (hPSCs).	Hu R et al.	—	2021	→
DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons.	Bachmann S et al.	—	2021	→
Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice.	Lim CS et al.	—	2021	→
Dyshomeostatic modulation of Ca<sup>2+</sup>-activated K<sup>+</sup> channels in a human neuronal model of KCNQ2 encephalopathy.	Simkin D et al.	—	2021	→
Efficient conversion of human induced pluripotent stem cells into microglia by defined transcription factors.	Chen SW et al.	—	2021	→
Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.	Song S et al.	—	2021	→
Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics.	Ng YH et al.	—	2021	→
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases.	Ye T et al.	—	2021	→
Epigenetic regulation during human cortical development: Seq-ing answers from the brain to the organoid.	Lewis EMA et al.	—	2021	→
Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis.	Lo TW et al.	—	2021	→
Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays.	Pelkonen A et al.	—	2021	→
Generation of region-specific and high-purity neurons from human feeder-free iPSCs.	Sato T et al.	—	2021	→
Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus.	Schmid B et al.	—	2021	→
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.	Sanchez CG et al.	—	2021	→
Global proteomics of Ubqln2-based murine models of ALS.	Whiteley AM et al.	—	2021	→
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.	Cheng C et al.	—	2021	→
High-Throughput Phenotypic Assay for Compounds That Influence Mitochondrial Health Using iPSC-Derived Human Neurons.	MacMullen C et al.	—	2021	→
Human inducible pluripotent stem cells: Realization of initial promise in drug discovery.	Kleiman RJ et al.	—	2021	→
Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging.	Chao CC et al.	—	2021	→
Humanized Biomimetic Nanovesicles for Neuron Targeting.	Zinger A et al.	—	2021	→
Human mini-brain models.	Tan HY et al.	—	2021	→
Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro.	Mossink B et al.	—	2021	→
Human stem cell models to study host-virus interactions in the central nervous system.	Harschnitz O et al.	—	2021	→
Identification and characterization of conserved noncoding <i>cis</i>-regulatory elements that impact <i>Mecp2</i> expression and neurological functions.	Shao Y et al.	—	2021	→
Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons.	Earley AM et al.	—	2021	→
Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons.	Ichise E et al.	—	2021	→
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.	Bassil R et al.	—	2021	→
Increased maturation of iPSC-derived neurons in a hydrogel-based 3D culture.	de Leeuw SM et al.	—	2021	→
Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective.	De Los Angeles A et al.	—	2021	→
<i>NGN2</i> mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities.	Tolomeo AM et al.	—	2021	→
Intronic enhancer region governs transcript-specific <i>Bdnf</i> expression in rodent neurons.	Tuvikene J et al.	—	2021	→
In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection.	Veldhuis Kroeze E et al.	—	2021	→
iPS Cell-Based Model for <i>MAPT</i> Haplotype as a Risk Factor for Human Tauopathies Identifies No Major Differences in TAU Expression.	Strauß T et al.	—	2021	→
Isolation and Neuronal Reprogramming of Mouse Embryonic Fibroblasts.	Adrian-Segarra JM et al.	—	2021	→
Label-free imaging for quality control of cardiomyocyte differentiation.	Qian T et al.	—	2021	→
Live Viral Vaccine Neurovirulence Screening: Current and Future Models.	May Fulton C et al.	—	2021	→
Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay.	Kurosaki T et al.	—	2021	→
Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds.	Sardar D et al.	—	2021	→
Methylation Analysis in Monozygotic Twins With Treatment-Resistant Schizophrenia and Discordant Responses to Clozapine.	Kikuchi M et al.	—	2021	→
Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets.	Pintacuda G et al.	—	2021	→
Modeling Brain Pathology of Niemann-Pick Disease Type C Using Patient-Derived Neurons.	Burbulla LF et al.	—	2021	→
Modeling Neurodevelopmental and Neuropsychiatric Diseases with Astrocytes Derived from Human-Induced Pluripotent Stem Cells.	Ren B et al.	—	2021	→
Modeling neurodevelopment in a dish with pluripotent stem cells.	Imaizumi K et al.	—	2021	→
Modelling Mitochondrial Disease in Human Pluripotent Stem Cells: What Have We Learned?	McKnight CL et al.	—	2021	→
Modulating the Electrical and Mechanical Microenvironment to Guide Neuronal Stem Cell Differentiation.	Oh B et al.	—	2021	→
Network Effects of the 15q13.3 Microdeletion on the Transcriptome and Epigenome in Human-Induced Neurons.	Zhang S et al.	—	2021	→
