Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis.
paper
Cited
Public
Unavailable
- Authors
- Merlo Pich, E; Lorang, M; Yeganeh, M; Rodriguez de Fonseca, F; Raber, J; Koob, G F; Weiss, F
- Year
- 1995
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 7643193
- DOI
- 10.1523/JNEUROSCI.15-08-05439.1995
- PMCID
- PMC6577636
Previous research has suggested a role for corticotropin-releasing factor (CRF) in the anxiogenic effects of stressful stimuli and ethanol withdrawal. This hypothesis was explored in a series of experiments using intracranial microdialysis to monitor CRF-like immunoreactivity (CRF-IR) in the extracellular compartment of the rat amygdala. The synaptic origin of CRF-IR release in the amygdala was determined in vitro by assessing the Ca2+ dependency of 4-aminopyridine stimulated CRF-IR release from tissue preparations of rat amygdala. In vivo experiments were performed in awake rats after the placement of microdialysis probes in the amygdala. In the first experiment, transient restraint stress (20 min) produced an increase of CRF-IR release (basal levels, 1.19 +/- 0.15 fmol/50 microliters; stress levels, 4.54 +/- 1.33 fmol/50 microliters; p < 0.05) that returned to basal values within 1 hr. When 4-aminopyridine (5 mM) was added to the perfusion medium, it consistently increased CRF-IR release (4.83 +/- 0.92 fmol/50 microliters, p < 0.05). In the second experiment, CRF-IR release was measured during ethanol withdrawal in rats previously maintained for 2-3 weeks on a liquid diet containing ethanol (8.5%). Basal CRF-IR levels were 2.10 +/- 0.43 fmol/50 microliters in ethanol exposed rats and 1.30 +/- 0.19 fmol/50 microliters in control rats. During withdrawal, a progressive increase of CRF-IR levels over time was observed, reaching peak values at 10-12 hr after the onset of withdrawal (10.65 +/- 0.49 fmol/50 microliters vs 1.15 +/- 0.30 fmol/50 microliters of control rats, p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Chronic alcohol exposure parametric effects on anxiety- and pain-related behaviors in adult rats. | Secci ME et al. | β | 2026 | β |
| A conceptual framework for the intersection of hyperalgesia and hyperkatifeia in alcohol addiction. | Koob GF et al. | β | 2025 | β |
| Alcohol exacerbates post-traumatic stress psychiatric behavior and its neuropathological sequalae in experimental mice: preventive effects of morin. | Ben-Azu B et al. | β | 2025 | β |
| Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice. | Gianessi CA et al. | β | 2025 | β |
| Distinct Amygdala Neuronal Populations Control Opioid Use and Withdrawal in Mice. | Tortorelli LS et al. | β | 2025 | β |
| Motivating Effects of Negative-hedonic Valence Encoded in Engrams | Nedelescu H et al. | β | 2025 | β |
| Recruitment of Neuronal Populations in the Paraventricular Thalamus of Alcohol-Seeking Rats With Withdrawal-Related Learning Experience. | Nedelescu H et al. | β | 2025 | β |
| Synaptic Effects Induced by Alcohol. | Lovinger DM et al. | β | 2025 | β |
| Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit/Stress Surfeit Disorder. | Koob GF et al. | β | 2025 | β |
| Acute stress activates basolateral amygdala neurons expressing corticotropin-releasing hormone receptor type 1 (CRHR1): Topographical distribution and projection-specific activation in male and female rats. | Aukema RJ et al. | β | 2024 | β |
| Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder. | Cruz B et al. | β | 2024 | β |
| Neurocircuitry underlying the actions of glucagon-like peptide 1 and peptide YY<sub>3</sub><sub>-</sub><sub>36</sub> in the suppression of food, drug-seeking, and anxiogenesis. | Dumiaty Y et al. | β | 2024 | β |
| Neuronal nicotinic acetylcholine receptor of the central amygdala modulates the ethanol-induced tolerance to anxiolysis and withdrawal-induced anxiety in male rats. | Duratkar A et al. | β | 2024 | β |
| Peri-ictal activation of dorsomedial dorsal raphe serotonin neurons reduces mortality associated with maximal electroshock seizures. | Petrucci AN et al. | β | 2024 | β |
| Psychopharmacological interaction of alcohol and posttraumatic stress disorder: Effective action of naringin. | Ben-Azu B et al. | β | 2024 | β |
| Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice. | Mueller LE et al. | β | 2024 | β |
| The CRF/Urocortin systems as therapeutic targets for alcohol use disorders. | Favoretto CA et al. | β | 2024 | β |
| The emerging role of rapid corticosteroid actions on excitatory and inhibitory synaptic signaling in the brain. | JoΓ«ls M et al. | β | 2024 | β |
| Astrocyte expression in the extended amygdala of C57BL/6J mice is sex-dependently affected by chronic intermittent and binge-like ethanol exposure. | Brewton HW et al. | β | 2023 | β |
| Neurotoxicology of alcohol: a bibliometric and science mapping analysis. | Mendes PFS et al. | β | 2023 | β |
| Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses. | Rodriguez L et al. | β | 2022 | β |
| Beyond appetite: Acylated ghrelin as a learning, memory and fear behavior-modulating hormone. | Reich N et al. | β | 2022 | β |
| Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF<sub>1</sub> and orexin receptor signaling. | Flores-Ramirez FJ et al. | β | 2022 | β |
| Central amygdala corticotropin-releasing factor neurons promote hyponeophagia but do not control alcohol drinking in mice. | Kreifeldt M et al. | β | 2022 | β |
| Compulsive alcohol seeking and relapse: Central role of conditioning factors associated with alleviation of withdrawal states by alcohol. | Kozanian OO et al. | β | 2022 | β |
| Corticotropin releasing factor and drug seeking in substance use disorders: Preclinical evidence and translational limitations. | Mantsch JR | β | 2022 | β |
| Generation of a CRF<sub>1</sub>-Cre transgenic rat and the role of central amygdala CRF<sub>1</sub> cells in nociception and anxiety-like behavior. | Weera MM et al. | β | 2022 | β |
| Neurobiological Bases of Alcohol Consumption After Social Stress. | Miczek KA et al. | β | 2022 | β |
| Serum Corticotrophin Releasing Factor (CRF) and its correlation with stress and craving in detoxified opioid-dependent subjects. | Chatterjee B et al. | β | 2022 | β |
| Synaptic effects of IL-1Ξ² and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques. | Patel RR et al. | β | 2022 | β |
| Detection of neuropeptides in vivo and open questions for current and upcoming fluorescent sensors for neuropeptides. | Inutsuka A et al. | β | 2021 | β |
| Drug addiction co-morbidity with alcohol: Neurobiological insights. | McGinn MA et al. | β | 2021 | β |
| Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development. | Koob GF | β | 2021 | β |
| Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs. | Bhat US et al. | β | 2021 | β |
| Roles of corticotropin-releasing factor signaling in the lateral habenula in anxiety-like and alcohol drinking behaviors in male rats. | Zuo W et al. | β | 2021 | β |
| The Role of the Central Amygdala in Alcohol Dependence. | Roberto M et al. | β | 2021 | β |
| Corticotropin releasing factor, but not alcohol, modulates norepinephrine release in the rat central nucleus of the amygdala. | Hedges DM et al. | β | 2020 | β |
| Hippocampal 2-Arachidonoyl Glycerol Signaling Regulates Time-of-Day- and Stress-Dependent Effects on Rat Short-Term Memory. | Santori A et al. | β | 2020 | β |
| Non-pharmacological factors that determine drug use and addiction. | Ahmed SH et al. | β | 2020 | β |
| Possible Role of CRF-Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol-Seeking Behavior. | Kim JS et al. | β | 2020 | β |
| Pre-clinical models of reward deficiency syndrome: A behavioral octopus. | GondrΓ©-Lewis MC et al. | β | 2020 | β |
| Addiction and stress: An allostatic view. | Koob GF et al. | β | 2019 | β |
| Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future. | Cannella N et al. | β | 2019 | β |
| Driving the Downward Spiral: Alcohol-Induced Dysregulation of Extended Amygdala Circuits and Negative Affect. | Centanni SW et al. | β | 2019 | β |
| Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. | de Guglielmo G et al. | β | 2019 | β |
| The neurobiology of addiction. | Uhl GR et al. | β | 2019 | β |
| Acute stress evokes sexually dimorphic, stressor-specific patterns of neural activation across multiple limbic brain regions in adult rats. | Sood A et al. | β | 2018 | β |
| Corticotropin-Releasing Factor (CRF) Neurocircuitry and Neuropharmacology in Alcohol Drinking. | Schreiber AL et al. | β | 2018 | β |
| CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety. | Pleil KE et al. | β | 2018 | β |
| Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. | Serrano A et al. | β | 2018 | β |
| Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence. | Somkuwar SS et al. | β | 2018 | β |
| Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a <i>Crhr1</i> Promoter Polymorphism. | Logrip ML et al. | β | 2018 | β |
| Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions. | Klenowski PM et al. | β | 2018 | β |
| Novel transmitters in brain stem vagal neurocircuitry: new players on the pitch. | BΓΌlbΓΌl M et al. | β | 2018 | β |
| Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol. | Harlan BA et al. | β | 2018 | β |
| Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking. | Lovinger DM | β | 2018 | β |
| The center of the emotional universe: Alcohol, stress, and CRF1 amygdala circuitry. | Agoglia AE et al. | β | 2018 | β |
| Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. | Varodayan FP et al. | β | 2017 | β |
| Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction. | Koob GF | β | 2017 | β |
| Corticotropin-Releasing Factor (CRF) and Addictive Behaviors. | Roberto M et al. | β | 2017 | β |
| Corticotropin Releasing Factor in the Bed Nucleus of the Stria Terminalis in Socially Defeated and Non-stressed Mice with a History of Chronic Alcohol Intake. | Albrechet-Souza L et al. | β | 2017 | β |
| CRF modulates glutamate transmission in the central amygdala of naΓ―ve and ethanol-dependent rats. | Varodayan FP et al. | β | 2017 | β |
| Distribution of type I corticotropin-releasing factor (CRF1) receptors on GABAergic neurons within the basolateral amygdala. | Calakos KC et al. | β | 2017 | β |
| Effects of binge-like ethanol exposure during adolescence on the hyperalgesia observed during sickness syndrome in rats. | de Oliveira BMT et al. | β | 2017 | β |
| Epigenetic basis of the dark side of alcohol addiction. | Pandey SC et al. | β | 2017 | β |
| Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses. | Burke AR et al. | β | 2017 | β |
| Individual differences in the neuropsychopathology of addiction. | George O et al. | β | 2017 | β |
| Influence of stress associated with chronic alcohol exposure on drinking. | Becker HC | β | 2017 | β |
| Localization of the delta opioid receptor and corticotropin-releasing factor in the amygdalar complex: role in anxiety. | Reyes BAS et al. | β | 2017 | β |
| The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target? | Pomrenze MB et al. | β | 2017 | β |
| An Update on CRF Mechanisms Underlying Alcohol Use Disorders and Dependence. | Quadros IM et al. | β | 2016 | β |
| CRF-like receptor SEB-3 in sex-common interneurons potentiates stress handling and reproductive drive in C. elegans. | Jee C et al. | β | 2016 | β |
| CRF receptor type 1 (but not type 2) located within the amygdala plays a role in the modulation of anxiety in mice exposed to the elevated plus maze. | Cipriano AC et al. | β | 2016 | β |
| Emerging targets for addiction neuropharmacology: From mechanisms to therapeutics. | Ubaldi M et al. | β | 2016 | β |
| Exposure to alcohol during adolescence exerts long-term effects on stress response and the adult brain stress circuits. | Allen CD et al. | β | 2016 | β |
| Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents. | Greenberg GD et al. | β | 2016 | β |
| Involvement of CRFR<sub>1</sub> in the Basolateral Amygdala in the Immediate Fear Extinction Deficit. | Hollis F et al. | β | 2016 | β |
| Neurobiological Interactions Between Stress and the Endocannabinoid System. | Morena M et al. | β | 2016 | β |
| Neurobiology of addiction: a neurocircuitry analysis. | Koob GF et al. | β | 2016 | β |
| Persistent adaptation by chronic alcohol is facilitated by neuroimmune activation linked to stress and CRF. | Breese GR et al. | β | 2016 | β |
| Serotonergic Neuroplasticity in Alcohol Addiction. | Belmer A et al. | β | 2016 | β |
| Sex differences in the ontogeny of CRF receptors during adolescent development in the dorsal raphe nucleus and ventral tegmental area. | Lukkes JL et al. | β | 2016 | β |
| Social stress-escalated intermittent alcohol drinking: modulation by CRF-R1 in the ventral tegmental area and accumbal dopamine in mice. | Hwa LS et al. | β | 2016 | β |
| Stress increases GABAergic neurotransmission in CRF neurons of the central amygdala and bed nucleus stria terminalis. | Partridge JG et al. | β | 2016 | β |
| Substance use modulates stress reactivity: Behavioral and physiological outcomes. | Fosnocht AQ et al. | β | 2016 | β |
| Brain pathways to recovery from alcohol dependence. | Cui C et al. | β | 2015 | β |
| Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. | Gray JM et al. | β | 2015 | β |
