Oscillatory responses to reward processing in borderline personality disorder.
- Authors
- Andreou, Christina; Kleinert, Julia; Steinmann, Saskia; Fuger, Ulrike; Leicht, Gregor; Mulert, Christoph
- Year
- 2015
- Journal
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- PMID
- 26212791
- DOI
- 10.3109/15622975.2015.1054880
OBJECTIVES: Previous electrophysiological studies have confirmed impaired reward processing in patients with BPD. However, it is not clear which aspects of reward processing are affected and which brain regions are involved. The present study investigated both evoked and induced event-related oscillations (EROs) to feedback events (thought to represent different aspects of feedback processing), and used source localization (sLORETA) to assess activity in two areas known to contribute to reward processing, the dorsomedial prefrontal/anterior cingulate cortex (dmPFC/ACC) and the orbitofrontal cortex (OFC). METHODS: Eighteen patients with BPD and 22 healthy controls performed a gambling task, while 64-channel electroencephalographic activity was recorded. Evoked and induced theta and high-beta band EROs as well as activity in the two regions of interest were investigated depending on the valence and magnitude of feedback events. RESULTS: Theta-band responses to negative feedback were reduced in BPD, an effect that involved only evoked responses and the dmPFC/ ACC region, and was associated with trait impulsivity in patients. sLORETA analyses revealed disturbed evoked responses depending on feedback magnitude in the theta (OFC) and high-beta (dmPFC/ACC and OFC) frequency range. CONCLUSIONS: The results indicate multiple dysfunctions of feedback processing in patients with BPD, implicating several distinct subsets of reward-processing mechanisms.
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External
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| Theta low-gamma phase amplitude coupling in the human orbitofrontal cortex increases during a conflict-processing task. | Chen KH et al. | — | 2022 | → |
| Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder. | Schauer PA et al. | — | 2021 | → |
| Aberrant functional connectivity profiles of brain regions associated with salience and reward processing in female patients with borderline personality disorder. | Sarkheil P et al. | — | 2020 | → |
| Alterations of oscillatory neuronal activity during reward processing in schizophrenia. | Leicht G et al. | — | 2020 | → |
| Dissociable effects of reward magnitude on fronto-medial theta and FRN during performance monitoring. | Paul K et al. | — | 2020 | → |
| Altered Oscillatory Responses to Feedback in Borderline Personality Disorder are Linked to Symptom Severity. | Schauer PA et al. | — | 2019 | → |
| Neurophysiological activity following rewards and losses among female adolescents and young adults with borderline personality disorder. | Stewart JG et al. | — | 2019 | → |
| Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine. | Curic S et al. | — | 2019 | → |
| Top-down control of the medial orbitofrontal cortex to nucleus accumbens core pathway in decisional impulsivity. | Wang Z et al. | — | 2019 | → |
| Alterations in interhemispheric gamma-band connectivity are related to the emergence of auditory verbal hallucinations in healthy subjects during NMDA-receptor blockade. | Thiebes S et al. | — | 2018 | → |
| Orbitofrontal overactivation in reward processing in borderline personality disorder: the role of non-suicidal self-injury. | Vega D et al. | — | 2018 | → |
| A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. | Kamarajan C et al. | — | 2017 | → |
| Auditory verbal hallucinations related to altered long-range synchrony of gamma-band oscillations. | Steinmann S et al. | — | 2017 | → |
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