Differences in brain function between relapsing and abstaining alcohol-dependent patients, evaluated by EEG mapping.
paper
Cited
Public
Unavailable
- Authors
- Saletu-Zyhlarz, Gerda M; Arnold, Oliver; Anderer, Peter; Oberndorfer, Stefan; Walter, Henriette; Lesch, Otto M; Böning, Jobst; Saletu, Bernd
- Year
- 2004
- Journal
- Alcohol and alcoholism (Oxford, Oxfordshire)
- PMID
- 15082461
- DOI
- 10.1093/alcalc/agh041
AIMS: Early clinical electroencephalographers reported that low-voltage fast desynchronized patterns were frequently seen in chronic alcoholism, suggesting hyperarousal of the central nervous system (CNS). The aim of the present study was to investigate the brain function of drug-free, detoxified alcoholics, and compare this with that of normal controls, utilizing computerized quantitative EEG analysis and subsequent EEG mapping. Moreover, differences between patients relapsing or abstaining during 6 months of relapse prevention therapy, pharmacologically supported by either flupentixol decanoate 10 mg or placebo i.m. every 2 weeks, were determined. METHODS: 22 drug-free, detoxified patients (15 men, seven women) aged between 27 and 58 (mean 41.5 +/- 8.1) years, diagnosed as alcohol-dependent (ICD-10: F10.23) were included in the study. They were subdivided into abstainers (n = 11) and relapsers (n = 11), and matched with normal healthy controls according to age (mean 41.5 +/- 8.4 years) and sex. A 3-min vigilance-controlled EEG (V-EEG) was obtained and analysed off-line by multi-lead EEG power spectral analysis and subsequent mapping methods. RESULTS: The drug-free, detoxified, alcohol-dependent patients showed, as compared with controls, aberrant brain function characterized by a decrease in delta and slow alpha and an increase in beta activity as well as an acceleration of the total centroid. These findings were more pronounced in relapsing than in abstaining patients. After 6 months of treatment, abstaining patients showed an increase in slow activity, a decrease in fast alpha, an acceleration of the delta/theta centroid and a deceleration of the alpha centroid, reflecting a normalization of brain function. CONCLUSION: EEG maps of alcohol-dependent patients differ significantly from those of normal controls and patients suffering from other mental disorders and thus EEG mapping may be used for diagnostic purposes. Moreover, the quantitative EEG may also be of prognostic value as relapsing patients differ from abstaining ones, since they show a significantly more pronounced hyperarousal of the CNS.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| EEG Microstate Correlates of Emotional Processing in Patients with Alcohol use Disorder and Healthy Controls: An Exploratory Resting-EEG Study. | Affentranger OB et al. | — | 2026 | → |
| Quantitative Electroencephalogram in Persons with Alcohol Dependence Syndrome: A Pre- and Post-Treatment Findings. | Sharma S et al. | — | 2026 | → |
| Altered Low-beta Characteristics in Individuals With Alcohol Use Disorder: A Pilot Resting Electroencephalography Study. | Li B et al. | — | 2025 | → |
| Decreasing brain activity caused by acute administration of ketamine and alcohol - A randomized, controlled, observer-blinded experimental study. | Ferreira LO et al. | — | 2024 | → |
| Measurement of craving among gamers with internet gaming disorder using repeated presentations of game videos: a resting-state electroencephalography study. | Park S et al. | — | 2023 | → |
| Problematic social media use is associated with depression and similar to behavioral addictions: Physiological and behavioral evidence. | Tsilosani A et al. | — | 2023 | → |
| Targeting electroencephalography for alcohol dependence: A narrative review. | Zhang H et al. | — | 2023 | → |
| A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment. | Bel-Bahar TS et al. | — | 2022 | → |
| EEG Neurofeedback in the Treatment of Adults with Binge-Eating Disorder: a Randomized Controlled Pilot Study. | Blume M et al. | — | 2022 | → |
| Electroencephalographic neurofeedback as a tool for reducing harm and risk associated with alcohol use disorder: A critical review. | Lima KHM et al. | — | 2022 | → |
| Sensation Seeking and Adolescent Drinking: Do Protective Behavioral Strategies Lower Risk? | Doumas DM et al. | — | 2022 | → |
| Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder. | Fish KN et al. | — | 2022 | → |
| Effectiveness of an Integrated Intervention Program for Alcoholism: Electrophysiological Findings. | Kumar R et al. | — | 2021 | → |
| Bridging the gap – Spontaneous fluctuations shape stimulus-evoked spectral power | Wainio-Theberge S et al. | — | 2020 | — |
| Computer-aided classifying and characterizing of methamphetamine use disorder using resting-state EEG. | Khajehpour H et al. | — | 2019 | → |
| Cortical networks are disturbed in people with cirrhosis even in the absence of neuropsychometric impairment. | Olesen SS et al. | — | 2019 | → |
| Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol-Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort. | Meda SA et al. | — | 2019 | → |
| A review on EEG-based methods for screening and diagnosing alcohol use disorder. | Mumtaz W et al. | — | 2018 | → |
| EEG Frequency Bands in Psychiatric Disorders: A Review of Resting State Studies. | Newson JJ et al. | — | 2018 | → |
| High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults. | Affan RO et al. | — | 2018 | → |
| A genome wide association study of fast beta EEG in families of European ancestry. | Meyers JL et al. | — | 2017 | → |
| An EEG-based machine learning method to screen alcohol use disorder. | Mumtaz W et al. | — | 2017 | → |
| An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. | Meyers JL et al. | — | 2017 | → |