| Direct targeting of peptidergic amygdalar neurons by noradrenergic afferents: linking stress-integrative circuitry. | Kravets JL et al. | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats. | Cippitelli A et al. | β | 2015 | β |
| Reduction of ethanol intake by corticotropin-releasing factor receptor-1 antagonist in "heavy-drinking" mice in a free-choice paradigm. | Correia D et al. | β | 2015 | β |
| Sociality and the telencephalic distribution of corticotrophin-releasing factor, urocortin 3, and binding sites for CRF type 1 and type 2 receptors: A comparative study of eusocial naked mole-rats and solitary Cape mole-rats. | Coen CW et al. | β | 2015 | β |
| The central amygdala as an integrative hub for anxiety and alcohol use disorders. | Gilpin NW et al. | β | 2015 | β |
| The darkness within: individual differences in stress. | Koob GF | β | 2015 | β |
| The dark side of emotion: the addiction perspective. | Koob GF | β | 2015 | β |
| Addiction as a stress surfeit disorder. | Koob GF et al. | β | 2014 | β |
| Corticotropin releasing factor: a key role in the neurobiology of addiction. | Zorrilla EP et al. | β | 2014 | β |
| Dopamine D2 receptor desensitization by dopamine or corticotropin releasing factor in ventral tegmental area neurons is associated with increased glutamate release. | Nimitvilai S et al. | β | 2014 | β |
| Drug withdrawal conceptualized as a stressor. | Chartoff EH et al. | β | 2014 | β |
| Effects of acupuncture at Zu-San-Li (ST36) on the activity of the hypothalamic--pituitary--adrenal axis during ethanol withdrawal in rats. | Zhao Z et al. | β | 2014 | β |
| Evidence of lasting dysregulation of neuroendocrine and HPA axis function following global cerebral ischemia in male rats and the effect of Antalarmin on plasma corticosterone level. | de la Tremblaye PB et al. | β | 2014 | β |
| Fear extinction learning can be impaired or enhanced by modulation of the CRF system in the basolateral nucleus of the amygdala. | Abiri D et al. | β | 2014 | β |
| Forced swim stress but not exogenous corticosterone could induce the reinstatement of extinguished morphine conditioned place preference in rats: involvement of glucocorticoid receptors in the basolateral amygdala. | Karimi S et al. | β | 2014 | β |
| Neurocircuitry of alcohol addiction: synthesis from animal models. | Koob GF | β | 2014 | β |
| Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. | Kallupi M et al. | β | 2014 | β |
| Predator odor stress alters corticotropin-releasing factor-1 receptor (CRF1R)-dependent behaviors in rats. | Roltsch EA et al. | β | 2014 | β |
| Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway. | Quadros IM et al. | β | 2014 | β |
| Rodent models for compulsive alcohol intake. | Hopf FW et al. | β | 2014 | β |
| Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats. | Grella SL et al. | β | 2014 | β |
| Sex differences in the neurobiology of drug addiction. | Bobzean SA et al. | β | 2014 | β |
| VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. | Grieder TE et al. | β | 2014 | β |
| Addiction is a Reward Deficit and Stress Surfeit Disorder. | Koob GF | β | 2013 | β |
| Adolescent drinking targets corticotropin-releasing factor peptide-labeled cells in the central amygdala of male and female rats. | Karanikas CA et al. | β | 2013 | β |
| Alcohol in excess: CRFβ receptors in the rat and mouse VTA and DRN. | Hwa LS et al. | β | 2013 | β |
| Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. | Zorrilla EP et al. | β | 2013 | β |
| CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food. | Iemolo A et al. | β | 2013 | β |
| CRF mediates the anxiogenic and anti-rewarding, but not the anorectic effects of PACAP. | Dore R et al. | β | 2013 | β |
| Differential activation of neuronal cell types in the basolateral amygdala by corticotropin releasing factor. | Rostkowski AB et al. | β | 2013 | β |
| Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. | Gozzi A et al. | β | 2013 | β |
| Effects of voluntary alcohol drinking on corticotropin-releasing factor and preprodynorphin mRNA levels in the central amygdala of Sardinian alcohol-preferring rats. | Zhou Y et al. | β | 2013 | β |
| Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward. | Silberman Y et al. | β | 2013 | β |
| Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. | Herman MA et al. | β | 2013 | β |
| Inhibition of corticotropin releasing factor expression in the central nucleus of the amygdala attenuates stress-induced behavioral and endocrine responses. | Callahan LB et al. | β | 2013 | β |
| Involvement of parasympathetic pelvic efferent pathway in psychological stress-induced defecation. | Suda K et al. | β | 2013 | β |
| Modeling relapse in animals. | Martin-Fardon R et al. | β | 2013 | β |
| New insights on neurobiological mechanisms underlying alcohol addiction. | Cui C et al. | β | 2013 | β |
| Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice. | Herman MA et al. | β | 2013 | β |
| Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats. | Ayanwuyi LO et al. | β | 2013 | β |
| SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans. | Jee C et al. | β | 2013 | β |
| Synaptic effects induced by alcohol. | Lovinger DM et al. | β | 2013 | β |
| The effects of acute stress on Pavlovian-instrumental transfer in rats. | Pielock SM et al. | β | 2013 | β |
| Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. | Koob GF | β | 2013 | β |
| Adolescent binge drinking leads to changes in alcohol drinking, anxiety, and amygdalar corticotropin releasing factor cells in adulthood in male rats. | Gilpin NW et al. | β | 2012 | β |
| Alcohol dependence as a chronic pain disorder. | Egli M et al. | β | 2012 | β |
| Alcohol withdrawal syndrome. | Carlson RW et al. | β | 2012 | β |
| Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. | George O et al. | β | 2012 | β |
| Behavioural and neuroinflammatory effects of the combination of binge ethanol and MDMA in mice. | Ros-SimΓ³ C et al. | β | 2012 | β |
| CB1 - cannabinoid receptor antagonist effects on cortisol in cannabis-dependent men. | Goodwin RS et al. | β | 2012 | β |
| Compulsive drug use and its neural substrates. | Lesscher HM et al. | β | 2012 | β |
| Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY): effects on inhibitory transmission in central amygdala, and anxiety- & alcohol-related behaviors. | Gilpin NW | β | 2012 | β |
| Corticotropin-releasing factor modulation of forebrain GABAergic transmission has a pivotal role in the expression of anabolic steroid-induced anxiety in the female mouse. | Oberlander JG et al. | β | 2012 | β |
| CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping. | Ingallinesi M et al. | β | 2012 | β |
| Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRFβ receptor antagonism. | Edwards S et al. | β | 2012 | β |
| Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala. | Serrano A et al. | β | 2012 | β |
| Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption. | Becker HC | β | 2012 | β |
| Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. | Gilpin NW et al. | β | 2012 | β |
| Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure. | Cruz MT et al. | β | 2012 | β |
| Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats. | Cippitelli A et al. | β | 2012 | β |
| Quantification of extracellular levels of corticosterone in the basolateral amygdaloid complex of freely-moving rats: a dialysis study of circadian variation and stress-induced modulation. | Bouchez G et al. | β | 2012 | β |
| Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. | Bajo M et al. | β | 2012 | β |
| Repeated restraint stress increases basolateral amygdala neuronal activity in an age-dependent manner. | Zhang W et al. | β | 2012 | β |
| Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity. | Haass-Koffler CL et al. | β | 2012 | β |
| Stress and the HPA axis: role of glucocorticoids in alcohol dependence. | Stephens MA et al. | β | 2012 | β |
| The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. | Burkett JP et al. | β | 2012 | β |
| The central amygdala and alcohol: role of Ξ³-aminobutyric acid, glutamate, and neuropeptides. | Roberto M et al. | β | 2012 | β |
| The genetics of alcohol dependence: advancing towards systems-based approaches. | Palmer RH et al. | β | 2012 | β |
| Tobacco addiction and the dysregulation of brain stress systems. | Bruijnzeel AW | β | 2012 | β |
| Treatment of alcohol dependence with drug antagonists of the stress response. | Higley AE et al. | β | 2012 | β |
| Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat. | Economidou D et al. | β | 2011 | β |
| Activation of corticotropin-releasing factor receptors from the basolateral or central amygdala increases the tonic immobility response in guinea pigs: an innate fear behavior. | Donatti AF et al. | β | 2011 | β |
| Acupuncture Attenuates Anxiety-Like Behavior by Normalizing Amygdaloid Catecholamines during Ethanol Withdrawal in Rats. | Zhao ZL et al. | β | 2011 | β |
| Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. | Breese GR et al. | β | 2011 | β |
| Effects of acute ethanol on corticotropin-releasing hormone and Ξ²-endorphin systems at the level of the rat central amygdala. | Lam MP et al. | β | 2011 | β |
| Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. | Cippitelli A et al. | β | 2011 | β |
| Evolutionary conservation of glucocorticoids and corticotropin releasing hormone: behavioral and physiological adaptations. | Schulkin J | β | 2011 | β |
| Facilitating influence of stress on the consolidation of fear memory induced by a weak training: reversal by midazolam pretreatment. | Maldonado NM et al. | β | 2011 | β |
| Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. | Allen CD et al. | β | 2011 | β |
| Intra-ventral tegmental area or intracerebroventricular orexin-A increases the intra-cranial self-stimulation threshold via activation of the corticotropin-releasing factor system in rats. | Hata T et al. | β | 2011 | β |
| In vivo levels of corticotropin-releasing hormone and gastrin-releasing peptide at the basolateral amygdala and medial prefrontal cortex in response to conditioned fear in the rat. | Mountney C et al. | β | 2011 | β |
| Molecular signaling and translational significance of the corticotropin releasing factor system. | Ronan PJ et al. | β | 2011 | β |
| Negative affect heightens opiate withdrawal-induced hyperalgesia in heroin dependent individuals. | Carcoba LM et al. | β | 2011 | β |
| Persistent escalation of alcohol drinking in C57BL/6J mice with intermittent access to 20% ethanol. | Hwa LS et al. | β | 2011 | β |
| Pharmacogenetic approaches to the treatment of alcohol addiction. | Heilig M et al. | β | 2011 | β |
| Preclinical studies of alcohol binge drinking. | Crabbe JC et al. | β | 2011 | β |
| Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. | Logrip ML et al. | β | 2011 | β |
| The dark side of food addiction. | Parylak SL et al. | β | 2011 | β |
| Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central Amygdala. | Cruz MT et al. | β | 2011 | β |
| Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference. | Giardino WJ et al. | β | 2011 | β |
| Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? | Heilig M et al. | β | 2010 | β |
| Binge-pattern alcohol exposure during puberty induces sexually dimorphic changes in genes regulating the HPA axis. | Przybycien-Szymanska MM et al. | β | 2010 | β |
| Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety. | Thorsell A | β | 2010 | β |
| Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. | Roberto M et al. | β | 2010 | β |
| Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats. | Bruijnzeel AW et al. | β | 2010 | β |
| CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. | Lowery EG et al. | β | 2010 | β |
| Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal. | Krishnan B et al. | β | 2010 | β |
| Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains. | Walker BM et al. | β | 2010 | β |
| Focus on: Neuroscience and treatment: the potential of neuroscience to inform treatment. | Koob GF | β | 2010 | β |
| Interactions of stress and CRF in ethanol-withdrawal induced anxiety in adolescent and adult rats. | Wills TA et al. | β | 2010 | β |
| Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice. | Zhou Y et al. | β | 2010 | β |
| Molecular and genetic substrates linking stress and addiction. | Briand LA et al. | β | 2010 | β |
| mRNA expression of corticotropin-releasing factor and urocortin 1 after restraint and foot shock together with alprazolam administration. | Cespedes IC et al. | β | 2010 | β |
| Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. | Koob GF et al. | β | 2010 | β |
| Neurobiology of dysregulated motivational systems in drug addiction. | Edwards S et al. | β | 2010 | β |
| Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. | Stuber GD et al. | β | 2010 | β |
| Neuroscience of alcoholism: molecular and cellular mechanisms. | Moonat S et al. | β | 2010 | β |
| Pre-clinical evidence that corticotropin-releasing factor (CRF) receptor antagonists are promising targets for pharmacological treatment of alcoholism. | Lowery EG et al. | β | 2010 | β |
| Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats. | Braconi S et al. | β | 2010 | β |
| Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin. | Martin-Fardon R et al. | β | 2010 | β |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | β | 2010 | β |