Neural In Vitro Models for Studying Substances Acting on the Central Nervous System.	Fritsche E et al.	—	2021	→
Neuronal Cell-type Engineering by Transcriptional Activation.	Liu S et al.	—	2021	→
Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs.	Hasan MF et al.	—	2021	→
Neuroproteomics of the Synapse: Subcellular Quantification of Protein Networks and Signaling Dynamics.	van Gelder CAGH et al.	—	2021	→
NFIB induces functional astrocytes from human pluripotent stem cell-derived neural precursor cells mimicking in vivo astrogliogenesis.	Yeon GB et al.	—	2021	→
NGN2 induces diverse neuron types from human pluripotency.	Lin HC et al.	—	2021	→
Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells.	Williford SE et al.	—	2021	→
Novel synthetic biology approaches for developmental systems.	Ho C et al.	—	2021	→
Optogenetic manipulation of cellular communication using engineered myosin motors.	Zhang Z et al.	—	2021	→
Organ-on-a-chip technologies to study neuromuscular disorders: possibilities, limitations, and future hopes.	Lauffer MC	—	2021	→
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.	Gowrishankar S et al.	—	2021	→
[Pharmacological studies using iPSC-derived neurons from patients with schizophrenia].	Nakazawa T	—	2021	→
Physiological and Pathological Ageing of Astrocytes in the Human Brain.	Verkerke M et al.	—	2021	→
Programmatic introduction of parenchymal cell types into blood vessel organoids.	Dailamy A et al.	—	2021	→
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells.	De Smedt J et al.	—	2021	→
Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia.	Dobrindt K et al.	—	2021	→
Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models.	Bauer L et al.	—	2021	→
Reprogramming Stars #2: Reprogramming Towards Neural Lineages-An Interview with Dr. Henrik Ahlenius.	Ahlenius H et al.	—	2021	→
Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy.	Tang Y et al.	—	2021	→
RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.	Wang J et al.	—	2021	→
Screening Platforms for Genetic Epilepsies-Zebrafish, iPSC-Derived Neurons, and Organoids.	Shcheglovitov A et al.	—	2021	→
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome.	Banfi F et al.	—	2021	→
Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development.	Zhang X et al.	—	2021	→
Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons.	Klein Gunnewiek TM et al.	—	2021	→
SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System.	Neyrinck K et al.	—	2021	→
SpikeOnChip : A Custom Embedded Platform for Neuronal Activity Recording and Analysis.	Wertenbroek R et al.	—	2021	→
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.	Lagomarsino VN et al.	—	2021	→
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.	Sidibé H et al.	—	2021	→
Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy.	Ordureau A et al.	—	2021	→
The application of in vitro-derived human neurons in neurodegenerative disease modeling.	D'Souza GX et al.	—	2021	→
The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.	Apicco DJ et al.	—	2021	→
The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models.	MacDougall G et al.	—	2021	→
Toxoplasma gondii infection and its implications within the central nervous system.	Matta SK et al.	—	2021	→
Transcription Factor Programming of Human Pluripotent Stem Cells to Functionally Mature Astrocytes for Monocultures and Cocultures with Neurons.	Quist E et al.	—	2021	→
Transcriptome analysis of human induced excitatory neurons supports a strong effect of clozapine on cholesterol biosynthesis.	Das D et al.	—	2021	→
Transcriptomic data of Clozapine-treated Ngn2-induced Human Excitatory Neurons.	Lam AN et al.	—	2021	→
Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease.	Wang M et al.	—	2021	→
Translating the Role of mTOR- and RAS-Associated Signalopathies in Autism Spectrum Disorder: Models, Mechanisms and Treatment.	Vasic V et al.	—	2021	→
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.	Alquezar C et al.	—	2021	→
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.	Ho GPH et al.	—	2021	→
Using the dCas9-KRAB system to repress gene expression in hiPSC-derived <i>NGN2</i> neurons.	Li A et al.	—	2021	→
Xenopus leads the way: Frogs as a pioneering model to understand the human brain.	Exner CRT et al.	—	2021	→
4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates.	Hirata K et al.	—	2020	→
A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity.	Pedersen H et al.	—	2020	→
A critical look: Challenges in differentiating human pluripotent stem cells into desired cell types and organoids.	Fowler JL et al.	—	2020	→
Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.	Behne R et al.	—	2020	→
