Evaluation of behavioral disinhibition in P/NP and HAD1/LAD1 rats.
- Authors
- Steinmetz, J E; Blankenship, M R; Green, J T; Smith, G B; Finn, P R
- Year
- 2000
- Journal
- Progress in neuro-psychopharmacology & biological psychiatry
- PMID
- 11041542
- DOI
- 10.1016/s0278-5846(00)00122-6
1. Two lines of rats specifically bred for alcohol preference were exposed to two different behavioral tasks that required behavioral inhibition to successfully solve. 2. Learning and performance of a step-down passive avoidance task and a differential reinforcement of low-rate responding task were studied in P/NP and HAD1/LAD1 rats. 3. While the P rats had difficulty in learning both tasks, HAD1, LAD1 and NP rats performed at control levels. 4. These data suggest that P rats, but not HAD1 rats, may have problems learning tasks that require inhibition of ongoing or previously learned behaviors.
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In this knowledge base
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|---|---|---|
| Understanding the construct of impulsivity and its relationship to alcohol use disorders. | 2010 | 20148781 |
External
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| Evaluating habit formation across pairs of female and male selectively bred alcohol-preferring and non-preferring rats. | Haines KM et al. | — | 2022 | → |
| Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence. | Somkuwar SS et al. | — | 2018 | → |
| Alcohol-Preferring P Rats Exhibit Elevated Motor Impulsivity Concomitant with Operant Responding and Self-Administration of Alcohol. | Beckwith SW et al. | — | 2016 | → |
| Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive. | Peña-Oliver Y et al. | — | 2015 | → |
| Enhanced alcohol self-administration and reinstatement in a highly impulsive, inattentive recombinant inbred mouse strain. | Loos M et al. | — | 2013 | → |
| Bridging Animal and Human Models: Translating From (and to) Animal Genetics. | Barkley-Levenson AM et al. | — | 2012 | → |
| Understanding the construct of impulsivity and its relationship to alcohol use disorders. | Dick DM et al. | — | 2010 | → |
| Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes. | Wilhelm CJ et al. | — | 2008 | → |
| Mouse lines selected for alcohol consumption differ on certain measures of impulsivity. | Wilhelm CJ et al. | — | 2007 | → |
| High-alcohol-drinking rats exhibit persistent freezing responses to discrete cues following Pavlovian fear conditioning. | Rorick LM et al. | — | 2003 | → |
| Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. | Murphy JM et al. | — | 2002 | → |
| A characterization of approach and avoidance learning in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. | Blankenship MR et al. | — | 2000 | → |