| The effect of restraint stress on prepulse inhibition and on corticotropin-releasing factor (CRF) and CRF receptor gene expression in Wistar-Kyoto and Brown Norway rats. | Sutherland JE et al. | β | 2010 | β |
| The expression of corticotropin-releasing factor in the central nucleus of the amygdala, induced by colorectal distension, is attenuated by general anesthesia. | Kim SH et al. | β | 2010 | β |
| The role of CRF and CRF-related peptides in the dark side of addiction. | Koob GF | β | 2010 | β |
| Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. | Heilig M et al. | β | 2010 | β |
| Amygdala protein kinase C epsilon controls alcohol consumption. | Lesscher HM et al. | β | 2009 | β |
| Brain stress systems in the amygdala and addiction. | Koob GF | β | 2009 | β |
| Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system. | Sherrin T et al. | β | 2009 | β |
| Combat posttraumatic stress disorder, substance use disorders, and traumatic brain injury. | Brady KT et al. | β | 2009 | β |
| Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents. | Lukkes JL et al. | β | 2009 | β |
| Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse. | Bruijnzeel AW et al. | β | 2009 | β |
| Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. | Marcinkiewcz CA et al. | β | 2009 | β |
| Development of pharmacotherapies for drug addiction: a Rosetta stone approach. | Koob GF et al. | β | 2009 | β |
| Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. | Koob GF | β | 2009 | β |
| Early life social isolation alters corticotropin-releasing factor responses in adult rats. | Lukkes JL et al. | β | 2009 | β |
| Functional CRH variation increases stress-induced alcohol consumption in primates. | Barr CS et al. | β | 2009 | β |
| Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. | Silberman Y et al. | β | 2009 | β |
| Neurobiological substrates for the dark side of compulsivity in addiction. | Koob GF | β | 2009 | β |
| Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala. | Nie Z et al. | β | 2009 | β |
| Stress, alcohol and drug interaction: an update of human research. | Uhart M et al. | β | 2009 | β |
| The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling. | Sparta DR et al. | β | 2009 | β |
| The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory. | Pitts MW et al. | β | 2009 | β |
| The genetics of alcoholism. | Stacey D et al. | β | 2009 | β |
| Transient forebrain over-expression of CRF induces plasma corticosterone and mild behavioural changes in adult conditional CRF transgenic mice. | Vicentini E et al. | β | 2009 | β |
| Young Investigator Award symposium. | Witkiewitz K et al. | β | 2009 | β |
| Acute stress differentially affects corticotropin-releasing hormone mRNA expression in the central amygdala of the "depressed" flinders sensitive line and the control flinders resistant line rats. | Zambello E et al. | β | 2008 | β |
| Addiction and the brain antireward system. | Koob GF et al. | β | 2008 | β |
| Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. | Richardson HN et al. | β | 2008 | β |
| A role for brain stress systems in addiction. | Koob GF | β | 2008 | β |
| Chronic binge-like moderate ethanol drinking in rats results in widespread decreases in brain serotonin, dopamine, and norepinephrine turnover rates reversed by ethanol intake. | Smith JE et al. | β | 2008 | β |
| Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew. | Kozicz T et al. | β | 2008 | β |
| Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems. | Sandi C et al. | β | 2008 | β |
| Combined exposure to nicotine and ethanol in adolescent mice differentially affects anxiety levels during exposure, short-term, and long-term withdrawal. | Abreu-VillaΓ§a Y et al. | β | 2008 | β |
| Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphΓ© differentially affect serotonin release in the nucleus accumbens. | Lukkes JL et al. | β | 2008 | β |
| CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. | Specio SE et al. | β | 2008 | β |
| Dopamine and corticotropin-releasing factor synergistically alter basolateral amygdala-to-medial prefrontal cortex synaptic transmission: functional switch after chronic cocaine administration. | Orozco-Cabal L et al. | β | 2008 | β |
| Early ethanol consumption predicts relapse-like behavior in adolescent male rats. | Schramm-Sapyta NL et al. | β | 2008 | β |
| Effects of acute ethanol on opioid peptide release in the central amygdala: an in vivo microdialysis study. | Lam MP et al. | β | 2008 | β |
| Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. | Gilpin NW et al. | β | 2008 | β |
| Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies. | Anisman H et al. | β | 2008 | β |
| Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. | Koob GF | β | 2008 | β |
| HPA-axis activity in alcoholism: examples for a gene-environment interaction. | Clarke TK et al. | β | 2008 | β |
| Importance of cocaine- and amphetamine-regulated transcript peptide in the central nucleus of amygdala in anxiogenic responses induced by ethanol withdrawal. | Dandekar MP et al. | β | 2008 | β |
| Lesions of the extended amygdala in C57BL/6J mice do not block the intermittent ethanol vapor-induced increase in ethanol consumption. | Dhaher R et al. | β | 2008 | β |
| Listening to neuropeptides by microdialysis: echoes and new sounds? | Wotjak CT et al. | β | 2008 | β |
| MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. | Richardson HN et al. | β | 2008 | β |
| Neurobiology of alcohol dependence: focus on motivational mechanisms. | Gilpin NW et al. | β | 2008 | β |
| Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. | Smith RJ et al. | β | 2008 | β |
| Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala. | Bajo M et al. | β | 2008 | β |
| Review. Neurobiological mechanisms for opponent motivational processes in addiction. | Koob GF et al. | β | 2008 | β |
| Shared mechanisms of alcohol and other drugs. | Cruz MT et al. | β | 2008 | β |
| The influence of stress on the transition from drug use to addiction. | Wand G | β | 2008 | β |
| Transient up-regulation of cocaine- and amphetamine-regulated transcript peptide (CART) immunoreactivity following ethanol withdrawal in rat hypothalamus. | Dandekar MP et al. | β | 2008 | β |
| A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. | Funk CK et al. | β | 2007 | β |
| A key role for corticotropin-releasing factor in alcohol dependence. | Heilig M et al. | β | 2007 | β |
| Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats. | Bruijnzeel AW et al. | β | 2007 | β |
| Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. | Funk CK et al. | β | 2007 | β |
