Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
paper
Cited
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- Authors
- Inagaki, Takeshi; Dutchak, Paul; Zhao, Guixiang; Ding, Xunshan; Gautron, Laurent; Parameswara, Vinay; Li, Yong; Goetz, Regina; Mohammadi, Moosa; Esser, Victoria; Elmquist, Joel K; Gerard, Robert D; Burgess, Shawn C; Hammer, Robert E; Mangelsdorf, David J; Kliewer, Steven A
- Year
- 2007
- Journal
- Cell metabolism
- PMID
- 17550777
- DOI
- 10.1016/j.cmet.2007.05.003
Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the utilization of fat as an energy source during starvation and is the molecular target for the fibrate dyslipidemia drugs. Here, we identify the endocrine hormone fibroblast growth factor 21 (FGF21) as a mediator of the pleiotropic actions of PPARalpha. FGF21 is induced directly by PPARalpha in liver in response to fasting and PPARalpha agonists. FGF21 in turn stimulates lipolysis in white adipose tissue and ketogenesis in liver. FGF21 also reduces physical activity and promotes torpor, a short-term hibernation-like state of regulated hypothermia that conserves energy. These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation.
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| Change of Fibroblast Growth Factor 21 Level Correlates with the Severity of Diabetic Sensory Polyneuropathy after Six-Week Physical Activity. | MolnΓ‘r Γ et al. | β | 2022 | β |
| Chitosan Oligosaccharide Inhibits the Synthesis of Milk Fat in Bovine Mammary Epithelial Cells through AMPK-Mediated Downstream Signaling Pathway. | Fan J et al. | β | 2022 | β |
| Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises. | Senesi P et al. | β | 2022 | β |
| Circadian clock controls rhythms in ketogenesis by interfering with PPARΞ± transcriptional network. | Mezhnina V et al. | β | 2022 | β |
| Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health. | Kim E et al. | β | 2022 | β |
| Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma. | Vachher M et al. | β | 2022 | β |
| Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure. | Katsumura S et al. | β | 2022 | β |
| Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles. | Jain R et al. | β | 2022 | β |
| Dietary induction of obesity and insulin resistance is associated with changes in Fgf21 DNA methylation in liver of mice. | GeiΓler C et al. | β | 2022 | β |
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| Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline. | Zhao L et al. | β | 2022 | β |
| Efruxifermin, a long-acting Fc-fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats. | Tillman EJ et al. | β | 2022 | β |
| Emerging roles of fibroblast growth factor 21 in critical disease. | Yan F et al. | β | 2022 | β |
| Endocrine Fibroblast Growth Factors in Relation to Stress Signaling. | Shimizu M et al. | β | 2022 | β |
| Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1Ξ±. | Wu Z et al. | β | 2022 | β |
| Factors mediating exercise-induced organ crosstalk. | Sabaratnam R et al. | β | 2022 | β |
| Feeding frequency affects glucose and lipid metabolism through SIRT1/AMPK pathway in growing pigs with the same amount of daily feed. | Zhang H et al. | β | 2022 | β |
| FGF1 and insulin control lipolysis by convergent pathways. | Sancar G et al. | β | 2022 | β |
| FGF21: A Novel Regulator of Glucose and Lipid Metabolism and Whole-Body Energy Balance. | SzczepaΕska E et al. | β | 2022 | β |
| FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes. | Samms RJ et al. | β | 2022 | β |
| FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk. | Chaffin AT et al. | β | 2022 | β |
| FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes. | Yanucil C et al. | β | 2022 | β |
| FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice. | Calubag MF et al. | β | 2022 | β |
| FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism. | SzczepaΕska E et al. | β | 2022 | β |
| FGF21 negatively affects long-term female fertility in mice. | Moeckli B et al. | β | 2022 | β |
| FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling. | Kong Y et al. | β | 2022 | β |
| FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis. | Song L et al. | β | 2022 | β |
| FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism. | Zhao F et al. | β | 2022 | β |
| FGFR4 inhibitors for the treatment of hepatocellular carcinoma: a synopsis of therapeutic potential. | Xie H et al. | β | 2022 | β |
| Fibroblast Growth Factor 19 and Fibroblast Growth Factor 21 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Gastric Bypass. | Guo JY et al. | β | 2022 | β |
| Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior. | Wu CT et al. | β | 2022 | β |
| Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients. | Corbee RJ et al. | β | 2022 | β |
| Fibroblast growth factor-21 improves insulin action in nonlactating ewes. | Lamb CL et al. | β | 2022 | β |
| Gemigliptin exerts protective effects against doxorubicin-induced hepatotoxicity by inhibiting apoptosis via the regulation of fibroblast growth factor 21 expression. | Lee KM et al. | β | 2022 | β |
| Glucagon receptor signaling at white adipose tissue does not regulate lipolysis. | Vasileva A et al. | β | 2022 | β |
| G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis. | Bielczyk-Maczynska E et al. | β | 2022 | β |
| Gut Microbiota: Target for Modulation of Gut-Liver-Adipose Tissue Axis in Ethanol-Induced Liver Disease. | Patel D et al. | β | 2022 | β |
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| Hepatic hormone FGF21 and its analogues in clinical trials. | Shao W et al. | β | 2022 | β |
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| Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice. | Yano K et al. | β | 2022 | β |
| Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review. | Tozzi R et al. | β | 2022 | β |
| Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart. | Kawakami R et al. | β | 2022 | β |
| KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction. | Cortes-Araya Y et al. | β | 2022 | β |
| Liver Brain Interactions: Focus on FGF21 a Systematic Review. | Prida E et al. | β | 2022 | β |
| Liver Protective Effect of Fenofibrate in NASH/NAFLD Animal Models. | Mahmoudi A et al. | β | 2022 | β |
| LKB1 acts as a critical brake for the glucagon-mediated fasting response. | Acevedo-Acevedo S et al. | β | 2022 | β |
| LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia. | Rader DJ et al. | β | 2022 | β |
| Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids. | Tagawa R et al. | β | 2022 | β |
| Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women-A Longitudinal Study. | Buell-Acosta JD et al. | β | 2022 | β |
| Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance. | Balakrishnan R et al. | β | 2022 | β |
| Mechanisms of autophagic responses to altered nutritional status. | Tao Z et al. | β | 2022 | β |
| Metabolic changes induced by dapagliflozin, an SGLT2 inhibitor, in Japanese patients with type 2 diabetes treated by oral anti-diabetic agents: A randomized, clinical trial. | Horibe K et al. | β | 2022 | β |
| Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical dependence. | Dorval L et al. | β | 2022 | β |
| Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. | Guo Q et al. | β | 2022 | β |
| Molecular Mechanisms for Ketone Body Metabolism, Signaling Functions, and Therapeutic Potential in Cancer. | Hwang CY et al. | β | 2022 | β |
| Multi-organ FGF21-FGFR1 signaling in metabolic health and disease. | Kaur N et al. | β | 2022 | β |
| Muscle-derived factors influencing bone metabolism. | Gries KJ et al. | β | 2022 | β |
| Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression. | Huang Q et al. | β | 2022 | β |
| Neurosecretory Protein GL Promotes Normotopic Fat Accumulation in Male ICR Mice. | Narimatsu Y et al. | β | 2022 | β |
| Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue. | Klein Hazebroek M et al. | β | 2022 | β |
| Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis. | Zhou B et al. | β | 2022 | β |
| Pathophysiology and risk factors of peripartum cardiomyopathy. | Hoes MF et al. | β | 2022 | β |
| Perfluorinated Carboxylic Acids with Increasing Carbon Chain Lengths Upregulate Amino Acid Transporters and Modulate Compensatory Response of Xenobiotic Transporters in HepaRG Cells. | Lim JJ et al. | β | 2022 | β |
| Performance and Metabolic, Inflammatory, and Oxidative Stress-Related Parameters in Early Lactating Dairy Cows with High and Low Hepatic FGF21 Expression. | Gessner DK et al. | β | 2022 | β |
| Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis. | Liu C et al. | β | 2022 | β |
| Phosphorylation of RXRΞ± mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. | Vernia S et al. | β | 2022 | β |
| Postnatal exercise protects offspring from high-fat diet-induced reductions in subcutaneous adipocyte beiging in C57Bl6/J mice. | Claycombe-Larson KJ et al. | β | 2022 | β |
| PPARΞ±: An emerging target of metabolic syndrome, neurodegenerative and cardiovascular diseases. | Lin Y et al. | β | 2022 | β |
| PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels. | Crespo-Masip M et al. | β | 2022 | β |
| Selective PPARΞ΄ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. | Kouno T et al. | β | 2022 | β |
| Short Term Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome <i>Via</i> B-hydroxybutyrate and Fibroblast Growth Factor 21. | Kim ER et al. | β | 2022 | β |
| SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice. | Mizumoto T et al. | β | 2022 | β |
| Spatial distribution of beta-klotho mRNA in the mouse hypothalamus, hippocampal region, subiculum, and amygdala. | Bono BS et al. | β | 2022 | β |
| Spontaneous Browning of White Adipose Tissue Improves Angiogenesis and Reduces Macrophage Infiltration After Fat Grafting in Mice. | Lin J et al. | β | 2022 | β |
