Hyperconnectivity in Dementia Is Early and Focal and Wanes with Progression.
- Authors
- Bonanni, Laura; Moretti, Davide; Benussi, Alberto; Ferri, Laura; Russo, Mirella; Carrarini, Claudia; Barbone, Filomena; Arnaldi, Dario; Falasca, Nicola Walter; Koch, Giacomo; Cagnin, Annachiara; Nobili, Flavio; Babiloni, Claudio; Borroni, Barbara; Padovani, Alessandro; Onofrj, Marco; Franciotti, Raffaella; FTD Italian study group-SINDEM
- Year
- 2021
- Journal
- Cerebral cortex (New York, N.Y. : 1991)
- PMID
- 32797208
- DOI
- 10.1093/cercor/bhaa209
We investigated in a longitudinal multicenter cohort study functional cortical connectivity changes along the course of frontotemporal dementia (FTD) and Alzheimer's disease (AD) from the prodromal stage of the diseases. Electroencephalography (EEG) was recorded in 18 FTD and 18 AD patients at the prodromal stage of dementia, at dementia onset, and 3Β years after dementia onset. Twenty healthy controls (HC) underwent EEG recordings at the same time interval as the patients. Mutual information (MI) analysis measured the strength of functional network connectivity. FTD and AD patients showed greater MI at the prodromal stage of dementia (FTD vs. HC Pβ=β2βΓβ10-8; AD vs. HC Pβ=β4βΓβ10-3). Local connectivity was higher in left and right frontal areas of FTD (Pβ=β7βΓβ10-5 and 0.03) and in left and right posterior areas in AD (Pβ=β3βΓβ10-5 and 5βΓβ10-5) versus HC. We showed cortical hyperconnectivity at the prodromal stage of dementia in areas involved in the specific pathological process of FTD (frontal regions) and AD (posterior regions). Hyperconnectivity disappeared during follow-up, thus suggesting that it is an early electrophysiological feature of dementia, potentially useful to identify prodromal FTD and AD.
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