Advances in Human Stem Cells and Genome Editing to Understand and Develop Treatment for Fragile X Syndrome.	Zhao X et al.	—	2020	→
A Guide to Understanding "State-of-the-Art" Basic Research Techniques in Anesthesiology.	Obal D et al.	—	2020	→
Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants.	Zhang S et al.	—	2020	→
A mini-review: Bridging the gap between autism spectrum disorder and pain comorbidities.	Brown CO et al.	—	2020	→
Amyloid-β-independent regulators of tau pathology in Alzheimer disease.	van der Kant R et al.	—	2020	→
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.	Sanderson JB et al.	—	2020	→
ApoER2: Functional Tuning Through Splicing.	Gallo CM et al.	—	2020	→
Application of induced pluripotent stem cells in epilepsy.	Hirose S et al.	—	2020	→
A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization.	Luong P et al.	—	2020	→
A roadmap for neurodevelopmental disease modeling for non-stem cell biologists.	Ernst C	—	2020	→
A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons.	Hsu CC et al.	—	2020	→
Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer's Disease Patients Effect Complement-Mediated Neurotoxicity.	Nogueras-Ortiz CJ et al.	—	2020	→
Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms.	Yumoto T et al.	—	2020	→
Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation.	Lee H et al.	—	2020	→
Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation.	Nimtz L et al.	—	2020	→
CIRM tools and technologies: Breaking bottlenecks to the development of stem cell therapies.	Collins LR et al.	—	2020	→
Cohen Syndrome Patient iPSC-Derived Neurospheres and Forebrain-Like Glutamatergic Neurons Reveal Reduced Proliferation of Neural Progenitor Cells and Altered Expression of Synapse Genes.	Lee YK et al.	—	2020	→
Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover.	Narendra DP et al.	—	2020	→
Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells.	Varderidou-Minasian S et al.	—	2020	→
Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.	Li J et al.	—	2020	→
Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids.	Sawada T et al.	—	2020	→
Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications.	Fantuzzo JA et al.	—	2020	→
Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity.	Vázquez-Vélez GE et al.	—	2020	→
Emerging proteomic approaches to identify the underlying pathophysiology of neurodevelopmental and neurodegenerative disorders.	Murtaza N et al.	—	2020	→
Exposure to phthalates impaired neurodevelopment through estrogenic effects and induced DNA damage in neurons.	Xu S et al.	—	2020	→
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons.	Mazzara PG et al.	—	2020	→
Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions.	Assetta B et al.	—	2020	→
Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells.	García-León JA et al.	—	2020	→
Generation of two NAGLU-mutated homozygous cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo B syndrome.	Benetó N et al.	—	2020	→
Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling.	Ordureau A et al.	—	2020	→
Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons.	Alquezar C et al.	—	2020	→
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.	Cavallo F et al.	—	2020	→
Human-Derived Brain Models: Windows into Neuropsychiatric Disorders and Drug Therapies.	Papariello A et al.	—	2020	→
Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology.	Schrank S et al.	—	2020	→
Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy.	Seranova E et al.	—	2020	→
Human in vitro models for understanding mechanisms of autism spectrum disorder.	Gordon A et al.	—	2020	→
Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.	Silva MC et al.	—	2020	→
Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease.	Garcia-Leon JA et al.	—	2020	→
Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction.	Cheffer A et al.	—	2020	→
Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons.	Whipple AJ et al.	—	2020	→
Innovations in 3-Dimensional Tissue Models of Human Brain Physiology and Diseases.	Lovett ML et al.	—	2020	→
Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems.	Rehbach K et al.	—	2020	→
Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics.	Matos MR et al.	—	2020	→
Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells.	Powell SK et al.	—	2020	→
In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment.	Rosa F et al.	—	2020	→
iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function.	Ni P et al.	—	2020	→
<i>SYNGAP1</i> Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons.	Llamosas N et al.	—	2020	→
