Reduced anterior prefrontal cortex activation in young binge drinkers during a visual working memory task.
paper
Cited
Public
Unavailable
- Authors
- Crego, Alberto; Rodriguez-Holguín, Socorro; Parada, María; Mota, Nayara; Corral, Montserrat; Cadaveira, Fernando
- Year
- 2010
- Journal
- Drug and alcohol dependence
- PMID
- 20079980
- DOI
- 10.1016/j.drugalcdep.2009.11.020
Working memory (WM) is a major cognitive function that is altered by chronic alcohol consumption. This impairment has been linked to alterations in the hippocampus and prefrontal cortex (PFC). Animal and human studies have shown that the adolescent brain is more sensitive to the neurotoxic effects of alcohol than the adult brain, particularly those structures that mature late on in development, such as the hippocampus and prefrontal brain. The aim of the present study was to assess visual working memory and its neural correlates in young university students who partake in intermittent consumption of large amounts of alcohol (binge drinkers). A sample of 42 binge drinkers and 53 corresponding control subjects performed an identical pairs continuous performance task (IP-CPT) in a combined event-related potential (ERP) and exact low-resolution brain electromagnetic tomography (eLORETA) study. The results revealed that, despite adequate performance, binge drinkers showed a smaller late positive component (LPC) associated with hypoactivation of the right anterior prefrontal cortex (aPFC) for matching stimuli, in comparison with control subjects. These findings may reveal binge drinking-related functional alteration in recognition working memory processes and suggest that impaired prefrontal cortex function may occur at an early age in binge drinkers.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Understanding alcohol use disorders with neuroelectrophysiology. | 2014 | 25307587 |
| Alcohol and the prefrontal cortex. | 2010 | 20813246 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Prefrontal TDCS does not improve working memory performance in individuals with chronic alcohol and tobacco use. | Göttgens F et al. | — | 2026 | → |
| Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma. | Heilner E et al. | — | 2025 | → |
| The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models. | Crombag HS et al. | — | 2025 | → |
| Associative memory in alcohol-related contexts: An fMRI study with young binge drinkers. | Rodrigues RPS et al. | — | 2024 | → |
| Linalool-rich rosewood essential oil (Aniba rosaeodora Ducke) mitigates emotional and neurochemical impairments induced by ethanol binge-like exposure during adolescence in female rats. | Dos Santos ÉRQ et al. | — | 2024 | → |
| Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach. | Sun D et al. | — | 2023 | → |
| Adolescent brain maturation and the neuropathological effects of binge drinking: A critical review. | Tetteh-Quarshie S et al. | — | 2022 | → |
| Effects of acute alcohol administration on working memory: a systematic review and meta-analysis. | Spinola S et al. | — | 2022 | → |
| Health-Promoting Behavior and Lifestyle Characteristics of Students as a Function of Sex and Academic Level. | Müller C et al. | — | 2022 | → |
| Alcohol Use Disrupts Age-Appropriate Cortical Thinning in Adolescence: A Data Driven Approach | Sun D et al. | — | 2021 | — |
| Electroencephalographic signatures of the binge drinking pattern during adolescence and young adulthood: A PRISMA-driven systematic review. | Almeida-Antunes N et al. | — | 2021 | → |
| Alcohol Consumption, Drinking Patterns, and Cognitive Performance in Young Adults: A Cross-Sectional and Longitudinal Analysis. | Hendriks H et al. | — | 2020 | → |
| Early Signs of Emotional Recognition Deficits in Adolescent High-Binge Drinkers. | Leganes-Fonteneau M et al. | — | 2020 | → |
| Effects of Intermittent versus Chronic-Moderate Ethanol Administration during Adolescence in the Adult Hippocampal Phosphoproteome. | Contreras A et al. | — | 2020 | → |
| Is Alcohol Consumption Associated with Poor Perceived Academic Performance? Survey of Undergraduates in Finland. | El Ansari W et al. | — | 2020 | → |
| Probing the relationship between late endogenous ERP components with fluid intelligence in healthy older adults. | Teixeira-Santos AC et al. | — | 2020 | → |
| An Event-Related Potential Study of Decision-Making and Feedback Utilization in Female College Students Who Binge Drink. | Na E et al. | — | 2019 | → |
| An Event-related Potential Study of Error-monitoring Deficits in Female College Students Who Participate in Binge Drinking. | Kim EH et al. | — | 2019 | → |
| Behavioral and Cerebral Impairments Associated with Binge Drinking in Youth: A Critical Review. | Lannoy S et al. | — | 2019 | → |
| Binge Drinking in Spanish University Students: Associated Factors and Repercussions: A Preliminary Study. | Herrero-Montes M et al. | — | 2019 | → |
| Increased Neural Activity in Hazardous Drinkers During High Workload in a Visual Working Memory Task: A Preliminary Assessment Through Event-Related Potentials. | Schroder E et al. | — | 2019 | → |
| Increased Nucleus Accumbens Volume in College Binge Drinkers - Preliminary Evidence From Manually Segmented MRI Analysis. | Sousa SS et al. | — | 2019 | → |
| Neural oscillatory dynamics of inhibitory control in young adult binge drinkers. | Holcomb LA et al. | — | 2019 | → |
| Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis. | Lees B et al. | — | 2019 | → |
| The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence. | Courtney KE et al. | — | 2019 | → |
| The intermittent administration of ethanol during the juvenile period produces changes in the expression of hippocampal genes and proteins and deterioration of spatial memory. | Contreras A et al. | — | 2019 | → |
