The prevalence of major anxiety disorders in relatives of alcohol dependent men and women.
- Authors
- Schuckit, M A; Hesselbrock, V M; Tipp, J; Nurnberger, J I; Anthenelli, R M; Crowe, R R
- Year
- 1995
- Journal
- Journal of studies on alcohol
- PMID
- 7623470
- DOI
- 10.15288/jsa.1995.56.309
OBJECTIVE: The relationship between alcohol dependence and lifelong major anxiety disorders is complex. The literature indicates a close association between anxiety symptoms and drinking behavior. However, it is difficult to determine whether the anxiety conditions are lifelong disorders or if they represent temporary organic conditions related to alcohol intoxication and withdrawal. One approach to understanding more about the relationships between alcohol dependence and major anxiety disorders is to observe the rate of anxiety-related diagnoses in close relatives of alcoholics. This approach evaluates whether alcoholism and major anxiety disorders might share a common genetic basis. METHOD: The data presented here describe the rates of four major anxiety disorders in 591 interviewed first-degree relatives of alcohol dependent men and women. The data were gathered through face-to-face structured standardized interviews. RESULTS: The analyses reveal that after focusing on DSM-III-R anxiety disorders, controlling for the potential presence of temporary organic conditions in the subject and considering the impact of assortative mating in their parents, the life-time risk for panic disorder in close biological family members of alcoholics is 3.4%; for agoraphobia, 1.4%; for social phobia, 2.3%; and for obsessive-compulsive disease, 1.4%. CONCLUSIONS: These data do not indicate an exceptionally high rate of anxiety disorders among close relatives of alcoholics. While other mechanisms might contribute to relationship between alcoholism and major anxiety disorders, the results do not support evidence of a common genotype for the two disorders.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Seventy-five years of comorbidity research. | Kushner MG | — | 2014 | → |
| Family history of alcohol dependence modulates functional neurophysiology in mood/anxiety disorders. | Sjoerds Z et al. | — | 2013 | → |
| Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety. | Chiavegatto S et al. | — | 2009 | → |
| Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding. | Mathews CA et al. | — | 2007 | → |
| Comorbidity between substance use disorders and psychiatric conditions. | Schuckit MA | — | 2006 | → |
| Association between anxiety disorders and substance use disorders among young persons: results of a 21-year longitudinal study. | Goodwin RD et al. | — | 2004 | → |
| Impaired emotional facial expression recognition in alcoholism compared with obsessive-compulsive disorder and normal controls. | Kornreich C et al. | — | 2001 | → |
| Risk of heavy drinking and alcohol use disorders in social phobia: a prospective analysis. | Crum RM et al. | — | 2001 | → |
| The genetics of panic disorder. | Finn CT et al. | — | 2001 | → |
| Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence? | Hammoumi S et al. | — | 1999 | → |
| A direct-interview family study of generalized social phobia. | Stein MB et al. | — | 1998 | → |
| Clinical relevance of the distinction between alcohol dependence with and without a physiological component. | Schuckit MA et al. | — | 1998 | → |
| Comorbidity of substance use disorders with mood and anxiety disorders: results of the International Consortium in Psychiatric Epidemiology. | Merikangas KR et al. | — | 1998 | → |
| Adulthood functioning: the joint effects of parental alcoholism, gender and childhood socio-economic stress. | Hill EM et al. | — | 1997 | → |
| Comparison of induced and independent major depressive disorders in 2,945 alcoholics. | Schuckit MA et al. | — | 1997 | → |
| The life-time rates of three major mood disorders and four major anxiety disorders in alcoholics and controls. | Schuckit MA et al. | — | 1997 | → |
| Alcohol, Anxiety, and Depressive Disorders. | Schuckit MA | — | 1996 | → |
| Female alcoholism: new perspectives-findings from the COGA Study. Collaborative Study on the Genetics of Alcoholism. | Hesselbrock V | — | 1996 | → |
| The Collaborative Study on the Genetics of Alcoholism. | — | — | 1995 | → |