Loss-of-function Mutations of CUL3, a High Confidence Gene for Psychiatric Disorders, Lead to Aberrant Neurodevelopment In Human Induced Pluripotent Stem Cells.	Fischer S et al.	—	2020	→
Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production.	Chen H et al.	—	2020	→
LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous <i>GBA1</i> Expression in Human iPSC-Derived Neurons.	Sanyal A et al.	—	2020	→
m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity.	Klein Gunnewiek TM et al.	—	2020	→
Mass Generation, Neuron Labeling, and 3D Imaging of Minibrains.	Govindan S et al.	—	2020	→
Massively parallel techniques for cataloguing the regulome of the human brain.	Townsley KG et al.	—	2020	→
Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens.	Black JB et al.	—	2020	→
MeCP2 links heterochromatin condensates and neurodevelopmental disease.	Li CH et al.	—	2020	→
miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro.	Ishikawa M et al.	—	2020	→
Mitochondrial Dysfunction and Calcium Dysregulation in Leigh Syndrome Induced Pluripotent Stem Cell Derived Neurons.	Galera-Monge T et al.	—	2020	→
Modeling Alzheimer's disease with iPSC-derived brain cells.	Penney J et al.	—	2020	→
Modeling genetic epilepsies in a dish.	Niu W et al.	—	2020	→
Modeling Neurodevelopmental Deficits in Tuberous Sclerosis Complex with Stem Cell Derived Neural Precursors and Neurons.	Sundberg M et al.	—	2020	→
Modeling neuronal consequences of autism-associated gene regulatory variants with human induced pluripotent stem cells.	Ross PJ et al.	—	2020	→
Modeling Psychiatric Disorder Biology with Stem Cells.	Das D et al.	—	2020	→
Modeling the complex genetic architectures of brain disease.	Fernando MB et al.	—	2020	→
Multiparametric Assays for Accelerating Early Drug Discovery.	Herholt A et al.	—	2020	→
Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs.	Yang CP et al.	—	2020	→
NEUROD1 Intrinsically Initiates Differentiation of Induced Pluripotent Stem Cells into Neural Progenitor Cells.	Choi WY et al.	—	2020	→
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection.	Ryan SK et al.	—	2020	→
Neuroligins and Neurodevelopmental Disorders: X-Linked Genetics.	Nguyen TA et al.	—	2020	→
Neuronal and Astrocytic Differentiation from Sanfilippo C Syndrome iPSCs for Disease Modeling and Drug Development.	Benetó N et al.	—	2020	→
Neuronal modeling of alternating hemiplegia of childhood reveals transcriptional compensation and replicates a trigger-induced phenotype.	Snow JP et al.	—	2020	→
Neuronal Reprogramming for Tissue Repair and Neuroregeneration.	Liou RH et al.	—	2020	→
New frontiers in modeling tuberous sclerosis with human stem cell-derived neurons and brain organoids.	Blair JD et al.	—	2020	→
Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery.	Marotta N et al.	—	2020	→
Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons.	Graef JD et al.	—	2020	→
Pluripotent stem cells for neurodegenerative disease modeling: an expert view on their value to drug discovery.	Chen SD et al.	—	2020	→
Probing disrupted neurodevelopment in autism using human stem cell-derived neurons and organoids: An outlook into future diagnostics and drug development.	Yang G et al.	—	2020	→
Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity.	Valdez C et al.	—	2020	→
Progress of Induced Pluripotent Stem Cell Technologies to Understand Genetic Epilepsy.	Sterlini B et al.	—	2020	→
Protocol for the Standardized Generation of Forward Programmed Cryopreservable Excitatory and Inhibitory Forebrain Neurons.	Peitz M et al.	—	2020	→
Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.	Ryan SK et al.	—	2020	→
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.	Corbett GT et al.	—	2020	→
Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons.	Lindhout FW et al.	—	2020	→
Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells.	Chen M et al.	—	2020	→
Recent advances in human stem cell-based modeling of Tuberous Sclerosis Complex.	Afshar Saber W et al.	—	2020	→
SCN2A channelopathies in the autism spectrum of neuropsychiatric disorders: a role for pluripotent stem cells?	Kruth KA et al.	—	2020	→
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS.	Weskamp K et al.	—	2020	→
SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	Gan KJ et al.	—	2020	→
Structural and Functional Analyses of the FAM46C/Plk4 Complex.	Chen H et al.	—	2020	→
Studying Brown Adipose Tissue in a Human <i>in vitro</i> Context.	Samuelson I et al.	—	2020	→
Studying Human Neurodevelopment and Diseases Using 3D Brain Organoids.	Tian A et al.	—	2020	→
The fusiform gyrus exhibits an epigenetic signature for Alzheimer's disease.	Ma D et al.	—	2020	→
The path from scientific discovery to cures for epilepsy.	Carvill GL et al.	—	2020	→
