Endogenous cannabinoids: structure and metabolism.
paper
Cited
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- Authors
- Bisogno, T
- Year
- 2008
- Journal
- Journal of neuroendocrinology
- PMID
- 18426492
- DOI
- 10.1111/j.1365-2826.2008.01676.x
The finding of specific binding sites for Delta(9)-tetrahydrocannabinol, the psychoactive component of Cannabis sativa, has led to the discovery of the endocannabinoid system and has emphasised the physiological and pathological relevance of endocannabidoid lipid signalling. Subsequently, an increasing number of papers have been published on the biochemistry and pharmacology of endocannabinoids. An overview of the current understanding of structure and metabolism of the best studied endocannabinoids is provided, with a focus on the mechanisms responsible for their biosynthesis and inactivation.
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| Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats. | Shimizu T et al. | β | 2010 | β |
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| Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. | Janero DR et al. | β | 2009 | β |
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| Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. | Hill MN et al. | β | 2009 | β |
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