Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.
paper
Cited
Public
Unavailable
- Authors
- Lin, Ren-Jye; Yu, Han-Pang; Chang, Bi-Lan; Tang, Wei-Chun; Liao, Ching-Len; Lin, Yi-Ling
- Year
- 2009
- Journal
- Journal of immunology (Baltimore, Md. : 1950)
- PMID
- 19923450
- DOI
- 10.4049/jimmunol.0902728
The 2',5'-oligoadenylate synthetase (OAS) and its downstream effector RNase L play important roles in host defense against virus infection. Oas1b, one of the eight Oas1 genes in the mouse genome, has been identified as a murine flavivirus-resistance gene. Four genes, OAS1, OAS2, OAS3, and OAS-like (OASL), have been identified in the human OAS gene family, and 10 isoforms, including OAS1 (p42, p44, p46, p48, and p52), OAS2 (p69 and p71), OAS3 (p100), and OASL (p30 and p59) can be generated by alternative splicing. In this study, we determined the role of the human OAS/RNase L pathway in host defense against dengue virus (DEN) infection and assessed the antiviral potential of each isoform in the human OAS family. DEN replication was reduced by overexpression and enhanced by knockdown of RNase L expression, indicating a protective role for RNase L against DEN replication in human cells. The human OAS1 p42, OAS1 p46, and OAS3 p100, but not the other OAS isoforms, blocked DEN replication via an RNase L-dependent mechanism. Furthermore, the anti-DEN activities of these three OAS isoforms correlated with their ability to trigger RNase L activation in DEN-infected cells. Thus, OAS1 p42/p46 and OAS3 p100 are likely to contribute to host defense against DEN infection and play a role in determining the outcomes of DEN disease severity.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| RNA alternative splicing impacts the risk for alcohol use disorder. | 2023 | 37217680 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Effects of beta-glucan and inactivated parapoxvirus ovis applications on serum 2'5' oligoadenylate synthetase in distemper infected dogs. | RΔ±htΔ±m MA et al. | β | 2026 | β |
| The OAS-RNase L pathway: Insights from experiments of nature. | Lee D et al. | β | 2026 | β |
| Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer's disease therapeutics. | Xie Z et al. | β | 2025 | β |
| Genetic ancestry shapes dengue virus infection in human skin explants. | Castanha PMS et al. | β | 2025 | β |
| Genetic insights into avian influenza resistance in Jeju Island chickens: the roles of Mx1 and oligoadenylate synthetase-like single nucleotide polymorphisms. | Kim YW et al. | β | 2025 | β |
| Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy. | Lin MH et al. | β | 2025 | β |
| New Insights into Host Genetic Ancestry as a Risk Factor for Dengue Disease. | Barratt-Boyes SM et al. | β | 2025 | β |
| Restriction of Zika Virus Replication in Human Monocyte-Derived Macrophages by Pro-Inflammatory (M1) Polarization. | Pagani I et al. | β | 2025 | β |
| Switching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection. | Iida K et al. | β | 2025 | β |
| The macrocyclic peptide rhesus theta defensin 1 activates interferon and antiviral pathways in human monocytes. | Tongaonkar P et al. | β | 2025 | β |
| The seven enigmas of SARS-CoV-2: from the past to the future. | Andreakos E et al. | β | 2025 | β |
| The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5'-3' XRN1-mediated RNA decay pathway in the replication complexes. | Lin RJ et al. | β | 2025 | β |
| Uridine as a hub in cancer metabolism and RNA biology. | Choi KM et al. | β | 2025 | β |
| Cross Talk between MicroRNAs and Dengue Virus. | Macha NO et al. | β | 2024 | β |
| Genomic Landscape of Susceptibility to Severe COVID-19 in the Slovenian Population. | Kovanda A et al. | β | 2024 | β |
| Innate immune responses to RNA: sensing and signaling. | Luan X et al. | β | 2024 | β |
| Interferon-stimulated genes and their antiviral activity against SARS-CoV-2. | Ortega-Prieto AM et al. | β | 2024 | β |
| NOD2 Responds to Dengue Virus Type 2 Infection in Macrophage-like Cells Interacting with MAVS Adaptor and Affecting IFN-Ξ± Production and Virus Titers. | DomΓnguez-MartΓnez DA et al. | β | 2024 | β |
| OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway. | Wang S et al. | β | 2024 | β |
| The Dynamic Relationship between Dengue Virus and the Human Cutaneous Innate Immune Response. | MartΓ MM et al. | β | 2024 | β |
| The Sdp-SH3b2 domain contained in <i>Lactobacillus johnsonii</i> N6.2-derived extracellular vesicles inhibit murine norovirus replication. | da Silva DR et al. | β | 2024 | β |
| Gene expression profile of HCT-8 cells following single or co-infections with Cryptosporidium parvum and bovine coronavirus. | JimΓ©nez-MelΓ©ndez A et al. | β | 2023 | β |
| Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis. | Buchynskyi M et al. | β | 2023 | β |
| Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children. | Lee D et al. | β | 2023 | β |
| Internalization of extracellular vesicles from <i>Lactobacillus johnsonii</i> N6.2 elicit an RNA sensory response in human pancreatic cell lines. | da Silva DR et al. | β | 2023 | β |
| OAS1 suppresses African swine fever virus replication by recruiting TRIM21 to degrade viral major capsid protein. | Sun H et al. | β | 2023 | β |
| Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family. | Torices S et al. | β | 2023 | β |
| RNA alternative splicing impacts the risk for alcohol use disorder. | Li R et al. | β | 2023 | β |
| RNase L-activating 2'-5' oligoadenylates bind ABCF1, ABCF3 and Decr-1. | Govande AA et al. | β | 2023 | β |
| The Many Faces of Oligoadenylate Synthetases. | Sarkar SN et al. | β | 2023 | β |
| Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. | Banday AR et al. | β | 2022 | β |
| Identification of novel drug targets for the risk and prognosis of COVID-19. | Gan YH et al. | β | 2022 | β |
| Integrative Multiomics and Regulatory Network Analyses Uncovers the Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in Hepatitis E Virus Infection. | Gupta S et al. | β | 2022 | β |
| Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia. | Mishra R et al. | β | 2022 | β |
| Transcriptome analysis of PK-15 cells expressing CSFV NS4A. | Lv H et al. | β | 2022 | β |
| Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer. | Gao L et al. | β | 2022 | β |
| Zinc Finger Protein ZFP36L1 Inhibits Flavivirus Infection by both 5'-3' XRN1 and 3'-5' RNA-Exosome RNA Decay Pathways. | Chiu H et al. | β | 2022 | β |
| Comparing Expression of OAS-RNaseL Pathway-Related Genes in SARS-CoV-2 and Similar Viruses | Chakravarty N et al. | β | 2021 | β |
| Endomembrane targeting of human OAS1 p46 augments antiviral activity. | Soveg FW et al. | β | 2021 | β |
| Flavivirus Persistence in Wildlife Populations. | Blahove MR et al. | β | 2021 | β |
| Innate Antiviral Cytokine Response to Swine Influenza Virus by Swine Respiratory Epithelial Cells. | Bakre AA et al. | β | 2021 | β |
| Mechanisms of Attenuation by Genetic Recoding of Viruses. | GonΓ§alves-Carneiro D et al. | β | 2021 | β |
| Membrane-Associated Flavivirus Replication Complex-Its Organization and Regulation. | Morita E et al. | β | 2021 | β |
| Time-Resolved Analysis of N-RNA Interactions during RVFV Infection Shows Qualitative and Quantitative Shifts in RNA Encapsidation and Packaging. | Hayashi M et al. | β | 2021 | β |
| USP18 Mediates Interferon Resistance of Dengue Virus Infection. | Ye H et al. | β | 2021 | β |
| Zika virus employs the host antiviral RNase L protein to support replication factory assembly. | Whelan JN et al. | β | 2021 | β |
| 2', 5'-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ξ IFN Signaling Pathway. | Liao X et al. | β | 2020 | β |
| All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes. | Yang E et al. | β | 2020 | β |
| Asian Zika Virus Isolate Significantly Changes the Transcriptional Profile and Alternative RNA Splicing Events in a Neuroblastoma Cell Line. | Bonenfant G et al. | β | 2020 | β |
| Characteristics of Human OAS1 Isoform Proteins. | Di H et al. | β | 2020 | β |
| Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection. | Michlmayr D et al. | β | 2020 | β |
| Discovering novel hub genes and pathways associated with the pathogenesis of psoriasis. | Gao LJ et al. | β | 2020 | β |
| Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections. | Acosta PL et al. | β | 2020 | β |
| New advances in our understanding of the "unique" RNase L in host pathogen interaction and immune signaling. | Gusho E et al. | β | 2020 | β |
| Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia. | Irving AT et al. | β | 2020 | β |
| Secretory Production of Functional Grouper Type I Interferon from <i>Epinephelus septemfasciatus</i> in <i>Escherichia coli</i> and <i>Bacillus subtilis</i>. | Lin HJ et al. | β | 2020 | β |
| Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2. | Koul A et al. | β | 2020 | β |
| Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death. | Kondratova AA et al. | β | 2020 | β |
| The Restrictome of Flaviviruses. | Berthoux L | β | 2020 | β |
| Zinc finger protein ZFP36L1 inhibits influenza A virus through translational repression by targeting HA, M and NS RNA transcripts. | Lin RJ et al. | β | 2020 | β |
| Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein. | Wiatrek DM et al. | β | 2019 | β |
| Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line. | Toka FN et al. | β | 2019 | β |
| Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [KΒ³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1. | Roy M et al. | β | 2019 | β |
| Drug repurposing of N-acetyl cysteine as antiviral against dengue virus infection. | Sreekanth GP et al. | β | 2019 | β |
| OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and enhance cytokine secretion. | Leisching G et al. | β | 2019 | β |
| RNA regulation of the antiviral protein 2'-5'-oligoadenylate synthetase. | Schwartz SL et al. | β | 2019 | β |
| Severe Dengue Prognosis Using Human Genome Data and Machine Learning. | Davi C et al. | β | 2019 | β |
| Zika Virus Production Is Resistant to RNase L Antiviral Activity. | Whelan JN et al. | β | 2019 | β |
| Conserved Active-Site Residues Associated with OAS Enzyme Activity and Ubiquitin-Like Domains Are Not Required for the Antiviral Activity of goOASL Protein against Avian Tembusu Virus. | Chen S et al. | β | 2018 | β |
| How Dengue Virus Circumvents Innate Immunity. | Kao YT et al. | β | 2018 | β |
| Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections. | Muffat J et al. | β | 2018 | β |
| Immune Response to Dengue and Zika. | Ngono AE et al. | β | 2018 | β |
| Immunomodulatory effect of 1, 25 dihydroxy vitamin D<sub>3</sub> on the expression of RNA sensing pattern recognition receptor genes and cytokine response in dengue virus infected U937-DC-SIGN cells and THP-1 macrophages. | Jadhav NJ et al. | β | 2018 | β |
| Intracellular Antiviral Immunity. | Bottermann M et al. | β | 2018 | β |
| RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5' Nontranslated Regions. | Yogarajah T et al. | β | 2018 | β |
| Suppression of Type I Interferon Signaling by <i>Flavivirus</i> NS5. | Thurmond S et al. | β | 2018 | β |
| The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-I Interferon Response. | Ji Z et al. | β | 2018 | β |
| An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus. | Zhang W et al. | β | 2017 | β |
| Association of the OAS3 rs1859330 G/A genetic polymorphism with severity of enterovirus-71 infection in Chinese Han children. | Tan Y et al. | β | 2017 | β |
| Distinguishing infections vs flares in patients with systemic lupus erythematosus. | Ospina FE et al. | β | 2017 | β |
| Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. | Kindler E et al. | β | 2017 | β |
| Host genetics and dengue fever. | Xavier-Carvalho C et al. | β | 2017 | β |
| Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways. | Al-Shujairi WH et al. | β | 2017 | β |
| Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication inΒ vitro. | Zhao M et al. | β | 2017 | β |
| Recent advances in Japanese encephalitis. | Basu A et al. | β | 2017 | β |
| Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model. | Morrison J et al. | β | 2017 | β |
| Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses. | Li Y et al. | β | 2016 | β |
| Association of Oligoadenylate Synthetase Gene Cluster and DC-SIGN (CD209) Gene Polymorphisms with Clinical Symptoms in Chikungunya Virus Infection. | Chaaithanya IK et al. | β | 2016 | β |
| Drug repurposing of minocycline against dengue virus infection. | Leela SL et al. | β | 2016 | β |
| Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection. | Li Y et al. | β | 2016 | β |
| Human heme oxygenase 1 is a potential host cell factor against dengue virus replication. | Tseng CK et al. | β | 2016 | β |
| Identification of 2'-5'-Oligoadenylate Synthetase-Like Gene in Goose: Gene Structure, Expression Patterns, and Antiviral Activity Against Newcastle Disease Virus. | Yang C et al. | β | 2016 | β |
| Porcine 2', 5'-oligoadenylate synthetases inhibit Japanese encephalitis virus replication in vitro. | Zheng S et al. | β | 2016 | β |
| Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses. | Clarke JN et al. | β | 2016 | β |
| Transcriptome meta-analysis reveals a dysregulation in extra cellular matrix and cell junction associated gene signatures during Dengue virus infection. | Afroz S et al. | β | 2016 | β |
| Transcriptome profiling reveals differential expression of interferon family induced by dengue virus 2 in human endothelial cells on tissue culture plastic and polyacrylamide hydrogel. | Pei H et al. | β | 2016 | β |
| Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte. | Shao Q et al. | β | 2016 | β |
| Characterization of the termini of the West Nile virus genome and their interactions with the small isoform of the 2' 5'-oligoadenylate synthetase family. | Deo S et al. | β | 2015 | β |
| Functions of the 3' and 5' genome RNA regions of members of the genus Flavivirus. | Brinton MA et al. | β | 2015 | β |
| High Anti-Dengue Virus Activity of the OAS Gene Family Is Associated With Increased Severity of Dengue. | Simon-Loriere E et al. | β | 2015 | β |
| Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins. | Zhang W et al. | β | 2015 | β |
| Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients. | Bader El Din NG et al. | β | 2015 | β |
| Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease. | Becker M et al. | β | 2015 | β |
| Interferon lambda inhibits dengue virus replication in epithelial cells. | Palma-Ocampo HK et al. | β | 2015 | β |
| Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases. | Choi UY et al. | β | 2015 | β |
| Polyomavirus T antigens activate an antiviral state. | Giacobbi NS et al. | β | 2015 | β |
| Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3. | Donovan J et al. | β | 2015 | β |
| The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. | Wood ER et al. | β | 2015 | β |
| Activation of 2' 5'-oligoadenylate synthetase by stem loops at the 5'-end of the West Nile virus genome. | Deo S et al. | β | 2014 | β |
| Association of dengue virus infection susceptibility with polymorphisms of 2'-5'-oligoadenylate synthetase genes: a case-control study. | Thamizhmani R et al. | β | 2014 | β |
| Can't RIDD off viruses. | Bhattacharyya S | β | 2014 | β |
| Expressional regulation of genes linked to immunity & programmed development in human early placental villi. | Khan MA et al. | β | 2014 | β |
| Flaviviral RNAs: weapons and targets in the war between virus and host. | Bidet K et al. | β | 2014 | β |
| HIV-1 translation and its regulation by cellular factors PKR and PACT. | Burugu S et al. | β | 2014 | β |
| Interferon stimulated gene 15 has an anti-apoptotic effect on MIN6 cells. | Yoshikawa A et al. | β | 2014 | β |
| MCPIP1 suppresses hepatitis C virus replication and negatively regulates virus-induced proinflammatory cytokine responses. | Lin RJ et al. | β | 2014 | β |
| Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism. | KjΓ¦r KH et al. | β | 2014 | β |
| Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication. | Tang WC et al. | β | 2014 | β |