| Supplementation with Eurycoma longifolia Extract Modulates Diurnal Body Temperature Fluctuation and Sleep Rhythm in Mice. | Miyazaki K et al. | β | 2022 | β |
| Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet. | Xu L et al. | β | 2022 | β |
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| The potential function and clinical application of FGF21 in metabolic diseases. | Chen Z et al. | β | 2022 | β |
| Transcriptional Regulation of Hepatic Autophagy by Nuclear Receptors. | Kim EY et al. | β | 2022 | β |
| Wogonin, a Compound in <i>Scutellaria baicalensis</i>, Activates ATF4-FGF21 Signaling in Mouse Hepatocyte AML12 Cells. | Yamada Y et al. | β | 2022 | β |
| Ξ²-Hydroxybutyrate upregulates FGF21 expression through inhibition of histone deacetylases in hepatocytes. | Yan A et al. | β | 2022 | β |
| Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice. | Yu Y et al. | β | 2021 | β |
| Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets. | Wang H et al. | β | 2021 | β |
| A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. | Han MS et al. | β | 2021 | β |
| Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction. | Kim YN et al. | β | 2021 | β |
| Altered adipokines in obese adolescents: a cross-sectional and longitudinal analysis across the spectrum of glycemia. | Wolf RM et al. | β | 2021 | β |
| Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers. | Domouzoglou EM et al. | β | 2021 | β |
| A stem cell based <i>in vitro</i> model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference. | Graffmann N et al. | β | 2021 | β |
| Beta-klotho in type 2 diabetes mellitus: From pathophysiology to therapeutic strategies. | Hua S et al. | β | 2021 | β |
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| CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions. | Nakagawa Y et al. | β | 2021 | β |
| (+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells <i>via</i> the PPARΞ±-FGF21 Pathway. | Xi Y et al. | β | 2021 | β |
| Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome. | Wang Q et al. | β | 2021 | β |
| Diet and exercise in NAFLD/NASH: Beyond the obvious. | Semmler G et al. | β | 2021 | β |
| Differential effects of protein intake versus intake of a defined oligopeptide on FGF-21 in obese human subjects inΒ vivo. | Fangmann D et al. | β | 2021 | β |
| Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response. | Kang SG et al. | β | 2021 | β |
| Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis. | Kim MJ et al. | β | 2021 | β |
| Effects of Glucagon-Like Peptide-1 Analogue and Fibroblast Growth Factor 21 Combination on the Atherosclerosis-Related Process in a Type 2 Diabetes Mouse Model. | Kim JH et al. | β | 2021 | β |
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| Effects of pemafibrate on glucose metabolism markers and liver function tests in patients with hypertriglyceridemia: a pooled analysis of six phase 2 and phase 3 randomized double-blind placebo-controlled clinical trials. | Yokote K et al. | β | 2021 | β |
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| FGF21 is required for the metabolic benefits of IKKΞ΅/TBK1 inhibition. | Reilly SM et al. | β | 2021 | β |
| FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction. | Diener JL et al. | β | 2021 | β |
| FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. | Abu-Odeh M et al. | β | 2021 | β |
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| Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation. | Huen SC et al. | β | 2021 | β |
| Hepatic Fibroblast Growth Factor 21 Is Involved in Mediating Functions of Liraglutide in Mice With Dietary Challenge. | Liu D et al. | β | 2021 | β |
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| Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice. | Bozadjieva-Kramer N et al. | β | 2021 | β |
| Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling. | GarcΓa-RodrΓguez D et al. | β | 2021 | β |
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| Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis. | Khan MS et al. | β | 2021 | β |
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| Roles of Fibroblast Growth Factors and Their Therapeutic Potential in Treatment of Ischemic Stroke. | Dordoe C et al. | β | 2021 | β |
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| <i>In vivo</i> protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice. | ParΓ© F et al. | β | 2020 | β |
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| Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis. | Watanabe M et al. | β | 2020 | β |
| Maintenance of liver glycogen during long-term fasting preserves energy state in mice. | LΓ³pez-Soldado I et al. | β | 2020 | β |
| Metabolic effects of bezafibrate in mitochondrial disease. | Steele H et al. | β | 2020 | β |
| Metabolic Factors Determining the Susceptibility to Weight Gain: Current Evidence. | Hollstein T et al. | β | 2020 | β |
| Multi-Target Approaches in Metabolic Syndrome. | Lillich FF et al. | β | 2020 | β |
| Non-alcoholic fatty liver disease: a metabolic burden promoting atherosclerosis. | Zhang L et al. | β | 2020 | β |
| Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy. | Hernandez G et al. | β | 2020 | β |
| Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease. | Fougerat A et al. | β | 2020 | β |
| PPARΞ± agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat. | Okishio S et al. | β | 2020 | β |
| PPARΞ± and NCOR/SMRT corepressor network in liver metabolic regulation. | Kang Z et al. | β | 2020 | β |
| PPARΞ³ and PPARΞ± synergize to induce robust browning of white fat inΒ vivo. | Kroon T et al. | β | 2020 | β |
| Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1. | Hinds TD et al. | β | 2020 | β |
| Recharacterizing the Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes. | Hollstein T et al. | β | 2020 | β |
| Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-Ξ± and insulin-dependent signalling in hepatocytes. | Smati S et al. | β | 2020 | β |
| Regulation of thermogenic adipocytes during fasting and cold. | Reinisch I et al. | β | 2020 | β |
| Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodeling. | Hui S et al. | β | 2020 | β |
| Serum Endocrine Fibroblast Growth Factors as Potential Biomarkers for Chronic Kidney Disease and Various Metabolic Dysfunctions in Aged Patients. | Yamamoto S et al. | β | 2020 | β |
| Sweroside ameliorates NAFLD in high-fat diet induced obese mice through the regulation of lipid metabolism and inflammatory response. | Yang Q et al. | β | 2020 | β |
| Synchronization of the circadian clock by time-restricted feeding with progressive increasing calorie intake. Resemblances and differences regarding a sustained hypocaloric restriction. | GarcΓa-GaytΓ‘n AC et al. | β | 2020 | β |
| Systemic effects of mitochondrial stress. | Bar-Ziv R et al. | β | 2020 | β |
| Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing. | Hanzawa N et al. | β | 2020 | β |
| Targeting FGF21 for the Treatment of Nonalcoholic Steatohepatitis. | Zarei M et al. | β | 2020 | β |
| The Impact of Moderate-Intensity Continuous or High-Intensity Interval Training on Adipogenesis and Browning of Subcutaneous Adipose Tissue in Obese Male Rats. | Khalafi M et al. | β | 2020 | β |
| The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review. | Gonzalez-Gil AM et al. | β | 2020 | β |
| The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic. | Geng L et al. | β | 2020 | β |
| Transplantation of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury. | Shahror RA et al. | β | 2020 | β |
| Valine Supplementation Does Not Reduce Lipid Accumulation and Improve Insulin Sensitivity in Mice Fed High-Fat Diet. | Ma Q et al. | β | 2020 | β |
| Activation of hepatic estrogen receptor-Ξ± increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice. | Allard C et al. | β | 2019 | β |
| A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21. | Kliewer SA et al. | β | 2019 | β |
| A New Vision for Therapeutic Hypothermia in the Era of Targeted Temperature Management: A Speculative Synthesis. | Jackson TC et al. | β | 2019 | β |
| A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors. | Goto T | β | 2019 | β |
| Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer. | Kang YE et al. | β | 2019 | β |
| Association of elevated circulating fibroblast growth factor 21 levels with prevalent and incident metabolic syndrome: The Multi-Ethnic Study of Atherosclerosis. | Ong KL et al. | β | 2019 | β |
| Astaxanthin plus berberine: a nutraceutical strategy for replicating the benefits of a metformin/fibrate regimen in metabolic syndrome. | DiNicolantonio JJ et al. | β | 2019 | β |
| Carbohydrate Sensing Through the Transcription Factor ChREBP. | Ortega-Prieto P et al. | β | 2019 | β |
| Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21. | Pol CJ et al. | β | 2019 | β |
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | Wang K et al. | β | 2019 | β |
| Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis. | Sommars MA et al. | β | 2019 | β |
| Effect of exercise intensity on circulating hepatokine concentrations in healthy men. | Willis SA et al. | β | 2019 | β |
| Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing. | FernΓ‘ndez A et al. | β | 2019 | β |
| Effects of Paramylon Extracted from <i>Euglena gracilis</i> EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice. | Aoe S et al. | β | 2019 | β |
| Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study. | Headland ML et al. | β | 2019 | β |
| Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes. | Goedeke L et al. | β | 2019 | β |
| Emerging Structure-Function Paradigm of Endocrine FGFs in Metabolic Diseases. | Luo Y et al. | β | 2019 | β |
| ER-associated degradation in health and disease - from substrate to organism. | Bhattacharya A et al. | β | 2019 | β |
| Evaluation of a cell model expressing Ξ²Klotho for screening FGF21 analogues. | Guo X et al. | β | 2019 | β |
| Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. | Geng L et al. | β | 2019 | β |
| FGF19 subfamily members: FGF19 and FGF21. | Dolegowska K et al. | β | 2019 | β |
| FGF21 as Modulator of Metabolism in Health and Disease. | Tezze C et al. | β | 2019 | β |
| FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics. | Li X et al. | β | 2019 | β |
| Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKΞ± signaling pathway. | Ying L et al. | β | 2019 | β |
| Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges. | MartΓnez-Garza Γ et al. | β | 2019 | β |
| Fibroblast growth factor 21: an endocrine inhibitor of sugar and alcohol appetite. | von Holstein-Rathlou S et al. | β | 2019 | β |
| Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice. | Larson KR et al. | β | 2019 | β |
| Fibroblast growth factor 21 controls mitophagy and muscle mass. | Oost LJ et al. | β | 2019 | β |
| Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions. | ForsstrΓΆm S et al. | β | 2019 | β |
| Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. II. Pharmacokinetics, whole-animal performance, and lipid metabolism. | Caixeta LS et al. | β | 2019 | β |
| Fibroblast growth factor 21 in chronic kidney disease. | Anuwatmatee S et al. | β | 2019 | β |
| Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease. | Su X et al. | β | 2019 | β |
| Fibroblast growth factor 21 in non-alcoholic fatty liver disease. | Tucker B et al. | β | 2019 | β |
| Fibroblast growth factor-21 protects against fibrosis in hypertensive heart disease. | Ferrer-Curriu G et al. | β | 2019 | β |
| Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application. | Struik D et al. | β | 2019 | β |
| Fibroblast Growth Factors in Depression. | Deng Z et al. | β | 2019 | β |
| FTO is a transcriptional repressor to auto-regulate its own gene and potentially associated with homeostasis of body weight. | Liu SJ et al. | β | 2019 | β |
| GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. | Patel S et al. | β | 2019 | β |
| Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor Ξ± Modulator (SPPARMΞ±) Pemafibrate. | Sasaki Y et al. | β | 2019 | β |
| Going Back to the Biology of FGF21: New Insights. | Lewis JE et al. | β | 2019 | β |
| Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting. | Zhang Y et al. | β | 2019 | β |
| Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. | Morita M et al. | β | 2019 | β |
| Hepatocyte peroxisome proliferator-activated receptor Ξ± regulates bile acid synthesis and transport. | Xie C et al. | β | 2019 | β |
| Hepatokines-a novel group of exercise factors. | Weigert C et al. | β | 2019 | β |
| Higher serum levels of fibroblast growth factor 21 in old patients with cachexia. | Franz K et al. | β | 2019 | β |
| High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study). | Ong KL et al. | β | 2019 | β |
| Identification and validation of common molecular targets of hydroxytyrosol. | LΓ³pez de Las Hazas MC et al. | β | 2019 | β |
| <i>Ishige okamurae</i> Extract Ameliorates the Hyperglycemia and Body Weight Gain of <i>db/db</i> Mice through Regulation of the PI3K/Akt Pathway and Thermogenic Factors by FGF21. | Seo YJ et al. | β | 2019 | β |
| Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction. | Xu L et al. | β | 2019 | β |
| Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation. | Nakano T et al. | β | 2019 | β |
| Increased fructose consumption has sex-specific effects on fibroblast growth factor 21 levels in humans. | Rodgers M et al. | β | 2019 | β |
| Insights From a Short-Term Protein-Calorie Restriction Exploratory Trial in Elective Carotid Endarterectomy Patients. | Kip P et al. | β | 2019 | β |
| Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight. | Palsdottir V et al. | β | 2019 | β |
| Inter-organ communication: a gatekeeper for metabolic health. | Castillo-Armengol J et al. | β | 2019 | β |
| Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice. | Albarazanji K et al. | β | 2019 | β |
| Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry. | Longo R et al. | β | 2019 | β |
| Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice. | Nakao R et al. | β | 2019 | β |
| Klotho and endocrine fibroblast growth factors: markers of chronic kidney disease progression and cardiovascular complications? | Kuro-O M | β | 2019 | β |
| Loss of hepatic PPARΞ± promotes inflammation and serum hyperlipidemia in diet-induced obesity. | Stec DE et al. | β | 2019 | β |
| Low bone mineral density in anorexia nervosa: Treatments and challenges. | Fazeli PK | β | 2019 | β |
| Metabolic Targets in Nonalcoholic Fatty Liver Disease. | Esler WP et al. | β | 2019 | β |
| Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue. | MΓ€kelΓ€ AM et al. | β | 2019 | β |
| MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal. | Zhang Q et al. | β | 2019 | β |
| Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet. | Luo Y et al. | β | 2019 | β |
| Oral administration of a new HRI activator as a new strategy to improve high-fat-diet-induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21. | Zarei M et al. | β | 2019 | β |
| Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner. | Pan Y et al. | β | 2019 | β |
| PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease. | Rana R et al. | β | 2019 | β |
| Pharmacological Therapy of Non-Alcoholic Fatty Liver Disease: What Drugs Are Available Now and Future Perspectives. | Pennisi G et al. | β | 2019 | β |
| Plasma fibroblast growth factor 21 levels increase with ectopic fat accumulation and its receptor levels are decreased in the visceral fat of patients with type 2 diabetes. | Hong ES et al. | β | 2019 | β |
| Regulation of metabolic health by essential dietary amino acids. | Green CL et al. | β | 2019 | β |
| Relationship of fibroblast growth factor 21 with subclinical atherosclerosis and cardiovascular events: Multi-Ethnic Study of Atherosclerosis. | Ong KL et al. | β | 2019 | β |
| Role of Peptide Hormones in the Adaptation to Altered Dietary Protein Intake. | Rose AJ | β | 2019 | β |
| Serum Fibroblast Growth Factor 21 Levels in Patients with Hyperthyroidism and its Association with Body Fat Percentage. | Bande AR et al. | β | 2019 | β |
| Sex Differences in Liver, Adipose Tissue, and Muscle Transcriptional Response to Fasting and Refeeding in Mice. | Bazhan N et al. | β | 2019 | β |
| SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms. | Osataphan S et al. | β | 2019 | β |
| Sterol 12Ξ±-Hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP-1C Pathway via FGF21 and FGF15. | Pathak P et al. | β | 2019 | β |
| Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion. | Geller S et al. | β | 2019 | β |
| The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism. | Cariello M et al. | β | 2019 | β |
| The FGF metabolic axis. | Li X | β | 2019 | β |
| The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines. | Sherrier M et al. | β | 2019 | β |
| The Klotho proteins in health and disease. | Kuro-O M | β | 2019 | β |
| The paradox of marrow adipose tissue in anorexia nervosa. | Fazeli PK et al. | β | 2019 | β |
| Therapeutic Approaches to Alzheimer's Type of Dementia: A Focus on FGF21 Mediated Neuroprotection. | Taliyan R et al. | β | 2019 | β |
| The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis. | Ma W et al. | β | 2019 | β |
| The roles of FGF21 in atherosclerosis pathogenesis. | Tabari FS et al. | β | 2019 | β |
| Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. | Johann K et al. | β | 2019 | β |
| An Integrated View of Immunometabolism. | Lee YS et al. | β | 2018 | β |
| A systematic dissection of sequence elements determining Ξ²-Klotho and FGF interaction and signaling. | Shi SY et al. | β | 2018 | β |
| Autophagic control of cardiac steatosis through FGF21 in obesity-associated cardiomyopathy. | RupΓ©rez C et al. | β | 2018 | β |
| A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways. | Agnew T et al. | β | 2018 | β |
| Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. | Sun Y et al. | β | 2018 | β |
| Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77. | Zhou F et al. | β | 2018 | β |
| Cardiomyokines from the heart. | Chiba A et al. | β | 2018 | β |
| Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21-Dependent Mechanism. | Ippagunta SM et al. | β | 2018 | β |
| ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption. | Kato T et al. | β | 2018 | β |
| Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats. | Sepa-Kishi DM et al. | β | 2018 | β |
| CREBH Regulates Systemic Glucose and Lipid Metabolism. | Nakagawa Y et al. | β | 2018 | β |
| Curcumin and dietary polyphenol research: beyond drug discovery. | Jin TR | β | 2018 | β |
| Cytochrome P450s and Alcoholic Liver Disease. | Lu Y et al. | β | 2018 | β |
| Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in <i>db/db</i> mice. | Hansen AMK et al. | β | 2018 | β |
| Divergent Role of Estrogen-Related Receptor Ξ± in Lipid- and Fasting-Induced Hepatic Steatosis in Mice. | B'chir W et al. | β | 2018 | β |
| Effective Food Ingredients for Fatty Liver: Soy Protein Ξ²-Conglycinin and Fish Oil. | Yamazaki T et al. | β | 2018 | β |
| Effect of fenofibrate on uric acid level in patients with gout. | Jung JY et al. | β | 2018 | β |
| Effects of Anorexia Nervosa on Bone Metabolism. | Fazeli PK et al. | β | 2018 | β |
| Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization. | Xu L et al. | β | 2018 | β |
| Enhanced Hepatic PPARΞ± Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. | Mayer AL et al. | β | 2018 | β |
| Enteric Microbiotaβ»Gutβ»Brain Axis from the Perspective of Nuclear Receptors. | Duszka K et al. | β | 2018 | β |
| Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood. | Yuan X et al. | β | 2018 | β |
| Exploration of serum sensitive biomarkers of fatty liver in dairy cows. | Shen Y et al. | β | 2018 | β |
| Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects | Nygaard EB et al. | β | 2018 | β |
| FGF21 acts as a negative regulator of bile acid synthesis. | Chen MM et al. | β | 2018 | β |
| FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions. | Maruyama R et al. | β | 2018 | β |
| FGF21 gene therapy as treatment for obesity and insulin resistance. | Jimenez V et al. | β | 2018 | β |
| FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway. | Joe Y et al. | β | 2018 | β |
| FGF21 Is Associated with Metabolic Effects and Treatment Response in Depressed Bipolar II Disorder Patients Treated with Valproate. | Chang HH et al. | β | 2018 | β |
| FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. | Pan X et al. | β | 2018 | β |
| FGF21 regulates insulin sensitivity following long-term chronic stress. | Jelenik T et al. | β | 2018 | β |
| FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia. | Manoli I et al. | β | 2018 | β |
| Fibroblast growth factor 21 and fructose dynamics in humans. | Migdal A et al. | β | 2018 | β |
| Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis. | BonDurant LD et al. | β | 2018 | β |
| Fibroblast growth factor 21 induces lipolysis more efficiently than it suppresses lipogenesis in goat adipocytes. | Zhang Y et al. | β | 2018 | β |
| Fibroblast growth factor 21 regulates glucose metabolism in part by reducing renal glucose reabsorption. | Li S et al. | β | 2018 | β |
| FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice. | Ling AV et al. | β | 2018 | β |
| Fructose metabolism and metabolic disease. | Hannou SA et al. | β | 2018 | β |
| Gene expression profiling during hibernation in the European hamster. | Gautier C et al. | β | 2018 | β |
| Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing. | Weng Y et al. | β | 2018 | β |
| HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation. | Qiu X et al. | β | 2018 | β |
| Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH. | Bhattacharya A et al. | β | 2018 | β |
| Homeostatic sensing of dietary protein restriction: A case for FGF21. | Hill CM et al. | β | 2018 | β |
| Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake. | Pineda C et al. | β | 2018 | β |
| Identification of IQ motif-containing GTPase-activating protein 1 as a regulator of long-term ketosis. | Erickson HL et al. | β | 2018 | β |
| Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation. | Li Y et al. | β | 2018 | β |
| Insights into the role of hepatocyte PPARΞ± activity in response to fasting. | RΓ©gnier M et al. | β | 2018 | β |
| Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity. | Fu T et al. | β | 2018 | β |
| Molecular Actions of PPARΞ± in Lipid Metabolism and Inflammation. | Bougarne N et al. | β | 2018 | β |
| Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. | Agrawal A et al. | β | 2018 | β |
| Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake. | Xiao Y et al. | β | 2018 | β |
| Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. | Samuel VT et al. | β | 2018 | β |
| Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches. | Kim KH et al. | β | 2018 | β |
| Physiological mechanisms of sustained fumagillin-induced weight loss. | An J et al. | β | 2018 | β |
| Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction. | Xu X et al. | β | 2018 | β |
| Protective Effects of Fibroblast Growth Factor 21 Against Amyloid-Beta<sub>1-42</sub>-Induced Toxicity in SH-SY5Y Cells. | Amiri M et al. | β | 2018 | β |
| Response of skeletal muscle UCP2-expression during metabolic adaptation to caloric restriction. | Heinitz S et al. | β | 2018 | β |
| Response of the insulin-like growth factor-1 (Igf1) system to nutritional status and growth rate variation in olive rockfish (Sebastes serranoides). | Hack NL et al. | β | 2018 | β |
| Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia. | Dong M et al. | β | 2018 | β |
| Serum adropin levels are decreased in Chinese type 2 diabetic patients and negatively correlated with body mass index. | Zang H et al. | β | 2018 | β |
| Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study. | Choi JR et al. | β | 2018 | β |
| Serum Levels of FGF21 and Prediction of Cardiovascular Events. | Luo Y et al. | β | 2018 | β |
| Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice. | Gasparin FRS et al. | β | 2018 | β |
| Skeletal muscle mitochondrial remodeling in exercise and diseases. | Gan Z et al. | β | 2018 | β |
| TCF4/Ξ²-catenin complex is directly upstream of <i>FGF21</i> in mouse stomach cancer cells. | Pei J et al. | β | 2018 | β |
| The dark side of browning. | Tamucci KA et al. | β | 2018 | β |
| The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women. | da Silveira Campos RM et al. | β | 2018 | β |
| The Influence of Gut Microbial Metabolism on the Development and Progression of Non-alcoholic Fatty Liver Disease. | Jia W et al. | β | 2018 | β |
| The Peroxisome Proliferator-Activated Receptor Ξ± (PPARΞ±) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. | Araki M et al. | β | 2018 | β |
| The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis. | Hui TH et al. | β | 2018 | β |
| The role of suppression of hepatic SCD1 expression in the metabolic effects of dietary methionine restriction. | Forney LA et al. | β | 2018 | β |
| TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP-ATF response elements in the Fgf21 promoter. | Γrd T et al. | β | 2018 | β |
| A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. | Fisher FM et al. | β | 2017 | β |
| Alcohol,Β AdiposeΒ TissueΒ andΒ LipidΒ Dysregulation. | Steiner JL et al. | β | 2017 | β |
| Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARΞ±-FGF21 axis. | Chen X et al. | β | 2017 | β |
| A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21). | PΓ©rez-MartΓ A et al. | β | 2017 | β |
| Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract. | Gessner DK et al. | β | 2017 | β |
| Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting. | Cushing EM et al. | β | 2017 | β |
| ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21. | Kang SG et al. | β | 2017 | β |
| A Specific ChREBP and PPARΞ± Cross-Talk Is Required for the Glucose-Mediated FGF21 Response. | Iroz A et al. | β | 2017 | β |
| Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease. | Kohara M et al. | β | 2017 | β |
| Bile acid receptors link nutrient sensing to metabolic regulation. | Li J et al. | β | 2017 | β |
| Brown and Beige Adipose Tissues in Health and Disease. | Rui L | β | 2017 | β |
| Chronic activation of PPARΞ± with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21. | Jo E et al. | β | 2017 | β |
| Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates. | Lundsgaard AM et al. | β | 2017 | β |
| Decreased levels of Fibroblast Growth Factor 21 are correlated with improved hypoglycemia in patients with insulinoma. | Li X et al. | β | 2017 | β |
| Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. | He L et al. | β | 2017 | β |
| Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice. | Lees EK et al. | β | 2017 | β |
| Distinct but complementary contributions of PPAR isotypes to energy homeostasis. | Dubois V et al. | β | 2017 | β |
| Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows. | Caixeta LS et al. | β | 2017 | β |
| Effect of Nutrition on Statural Growthβ©. | Gat-Yablonski G et al. | β | 2017 | β |
| Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes. | Kruse R et al. | β | 2017 | β |
| Effects of K-877, a novel selective PPARΞ± modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice. | Takei K et al. | β | 2017 | β |
| Fasting-induced hormonal regulation of lysosomal function. | Chen L et al. | β | 2017 | β |
| Fasting the Microbiota to Improve Metabolism? | Haas JT et al. | β | 2017 | β |
| Fatty liver and FGF21 physiology. | Maratos-Flier E | β | 2017 | β |
| Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine <i>N</i>-methyltransferase. | van der Veen JN et al. | β | 2017 | β |
| FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process. | Salminen A et al. | β | 2017 | β |
| FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study. | Li G et al. | β | 2017 | β |
| FGF21 inhibitor suppresses the proliferation and migration of human umbilical vein endothelial cells through the eNOS/PI3K/AKT pathway. | Li Y et al. | β | 2017 | β |
| FGF21 Is an Exocrine Pancreas Secretagogue. | Coate KC et al. | β | 2017 | β |
| FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. | SΓΈberg S et al. | β | 2017 | β |
| FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARΞ± and PPARΞ³ Agonists. | Li X et al. | β | 2017 | β |
| Fgf21 is required for cardiac remodeling in pregnancy. | Redondo-Angulo I et al. | β | 2017 | β |
| FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases. | Sonoda J et al. | β | 2017 | β |
| Fgf21 regulates T-cell development in the neonatal and juvenile thymus. | Nakayama Y et al. | β | 2017 | β |
| FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue. | Markan KR et al. | β | 2017 | β |
| FGF23-Ξ±Klotho as a paradigm for a kidney-bone network. | Kuro-O M et al. | β | 2017 | β |
| Fibroblast growth factor 21: a regulator of metabolic disease and health span. | Xie T et al. | β | 2017 | β |
| Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states. | Santoso P et al. | β | 2017 | β |
| Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis. | Liu L et al. | β | 2017 | β |
| Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury. | Desai BN et al. | β | 2017 | β |
| Fibroblast Growth Factor 21-Metabolic Role in Mice and Men. | Staiger H et al. | β | 2017 | β |
| Fibroblast growth factor 21 night watch: advances and uncertainties in the field. | Kharitonenkov A et al. | β | 2017 | β |
| From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. | Caputo T et al. | β | 2017 | β |
| G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux. | Zhang X et al. | β | 2017 | β |
| Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4. | Alonge KM et al. | β | 2017 | β |
| Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis. | Han HS et al. | β | 2017 | β |
| Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice. | Kim KH et al. | β | 2017 | β |
| Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system. | Lee HU et al. | β | 2017 | β |
| Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression. | Chen S et al. | β | 2017 | β |
| Impact of FGF21 on glycemic control. | Strowski MZ | β | 2017 | β |
| Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism. | Patton A et al. | β | 2017 | β |
| Increased glucose-stimulated FGF21 response to oral glucose in obese nondiabetic subjects after Roux-en-Y gastric bypass. | Vienberg SG et al. | β | 2017 | β |
| Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice. | Olivares S et al. | β | 2017 | β |
| Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the GutΒ Microbiota. | Li G et al. | β | 2017 | β |
| Inter-organ regulation of adipose tissue browning. | Wang S et al. | β | 2017 | β |
| Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis. | Nakao R et al. | β | 2017 | β |
| Long-Term Cold Adaptation Does Not Require FGF21 or UCP1. | Keipert S et al. | β | 2017 | β |
| LPS infusion suppresses serum FGF21 levels in healthy adult volunteers. | Lauritzen ES et al. | β | 2017 | β |
| Mechanistic insight into nuclear receptor-mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE). | Downing LE et al. | β | 2017 | β |
| Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues. | Lin X et al. | β | 2017 | β |
| Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. | Morrow RM et al. | β | 2017 | β |
| Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. | Puchalska P et al. | β | 2017 | β |
| N-3 polyunsaturated fatty acids increase hepatic fibroblast growth factor 21 sensitivity via a PPAR-Ξ³-Ξ²-klotho pathway. | Yang W et al. | β | 2017 | β |
| Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1Ξ± Signaling Axis. | Wu H et al. | β | 2017 | β |
| Nutrient-sensing nuclear receptors PPARΞ± and FXR control liver energy balance. | Preidis GA et al. | β | 2017 | β |
| Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARΞ±-Dependent AMPK Activation. | de Souza CO et al. | β | 2017 | β |
| Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis. | Honda Y et al. | β | 2017 | β |
| Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster. | Lewis JE et al. | β | 2017 | β |
| Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses. | Salminen A et al. | β | 2017 | β |
| Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet. | Chapnik N et al. | β | 2017 | β |
| Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution. | Maida A et al. | β | 2017 | β |
| REV-ERBΞ± regulates Fgf21 expression in the liver via hepatic nuclear factor 6. | Chavan R et al. | β | 2017 | β |
| Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage. | Luo Y et al. | β | 2017 | β |
| Selective peroxisome proliferator-activated receptor-Ξ± modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-Ξ± pathway and improves lipid metabolism in mice. | Takei K et al. | β | 2017 | β |
| SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice. | Xu L et al. | β | 2017 | β |
| Sweet Sixteenth for ChREBP: Established Roles and Future Goals. | Abdul-Wahed A et al. | β | 2017 | β |
| System-wide Benefits of Intermeal Fasting by Autophagy. | Martinez-Lopez N et al. | β | 2017 | β |
| Targeting nuclear receptors for the treatment of fatty liver disease. | Tanaka N et al. | β | 2017 | β |
| The endocrine manifestations of anorexia nervosa: mechanisms and management. | Schorr M et al. | β | 2017 | β |
| The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity. | Huang Z et al. | β | 2017 | β |
| The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-Ξ± agonist-induced amelioration of metabolic disorders in obese mice. | Goto T et al. | β | 2017 | β |
| The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes. | Izaguirre M et al. | β | 2017 | β |
| The role of fibroblast growth factor 21 in atherosclerosis. | Kokkinos J et al. | β | 2017 | β |
| Ξ±1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice. | Nonogaki K et al. | β | 2017 | β |
| Ξ²-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. | Somm E et al. | β | 2017 | β |
| Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men. | Taniguchi H et al. | β | 2016 | β |
| Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation. | Tanimura Y et al. | β | 2016 | β |
| Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption. | Bowman TA et al. | β | 2016 | β |
| A Fibroblast Growth Factor 21-Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease. | Woolsey SJ et al. | β | 2016 | β |
| An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function. | Lee JH et al. | β | 2016 | β |
| Anti-human fibroblast growth factor-21 monoclonal antibody preparation, characterization and analysis of <i>in vitro</i> bioactivity. | Ding L et al. | β | 2016 | β |
| Blocking the FGF/FGFR system as a "two-compartment" antiangiogenic/antitumor approach in cancer therapy. | Giacomini A et al. | β | 2016 | β |
| Circulating Fibroblast Growth Factor 21 (Fgf21) as Diagnostic and Prognostic Biomarker in Renal Cancer. | Knott ME et al. | β | 2016 | β |
| Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation. | Ye D et al. | β | 2016 | β |
| CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARΞ±. | Nakagawa Y et al. | β | 2016 | β |
| CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis. | Park JG et al. | β | 2016 | β |
| Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in Sprague-Dawley rats fed prenatal low protein and postnatal high-fat diets. | Claycombe KJ et al. | β | 2016 | β |
| Defining the Nutritional and Metabolic Context of FGF21Β Using the Geometric Framework. | Solon-Biet SM et al. | β | 2016 | β |
| Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice. | Ejaz A et al. | β | 2016 | β |
| Effect of Metformin on Fibroblast Growth Factor-21 Levels in Patients with Newly Diagnosed Type 2 Diabetes. | Fan H et al. | β | 2016 | β |
| Effects of K-877, a novel selective PPARΞ± modulator (SPPARMΞ±), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial. | Ishibashi S et al. | β | 2016 | β |
| Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia. | Cawthorn WP et al. | β | 2016 | β |
| Expression of fibroblast growth factor 21 in patients with biliary atresia. | Li D et al. | β | 2016 | β |
| FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency. | Dollet L et al. | β | 2016 | β |
| FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. | Huang Y et al. | β | 2016 | β |
| FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. | von Holstein-Rathlou S et al. | β | 2016 | β |
| FGF21 Regulates Sweet and Alcohol Preference. | Talukdar S et al. | β | 2016 | β |
| FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner. | Wang XM et al. | β | 2016 | β |
| Fibroblast activation protein (FAP) as a novel metabolic target. | SΓ‘nchez-Garrido MA et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus. | So WY et al. | β | 2016 | β |
| Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents. | Khan FH et al. | β | 2016 | β |
| Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury. | Liu Y et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet. | Hao L et al. | β | 2016 | β |
| Fibroblast growth factor 21 (FGF-21) in obese children: no relationship to growth, IGF-1, and IGFBP-3. | Reinehr T et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. | Singhal G et al. | β | 2016 | β |
| Fibroblast growth factor 21 has no direct role in regulating fertility in female mice. | Singhal G et al. | β | 2016 | β |
| Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. | Gong Q et al. | β | 2016 | β |
| Fibroblast growth factor 21 induction by activating transcription factor 4 is regulated through three amino acid response elements in its promoter region. | Maruyama R et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK. | Vernia S et al. | β | 2016 | β |
| Fibroblast Growth Factor 21-Null Mice Do Not Exhibit an Impaired Response to Fasting. | Antonellis PJ et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk. | Jin L et al. | β | 2016 | β |
| Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice. | Rusli F et al. | β | 2016 | β |
| Fibroblast growth factors, old kids on the new block. | Li X et al. | β | 2016 | β |
| Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress. | Mosinski JD et al. | β | 2016 | β |
| Growth and the Growth Hormone-Insulin Like Growth Factor 1 Axis in Children With Chronic Inflammation: Current Evidence, Gaps in Knowledge, and Future Directions. | Wong SC et al. | β | 2016 | β |
| Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression. | Girer NG et al. | β | 2016 | β |
| Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor Ξ±. | Chen X et al. | β | 2016 | β |
| Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation. | Lee J et al. | β | 2016 | β |
| Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice. | Ziros P et al. | β | 2016 | β |
| Hepatocyte Ξ²-Klotho regulates lipid homeostasis but not body weight in mice. | Kobayashi K et al. | β | 2016 | β |
| High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice. | Dandapat A et al. | β | 2016 | β |
| Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. | Pirozzi C et al. | β | 2016 | β |
| Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle. | Vandanmagsar B et al. | β | 2016 | β |
| Lipid droplet dynamics in skeletal muscle. | Bosma M | β | 2016 | β |
| Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD. | Softic S et al. | β | 2016 | β |
| Lipodystrophy HIV-related and FGF21: A new marker to follow the progression of lipodystrophy? | Benedini S et al. | β | 2016 | β |