| Corticotropin releasing factor-1 receptor antagonist, CP-154,526, blocks the expression of ethanol-induced behavioral sensitization in DBA/2J mice. | Fee JR et al. | β | 2007 | β |
| CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. | George O et al. | β | 2007 | β |
| Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. | Chu K et al. | β | 2007 | β |
| Differential effects of stress and amphetamine administration on Fos-like protein expression in corticotropin releasing factor-neurons of the rat brain. | Rotllant D et al. | β | 2007 | β |
| Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41). | Finn DA et al. | β | 2007 | β |
| Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol. | Hansson AC et al. | β | 2007 | β |
| Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats. | Zhao Y et al. | β | 2007 | β |
| Role of the amygdala in ethanol withdrawal seizures. | Feng HJ et al. | β | 2007 | β |
| The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. | Marinelli PW et al. | β | 2007 | β |
| The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. | Skelton KH et al. | β | 2007 | β |
| The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal. | Skelton KH et al. | β | 2007 | β |
| The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. | Walker BM et al. | β | 2007 | β |
| A study of the rat neuropeptide B/neuropeptide W system using in situ techniques. | Jackson VR et al. | β | 2006 | β |
| Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA. | Pollandt S et al. | β | 2006 | β |
| Corticotropin-releasing factor (CRF), but not corticosterone, increases basolateral amygdala CRF-binding protein. | Herringa RJ et al. | β | 2006 | β |
| Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system in relation to fear behavior. | Forster GL et al. | β | 2006 | β |
| Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. | Funk CK et al. | β | 2006 | β |
| Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. | Sabino V et al. | β | 2006 | β |
| Glucocorticoids, chronic stress, and obesity. | Dallman MF et al. | β | 2006 | β |
| Individual differences in ethanol self-administration following withdrawal are associated with asymmetric changes in dopamine and serotonin in the medial prefrontal cortex and amygdala. | Carlson JN et al. | β | 2006 | β |
| The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. | Koob GF | β | 2006 | β |
| The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the rat. | Sajdyk TJ et al. | β | 2006 | β |
| Understanding and treating alcohol dependence. | Johnson BA et al. | β | 2006 | β |
| Age-specific threats induce CRF expression in the paraventricular nucleus of the hypothalamus and hippocampus of young rats. | Wiedenmayer CP et al. | β | 2005 | β |
| Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. | Stinus L et al. | β | 2005 | β |
| Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats. | Lawrence AJ et al. | β | 2005 | β |
| Chronic ethanol ingestion modulates proanxiety factors expressed in rat central amygdala. | LΓ€ck AK et al. | β | 2005 | β |
| Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains. | Hayes DM et al. | β | 2005 | β |
| Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis. | Breese GR et al. | β | 2005 | β |
| Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress. | Brady KT et al. | β | 2005 | β |
| Involvement of melanocortin-4 receptor in anxiety and depression. | Chaki S et al. | β | 2005 | β |
| Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. | Plotsky PM et al. | β | 2005 | β |
| Previous stress facilitates fear memory, attenuates GABAergic inhibition, and increases synaptic plasticity in the rat basolateral amygdala. | RodrΓguez Manzanares PA et al. | β | 2005 | β |
| Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety. | Shekhar A et al. | β | 2005 | β |
| Stress enhancement of craving during sobriety: a risk for relapse. | Breese GR et al. | β | 2005 | β |
| The corticotropin-releasing factor (CRF)-system and monoaminergic afferents in the central amygdala: investigations in different mouse strains and comparison with the rat. | Asan E et al. | β | 2005 | β |
| The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal. | Contarino A et al. | β | 2005 | β |
| The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity. | Hayley S et al. | β | 2005 | β |
| The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence. | Bruijnzeel AW et al. | β | 2005 | β |
| Time- and dose-dependent effects of corticotropin releasing factor on cerebral glucose metabolism in rats. | Freo U et al. | β | 2005 | β |
| Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis. | Roberto M et al. | β | 2004 | β |
| A role for GABA mechanisms in the motivational effects of alcohol. | Koob GF | β | 2004 | β |
| Bacterial lipopolysaccharide (LPS) modulates corticotropin-releasing hormone (CRH) content and release in the brain of juvenile and adult tilapia (Oreochromis mossambicus; Teleostei). | Pepels PP et al. | β | 2004 | β |
| Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress. | Dunn AJ et al. | β | 2004 | β |
| Characterization of the human corticotropin-releasing factor2(a) receptor promoter: regulation by glucocorticoids and the cyclic adenosine 5'-monophosphate pathway. | Nanda SA et al. | β | 2004 | β |
| Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders. | Rainnie DG et al. | β | 2004 | β |
| Corticotropin-releasing factor gene expression is down-regulated in the central nucleus of the amygdala of alcohol-preferring rats which exhibit high anxiety: a comparison between rat lines selectively bred for high and low alcohol preference. | Hwang BH et al. | β | 2004 | β |
| Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol. | Palmer AA et al. | β | 2004 | β |
| Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior. | Risbrough VB et al. | β | 2004 | β |
| Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release. | Merali Z et al. | β | 2004 | β |
| Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. | O'Dell LE et al. | β | 2004 | β |
| Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation. | Valdez GR et al. | β | 2004 | β |
| Interactions between NPY and CRF in the amygdala to regulate emotionality. | Sajdyk TJ et al. | β | 2004 | β |
| Neonatal thyroxine treatment: changes in the number of corticotropin-releasing-factor (CRF) and neuropeptide Y (NPY) containing neurons and density of tyrosine hydroxylase positive fibers (TH) in the amygdala correlate with anxiety-related behavior of wistar rats. | Yilmazer-Hanke DM et al. | β | 2004 | β |
| Neurobiological mechanisms in addictive and psychiatric disorders. | Bruijnzeel AW et al. | β | 2004 | β |
| Neuroendocrine pathways of addictive behaviour. | Kiefer F et al. | β | 2004 | β |