ToolBox: Live Imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons.	Boecker CA et al.	—	2020	→
Topiramate Decelerates Bicarbonate-Driven Acid-Elimination of Human Neocortical Neurons: Strategic Significance for its Antiepileptic, Antimigraine and Neuroprotective Properties.	Bonnet U et al.	—	2020	→
Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells.	Nickolls AR et al.	—	2020	→
Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration.	Flitsch LJ et al.	—	2020	→
Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats.	Forostyak S et al.	—	2020	→
Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms.	Cota-Coronado A et al.	—	2020	→
Unraveling Mechanisms of Patient-Specific NRXN1 Mutations in Neuropsychiatric Diseases Using Human Induced Pluripotent Stem Cells.	De Los Angeles A et al.	—	2020	→
Using brain organoids to study human neurodevelopment, evolution and disease.	Kyrousi C et al.	—	2020	→
Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk.	Raman S et al.	—	2020	→
Using human pluripotent stem cell models to study autism in the era of big data.	Nehme R et al.	—	2020	→
Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases.	Zhang X et al.	—	2020	→
Using iPSC-Based Models to Understand the Signaling and Cellular Phenotypes in Idiopathic Autism and 16p11.2 Derived Neurons.	Turkalj L et al.	—	2020	→
Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons.	Tidball AM et al.	—	2020	→
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.	Shlevkov E et al.	—	2019	→
Alzheimer's in a dish - induced pluripotent stem cell-based disease modeling.	de Leeuw S et al.	—	2019	→
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.	Rhee HJ et al.	—	2019	→
Angiomotin Regulates YAP Localization during Neural Differentiation of Human Pluripotent Stem Cells.	Zaltsman Y et al.	—	2019	→
Application of CRISPR genetic screens to investigate neurological diseases.	So RWL et al.	—	2019	→
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.	Sridharan B et al.	—	2019	→
A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.	Meijer M et al.	—	2019	→
Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer's disease using patient iPSC-derived neurons.	Wu PC et al.	—	2019	→
Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology.	Fenske P et al.	—	2019	→
Biallelic Mutations in <i>TSC2</i> Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons.	Winden KD et al.	—	2019	→
Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders.	Adams JW et al.	—	2019	→
Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis.	Sullivan SE et al.	—	2019	→
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.	Imberdis T et al.	—	2019	→
Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology.	Zhang P et al.	—	2019	→
Comparison between Polybutylcyanoacrylate Nanoparticles with Either Surface-Adsorbed or Encapsulated Brain-Derived Neurotrophic Factor on the Neural Differentiation of iPSCs.	Lin MH et al.	—	2019	→
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.	Tian R et al.	—	2019	→
Decoding epigenetic cell signaling in neuronal differentiation.	Vieira MS et al.	—	2019	→
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.	Huang YA et al.	—	2019	→
Directed Differentiation of Pluripotent Stem Cells by Transcription Factors.	Oh Y et al.	—	2019	→
Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors.	Colasante G et al.	—	2019	→
Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity.	Chanda S et al.	—	2019	→
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.	Shao Z et al.	—	2019	→
Early Actions of Neurotransmitters During Cortex Development and Maturation of Reprogrammed Neurons.	Ojeda J et al.	—	2019	→
Energetic substrate availability regulates synchronous activity in an excitatory neural network.	Tourigny DS et al.	—	2019	→
Evolving principles underlying neural lineage conversion and their relevance for biomedical translation.	Flitsch LJ et al.	—	2019	→
EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.	Hübner JM et al.	—	2019	→
Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes.	Trajkovic K et al.	—	2019	→
From enhanceropathies to the epigenetic manifold underlying human cognition.	Vitriolo A et al.	—	2019	→
From Schizophrenia Genetics to Disease Biology: Harnessing New Concepts and Technologies.	Duan J et al.	—	2019	→
Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures.	Hyvärinen T et al.	—	2019	→
Functional Cortical Axon Tracts Generated from Human Stem Cell-Derived Neurons.	Chen HI et al.	—	2019	→
Generation of two compound heterozygous HGSNAT-mutated lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo C syndrome.	Benetó N et al.	—	2019	→
Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome.	Carbonell AU et al.	—	2019	→
Human Brain Slice Culture: A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds.	Qi XR et al.	—	2019	→
Human iPSC application in Alzheimer's disease and Tau-related neurodegenerative diseases.	Tcw J	—	2019	→
<i>CNTN5</i><sup>-</sup><i><sup>/+</sup></i>or <i>EHMT2</i><sup>-</sup><i><sup>/+</sup></i>human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks.	Deneault E et al.	—	2019	→
<i>In Vitro</i> Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of <i>PCDH1</i>5 and <i>RELN</i>.	Ishii T et al.	—	2019	→
Immunosuppressive mechanisms for stem cell transplant survival in spinal cord injury.	Antonios JP et al.	—	2019	→
Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders.	Sauter EJ et al.	—	2019	→
Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease.	Weykopf B et al.	—	2019	→
Inhibitor of DNA binding 2 promotes axonal growth through upregulation of Neurogenin2.	Huang Z et al.	—	2019	→
In Vitro Models of Brain Disorders.	le Feber J	—	2019	→
Kinetochore Proteins Have a Post-Mitotic Function in Neurodevelopment.	Zhao G et al.	—	2019	→
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.	Bieri G et al.	—	2019	→
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.	Song M et al.	—	2019	→
Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer.	Gao L et al.	—	2019	→
Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia.	Li J et al.	—	2019	→
Modeling Alzheimer's disease with human iPS cells: advancements, lessons, and applications.	Essayan-Perez S et al.	—	2019	→
Modeling neuronopathic storage diseases with patient-derived culture systems.	Zunke F et al.	—	2019	→
Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells.	Naphade S et al.	—	2019	→
Modeling Psychiatric Diseases with Induced Pluripotent Stem Cells.	van Hugte E et al.	—	2019	→
Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells.	Hawkins KE et al.	—	2019	→
mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome.	Crutcher E et al.	—	2019	→
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.	International Multiple Sclerosis Genetics Consortium	—	2019	→
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.	Marro SG et al.	—	2019	→
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.	Patzke C et al.	—	2019	→
Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease.	Wadhwani AR et al.	—	2019	→
Neuronal impact of patient-specific aberrant NRXN1α splicing.	Flaherty E et al.	—	2019	→
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.	Frega M et al.	—	2019	→
Next-generation disease modeling with direct conversion: a new path to old neurons.	Traxler L et al.	—	2019	→
ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility.	van der Raadt J et al.	—	2019	→
Organs to Cells and Cells to Organoids: The Evolution of <i>in vitro</i> Central Nervous System Modelling.	Pacitti D et al.	—	2019	→
Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons.	Lu C et al.	—	2019	→
Past, Present, and Future of Neuronal Models In Vitro.	Keller JM et al.	—	2019	→
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.	Sohn PD et al.	—	2019	→
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.	Schafer ST et al.	—	2019	→
Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs.	Nakamura M et al.	—	2019	→
Plasmid-based generation of neural cells from human fibroblasts using non-integrating episomal vectors.	Dai SB et al.	—	2019	→
Potassium channel dysfunction in human neuronal models of Angelman syndrome.	Sun AX et al.	—	2019	→
Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation.	Hildebrandt MR et al.	—	2019	→
Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes.	Aydin B et al.	—	2019	→
Recent Progress in the Regeneration of Spinal Cord Injuries by Induced Pluripotent Stem Cells.	Csobonyeiova M et al.	—	2019	→
Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.	Valencia AM et al.	—	2019	→
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.	Meyer K et al.	—	2019	→
Scalable Measurements of Intrinsic Excitability in Human iPS Cell-Derived Excitatory Neurons Using All-Optical Electrophysiology.	Williams LA et al.	—	2019	→
SCN1A/Na<sub>V</sub> 1.1 channelopathies: Mechanisms in expression systems, animal models, and human iPSC models.	Mantegazza M et al.	—	2019	→
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons.	Zaslavsky K et al.	—	2019	→
Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment.	Gan KJ et al.	—	2019	→
Synergistic effects of common schizophrenia risk variants.	Schrode N et al.	—	2019	→
The novel lncRNA <i>lnc-NR2F1</i> is pro-neurogenic and mutated in human neurodevelopmental disorders.	Ang CE et al.	—	2019	→