Prenatal ethanol exposure, generalized learning impairment, and medial prefrontal cortical deficits in rats.
paper
Cited
Public
Unavailable
- Authors
- Mihalick, S M; Crandall, J E; Langlois, J C; Krienke, J D; Dube, W V
- Year
- 2001
- Journal
- Neurotoxicology and teratology
- PMID
- 11711248
- DOI
- 10.1016/s0892-0362(01)00168-4
Prenatal ethanol exposure may cause neurological damage and subsequent mental retardation in humans, with learning deficits similar to those following damage to the prefrontal cortex. This study examined cognitive dysfunction and cortical damage after prenatal exposure to ethanol using a chronic administration model. Pregnant Sprague-Dawley rats received one of three diets during gestation: a liquid diet containing 35% ethanol-derived calories (ETOH), an isocaloric liquid diet (ISO), or standard chow (CHOW). Subjects were obtained from ETOH dams with blood alcohol concentrations (BACs) above 90 mg/dl and corresponding ISO and CHOW controls (one male pup/litter; n=6 pups/group). At approximately 90 days of age, subjects began training on a series of unique auditory discrimination problems using a successive go/no-go procedure. A criterion of 85% accuracy determined when a rat continued to the next problem. Subjects completed a varying number of problems within a 30-session limit, after which all rats were tested on a tone/click discrimination and reversal. Subjects were then sacrificed and neuronal number in the medial prefrontal cortex (mPFC) was estimated by the optical fractionator method. Prenatal ethanol exposure induced significant cell loss in the mPFC, which was associated with significantly impaired reversal learning. Poor performance by ETOH subjects on the tone/click reversal indicates a transfer of training deficit that may reflect failures of inhibitory control.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Animal Models of Prenatal Alcohol Exposure. | Reid HMO et al. | — | 2026 | → |
| CE-123, a novel dopamine transporter inhibitor, attenuates locomotor hyperactivity and improves cognitive functions in rat model of fetal alcohol spectrum disorders. | Gibula-Tarlowska E et al. | — | 2021 | → |
| Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry. | Dannenhoffer CA et al. | — | 2021 | → |
| Corticostriatal Circuit Models of Cognitive Impairments Induced by Fetal Exposure to Alcohol. | Bariselli S et al. | — | 2021 | → |
| How prenatal exposures shape the infant brain: Insights from infant neuroimaging studies. | Dufford AJ et al. | — | 2021 | → |
| Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function. | Savage LM et al. | — | 2021 | → |
| Moderate prenatal alcohol exposure impairs cognitive control, but not attention, on a rodent touchscreen continuous performance task. | Olguin SL et al. | — | 2021 | → |
| An Emergent Discriminative Learning Is Elicited During Multifrequency Testing. | Zhang X et al. | — | 2019 | → |
| Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study. | Tang S et al. | — | 2019 | → |
| Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure. | Gursky ZH et al. | — | 2019 | → |
| [Experimental approaches to the investigation of behavioral disorders associated with prenatal alcohol exposure]. | Razumkina EV et al. | — | 2018 | → |
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | Wetherill L et al. | — | 2018 | → |
| Prenatal alcohol exposure disrupts male adolescent social behavior and oxytocin receptor binding in rodents. | Holman PJ et al. | — | 2018 | → |
| Preserved cortical asymmetry despite thinner cortex in children and adolescents with prenatal alcohol exposure and associated conditions. | Zhou D et al. | — | 2018 | → |
| Choline and Working Memory Training Improve Cognitive Deficits Caused by Prenatal Exposure to Ethanol. | Waddell J et al. | — | 2017 | → |
| [Formula: see text]Parent rating of executive function in fetal alcohol spectrum disorder: A review of the literature and new data on Aboriginal Canadian children. | Rai JK et al. | — | 2017 | → |
| Behavioral deficits induced by third-trimester equivalent alcohol exposure in male C57BL/6J mice are not associated with reduced adult hippocampal neurogenesis but are still rescued with voluntary exercise. | Hamilton GF et al. | — | 2016 | → |
| Modeling Symptoms of Attention-Deficit Hyperactivity Disorder in a Rat Model of Fetal Alcohol Syndrome. | Atalar EG et al. | — | 2016 | → |
| The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models. | Marquardt K et al. | — | 2016 | → |
| Alcohol exposure in utero perturbs retinoid homeostasis in adult rats. | Kim YK et al. | — | 2015 | → |
| An fMRI study of behavioral response inhibition in adolescents with and without histories of heavy prenatal alcohol exposure. | Ware AL et al. | — | 2015 | → |
| Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex. | Bird CW et al. | — | 2015 | → |
| A comparison of the different animal models of fetal alcohol spectrum disorders and their use in studying complex behaviors. | Patten AR et al. | — | 2014 | → |
| Examination of age-dependent effects of fetal ethanol exposure on behavior, hippocampal cell counts, and doublecortin immunoreactivity in rats. | Elibol-Can B et al. | — | 2014 | → |
| Sex differences in cognitive impairment and Alzheimer's disease. | Li R et al. | — | 2014 | → |
| An NCAM mimetic, FGL, alters hippocampal cellular morphometry in young adult (4 month-old) rats. | Ojo B et al. | — | 2013 | → |
| Effects of exercise and environmental complexity on deficits in trace and contextual fear conditioning produced by neonatal alcohol exposure in rats. | Schreiber WB et al. | — | 2013 | → |
| Hippocampal-dependent Pavlovian conditioning in adult rats exposed to binge-like doses of ethanol as neonates. | Lindquist DH | — | 2013 | → |
| The effect of low-to-moderate-dose ethanol consumption on rat mammary gland structure and function and early postnatal growth of offspring. | Probyn ME et al. | — | 2013 | → |
| The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior. | Gulley JM et al. | — | 2013 | → |
| Acute and long-term Purkinje cell loss following a single ethanol binge during the early third trimester equivalent in the rat. | Idrus NM et al. | — | 2012 | → |
| Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure. | Bañuelos C et al. | — | 2012 | → |
| Effects of ethanol during adolescence on the number of neurons and glia in the medial prefrontal cortex and basolateral amygdala of adult male and female rats. | Koss WA et al. | — | 2012 | → |
| Selective effects of perinatal ethanol exposure in medial prefrontal cortex and nucleus accumbens. | Lawrence RC et al. | — | 2012 | → |
| Alcohol exposure in utero leads to enhanced prepubertal mammary development and alterations in mammary IGF and estradiol systems. | Polanco TA et al. | — | 2011 | → |
| Developmental cortical thinning in fetal alcohol spectrum disorders. | Zhou D et al. | — | 2011 | → |
| Executive function and memory in children with Fetal Alcohol Spectrum Disorder. | Pei J et al. | — | 2011 | → |
| The effects of prenatal alcohol exposure on behavior: rodent and primate studies. | Schneider ML et al. | — | 2011 | → |
| Fetal alcohol exposure increases mammary tumor susceptibility and alters tumor phenotype in rats. | Polanco TA et al. | — | 2010 | → |
| Magnetic resonance microscopy-based analyses of the brains of normal and ethanol-exposed fetal mice. | O'Leary-Moore SK et al. | — | 2010 | → |
| Deficits in trace fear conditioning in a rat model of fetal alcohol exposure: dose-response and timing effects. | Hunt PS et al. | — | 2009 | → |
| Executive functioning in children with Fetal Alcohol Spectrum Disorders: profiles and age-related differences. | Rasmussen C et al. | — | 2009 | → |
| Neuronal reduction in frontal cortex of primates after prenatal alcohol exposure. | Burke MW et al. | — | 2009 | → |
| Prenatal psychosocial stress exposure is associated with subsequent working memory performance in young women. | Entringer S et al. | — | 2009 | → |
| Computational models of ethanol-induced neurodevelopmental toxicity across species: Implications for risk assessment. | Gohlke JM et al. | — | 2008 | → |
| Postnatal binge-like alcohol exposure reduces spine density without affecting dendritic morphology in rat mPFC. | Whitcher LT et al. | — | 2008 | → |
| Fetal alcohol syndrome and the developing socio-emotional brain. | Niccols A | — | 2007 | → |
| Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle. | Day-Wilson KM et al. | — | 2006 | → |
| Reversal learning after prenatal or early postnatal alcohol exposure in juvenile and adult rats. | O'Leary-Moore SK et al. | — | 2006 | → |
| A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. | Gohlke JM et al. | — | 2005 | → |
| Contextual modulation of spatial discrimination reversal in developing rats. | Pagani JH et al. | — | 2005 | → |
| Executive functioning and working memory in fetal alcohol spectrum disorder. | Rasmussen C | — | 2005 | → |
| Prenatal alcohol exposure alters the size, but not the pattern, of the whisker representation in neonatal rat barrel cortex. | Margret CP et al. | — | 2005 | → |
| Prenatal ethanol exposure in rats decreases levels of complexin proteins in the frontal cortex. | Barr AM et al. | — | 2005 | → |
| Chronic prenatal ethanol exposure impairs conditioned responding and enhances GABA release in the hippocampus of the adult guinea pig. | Hayward ML et al. | — | 2004 | → |
| Executive functioning in preschool-age children prenatally exposed to alcohol, cocaine, and marijuana. | Noland JS et al. | — | 2003 | → |