| Neuropeptides: implications for alcoholism. | Cowen MS et al. | β | 2004 | β |
| Region-specific alterations of neuronal nitric oxide synthase (nNOS) expression in the amygdala of the aged rats. | Joo KM et al. | β | 2004 | β |
| Regulation of CRF, POMC and MC4R gene expression after electrical foot shock stress in the rat amygdala and hypothalamus. | Yamano Y et al. | β | 2004 | β |
| Regulation of hypoxia-induced release of corticotropin-releasing factor in the rat hypothalamus by norepinephrine. | Chen XQ et al. | β | 2004 | β |
| SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats. | Knapp DJ et al. | β | 2004 | β |
| Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression. | Skelton KH et al. | β | 2004 | β |
| Stress induces CRF release in the paraventricular nucleus, and both CRF and GABA release in the amygdala. | Cook CJ | β | 2004 | β |
| Systemic adrenocorticotropic hormone administration down-regulates the expression of corticotropin-releasing hormone (CRH) and CRH-binding protein in infant rat hippocampus. | Wang W et al. | β | 2004 | β |
| The effects of acute stress on the regulation of central and basolateral amygdala CRF-binding protein gene expression. | Herringa RJ et al. | β | 2004 | β |
| The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. | Pandey SC | β | 2004 | β |
| Time-dependent changes in CRH concentrations and release in discrete brain regions following global ischemia: effects of MK-801 pretreatment. | Khan S et al. | β | 2004 | β |
| Alcohol and withdrawal: from animal research to clinical issues. | De Witte P et al. | β | 2003 | β |
| Alcoholism: allostasis and beyond. | Koob GF | β | 2003 | β |
| Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. | Valdez GR et al. | β | 2003 | β |
| A robust animal model of state anxiety: fear-potentiated behaviour in the elevated plus-maze. | Korte SM et al. | β | 2003 | β |
| Cannabinoids: reward, dependence, and underlying neurochemical mechanisms--a review of recent preclinical data. | Tanda G et al. | β | 2003 | β |
| c-Fos and peptide immunoreactivities in the central extended amygdala of morphine-dependent rats after naloxone-precipitated withdrawal. | Veinante P et al. | β | 2003 | β |
| Differential impact of audiogenic stressors on Lewis and Fischer rats: behavioral, neurochemical, and endocrine variations. | Michaud DS et al. | β | 2003 | β |
| Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli. | Merali Z et al. | β | 2003 | β |
| Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. | Roberto M et al. | β | 2003 | β |
| Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine. | Zhou Y et al. | β | 2003 | β |
| Interrelations between monoaminergic afferents and corticotropin-releasing factor-immunoreactive neurons in the rat central amygdaloid nucleus: ultrastructural evidence for dopaminergic control of amygdaloid stress systems. | Eliava M et al. | β | 2003 | β |
| Monoaminergic activity in subregions of raphΓ© nuclei elicited by prior stress and the neuropeptide corticotropin-releasing factor. | Summers CH et al. | β | 2003 | β |
| Neuroadaptive mechanisms of addiction: studies on the extended amygdala. | Koob GF | β | 2003 | β |
| Stimulus conditioned to foot-shock stress reinstates alcohol-seeking behavior in an animal model of relapse. | Liu X et al. | β | 2003 | β |
| The effects of corticotropin-releasing factor on the cortical EEG are reduced following adolescent nicotine exposure. | Slawecki CJ et al. | β | 2003 | β |
| The neurobiology of addiction. | Maldonado R | β | 2003 | β |
| The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review. | Seymour PA et al. | β | 2003 | β |
| The reinstatement model of drug relapse: history, methodology and major findings. | Shaham Y et al. | β | 2003 | β |
| Addictive potential of cannabinoids: the underlying neurobiology. | Gardner EL | β | 2002 | β |
| Altered EEG responses to ethanol in adult rats exposed to ethanol during adolescence. | Slawecki CJ | β | 2002 | β |
| Behavioral neurobiology of alcohol addiction: recent advances and challenges. | Weiss F et al. | β | 2002 | β |
| Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake. | Olive MF et al. | β | 2002 | β |
| ERK regulation in chronic ethanol exposure and withdrawal. | Sanna PP et al. | β | 2002 | β |
| Gastrin-releasing peptide mediated regulation of 5-HT neuronal activity in the hypothalamic paraventricular nucleus under basal and restraint stress conditions. | Garrido MM et al. | β | 2002 | β |
| Glucocorticoid feedback increases the sensitivity of the limbic system to stress. | Cook CJ | β | 2002 | β |
| Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. | Valdez GR et al. | β | 2002 | β |
| Multiple feedback mechanisms activating corticotropin-releasing hormone system in the brain during stress. | Makino S et al. | β | 2002 | β |
| Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. | Murphy JM et al. | β | 2002 | β |
| Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment. | Stout SC et al. | β | 2002 | β |
| The corticotropin-releasing factor/urocortin system and alcohol. | Ryabinin AE et al. | β | 2002 | β |
| Alterations in central preproenkephalin mRNA expression after chronic free-choice ethanol consumption by fawn-hooded rats. | Cowen MS et al. | β | 2001 | β |
| Central CRH suppresses specific antibody responses: effects of beta-adrenoceptor antagonism and adrenalectomy. | Friedman EM et al. | β | 2001 | β |
| Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. | Weiss F et al. | β | 2001 | β |
| Corticosteroids in relation to fear, anxiety and psychopathology. | Korte SM | β | 2001 | β |
| Corticotropin-releasing hormone in depression and post-traumatic stress disorder. | Kasckow JW et al. | β | 2001 | β |
| Corticotropin-releasing hormone messenger RNA distribution and stress-induced activation in the thalamus. | Hsu DT et al. | β | 2001 | β |
| Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat. | Merali Z et al. | β | 2001 | β |
| Drug addiction: functional neurotoxicity of the brain reward systems. | Weiss F et al. | β | 2001 | β |
| Effects of acute and repeated restraint stress on corticotropin-releasing hormone binding protein mRNA in rat amygdala and dorsal hippocampus. | Lombardo KA et al. | β | 2001 | β |
| Elevated corticotropin releasing hormone/corticotropin releasing hormone-R1 expression in postmortem brain obtained from children with generalized epilepsy. | Wang W et al. | β | 2001 | β |
| Measuring of extracellular cortisol and corticotropin-releasing hormone in the amygdala using immunosensor coupled microdialysis. | Cook CJ | β | 2001 | β |