| Associations between prospective symptom changes and slow-wave activity in patients with Internet gaming disorder: A resting-state EEG study. | Kim YJ et al. | — | 2017 | → |
| Quantitative EEG during normal aging: association with the Alzheimer's disease genetic risk variant in PICALM gene. | Ponomareva NV et al. | — | 2017 | → |
| Short-term Beneficial Effects of 12 Sessions of Neurofeedback on Avoidant Personality Accentuation in the Treatment of Alcohol Use Disorder. | Dalkner N et al. | — | 2017 | → |
| The Brain of Binge Drinkers at Rest: Alterations in Theta and Beta Oscillations in First-Year College Students with a Binge Drinking Pattern. | López-Caneda E et al. | — | 2017 | → |
| EEG neurofeedback effects in the treatment of adolescent anorexia nervosa. | Lackner N et al. | — | 2016 | → |
| Electroencephalogram variability in patients with cirrhosis associates with the presence and severity of hepatic encephalopathy. | Olesen SS et al. | — | 2016 | → |
| Functional Connectivity and Quantitative EEG in Women with Alcohol Use Disorders: A Resting-State Study. | Herrera-Díaz A et al. | — | 2016 | → |
| Resting-state EEG, impulsiveness, and personality in daily and nondaily smokers. | Rass O et al. | — | 2016 | → |
| The Effectiveness of Visual Short-Time Neurofeedback on Brain Activity and Clinical Characteristics in Alcohol Use Disorders: Practical Issues and Results. | Lackner N et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Exploratory Analysis of Power Spectrum and Functional Connectivity During Resting State in Young Binge Drinkers: A MEG Study. | Correas A et al. | — | 2015 | → |
| Neurofeedback reduces overeating episodes in female restrained eaters: a randomized controlled pilot-study. | Schmidt J et al. | — | 2015 | → |
| Neurophysiological features of Internet gaming disorder and alcohol use disorder: a resting-state EEG study. | Son KL et al. | — | 2015 | → |
| Reduced processing of alcohol cues predicts abstinence in recently detoxified alcoholic patients in a three-month follow up period: an ERP study. | Petit G et al. | — | 2015 | → |
| Alcohol and the sleeping brain. | Colrain IM et al. | — | 2014 | → |
| Differential resting-state EEG patterns associated with comorbid depression in Internet addiction. | Lee J et al. | — | 2014 | → |
| Ethosuximide reduces electrographical and behavioral correlates of alcohol withdrawal seizure in DBA/2J mice. | Riegle MA et al. | — | 2014 | → |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Mechanisms underlying sleep-wake disturbances in alcoholism: focus on the cholinergic pedunculopontine tegmentum. | Knapp CM et al. | — | 2014 | → |
| Oscillatory spatial profile of alcohol's effects on the resting state: anatomically-constrained MEG. | Rosen BQ et al. | — | 2014 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| EEG abnormalities in psychopath and non-psychopath violent offenders. | Calzada-Reyes A et al. | — | 2013 | → |
| Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. | Wiggins WF et al. | — | 2013 | → |
| Neurofeedback: an integrative treatment of substance use disorders. | Ross SM | — | 2013 | → |
| Repeated injections of D-Amphetamine evoke rapid and dynamic changes in phase synchrony between the prefrontal cortex and hippocampus. | Ahn S et al. | — | 2013 | → |
| Resting-state synchrony during early alcohol abstinence can predict subsequent relapse. | Camchong J et al. | — | 2013 | → |
| Alcoholism-related alterations in spectrum, coherence, and phase synchrony of topical electroencephalogram. | Tcheslavski GV et al. | — | 2012 | → |
| EEG delta oscillations as a correlate of basic homeostatic and motivational processes. | Knyazev GG | — | 2012 | → |
| Frontal white matter integrity predictors of adult alcohol treatment outcome. | Sorg SF et al. | — | 2012 | → |
| Oscillatory power and synchrony in the rat forebrain are altered by a sensitizing regime of D-amphetamine. | Lapish CC et al. | — | 2012 | → |
| Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence. | Lydall GJ et al. | — | 2011 | → |
| Neuroimaging for drug addiction and related behaviors. | Parvaz MA et al. | — | 2011 | → |
| Binge drinking effects on EEG in young adult humans. | Courtney KE et al. | — | 2010 | → |
| Brain electrical activity during food presentation in obese binge-eating women. | Tammela LI et al. | — | 2010 | → |
| Quantitative EEG in patients with alcohol-related seizures. | Sand T et al. | — | 2010 | → |
| Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances. | Brower KJ et al. | — | 2010 | → |
| Chronic alcoholism: insights from neurophysiology. | Campanella S et al. | — | 2009 | → |
| EEG biofeedback as a treatment for substance use disorders: review, rating of efficacy, and recommendations for further research. | Sokhadze TM et al. | — | 2008 | → |
| EEG of chronic marijuana users during abstinence: relationship to years of marijuana use, cerebral blood flow and thyroid function. | Herning RI et al. | — | 2008 | → |
| Intracranial current density (LORETA) differences in QEEG frequency bands between depressed and non-depressed alcoholic patients. | Coutin-Churchman P et al. | — | 2008 | → |
| Variation in GABRA2 predicts drinking behavior in project MATCH subjects. | Bauer LO et al. | — | 2007 | → |
| Clinical correlates of quantitative EEG alterations in alcoholic patients. | Coutin-Churchman P et al. | — | 2006 | → |
| Moderate-to-heavy alcohol intake is associated with differences in synchronization of brain activity during rest and mental rehearsal. | de Bruin EA et al. | — | 2006 | → |
| Quantitative electroencephalographic measures in homicidal men with antisocial personality disorder. | Lindberg N et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |