Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
paper
Cited
Public
Unavailable
- Authors
- Roth, B L; Craigo, S C; Choudhary, M S; Uluer, A; Monsma, F J; Shen, Y; Meltzer, H Y; Sibley, D R
- Year
- 1994
- Journal
- The Journal of pharmacology and experimental therapeutics
- PMID
- 7908055
The authors examined the affinities of 36 typical and atypical antipsychotic agents for the cloned rat 5-hydroxytryptamine-6 (5-HT6) and rat 5-hydroxytryptamine-7 (5-HT7) receptors in transiently expressed COS-7 cells (5-HT7) or stably transfected HEK-293 cells (5-HT6 receptors). Clozapine and several related atypical antipsychotic agents (rilapine, olanzepine, tiospirone, fluperlapine, clorotepine and zotepine) had high affinities for the newly discovered 5-HT6 receptor (Kis < 20 nM). The 5-HT7 receptor bound clozapine, rilapine, fluperlapine, clorotepine, zotepine and risperidone but not tiospirone and olanzepine, with affinities less than 15 nM. In addition, several typical antipsychotic agents (chloroprothixene, chlorpromazine, clothiapine and fluphenazine) had high affinities for both the 5-HT6 and 5-HT7 receptors. Pimozide, a diphenylbutylpiperidine, had the highest affinity of all the typical antipsychotic agents tested for the 5-HT7 receptor (Ki = 0.5 nM). Three putative atypical antipsychotic agents melperone, amperozide and MDL 100907 did not bind with high affinities to either the 5-HT6 or 5-HT7 receptors (Kis > 50 nM). Several dopamine-selective antipsychotic agents (raclopride, rimcazole and penfluridol) had essentially no affinity for either the 5-HT6 or 5-HT7 receptors (Ki values > 5000 nM).(ABSTRACT TRUNCATED AT 250 WORDS)
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| Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. | Dietz BM et al. | β | 2005 | β |
| A 5-HT7 heteroreceptor-mediated inhibition of [3H]serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction. | Harsing LG et al. | β | 2004 | β |
| Autoradiographic distribution of 5-HT7 receptors in the human brain using [3H]mesulergine: comparison to other mammalian species. | MartΓn-Cora FJ et al. | β | 2004 | β |
| Combination of "atypical" antipsychotic medication in the management of treatment-resistant schizophrenia and schizoaffective disorder. | Lerner V et al. | β | 2004 | β |
| Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study. | Minabe Y et al. | β | 2004 | β |
| Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness. | Lattuada E et al. | β | 2004 | β |
| Hologram quantitative structure activity relationship studies on 5-HT6 antagonists. | Doddareddy MR et al. | β | 2004 | β |
| Review of the pharmacological and clinical profile of rimcazole. | Gilmore DL et al. | β | 2004 | β |
| Role of neuroactive steroid allopregnanolone in antipsychotic-like action of olanzapine in rodents. | Ugale RR et al. | β | 2004 | β |
| Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. | Roth BL et al. | β | 2004 | β |
| 5-HT7 receptors increase the excitability of rat hippocampal CA1 pyramidal neurons. | Tokarski K et al. | β | 2003 | β |
| 5-Hydroxytryptamine7 (5-HT7) receptor immunoreactivity-positive 'stigmoid body'-like structure in developing rat brains. | Muneoka KT et al. | β | 2003 | β |
| 8-[3H]-hydroxy-2-(di-n-propylamino)tetralin binding sites in blood lymphocytes of rats and the modulation by mitogens and immobilization. | Sempere T et al. | β | 2003 | β |
| A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens. | Li Z et al. | β | 2003 | β |
| Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. | Hameg A et al. | β | 2003 | β |
| Antipsychotic drug interactions with specific [3H]ketanserin binding sites in membrane fragments derived from human prefrontal cortex and human amygdala. | Andorn AC et al. | β | 2003 | β |
| A retrospective chart review of the use of olanzapine for the prevention of delayed emesis in cancer patients. | Passik SD et al. | β | 2003 | β |
| Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. | Shapiro DA et al. | β | 2003 | β |
| Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein. | Zhang JY et al. | β | 2003 | β |
| Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats. | Samarghandian S et al. | β | 2003 | β |
| Creation, expression, and characterization of a constitutively active mutant of the human serotonin 5-HT6 receptor. | Purohit A et al. | β | 2003 | β |
| Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm. | Gemperle AY et al. | β | 2003 | β |
| Effect of the 5-HT6 receptor antagonists Ro04-6790 and Ro65-7199 on latent inhibition and prepulse inhibition in the rat: comparison to clozapine. | Leng A et al. | β | 2003 | β |
| H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. | Kroeze WK et al. | β | 2003 | β |
| N1-benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT6 receptor ligand templates. | Pullagurla MR et al. | β | 2003 | β |
| New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. | Kikuchi C et al. | β | 2003 | β |
| Pharmacological characterization of an adenylyl cyclase-coupled 5-HT receptor in aplysia: comparison with mammalian 5-HT receptors. | Cohen JE et al. | β | 2003 | β |
| Potentiation of amphetamine-induced changes in dopamine and 5-HT by a 5-HT(6) receptor antagonist. | Dawson LA et al. | β | 2003 | β |
| Serotonin receptors: their key role in drugs to treat schizophrenia. | Meltzer HY et al. | β | 2003 | β |
| The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. | Guscott MR et al. | β | 2003 | β |
| Why mice are neither miniature humans nor small rats: a cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants. | Setola V et al. | β | 2003 | β |
| 5-HT(1B) but not 5-HT(6) or 5-HT(7) receptors mediate depression of spinal nociceptive reflexes in vitro. | Hedo G et al. | β | 2002 | β |
| 5-HT(6) receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine. | Frantz KJ et al. | β | 2002 | β |
| 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585. | East SZ et al. | β | 2002 | β |
| 5-HT7 receptors modulate synchronized network activity in rat hippocampus. | Gill CH et al. | β | 2002 | β |
| An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia. | East SZ et al. | β | 2002 | β |
| A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain. | Passik SD et al. | β | 2002 | β |
| Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. | Ichikawa J et al. | β | 2002 | β |
| Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists. | Bromidge SM et al. | β | 2002 | β |
| Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo. | Di Matteo V et al. | β | 2002 | β |
| Differential diagnosis of depressed mood in patients with schizophrenia: a diagnostic algorithm based on a review. | Hausmann A et al. | β | 2002 | β |
| Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum. | Bubser M et al. | β | 2002 | β |
| DR4004, a putative 5-HT(7) receptor antagonist, also has functional activity at the dopamine D2 receptor. | Kogan HA et al. | β | 2002 | β |
| Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia. | Pouzet B et al. | β | 2002 | β |
| Effects of the 5-HT(7) receptor antagonist SB-258741 in animal models for schizophrenia. | Pouzet B et al. | β | 2002 | β |
| Mianserin or placebo as adjuncts to typical antipsychotics in resistant schizophrenia. | Shiloh R et al. | β | 2002 | β |
| Molecular, pharmacological and functional diversity of 5-HT receptors. | Hoyer D et al. | β | 2002 | β |
| Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist. | Stean TO et al. | β | 2002 | β |
| Role of the cholinergic muscarinic system in bipolar disorder and related mechanism of action of antipsychotic agents. | Bymaster FP et al. | β | 2002 | β |
| SB-258741: a 5-HT7 receptor antagonist of potential clinical interest. | Pouzet B | β | 2002 | β |
| The atypical 5-HT2 receptor mediating tachycardia in pithed rats: pharmacological correlation with the 5-HT2A receptor subtype. | CenturiΓ³n D et al. | β | 2002 | β |
| 5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells. | Van de Kar LD et al. | β | 2001 | β |
