Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens.
paper
Cited
Public
Unavailable
- Authors
- Henry, D J; White, F J
- Year
- 1991
- Journal
- The Journal of pharmacology and experimental therapeutics
- PMID
- 1890623
The rewarding effects of cocaine are mediated primarily by the mesoaccumbens dopamine (DA) system, which projects from A10 DA cell bodies within the ventral tegmental area to the nucleus accumbens (NAc). This pathway is also intricately involved in the locomotor stimulating effect of cocaine and the progressive increases (sensitization) in this behavior observed after repeated administration of cocaine and other psychomotor stimulants. By using single-cell electrophysiological recording and microiontophoretic techniques, we demonstrated previously that repeated cocaine administration (10 mg/kg i.p., twice daily, 14 days) renders impulse-regulating somatodendritic A10 DA autoreceptors subsensitive, thereby increasing impulse flow within the mesoaccumbens DA system. In striking contrast, inhibitory responses of NAc neurons to iontophoretic DA were significantly increased in cocaine-treated rats tested 16 to 24 hr after the last cocaine injection. In the present study, iontophoretic application of selective D1 (SKF 38393) and D2 (quinpirole) DA receptor agonists was utilized to determine the extent to which each of these DA receptor subtypes is altered by repeated cocaine administration. After 2 weeks of twice daily cocaine (10 mg/kg i.p.) injections, significant increases in the inhibitory responses of NAc neurons to SKF 38393, but not quinpirole, were observed. In addition, this D1 receptor sensitization was still evident when animals were tested either 7 days or 1 month after the final cocaine injection. After 2 months of withdrawal from cocaine treatment, D1 receptor sensitivity in the NAc had returned to control levels.(ABSTRACT TRUNCATED AT 250 WORDS)
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| Title | Year | PMID |
|---|---|---|
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | 2012 | 22358648 |
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| Habenula lesions decrease the responsiveness of dorsal raphe serotonin neurons to cocaine. | Paris JM et al. | — | 1994 | → |
| Increased occupation of D1 and D2 dopamine receptors accompanies cocaine-induced behavioral sensitization. | Burger LY et al. | — | 1994 | → |
| Influence of repeated cocaine exposure on the endocrine and behavioral responses to stress in rats. | Levy AD et al. | — | 1994 | → |
| Loss of D1/D2 dopamine receptor synergisms following repeated administration of D1 or D2 receptor selective antagonists: electrophysiological and behavioral studies. | Hu XT et al. | — | 1994 | → |
| Mesoaccumbens dopamine-opiate interactions in the control over behaviour by a conditioned reinforcer. | Phillips GD et al. | — | 1994 | → |
| MK-801 does not prevent acute stimulatory effects of amphetamine or cocaine on locomotor activity or extracellular dopamine levels in rat nucleus accumbens. | Wolf ME et al. | — | 1994 | → |
| Repeated and chronic morphine administration causes differential long-lasting changes in dopaminergic neurotransmission in rat striatum without changing its delta- and kappa-opioid receptor regulation. | Tjon GH et al. | — | 1994 | → |
| Second messenger and protein phosphorylation mechanisms underlying possible genetic vulnerability to alcoholism. | Nestler EJ et al. | — | 1994 | → |
| Selective antagonism of dopamine D1 and D2 receptors does not block the development of behavioral sensitization to cocaine. | Mattingly BA et al. | — | 1994 | → |
| Time-dependent changes in sensitivity to apomorphine and monoamine receptors following withdrawal from continuous cocaine administration in rats. | Neisewander JL et al. | — | 1994 | → |
| Alterations in the dopaminergic receptor system after chronic administration of cocaine. | Alburges ME et al. | — | 1993 | → |
| Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat. | Vezina P | — | 1993 | → |
| Behavioral and neurochemical changes caused by repeated ethanol and cocaine administration. | Pecins-Thompson M et al. | — | 1993 | → |
| Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering mu-opioid receptor sensitivity. | De Vries TJ et al. | — | 1993 | → |
| Day/night differences in D1 but not D2 DA receptor protection from EEDQ denaturation in rats treated with continuous cocaine. | Burger LY et al. | — | 1993 | → |
| Drug addiction: a model for the molecular basis of neural plasticity. | Nestler EJ et al. | — | 1993 | → |
| Effects of daily SKF 38393, quinpirole, and SCH 23390 treatments on locomotor activity and subsequent sensitivity to apomorphine. | Mattingly BA et al. | — | 1993 | → |
| Neurochemical correlates of behavioral sensitization following repeated apomorphine treatment: assessment of the role of D1 dopamine receptor stimulation. | Rowlett JK et al. | — | 1993 | → |
| Robustness of G protein changes in cocaine sensitization shown with immunoblotting. | Striplin CD et al. | — | 1993 | → |
| Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration. | Parsons LH et al. | — | 1993 | → |
| Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions. | Hammer RP et al. | — | 1993 | → |
| Cocaine-induced behavioral sensitization and D1 dopamine receptor function in rat nucleus accumbens and striatum. | Mayfield RD et al. | — | 1992 | → |
| Cocaine in utero enhances the behavioral response to cocaine in adult rats. | Peris J et al. | — | 1992 | → |
| Common intracellular actions of chronic morphine and cocaine in dopaminergic brain reward regions. | Beitner-Johnson D et al. | — | 1992 | → |
| Electrophysiological correlates of psychomotor stimulant-induced sensitization. | Henry DJ et al. | — | 1992 | → |
| Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. | Hope B et al. | — | 1992 | → |