| Liver PPARΞ± is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. | Montagner A et al. | β | 2016 | β |
| Low-protein diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes. | Chalvon-Demersay T et al. | β | 2016 | β |
| Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. | Oh KJ et al. | β | 2016 | β |
| Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis. | Markan KR et al. | β | 2016 | β |
| Metabolic interplay between white, beige, brown adipocytes and the liver. | Scheja L et al. | β | 2016 | β |
| Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2. | Laeger T et al. | β | 2016 | β |
| Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. | Liu HX et al. | β | 2016 | β |
| MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity. | Fu T et al. | β | 2016 | β |
| Modulation of energy balance by fibroblast growth factor 21. | Cuevas-Ramos D et al. | β | 2016 | β |
| Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action. | Ost M et al. | β | 2016 | β |
| Nuclear receptors and AMPK: can exercise mimetics cure diabetes? | Wall CE et al. | β | 2016 | β |
| Nutritional regulation of fibroblast growth factor 21: from macronutrients to bioactive dietary compounds. | PΓ©rez-MartΓ A et al. | β | 2016 | β |
| Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. | Wang A et al. | β | 2016 | β |
| Overexpression of Ξ²-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity. | Samms RJ et al. | β | 2016 | β |
| Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions. | Vitale SG et al. | β | 2016 | β |
| Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules. | Copple BL et al. | β | 2016 | β |
| Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases. | Cheng P et al. | β | 2016 | β |
| Potential roles of fibroblast growth factor 21 in the brain. | Sa-Nguanmoo P et al. | β | 2016 | β |
| Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. | Youm YH et al. | β | 2016 | β |
| Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state. | Guan D et al. | β | 2016 | β |
| Regulation of Ketone Body Metabolism and the Role of PPARΞ±. | Grabacka M et al. | β | 2016 | β |
| Reply. | Lu P et al. | β | 2016 | β |
| Roux-en-Y gastric bypass surgery is effective in fibroblast growth factor-21 deficient mice. | Morrison CD et al. | β | 2016 | β |
| Serum concentrations of fibroblast growth factor 21 are elevated in patients with congenital or acquired lipodystrophy. | Miehle K et al. | β | 2016 | β |
| Single ingestion of soy Ξ²-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects. | Hashidume T et al. | β | 2016 | β |
| Skeletal muscle-specific eukaryotic translation initiation factor 2Ξ± phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism. | Miyake M et al. | β | 2016 | β |
| The FGF21-adiponectin axis in controlling energy and vascular homeostasis. | Hui X et al. | β | 2016 | β |
| The FGF21 Receptor Signaling Complex: KlothoΞ², FGFR1c, and Other Regulatory Interactions. | Kilkenny DM et al. | β | 2016 | β |
| The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. | Quesada-LΓ³pez T et al. | β | 2016 | β |
| The Orphan Nuclear Receptor ERRΞ³ Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression. | Jung YS et al. | β | 2016 | β |
| Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. | Degirolamo C et al. | β | 2016 | β |
| Therapeutic uses of FGFs. | Zhang J et al. | β | 2016 | β |
| The regulation of FGF21 gene expression by metabolic factors and nutrients. | Erickson A et al. | β | 2016 | β |
| The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. | Herman MA et al. | β | 2016 | β |
| Transcriptional coordination of hepatic autophagy by nutrient-sensing nuclear receptor PPARΞ± and FXR. | Lee JM | β | 2016 | β |
| Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of Ξ±-tubulin acetylation and FGF-21 up-regulation. | Wang Z et al. | β | 2016 | β |
| Understanding the Physiology of FGF21. | Fisher FM et al. | β | 2016 | β |
| Upregulation of rat liver PPARΞ±-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol. | Videla LA et al. | β | 2016 | β |
| Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3. | Leng Y et al. | β | 2016 | β |
| Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21. | Lu P et al. | β | 2015 | β |
| Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. | Guridi M et al. | β | 2015 | β |
| Adaptation of peroxisome proliferator-activated receptor alpha to hibernation in bats. | Han Y et al. | β | 2015 | β |
| A Grape Seed Procyanidin Extract Ameliorates Fructose-Induced Hypertriglyceridemia in Rats via Enhanced Fecal Bile Acid and Cholesterol Excretion and Inhibition of Hepatic Lipogenesis. | Downing LE et al. | β | 2015 | β |
| A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption. | Wang X et al. | β | 2015 | β |
| Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows. | Akbar H et al. | β | 2015 | β |
| Altered circadian rhythm and metabolic gene profile in rats subjected to advanced light phase shifts. | Herrero L et al. | β | 2015 | β |
| A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. | Shimizu N et al. | β | 2015 | β |
| Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes. | Kim WJ et al. | β | 2015 | β |
| Bariatric surgery: prevalence, predictors, and mechanisms of diabetes remission. | Argyropoulos G | β | 2015 | β |
| Biological Role of Anti-aging Protein Klotho. | Kim JH et al. | β | 2015 | β |
| Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice. | Douris N et al. | β | 2015 | β |
| Circulating FGF19 and FGF21 surge in early infancy from infra- to supra-adult concentrations. | SΓ‘nchez-Infantes D et al. | β | 2015 | β |
| Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons. | Jackson TC et al. | β | 2015 | β |
| Cord blood FGF21 in gestational diabetes and its relationship with postnatal growth. | Megia A et al. | β | 2015 | β |
| Dietary restriction in obese children and its relation with eating behavior, fibroblast growth factor 21 and leptin: a prospective clinical intervention study. | Ibarra-Reynoso Ldel R et al. | β | 2015 | β |
| Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1. | Samms RJ et al. | β | 2015 | β |
| Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. | Samms RJ et al. | β | 2015 | β |
| Effect of mitochondrial stress on systemic metabolism. | Lee MS | β | 2015 | β |
| Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy. | Itoh N et al. | β | 2015 | β |
| Endoplasmic reticulum stress induces up-regulation of hepatic Ξ²-Klotho expression through ATF4 signaling pathway. | Dong K et al. | β | 2015 | β |
| Energy Expenditure Responses to Fasting and Overfeeding Identify Phenotypes Associated With Weight Change. | SchlΓΆgl M et al. | β | 2015 | β |
| Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids. | Jaeger D et al. | β | 2015 | β |
| FGF21 and Cardiac Physiopathology. | Planavila A et al. | β | 2015 | β |
| FGF21 and the late adaptive response to starvation in humans. | Fazeli PK et al. | β | 2015 | β |
| FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers. | Leng Y et al. | β | 2015 | β |
| FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs. | Kim KH et al. | β | 2015 | β |
| FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance. | Bernardo B et al. | β | 2015 | β |
| FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice. | Stemmer K et al. | β | 2015 | β |
| FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice. | Zhao C et al. | β | 2015 | β |
| FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties. | Kharitonenkov A et al. | β | 2015 | β |
| Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders. | Zhang J et al. | β | 2015 | β |
| Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females. | Hanks LJ et al. | β | 2015 | β |
| Fibroblast growth factor-21, energy balance and obesity. | Giralt M et al. | β | 2015 | β |
| Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress. | Kim SH et al. | β | 2015 | β |
| Fibroblast growth factor 21 prevents glycemic deterioration in insulin deficient mouse models of diabetes. | Andersen B et al. | β | 2015 | β |
| Fibroblast growth factor 21 protects the heart from oxidative stress. | Planavila A et al. | β | 2015 | β |
| Fibroblast Growth Factor 21 Suppresses Adipogenesis in Pig Intramuscular Fat Cells. | Wang Y et al. | β | 2015 | β |
| Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways. | Yu Y et al. | β | 2015 | β |
| Fibroblast Growth Factor Signaling in Metabolic Regulation. | Nies VJ et al. | β | 2015 | β |
| Fish oil decreases hepatic lipogenic genes in rats fasted and refed on a high fructose diet. | de Castro GS et al. | β | 2015 | β |
| Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. | Qin Y et al. | β | 2015 | β |
| Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARΞ±(PAC) mice due to dysregulated bile acid synthesis. | Liu HX et al. | β | 2015 | β |
| Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance. | Al-Share QY et al. | β | 2015 | β |
| Fructose ingestion acutely stimulates circulating FGF21 levels in humans. | Dushay JR et al. | β | 2015 | β |
| Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans. | Hansen JS et al. | β | 2015 | β |
| Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. | Patel R et al. | β | 2015 | β |
| Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue. | Lester SG et al. | β | 2015 | β |
| Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. | Lawan A et al. | β | 2015 | β |
| High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice. | Wall CE et al. | β | 2015 | β |
| Homeostasis, inflammation, and disease susceptibility. | Kotas ME et al. | β | 2015 | β |
| Induction of peroxisomes by butyrate-producing probiotics. | Weng H et al. | β | 2015 | β |
| Leptin and the brain: influences on brain development, cognitive functioning and psychiatric disorders. | Farr OM et al. | β | 2015 | β |
| Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation. | Zhang Q et al. | β | 2015 | β |