| 5-substituted 3,4-dihydro-3-amino-2H-1-benzopyran derivatives: synthesis and interaction with serotoninergic receptors. | Rezaie R et al. | β | 2001 | β |
| Acute restraint stress increases 5-HT7 receptor mRNA expression in the rat hippocampus. | Yau JL et al. | β | 2001 | β |
| An endogenous 5-HT(7) receptor mediates pigment granule dispersion in Xenopus laevis melanophores. | Teh MT et al. | β | 2001 | β |
| Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum. | Westerink BH et al. | β | 2001 | β |
| Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop. | Kohen R et al. | β | 2001 | β |
| Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain. | Kinsey AM et al. | β | 2001 | β |
| Further characterization of 5-HT1A receptors in the goldfish retina: role of cyclic AMP in the regulation of the in vitro outgrowth of retinal explants. | Schmeer C et al. | β | 2001 | β |
| Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. | Masellis M et al. | β | 2001 | β |
| Manic symptoms induced by olanzapine. | Lykouras L et al. | β | 2001 | β |
| Olanzapine: an updated review of its use in the management of schizophrenia. | Bhana N et al. | β | 2001 | β |
| Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine. | Bymaster FP et al. | β | 2001 | β |
| Solid phase synthesis of sulphonamides: novel ligands of 5-HT6 receptors. | Renault J et al. | β | 2001 | β |
| The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia. | Scheepers FE et al. | β | 2001 | β |
| [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors. | Thomas DR et al. | β | 2000 | β |
| 5-ht6 receptors as emerging targets for drug discovery. | Branchek TA et al. | β | 2000 | β |
| 5-HT7 receptors: current knowledge and future prospects. | Vanhoenacker P et al. | β | 2000 | β |
| Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT(7) receptor. | Wood M et al. | β | 2000 | β |
| [Atypical neuroleptics in child- and adolescent psychiatry]. | Remschmidt H et al. | β | 2000 | β |
| Atypical neuroleptics in child and adolescent psychiatry. | Remschmidt H et al. | β | 2000 | β |
| Changes in 5-HT(7) serotonin receptor mRNA expression with aging in rat brain. | Kohen R et al. | β | 2000 | β |
| Characterisation of a 5-HT(7) binding site in mouse ileum. | Hemedah M et al. | β | 2000 | β |
| Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue. | Hirst WD et al. | β | 2000 | β |
| Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. | Hagan JJ et al. | β | 2000 | β |
| Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. | Routledge C et al. | β | 2000 | β |
| Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. | Zhukovskaya NL et al. | β | 2000 | β |
| Definition, psychopharmacological basis and clinical evaluation of novel/atypical neuroleptics: methodological issues and clinical consequences. | MΓΆller HJ | β | 2000 | β |
| Design, synthesis and biological evaluation of pyridine-phenylpiperazines: a novel series of potent and selective alpha1a-adrenergic receptor antagonist. | Kuo GH et al. | β | 2000 | β |
| Differential effects of acute administration of haloperidol and clozapine on ethanol-induced ascorbic acid release in rat striatum. | Liu W et al. | β | 2000 | β |
| Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors. | Glusa E et al. | β | 2000 | β |
| Investigation of the human serotonin 6 [5-HT6] receptor gene in bipolar affective disorder and schizophrenia. | Vogt IR et al. | β | 2000 | β |
| In vivo effects of the 5-HT(6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate. | Dawson LA et al. | β | 2000 | β |
| Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice. | Rasmussen T et al. | β | 2000 | β |
| Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. | Arolfo MP et al. | β | 2000 | β |
| [3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum. | Hemedah M et al. | β | 1999 | β |
| Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease. | Tsai SJ et al. | β | 1999 | β |
| Association study of serotonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior. | Tsai SJ et al. | β | 1999 | β |
| Association study of the 5-HT6 receptor gene in schizophrenia. | Shinkai T et al. | β | 1999 | β |
| Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex. | Matsumoto M et al. | β | 1999 | β |
| Characterization of radioactive metabolites of 5-HT2A receptor PET ligand [18F]altanserin in human and rodent. | Tan PZ et al. | β | 1999 | β |
| Cloning, mRNA localization and evolutionary conservation of a human 5-HT7 receptor pseudogene. | Olsen MA et al. | β | 1999 | β |
| Complicated delirium in a cancer patient successfully treated with olanzapine. | Passik SD et al. | β | 1999 | β |
| Effects of chronic administration of interferon alpha A/D on serotonergic receptors in rat brain. | Abe S et al. | β | 1999 | β |
| Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain. | Frederick JA et al. | β | 1999 | β |
| Identification of a human 5-HT6 receptor variant produced by alternative splicing. | Olsen MA et al. | β | 1999 | β |
| Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats. | Bentley JC et al. | β | 1999 | β |
| Olanzapine treatment of children, adolescents, and adults with pervasive developmental disorders: an open-label pilot study. | Potenza MN et al. | β | 1999 | β |
| Pharmacokinetics and tissue distribution of olanzapine in rats. | Aravagiri M et al. | β | 1999 | β |
| Pharmacological and molecular characterization of 5-hydroxytryptamine(7) receptors in the rat adrenal gland. | Contesse V et al. | β | 1999 | β |
| Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder. | Lassig JP et al. | β | 1999 | β |
| Pindolol-insensitive [3H]-5-hydroxytryptamine binding in the rat hypothalamus; identity with 5-hydroxytryptamine7 receptors. | Clemett DA et al. | β | 1999 | β |
| Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. | Herrick-Davis K et al. | β | 1999 | β |
| 5-hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries. | Morecroft I et al. | β | 1998 | β |
| A human serotonin-7 receptor pseudogene. | Qian IH et al. | β | 1998 | β |
| Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. | Kalkman HO et al. | β | 1998 | β |
| Central distribution and function of 5-HT6 receptor subtype in the rat brain. | Yoshioka M et al. | β | 1998 | β |
| Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. | Sleight AJ et al. | β | 1998 | β |
| Dopamine D2 and D4 receptor ligands: relation to antipsychotic action. | Wilson JM et al. | β | 1998 | β |
| Effects of idazoxan on dopamine release in the prefrontal cortex of freely moving rats. | Matsumoto M et al. | β | 1998 | β |
| Involvement of 5-HT6 receptors in nigro-striatal function in rodents. | Bourson A et al. | β | 1998 | β |
| Mutation screening of the 5-hydroxytryptamine7 receptor gene among Finnish alcoholics and controls. | Pesonen U et al. | β | 1998 | β |
| Selective labelling of 5-HT7 receptor recognition sites in rat brain using [3H]5-carboxamidotryptamine. | Stowe RL et al. | β | 1998 | β |
| Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor. | Baker LP et al. | β | 1998 | β |
| The human serotonin-7 receptor pseudogene: variation and chromosome location. | Nam D et al. | β | 1998 | β |
| The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis. | Kroeze WK et al. | β | 1998 | β |
| The putative 5-ht6 receptor: localization and function. | Sleight AJ et al. | β | 1998 | β |
| The use of clozapine in the treatment of aggressive schizophrenia. | Hector RI | β | 1998 | β |
| Binding profile of the novel 5-HT1B/1D receptor antagonist, [3H]GR 125,743, in guinea-pig brain: a comparison with [3H]5-carboxamidotryptamine. | Audinot V et al. | β | 1997 | β |
| Double-blind comparison of olanzapine versus risperidone in the treatment of schizophrenia and other psychotic disorders. | Tran PV et al. | β | 1997 | β |
| Drug treatment of schizophrenia in the 1990s. Achievements and future possibilities in optimising outcomes. | Fleischhacker WW et al. | β | 1997 | β |
| Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells. | Boess FG et al. | β | 1997 | β |
| Functional characteristics of heterologously expressed 5-HT receptors. | Gerhardt CC et al. | β | 1997 | β |
