Specificity of familial vulnerability for alcoholism versus major depression in men.
- Authors
- Lyons, Michael J; Schultz, Mark; Neale, Michael; Brady, Kathleen; Eisen, Seth; Toomey, Rosemary; Rhein, Andrew; Faraone, Stephen; Tsuang, Ming
- Year
- 2006
- Journal
- The Journal of nervous and mental disease
- PMID
- 17102704
- DOI
- 10.1097/01.nmd.0000244480.78431.49
There are various hypotheses regarding comorbidity between alcohol dependence (AD) and major depression (MD). We interviewed 3372 pairs of male twins assessing DSM-III-R MD and AD. Individuals with comorbid MD and AD exhibited greater severity of each disorder than individuals with only one. MD in one twin was associated with risk of MD alone and MD plus AD, but not AD alone in the cotwin. AD in one twin was associated with risk of AD alone and AD plus MD, but not MD alone in the cotwin. The best fitting biometrical comorbidity model was the reciprocal causation model in which AD can cause MD and vice versa. However, a model in which genetic and environmental influences on each disorder were correlated could not be definitively rejected. Our data are most consistent with a mechanism of reciprocal causation, whereby MD increases risk for AD and AD increases risk of MD.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | 2012 | 22064162 |
External
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| Predictors of alcohol use disorder in patients with hypertension: a national registry-based cohort study. | Bramness JG et al. | — | 2025 | → |
| Alcohol consumption predicts incidence of depressive episodes across 10 years among older adults in 19 countries. | Keyes KM et al. | — | 2019 | → |
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| Festschrift celebrating the career of Ming T. Tsuang. | Faraone SV et al. | — | 2013 | → |
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