| Alcohol Consumption during Adolescence in a Mouse Model of Binge Drinking Alters the Intrinsic Excitability and Function of the Prefrontal Cortex through a Reduction in the Hyperpolarization-Activated Cation Current. | Salling MC et al. | — | 2018 | → |
| Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood. | Fernandes LMP et al. | — | 2018 | → |
| Role of the innate immune system in the neuropathological consequences induced by adolescent binge drinking. | Pascual M et al. | — | 2018 | → |
| The involuntary nature of binge drinking: goal directedness and awareness of intention. | Doñamayor N et al. | — | 2018 | → |
| Alcohol Binge Drinking and Executive Functioning during Adolescent Brain Development. | Gil-Hernandez S et al. | — | 2017 | → |
| Electrophysiological Anomalies in Face-Name Memory Encoding in Young Binge Drinkers. | Folgueira-Ares R et al. | — | 2017 | → |
| Neural correlates of correct and failed response inhibition in heavy versus light social drinkers: an fMRI study during a go/no-go task by healthy participants. | Campanella S et al. | — | 2017 | → |
| The Role of Working Memory for Cognitive Control in Anorexia Nervosa versus Substance Use Disorder. | Brooks SJ et al. | — | 2017 | → |
| A history of adolescent binge drinking in humans is associated with impaired self-movement cue processing on manipulatory scale navigation tasks. | Blankenship PA et al. | — | 2016 | → |
| Binge Drinkers Are Fast, Able to Stop - but They Fail to Adjust. | Bø R et al. | — | 2016 | → |
| Binge Drinking in Young University Students Is Associated with Alterations in Executive Functions Related to Their Starting Age. | Salas-Gomez D et al. | — | 2016 | → |
| Conflict anticipation in alcohol dependence - A model-based fMRI study of stop signal task. | Hu S et al. | — | 2015 | → |
| Electrophysiological correlates of problematic Internet use: Critical review and perspectives for future research. | D'Hondt F et al. | — | 2015 | → |
| Exploratory Analysis of Power Spectrum and Functional Connectivity During Resting State in Young Binge Drinkers: A MEG Study. | Correas A et al. | — | 2015 | → |
| Two Binges of Ethanol a Day Keep the Memory Away in Adolescent Rats: Key Role for GLUN2B Subunit. | Silvestre de Ferron B et al. | — | 2015 | → |
| Addicted to palatable foods: comparing the neurobiology of Bulimia Nervosa to that of drug addiction. | Hadad NA et al. | — | 2014 | → |
| Alcohol and Relatively Pure Cannabis Use, but Not Schizotypy, are Associated with Cognitive Attenuations. | Herzig DA et al. | — | 2014 | → |
| Binge drinking in adolescents: a review of neurophysiological and neuroimaging research. | Petit G et al. | — | 2014 | → |
| Electrophysiological correlates of alcohol- and non-alcohol-related stimuli processing in binge drinkers: a follow-up study. | Petit G et al. | — | 2014 | → |
| Evolution of the binge drinking pattern in college students: neurophysiological correlates. | López-Caneda E et al. | — | 2014 | → |
| GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics. | Bhandage AK et al. | — | 2014 | → |
| Influence of adolescent heavy session drinking on the systemic and brain innate immune system. | Ward RJ et al. | — | 2014 | → |
| Larger mid-dorsolateral prefrontal gray matter volume in young binge drinkers revealed by voxel-based morphometry. | Doallo S et al. | — | 2014 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Binge drinking trajectory and neuropsychological functioning among university students: a longitudinal study. | Mota N et al. | — | 2013 | → |
| Changes in alcohol-related brain networks across the first year of college: a prospective pilot study using fMRI effective connectivity mapping. | Beltz AM et al. | — | 2013 | → |
| Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function. | Lisdahl KM et al. | — | 2013 | → |
| Effects of a persistent binge drinking pattern of alcohol consumption in young people: a follow-up study using event-related potentials. | López-Caneda E et al. | — | 2013 | → |
| Gender differences in reactivity to alcohol cues in binge drinkers: a preliminary assessment of event-related potentials. | Petit G et al. | — | 2013 | → |
| Increased cortical activity in binge drinkers during working memory task: a preliminary assessment through a functional magnetic resonance imaging study. | Campanella S et al. | — | 2013 | → |
| Neurotoxic effects of alcohol in adolescence. | Jacobus J et al. | — | 2013 | → |
| Pathways to alcohol-induced brain impairment in young people: a review by Hermens et al., 2013. | Maurage P et al. | — | 2013 | → |
| The burden of alcohol use: excessive alcohol consumption and related consequences among college students. | White A et al. | — | 2013 | → |
| Cerebral effects of binge drinking: respective influences of global alcohol intake and consumption pattern. | Maurage P et al. | — | 2012 | → |
| Early attentional modulation by alcohol-related cues in young binge drinkers: an event-related potentials study. | Petit G et al. | — | 2012 | → |
| Executive functioning and alcohol binge drinking in university students. | Parada M et al. | — | 2012 | → |
| Increased amplitude of P3 event-related potential in young binge drinkers. | Crego A et al. | — | 2012 | → |
| Binge drinking and declarative memory in university students. | Parada M et al. | — | 2011 | → |
| Effectiveness of public health programs for decreasing alcohol consumption. | Kelly-Weeder S et al. | — | 2011 | → |
| Electrophysiological indices of altered working memory processes in long-term ecstasy users. | Nulsen C et al. | — | 2011 | → |
| Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics. | Jin Z et al. | — | 2011 | → |
| Alcohol and the prefrontal cortex. | Abernathy K et al. | — | 2010 | → |