Genetic analysis of the psychomotor stimulant effect of ethanol.
- Authors
- Downing, C; Rodd-Henricks, K K; Flaherty, L; Dudek, B C
- Year
- 2003
- Journal
- Genes, brain, and behavior
- PMID
- 12931787
- DOI
- 10.1034/j.1601-183x.2003.00022.x
Genetic influences on the psychomotor stimulant effect of ethanol may be a key feature of abuse liability. While earlier work has shown the activational effects of ethanol to be under the influence of a relatively uncomplicated additive genetic system, preliminary data from our laboratory suggested the possibility of nonadditive genetic variance. In the present study, a full Mendelian cross was conducted to further characterize gene action and search for quantitative trait loci (QTL) influencing the psychomotor stimulant properties of ethanol. We tested 3062 mice of the six Mendelian cross genotypes (P1, P2, F1, F2, BC1 and BC2) derived from a cross between the C57BL/6J (B6) and C3H/HeJ (C3H) inbred strains of mice. On day 1, mice were injected with saline, put in a holding cage for 5 min, then placed in an activity monitor for 5 min. On day 2, mice were injected with 1.5 g/kg ethanol, and activity again monitored for 5 min. Analysis showed the expected activation in the C3H strain and little activation in the B6 strain, with no effect of sex. Biometrical genetic analysis showed a best-fit model that included the mean (m), additive effect (a), and an epistatic parameter (i = homozygote by homozygote interaction). Analysis showed good evidence for QTL on chromosomes 1 (logarithm of odds (LOD) 3.4-7.5, 88-100 cM), 6 (LOD 9.1-10.4, 46-50 cM) and 15 (LOD 7.3-8.8, 28-32 cM). While the regions on chromosomes 1 and 6 have previously been implicated in several different ethanol-related phenotypes, this is the first report of a QTL influencing the psychomotor stimulant properties of ethanol on chromosome 15. Other studies have identified QTL in this region of chromosome 15 mediating locomotor activation caused by other psychostimulants, including cocaine, amphetamine and phencyclidine.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Investigating Motor Coordination Using BXD Recombinant Inbred Mice to Model the Genetic Underpinnings of Developmental Coordination Disorder. | Rajan JRS et al. | — | 2025 | → |
| Developmental coordination disorder: What can we learn from RI mice using motor learning tasks and QTL analysis. | Gill K et al. | — | 2023 | → |
| Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. | Parker CC et al. | — | 2020 | → |
| Genetic evidence for chromosome 4 loci influencing learning and memory. | Anselmi M et al. | — | 2016 | → |
| Use of the expanded panel of BXD mice narrow QTL regions in ethanol-induced locomotor activation and motor incoordination. | DuBose CS et al. | — | 2013 | → |
| JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity. | Kapfhamer D et al. | — | 2012 | → |
| Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J×129S1/SvImJ inbred mouse cross. | Chesler EJ et al. | — | 2012 | → |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | — | 2010 | → |
| Quantitative trait loci contributing to physiological and behavioural ethanol responses after acute and chronic treatment. | Drews E et al. | — | 2010 | → |
| Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression. | Mozhui K et al. | — | 2008 | → |
| Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens. | Potenza MN et al. | — | 2008 | → |
| Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. | Vadasz C et al. | — | 2007 | → |
| QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains. | Downing C et al. | — | 2006 | → |
| Sensitivity to the locomotor-stimulant effects of ethanol and allopregnanolone: a quantitative trait locus study of common genetic influence. | Palmer AA et al. | — | 2006 | → |
| Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice. | Kovacs KM et al. | — | 2005 | → |
| No difference in responsiveness to a low dose of alcohol between healthy women and men. | Nyberg S et al. | — | 2004 | → |
| A region on chromosome 15 controls intersession habituation in mice. | Bolivar V et al. | — | 2003 | → |