EEG abnormalities before clozapine therapy predict a good clinical response to clozapine.
- Authors
- Pillay, S S; Stoll, A L; Weiss, M K; Tohen, M; Zarate, C A; Banov, M D; Cole, J O
- Year
- 1996
- Journal
- Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
- PMID
- 8743641
- DOI
- 10.3109/10401239609149083
The purpose of this study was to test the hypothesis that minor EEG abnormalities predict a favorable response to clozapine. Eighty-six psychotic clozapine-treated psychiatric inpatients with EEG records before starting clozapine were included in the study. When all diagnostic groups were combined, there were no significant differences in clinical outcome between patients with abnormal EEGs and patients with normal EEGs. However, female patients with abnormal EEGs had a significantly greater improvement in Global Assessment of Functioning (GAF) scores compared to female patients with normal EEGs. In addition, patients with major depressive episodes (bipolar, schizoaffective, unipolar) and abnormal EEGs had a significantly greater improvement in GAF scores compared to the same subgroup of patients with normal EEGs. The results suggest that EEG abnormalities before clozapine treatment many predict a favorable clinical response in specific groups of patients.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Pharmaco-EEG of antipsychotic treatment response: a systematic review. | De Pieri M et al. | — | 2023 | → |
| Evaluating the evidence for sex differences: a scoping review of human neuroimaging in psychopharmacology research. | Duffy KA et al. | — | 2022 | → |
| Clozapine: Why Is It So Uniquely Effective in the Treatment of a Range of Neuropsychiatric Disorders? | Gammon D et al. | — | 2021 | → |
| A Machine Learning Approach Using Effective Connectivity to Predict Response to Clozapine Treatment. | Ciprian C et al. | — | 2020 | → |
| Biological Predictors of Clozapine Response: A Systematic Review. | Samanaite R et al. | — | 2018 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
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| Clozapine in bipolar disorder: treatment implications for other atypical antipsychotics. | Frye MA et al. | — | 1998 | → |