| Metabolic Effects of FGF-21: Thermoregulation and Beyond. | Ni B et al. | β | 2015 | β |
| Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases. | Zhang F et al. | β | 2015 | β |
| Molecular basis of Klotho: from gene to function in aging. | Xu Y et al. | β | 2015 | β |
| Molecular insights into the mechanisms of liver-associated diseases in early-lactating dairy cows: hypothetical role of endoplasmic reticulum stress. | Ringseis R et al. | β | 2015 | β |
| Molecular mechanisms of fatty liver in obesity. | Gan L et al. | β | 2015 | β |
| Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue. | Fu J et al. | β | 2015 | β |
| Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21. | Assini JM et al. | β | 2015 | β |
| Neuroendocrine causes of amenorrhea--an update. | Fourman LT et al. | β | 2015 | β |
| New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond. | Beuers U et al. | β | 2015 | β |
| Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients. | Gallego-Escuredo JM et al. | β | 2015 | β |
| Perturbations of fibroblast growth factors 19 and 21 in type 2 diabetes. | Roesch SL et al. | β | 2015 | β |
| PPARΞ± gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis. | Francque S et al. | β | 2015 | β |
| Protein-dependent regulation of feeding and metabolism. | Morrison CD et al. | β | 2015 | β |
| Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism. | Ozaki Y et al. | β | 2015 | β |
| Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats. | Wang WF et al. | β | 2015 | β |
| Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD. | Inagaki T | β | 2015 | β |
| Response of fibroblast growth factor 21 to meal intake and insulin infusion in patients on maintenance haemodialysis. | Reinhard M et al. | β | 2015 | β |
| Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. | Tanaka N et al. | β | 2015 | β |
| Serum FGF21 levels are associated with brown adipose tissue activity in humans. | Hanssen MJ et al. | β | 2015 | β |
| Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. | Fazeli PK et al. | β | 2015 | β |
| Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. | Lee SM et al. | β | 2015 | β |
| The brain and brown fat. | Contreras C et al. | β | 2015 | β |
| The brown fat secretome: metabolic functions beyond thermogenesis. | Wang GX et al. | β | 2015 | β |
| The effect of grape seed and grape marc meal extract on milk performance and the expression of genes of endoplasmic reticulum stress and inflammation in the liver of dairy cows in early lactation. | Gessner DK et al. | β | 2015 | β |
| The Fibroblast Growth Factor signaling pathway. | Ornitz DM et al. | β | 2015 | β |
| The impact of diabetes and diabetes medications on bone health. | Gilbert MP et al. | β | 2015 | β |
| The impact of LDLR function on fibroblast growth factor 21 levels. | Besseling J et al. | β | 2015 | β |
| The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes study. | Ong KL et al. | β | 2015 | β |
| Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver. | Zhang A et al. | β | 2015 | β |
| Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. | Owen BM et al. | β | 2015 | β |
| TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways. | Jung JG et al. | β | 2015 | β |
| Transcriptional and Chromatin Regulation during Fasting - The Genomic Era. | Goldstein I et al. | β | 2015 | β |
| Transcriptome Analysis of K-877 (a Novel Selective PPARΞ± Modulator (SPPARMΞ±))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver. | Raza-Iqbal S et al. | β | 2015 | β |
| Trans-system mechanisms against ischemic myocardial injury. | Liu SQ et al. | β | 2015 | β |
| Ξ±-Lipoic acid as a triglyceride-lowering nutraceutical. | Pashaj A et al. | β | 2015 | β |
| Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH. | Bae KH et al. | β | 2014 | β |
| A new avenue for lithium: intervention in traumatic brain injury. | Leeds PR et al. | β | 2014 | β |
| Anorexia nervosa and bone metabolism. | Fazeli PK et al. | β | 2014 | β |
| ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress. | Wan XS et al. | β | 2014 | β |
| Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism. | Kim KH et al. | β | 2014 | β |
| Bile acid signaling in metabolic disease and drug therapy. | Li T et al. | β | 2014 | β |
| Bone metabolism in anorexia nervosa. | Fazeli PK et al. | β | 2014 | β |
| Determinants of GH resistance in malnutrition. | Fazeli PK et al. | β | 2014 | β |
| Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hormones of energy balance in a TCDD-sensitive and a TCDD-resistant rat strain. | LindΓ©n J et al. | β | 2014 | β |
| Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. | Raso GM et al. | β | 2014 | β |
| Effects of fibroblast growth factor 21 on cell damage in vitro and atherosclerosis in vivo. | Zhu W et al. | β | 2014 | β |
| Elevated FGF21 secretion, PGC-1Ξ± and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle. | Crooks DR et al. | β | 2014 | β |
| Energy metabolism in the liver. | Rui L | β | 2014 | β |
| Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. | Tripathy S et al. | β | 2014 | β |
| FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases. | Kim KH et al. | β | 2014 | β |
| FGF21-based pharmacotherapy--potential utility for metabolic disorders. | Gimeno RE et al. | β | 2014 | β |
| FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling. | Ribas F et al. | β | 2014 | β |
| FGF21 is an endocrine signal of protein restriction. | Laeger T et al. | β | 2014 | β |
| FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. | Liang Q et al. | β | 2014 | β |
| Fibroblast growth factor 21 and its relation to metabolic parameters in women with polycystic ovary syndrome. | Sahin SB et al. | β | 2014 | β |
| Fibroblast growth factor-21 and the beneficial effects of long-chain n-3 polyunsaturated fatty acids. | Villarroya J et al. | β | 2014 | β |
| Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases. | Cheung BM et al. | β | 2014 | β |
| Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1Ξ± in human dopaminergic neurons via Sirtuin-1. | MΓ€kelΓ€ J et al. | β | 2014 | β |
| Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis. | Brahma MK et al. | β | 2014 | β |
| Fibroblast growth factor 21 is not required for the reductions in circulating insulin-like growth factor-1 or global cell proliferation rates in response to moderate calorie restriction in adult mice. | Thompson AC et al. | β | 2014 | β |
| Fibroblast growth factor 21 is regulated by the IRE1Ξ±-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. | Jiang S et al. | β | 2014 | β |
| Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. | Fisher FM et al. | β | 2014 | β |
| Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1Ξ±-mediated antioxidant capacity in mice. | Ye D et al. | β | 2014 | β |
| Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. | Zhang J et al. | β | 2014 | β |
| Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR). | Cheng X et al. | β | 2014 | β |
| GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets. | McCarty MF | β | 2014 | β |
| Glucagon is essential for adaptive thermogenesis in brown adipose tissue. | Kinoshita K et al. | β | 2014 | β |
| Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism. | Cyphert HA et al. | β | 2014 | β |
| Head over hepatocytes for FGF21. | Potthoff MJ et al. | β | 2014 | β |
| Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. | Nakagawa Y et al. | β | 2014 | β |
| Hepatic FGF21 production is increased in late pregnancy in the mouse. | Cui Y et al. | β | 2014 | β |
| Hepatic IRE1Ξ± regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARΞ± axis signalling. | Shao M et al. | β | 2014 | β |
| Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. | Cornu M et al. | β | 2014 | β |
| Impairments of hepatic gluconeogenesis and ketogenesis in PPARΞ±-deficient neonatal mice. | Cotter DG et al. | β | 2014 | β |
| Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta). | Nygaard EB et al. | β | 2014 | β |
| Integrated physiology and systems biology of PPARΞ±. | Kersten S | β | 2014 | β |
| Interplay between FGF21 and insulin action in the liver regulates metabolism. | Emanuelli B et al. | β | 2014 | β |
| Inventing new medicines: The FGF21 story. | Kharitonenkov A et al. | β | 2014 | β |
| Lifelong caloric restriction reprograms hepatic fat metabolism in mice. | Kuhla A et al. | β | 2014 | β |
| Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor Ξ± to regulate metabolic hormone FGF21. | Kim H et al. | β | 2014 | β |
| Liver functional genomics in beef cows on grazing systems: novel genes and pathways revealed. | Laporta J et al. | β | 2014 | β |
| LT175 is a novel PPARΞ±/Ξ³ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. | Gilardi F et al. | β | 2014 | β |
| Metabolic syndrome in pediatrics. | Kursawe R et al. | β | 2014 | β |
| MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. | Fu T et al. | β | 2014 | β |
| Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues. | Patel R et al. | β | 2014 | β |
| Modulation of fibroblast growth factor 19 expression by bile acids, meal replacement and energy drinks, milk, and coffee. | Styer AM et al. | β | 2014 | β |
| Molecular characterization and mapping of Fgf21 gene in a foodfish species asian seabass. | Wang L et al. | β | 2014 | β |
| Myokines in insulin resistance and type 2 diabetes. | Eckardt K et al. | β | 2014 | β |
| Novel sandwich immunoassays for the measurement of total and active FGF21. | Umberger TS et al. | β | 2014 | β |
| Nrf2 induces fibroblast growth factor 21 in diabetic mice. | Furusawa Y et al. | β | 2014 | β |
| Nuclear receptors and metabolism: from feast to famine. | Hong SH et al. | β | 2014 | β |
| Photoperiodic regulation of FGF21 production in the Siberian hamster. | Samms RJ et al. | β | 2014 | β |
| Play down protein to play up metabolism? | MΓΌller TD et al. | β | 2014 | β |
| Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3. | Lateef DM et al. | β | 2014 | β |
| Regulation of energy metabolism by long-chain fatty acids. | Nakamura MT et al. | β | 2014 | β |
| Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training. | Scalzo RL et al. | β | 2014 | β |
| Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH). | Jha P et al. | β | 2014 | β |
| Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models. | Su N et al. | β | 2014 | β |
| Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. | Tanaka N et al. | β | 2014 | β |
| Serum FGF21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status. | Lee Y et al. | β | 2014 | β |
| Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents. | Bisgaard A et al. | β | 2014 | β |
| Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1. | Johnson CL et al. | β | 2014 | β |
| Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. | Keipert S et al. | β | 2014 | β |
| SUMO wars. | Fisher FM et al. | β | 2014 | β |
| The broadening spectrum of mitochondrial disease: shifts in the diagnostic paradigm. | Liang C et al. | β | 2014 | β |
| The PPARΞ±-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. | Vernia S et al. | β | 2014 | β |
| The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target. | Liu WY et al. | β | 2014 | β |
| The single nucleotide polymorphism rs499765 is associated with fibroblast growth factor 21 and nonalcoholic fatty liver disease in a Chinese population with normal glucose tolerance. | Jiang S et al. | β | 2014 | β |
| Transcriptional regulation of fibroblast growth factor 21 expression. | Bae KH et al. | β | 2014 | β |
| Up-regulation of endoplasmic reticulum stress induced genes of the unfolded protein response in the liver of periparturient dairy cows. | Gessner DK et al. | β | 2014 | β |
| Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. | Yang C et al. | β | 2013 | β |
| Activation of PPARΞ± ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. | Chan SM et al. | β | 2013 | β |
| Acute exercise induces FGF21 expression in mice and in healthy humans. | Kim KH et al. | β | 2013 | β |
| Adaptive thermogenesis in adipocytes: is beige the new brown? | Wu J et al. | β | 2013 | β |
| Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. | Lin Z et al. | β | 2013 | β |
| A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass. | Gerhard GS et al. | β | 2013 | β |
| Association of fibroblast growth factor (FGF-21) as a biomarker with primary mitochondrial disorders, but not with secondary mitochondrial disorders (Friedreich Ataxia). | Salehi MH et al. | β | 2013 | β |
| Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. | Kim KH et al. | β | 2013 | β |
| Bile acid receptors in non-alcoholic fatty liver disease. | Li Y et al. | β | 2013 | β |
| Bioconversion of Ξ±-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | Alhazzaa R et al. | β | 2013 | β |
| Brown adipose tissue: development, metabolism and beyond. | Schulz TJ et al. | β | 2013 | β |
| Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice. | Gao M et al. | β | 2013 | β |
| CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. | Peterson JM et al. | β | 2013 | β |
| Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody. | Huang J et al. | β | 2013 | β |
| Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine. | Unger RH et al. | β | 2013 | β |
| Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21. | Muise ES et al. | β | 2013 | β |
| Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue. | Liu SQ et al. | β | 2013 | β |
| Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. | Chang I et al. | β | 2013 | β |
| Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV. | Lindegaard B et al. | β | 2013 | β |
| FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress. | Shimizu M et al. | β | 2013 | β |
| FGF-21, a newcomer in the field of hypertension research. | Eto K | β | 2013 | β |
| FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/Ξ²-Klotho bispecific protein. | Smith R et al. | β | 2013 | β |
| FGF21 contributes to neuroendocrine control of female reproduction. | Owen BM et al. | β | 2013 | β |
| Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet. | Murata Y et al. | β | 2013 | β |
| FGF21 mediates the lipid metabolism response to amino acid starvation. | De Sousa-Coelho AL et al. | β | 2013 | β |
| FGF21 regulates metabolism and circadian behavior by acting on the nervous system. | Bookout AL et al. | β | 2013 | β |
| Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology. | Li H et al. | β | 2013 | β |
| Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives. | Woo YC et al. | β | 2013 | β |
| Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. | Schaap FG et al. | β | 2013 | β |
| Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones. | Adams AC et al. | β | 2013 | β |
| Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway. | Foo JP et al. | β | 2013 | β |
| Fibroblast growth factor 21 mediates specific glucagon actions. | Habegger KM et al. | β | 2013 | β |
| Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. | Planavila A et al. | β | 2013 | β |
| Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans. | Kralisch S et al. | β | 2013 | β |
| Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. | Hu MC et al. | β | 2013 | β |
| Forever (FGF) 21. | Bass J | β | 2013 | β |
| Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. | Tanaka T et al. | β | 2013 | β |
| Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis? | Arafat AM et al. | β | 2013 | β |
| Glutamate release mediates leptin action on energy expenditure. | Xu Y et al. | β | 2013 | β |
| High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China. | Li H et al. | β | 2013 | β |
| High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR- Ξ΄ agonism. | Benetti E et al. | β | 2013 | β |
| Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression. | Wu S et al. | β | 2013 | β |
| Increased FGF21 plasma levels in humans with sepsis and SIRS. | Gariani K et al. | β | 2013 | β |
| Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity. | Murphy M et al. | β | 2013 | β |
| Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans. | Lundberg J et al. | β | 2013 | β |
| Ketone body metabolism and cardiovascular disease. | Cotter DG et al. | β | 2013 | β |
| Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. | Kuro-o M | β | 2013 | β |
| Lipocalin 13 regulation of glucose and lipid metabolism in obesity. | Zhou Y et al. | β | 2013 | β |
| Markers in nonalcoholic steatohepatitis. | Armutcu F et al. | β | 2013 | β |
| Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis. | Zeisel SH | β | 2013 | β |
| Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor. | Nelson BT et al. | β | 2013 | β |
| Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues. | Schupp M et al. | β | 2013 | β |
| Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation. | Kim KH et al. | β | 2013 | β |
| Methionine and choline regulate the metabolic phenotype of a ketogenic diet. | Pissios P et al. | β | 2013 | β |
| Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. | Lee P et al. | β | 2013 | β |
| Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology. | Belov AA et al. | β | 2013 | β |
| Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice. | Camacho RC et al. | β | 2013 | β |
| Plasma FGF21 levels are increased in patients with hypothyroidism independently of lipid profile. | Lee Y et al. | β | 2013 | β |
| PPAR-Ξ± as a key nutritional and environmental sensor for metabolic adaptation. | Contreras AV et al. | β | 2013 | β |
| Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model. | Jiang X et al. | β | 2013 | β |
| Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein. | Tong X et al. | β | 2013 | β |
| Regulation of glucose homoeostasis by brown adipose tissue. | Peirce V et al. | β | 2013 | β |
| Retinoic acid receptor Ξ² stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. | Li Y et al. | β | 2013 | β |
| Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. | Stemmer K et al. | β | 2013 | β |
| Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation. | StrΔ czkowski M et al. | β | 2013 | β |
| Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia. | Stepan H et al. | β | 2013 | β |
| Stressed Liver and Muscle Call on Adipocytes with FGF21. | Luo Y et al. | β | 2013 | β |
| TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. | Settembre C et al. | β | 2013 | β |
| The role of mitochondrial DNA mutations and free radicals in disease and ageing. | Lagouge M et al. | β | 2013 | β |
| Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism. | Sun MY et al. | β | 2012 | β |
| Circulating fibroblast growth factors as metabolic regulators--a critical appraisal. | Angelin B et al. | β | 2012 | β |
| Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress. | Yang C et al. | β | 2012 | β |
| Core temperature: a forgotten variable in energy expenditure and obesity? | Landsberg L | β | 2012 | β |
| Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver. | Cicione C et al. | β | 2012 | β |
| Fgf signaling in adipocytes as a target for metabolic diseases. | Ohta H et al. | β | 2012 | β |
| Fibroblast growth factor-21 is a promising dietary restriction mimetic. | Mendelsohn AR et al. | β | 2012 | β |
| Long-term fenofibrate therapy increases fibroblast growth factor 21 and retinol-binding protein 4 in subjects with type 2 diabetes. | Ong KL et al. | β | 2012 | β |
| Metabolic syndrome in youth: current insights and novel serum biomarkers. | Santoro N et al. | β | 2012 | β |
| The use of fish oil lipid emulsion in the treatment of intestinal failure associated liver disease (IFALD). | Chang MI et al. | β | 2012 | β |
| Treating diabetes and obesity with an FGF21-mimetic antibody activating the Ξ²Klotho/FGFR1c receptor complex. | Foltz IN et al. | β | 2012 | β |