| Interaction of the novel antipsychotic drug amperozide and its metabolite FG5620 with central nervous system receptors and monoamine uptake sites: relation to behavioral and clinical effects. | Svartengren J et al. | β | 1997 | β |
| Olanzapine. A review of its pharmacological properties and therapeutic efficacy in the management of schizophrenia and related psychoses. | Fulton B et al. | β | 1997 | β |
| Olanzapine (Zyprexa):characteristics of a new antipsychotic. | Tamminga CA et al. | β | 1997 | β |
| Role of 5-ht7 receptors in the long-lasting hypotensive response induced by 5-hydroxytryptamine in the rat. | TerrΓ³n JA | β | 1997 | β |
| The 5-HT7 receptor: orphan found. | Eglen RM et al. | β | 1997 | β |
| The role of muscarinic cholinergic receptors in the discriminative stimulus properties of clozapine in rats. | Kelley BM et al. | β | 1997 | β |
| [3H]MDL 100,907: a novel selective 5-HT2A receptor ligand. | Johnson MP et al. | β | 1996 | β |
| 5HT1A receptor agonist differentially increases cyclic AMP concentration in intact and lesioned goldfish retina. In vitro inhibition of outgrowth by forskolin. | Urbina M et al. | β | 1996 | β |
| A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5-ht7 receptor in rat brain. | Gustafson EL et al. | β | 1996 | β |
| Bodyweight change as an adverse effect of drug treatment. Mechanisms and management. | Pijl H et al. | β | 1996 | β |
| Characterisation of a postjunctional 5-ht7-like and a prejunctional 5-HT3 receptor mediating contraction of rat isolated jejunum. | McLean PG et al. | β | 1996 | β |
| Characterization of putative 5-ht7 receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein. | Leung E et al. | β | 1996 | β |
| Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum. | Ward RP et al. | β | 1996 | β |
| Different effects of chronic administration of haloperidol and pimozide on dopamine metabolism in the rat brain. | Karolewicz B et al. | β | 1996 | β |
| Dopamine and serotonin receptors: amino acid sequences, and clinical role in neuroleptic parkinsonism. | Seeman P et al. | β | 1996 | β |
| Effects of dopamine and fluphenazine on field potential amplitude in the salamander olfactory bulb. | Gurski MR et al. | β | 1996 | β |
| Individual variation in D2 dopamine receptor occupancy in clozapine-treated patients. | Pickar D et al. | β | 1996 | β |
| Mechanisms of action of atypical antipsychotic drugs: a critical analysis. | Kinon BJ et al. | β | 1996 | β |
| Pharmacology of serotonin as related to anesthesia. | Gyermek L | β | 1996 | β |
| Risperidone and related 5HT2/D2 antagonists: a new type of antipsychotic agent? | Megens AA et al. | β | 1996 | β |
| Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. | Schotte A et al. | β | 1996 | β |
| The antipsychotic potential of subtype-selective 5-HT receptor ligands based on interactions with mesolimbic dopamine systems. | Tricklebank MD | β | 1996 | β |
| The relaxant 5-HT receptor in the dog coronary artery smooth muscle: pharmacological resemblance to the cloned 5-ht7 receptor subtype. | TerrΓ³n JA | β | 1996 | β |
| Characterization and distribution of putative 5-ht7 receptors in guinea-pig brain. | To ZP et al. | β | 1995 | β |
| Clozapine: selective labeling of sites resembling 5HT6 serotonin receptors may reflect psychoactive profile. | Glatt CE et al. | β | 1995 | β |
| D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs. | Roth BL et al. | β | 1995 | β |
| Differences between haloperidol- and pimozide-induced withdrawal syndrome: a role for Ca2+ channels. | Antkiewicz-Michaluk L et al. | β | 1995 | β |
| Ligand selectivity of cloned human and rat opioid mu receptors. | Rothman RB et al. | β | 1995 | β |
| Neurotransmitter systems in schizophrenia. | Reynolds GP | β | 1995 | β |
| New players in the 5-HT receptor field: genes and knockouts. | Lucas JJ et al. | β | 1995 | β |
| Prospects for pharmacotherapy of schizophrenia. | Pickar D | β | 1995 | β |
| The role of 5-HT2A receptors in antipsychotic activity. | Schmidt CJ et al. | β | 1995 | β |