| Neurobiological processes in alcohol addiction. | LΓͺ AD et al. | β | 2001 | β |
| Neurobiology of the nicotine withdrawal syndrome. | Kenny PJ et al. | β | 2001 | β |
| Recent research on alcohol tolerance and dependence. | Suwaki H et al. | β | 2001 | β |
| Stress-induced sensitization of CRH-ir but not P-CREB-ir responsivity in the rat central nervous system. | Bruijnzeel AW et al. | β | 2001 | β |
| Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. | Jacobsen LK et al. | β | 2001 | β |
| The combined dexamethasone-suppression/CRH-stimulation test in alcoholics during and after acute withdrawal. | Hundt W et al. | β | 2001 | β |
| Acute ethanol induction of c-Fos immunoreactivity in pre-pro-enkephalin expressing neurons of the central nucleus of the amygdala. | Criado JR et al. | β | 2000 | β |
| Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats. | Pisarska M et al. | β | 2000 | β |
| Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study. | Richter RM et al. | β | 2000 | β |
| Cerebrospinal fluid corticotropin-releasing hormone levels are elevated in monkeys with patterns of brain activity associated with fearful temperament. | Kalin NH et al. | β | 2000 | β |
| Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems. | Skelton KH et al. | β | 2000 | β |
| Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior. | Shepard JD et al. | β | 2000 | β |
| Hypothalamic and amygdalar neuronal responses to various tastant solutions during ingestive behavior in rats. | Nishijo H et al. | β | 2000 | β |
| Neurobiology of addiction. Toward the development of new therapies. | Koob GF | β | 2000 | β |
| Role of corticotropin-releasing factor receptor-1 in opiate withdrawal. | Iredale PA et al. | β | 2000 | β |
| Stress-induced relapse to heroin and cocaine seeking in rats: a review. | Shaham Y et al. | β | 2000 | β |
| Alcohol withdrawal in the surgical patient: prevention and treatment. | Spies CD et al. | β | 1999 | β |
| A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. | Koob GF et al. | β | 1999 | β |
| Corticotropin-releasing factor, norepinephrine, and stress. | Koob GF | β | 1999 | β |
| Corticotropin-releasing hormone receptor subtypes and emotion. | Steckler T et al. | β | 1999 | β |
| Effect of 6-hydroxydopamine on neuropeptide Y and corticotropin-releasing factor expression in rat amygdala. | SmiaΕowska M et al. | β | 1999 | β |
| Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress. | Dunn AJ et al. | β | 1999 | β |
| Hypothalamus, anterior pituitary and adrenal gland involvement in the activation of adrenocorticotropin and corticosterone secretion by gastrin-releasing peptide. | Garrido MM et al. | β | 1999 | β |
| Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists. | Baram TZ et al. | β | 1999 | β |
| In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self-administering rats. | Richter RM et al. | β | 1999 | β |
| N-methyl-D-aspartate (NMDA)-mediated corticotropin-releasing factor (CRF) release in cultured rat amygdala neurons. | Cratty MS et al. | β | 1999 | β |
| Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat. | Makino S et al. | β | 1999 | β |
| Regulation of corticotropin-releasing factor messenger RNA by nicotine in an immortalized amygdalar cell line. | Kasckow JW et al. | β | 1999 | β |
| Stress, corticotropin-releasing factor, and drug addiction. | Koob GF | β | 1999 | β |
| A chilled-out knockout. | Borrelli E | β | 1998 | β |
| Aversive and appetitive events evoke the release of corticotropin-releasing hormone and bombesin-like peptides at the central nucleus of the amygdala. | Merali Z et al. | β | 1998 | β |
| Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol. | Hutcheson DM et al. | β | 1998 | β |
| Cannabinoid transmission and reward-related events. | Gardner EL et al. | β | 1998 | β |
| Circuits, drugs, and drug addiction. | Koob GF | β | 1998 | β |
| Detrimental effects of chronic hypothalamic-pituitary-adrenal axis activation. From obesity to memory deficits. | Raber J | β | 1998 | β |
| Drug dependence: stress and dysregulation of brain reward pathways. | Kreek MJ et al. | β | 1998 | β |
| Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. | Timpl P et al. | β | 1998 | β |
| Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. | Schulkin J et al. | β | 1998 | β |
| Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function. | Raber J et al. | β | 1998 | β |
| Neurocircuitry targets in ethanol reward and dependence. | Koob GF et al. | β | 1998 | β |
| Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain. | Baram TZ et al. | β | 1998 | β |
| Neuroscience of addiction. | Koob GF et al. | β | 1998 | β |
| Relapse to drug-seeking: neural and molecular mechanisms. | Self DW et al. | β | 1998 | β |
| Role of the limbic system in dependence on drugs. | RodrΓguez de Fonseca F et al. | β | 1998 | β |
| Serotonin modulation of sensory inputs to the lateral amygdala: dependency on corticosterone. | Stutzmann GE et al. | β | 1998 | β |
| The role of corticotropin-releasing factor and corticosterone in stress- and cocaine-induced relapse to cocaine seeking in rats. | Erb S et al. | β | 1998 | β |
| Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. | RodrΓguez de Fonseca F et al. | β | 1997 | β |
| Alcohol increases the expression of type 1, but not type 2 alpha corticotropin-releasing factor (CRF) receptor messenger ribonucleic acid in the rat hypothalamus. | Lee S et al. | β | 1997 | β |
| Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. | Shaham Y et al. | β | 1997 | β |
| Drug abuse: hedonic homeostatic dysregulation. | Koob GF et al. | β | 1997 | β |
| Neurobiology of fear responses: the role of the amygdala. | Davis M | β | 1997 | β |
| Regulation of corticotropin-releasing factor (CRF) messenger ribonucleic acid and CRF peptide in the amygdala: studies in primary amygdalar cultures. | Kasckow JW et al. | β | 1997 | β |
| Role of the hippocampus, the bed nucleus of the stria terminalis, and the amygdala in the excitatory effect of corticotropin-releasing hormone on the acoustic startle reflex. | Lee Y et al. | β | 1997 | β |
| The neurobiology of addiction: an overview. | Roberts AJ et al. | β | 1997 | β |
| The neurobiology of drug addiction. | Koob GF et al. | β | 1997 | β |
| CRH-R1 mRNA expression in two strains of inbred mice and its regulation after repeated restraint stress. | Giardino L et al. | β | 1996 | β |
| Drug addiction: the yin and yang of hedonic homeostasis. | Koob GF | β | 1996 | β |
| Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. | Weiss F et al. | β | 1996 | β |
| Reinforcement processes in opiate addiction: a homeostatic model. | Schulteis G et al. | β | 1996 | β |