| Revisiting dengue virus-host cell interaction: new insights into molecular and cellular virology. | Acosta EG et al. | β | 2014 | β |
| Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. | Han Y et al. | β | 2014 | β |
| Targeting host factors to treat West Nile and dengue viral infections. | Krishnan MN et al. | β | 2014 | β |
| The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation. | Ibsen MS et al. | β | 2014 | β |
| Adjuvant PIKA protects hepatoma cells from dengue virus infection by promoting a TBK-1-dependent innate immune response. | Zhang P et al. | β | 2013 | β |
| Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells. | Noguchi S et al. | β | 2013 | β |
| Evaluate the relationship between polymorphisms of OAS1 gene and susceptibility to chronic hepatitis C with high resolution melting analysis. | Zhao Y et al. | β | 2013 | β |
| Japanese encephalitis virus infection modulates the expression of suppressors of cytokine signaling (SOCS) in macrophages: implications for the hosts' innate immune response. | Kundu K et al. | β | 2013 | β |
| MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation. | Lin RJ et al. | β | 2013 | β |
| microRNA control of interferons and interferon induced anti-viral activity. | Sedger LM | β | 2013 | β |
| Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection. | Alagarasu K et al. | β | 2013 | β |
| Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling. | Zhou Y et al. | β | 2013 | β |
| Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii. | Colonne PM et al. | β | 2013 | β |
| The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus. | Kwon YC et al. | β | 2013 | β |
| A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus. | Zhao H et al. | β | 2012 | β |
| Dengue virus serotype 2 blocks extracellular signal-regulated kinase and nuclear factor-ΞΊB activation to downregulate cytokine production. | Chang TH et al. | β | 2012 | β |
| Dengue virus targets the adaptor protein MITA to subvert host innate immunity. | Yu CY et al. | β | 2012 | β |
| DNA microarray analysis of transcriptional responses of rats housed on solid and grid cage flooring. | Uehara M et al. | β | 2012 | β |
| Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis. | Cagliani R et al. | β | 2012 | β |
| Prostaglandin reductase 2 modulates ROS-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in gastric cancer patients. | Chang EY et al. | β | 2012 | β |
| Quantification of the host response proteome after mammalian reovirus T1L infection. | Berard AR et al. | β | 2012 | β |
| A central role for RNA in the induction and biological activities of type 1 interferons. | Li XL et al. | β | 2011 | β |
| Activation of Toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-Ξ² in cultured hepatoma cells. | Liang Z et al. | β | 2011 | β |
| Coronavirus gene 7 counteracts host defenses and modulates virus virulence. | Cruz JL et al. | β | 2011 | β |
| Dengue virus replication in infected human keratinocytes leads to activation of antiviral innate immune responses. | Surasombatpattana P et al. | β | 2011 | β |
| Host genetic risk factors for West Nile virus infection and disease progression. | Bigham AW et al. | β | 2011 | β |
| Japanese encephalitis virus infection induces changes of mRNA profile of mouse spleen and brain. | Yang Y et al. | β | 2011 | β |
| New developments in the induction and antiviral effectors of type I interferon. | Liu SY et al. | β | 2011 | β |
| RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression. | Lalonde E et al. | β | 2011 | β |
| Specificity protein 1 is pivotal in the skin's antiviral response. | Bin L et al. | β | 2011 | β |
| The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. | Kristiansen H et al. | β | 2011 | β |
| Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity. | Kristiansen H et al. | β | 2010 | β |
| Polymorphism of 2'-5'-oligoadenylate synthetase (<i>OAS</i>) genes, associated with predisposition to severe forms of tick-borne encephalitis, in human populations of North Eurasia. | Barkhash AV et al. | β | 2010 | β |