Suicidal behavior, smoking, and familial vulnerability.
- Authors
- Scherrer, Jeffrey F; Grant, Julia D; Agrawal, Arpana; Madden, Pamela A F; Fu, Qiang; Jacob, Theodore; Bucholz, Kathleen K; Xian, Hong
- Year
- 2012
- Journal
- Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
- PMID
- 22080587
- DOI
- 10.1093/ntr/ntr230
- PMCID
- PMC3313784
INTRODUCTION: Smoking is a well-established correlate of suicidal behavior. It is not known if familial risk factors contribute to this association. METHODS: Data were obtained via semistructured interviews with 1,107 twin fathers, 1,919 offspring between ages 12-32 years, and 1,023 mothers. Familial vulnerability to nicotine dependence and suicidal behavior was modeled via father and maternal self-report of these behaviors. Multinomial logistic regression models were computed with and without familial risk factors to estimate the association between offspring ever smoking, regular smoking, nicotine dependence, and a 4-level offspring suicide variable: (a) none, (b) ideation, (c) ideation + plan, and (d) ideation + plan + attempt or ideation + attempt. All models were stratified by gender and adjusted for sociodemographics, familial risk factors including parental suicidal behavior, nicotine dependence, and conduct disorder, and offspring conduct disorder, depression, alcohol abuse/dependence, and illicit drug abuse/dependence. RESULTS: After adjusting for covariates and familial risk factors, ever smoking was not significantly associated with suicidal behavior in males and females. In males, regular smoking was associated with ideation + plan (odds ratio [OR] = 5.47; 95% CI: 1.05-28.60), and in females, regular smoking was associated with ideation + plan + attempt or ideation + attempt. In both genders, nicotine-dependent smoking was associated with ideation + plan + attempt or ideation + attempt (males: OR = 6.59; 95% CI: 1.91-22.70, females: OR = 3.37; 95% CI: 1.25-9.04). Comparison of models with and without familial risk factors indicated that there is no mediation of smoking status and suicidal behavior by familial risk. CONCLUSIONS: Smoking and nicotine dependence are correlated with suicidal behaviour. Contributions from familial risk factors did not significantly alter this association.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood. | 2018 | 29245024 |
External
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| Adolescent suicide attempts in three diverse island nations: patterns, contextual differences and demographic associations. | Fu J et al. | — | 2021 | → |
| Correlates of Suicide Attempts in Filipino Youths: An Analysis Based on the 2015 Global School-Based Student Health Survey. | Lagman JG et al. | — | 2021 | → |
| Examining the effect of smoking on suicidal ideation and attempts: triangulation of epidemiological approaches. | Harrison R et al. | — | 2020 | → |
| Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood. | Korhonen T et al. | — | 2018 | → |
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| Smoking and suicidal behaviours in a sample of US adults with low mood: a retrospective analysis of longitudinal data. | Covey LS et al. | — | 2012 | → |