Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.
paper
Cited
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- Authors
- Sundstrom-Poromaa, Inger; Smith, Deborah H; Gong, Qi Hua; Sabado, Thomas N; Li, Xinshe; Light, Adam; Wiedmann, Martin; Williams, Keith; Smith, Sheryl S
- Year
- 2002
- Journal
- Nature neuroscience
- PMID
- 12118257
- DOI
- 10.1038/nn888
- PMCID
- PMC2887346
Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.
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| Title | Authors | Journal | Year | Link |
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| Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory results. | Borghese CM et al. | β | 2007 | β |
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| Alcohol alternatives--a goal for psychopharmacology? | Nutt DJ | β | 2006 | β |
| Alcohol alternatives--a goal for psychopharmacology? | Ragan CI | β | 2006 | β |
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| Basis of the gabamimetic profile of ethanol. | Breese GR et al. | β | 2006 | β |
| Changes in expression of the delta subunit of the GABA (A) receptor and in receptor function induced by progesterone exposure and withdrawal. | Mostallino MC et al. | β | 2006 | β |
| Characterization of a novel tonic gamma-aminobutyric acidA receptor-mediated inhibition in magnocellular neurosecretory neurons and its modulation by glia. | Park JB et al. | β | 2006 | β |
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| Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. | Rasmusson AM et al. | β | 2006 | β |
| delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol. | Boehm SL et al. | β | 2006 | β |
| Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors. | Yamashita M et al. | β | 2006 | β |
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| GABA(A) receptor subtypes as targets for neuropsychiatric drug development. | Korpi ER et al. | β | 2006 | β |
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| Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. | Werner DF et al. | β | 2006 | β |
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| Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function. | Serra M et al. | β | 2006 | β |
| Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder. | Smith SS et al. | β | 2006 | β |
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| Distinct patterns of expression and regulation of GABA receptors containing the delta subunit in cerebellar granule and hippocampal neurons. | Follesa P et al. | β | 2005 | β |
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| Laboratory models of alcoholism: treatment target identification and insight into mechanisms. | Lovinger DM et al. | β | 2005 | β |
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| Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety. | Maguire JL et al. | β | 2005 | β |
| Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol. | Olsen RW et al. | β | 2005 | β |
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| The tipsy terminal: presynaptic effects of ethanol. | Siggins GR et al. | β | 2005 | β |
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| Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability. | Carta M et al. | β | 2004 | β |
| Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence. | Liang J et al. | β | 2004 | β |
| A role for GABA mechanisms in the motivational effects of alcohol. | Koob GF | β | 2004 | β |
| Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus. | Verkuyl JM et al. | β | 2004 | β |
| Effects of a low dose of ethanol in an animal model of premenstrual anxiety. | Smith SS et al. | β | 2004 | β |
| Ethanol administration rapidly reverses alpha4 GABAA receptor subunit upregulation following steroid exposure. | Smith SS et al. | β | 2004 | β |
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| Long-term ethanol self-administration by cynomolgus macaques alters the pharmacology and expression of GABAA receptors in basolateral amygdala. | Floyd DW et al. | β | 2004 | β |
| Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons. | Wei W et al. | β | 2004 | β |
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| Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics. | Kralic JE et al. | β | 2003 | β |
| Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans. | Wallner M et al. | β | 2003 | β |
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| Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. | Stell BM et al. | β | 2003 | β |
| Neurosteroid effects on GABAergic synaptic plasticity in hippocampus. | Hsu FC et al. | β | 2003 | β |
| Perinatal neurosteroid levels influence GABAergic interneuron localization in adult rat prefrontal cortex. | Grobin AC et al. | β | 2003 | β |
| Progesterone withdrawal increases the anxiolytic actions of gaboxadol: role of alpha4betadelta GABA(A) receptors. | Gulinello M et al. | β | 2003 | β |
| Progesterone withdrawal reduces paired-pulse inhibition in rat hippocampus: dependence on GABA(A) receptor alpha4 subunit upregulation. | Hsu FC et al. | β | 2003 | β |
| Sex differences in anxiety, sensorimotor gating and expression of the alpha4 subunit of the GABAA receptor in the amygdala after progesterone withdrawal. | Gulinello M et al. | β | 2003 | β |
| Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol. | Serra M et al. | β | 2003 | β |
| The neurobiology and control of anxious states. | Millan MJ | β | 2003 | β |
| The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. | Davies M | β | 2003 | β |
| Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. | Cagetti E et al. | β | 2003 | β |
| The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors. | Belelli D et al. | β | 2002 | β |