The familial association between cigarette smoking and ADHD: a study of clinically referred girls with and without ADHD, and their families.
- Authors
- Monuteaux, Michael C; Faraone, Stephen V; Hammerness, Paul; Wilens, Timothy E; Fraire, Maria; Biederman, Joseph
- Year
- 2008
- Journal
- Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
- PMID
- 18946774
- DOI
- 10.1080/14622200802326137
Attention-deficit/hyperactivity disorder (ADHD) is a strong risk factor for smoking. Since both ADHD and smoking are familial disorders, one way to further our understanding of this association is to examine the familial relationship between them. Our aim was to evaluate the familial association between ADHD and smoking in families ascertained from girls with and without ADHD. Subjects were derived from a longitudinal case-control family study of girls with (n = 140) and without (n = 122) ADHD ascertained from pediatric and psychiatric clinics, and their biological first-degree relatives. Diagnoses of ADHD and smoking (i.e., full or subthreshold nicotine dependence) were made with structured psychiatric interviews. We stratified the relatives into four groups based on probands' ADHD and smoking status: (1) relatives of controls without smoking (probands n = 100, relatives n = 317), (2) relatives of controls with smoking (probands n = 22, relatives n = 71), (3) relatives of ADHD girls without smoking (probands n = 100, relatives n = 320), and (4) relatives of ADHD girls with smoking (probands n = 39, relatives n = 133). We compared the rates of ADHD and smoking across the four relative groups using survival analysis. ADHD in the proband increased the risk for ADHD in the relatives irrespective of probands' smoking and smoking in the proband increased the risk for smoking in the relatives irrespective of probands' ADHD status. Furthermore, we found statistically significant evidence for cosegregation of smoking and ADHD, suggesting that the two disorders are transmitted together through families more often than expected by chance. These findings support the hypothesis that the combination of ADHD and smoking comprises an etiologically distinct familial subtype of ADHD in girls.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. | 2013 | 23089632 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Reciprocal relations between ADHD and risky behavior in adolescence: a between and within-person longitudinal analysis. | Goueta N et al. | — | 2025 | → |
| The association between attention deficit hyperactivity disorder (ADHD) and smoking experience or exposure to environmental tobacco smoke among children and adolescents. | Lee S et al. | — | 2023 | → |
| A prenatal nicotine exposure mouse model of methylphenidate responsive ADHD-associated cognitive phenotypes. | Zhu J et al. | — | 2017 | → |
| Childhood attention-deficit/hyperactivity disorder symptoms and the development of adolescent alcohol problems: A prospective, population-based study of Swedish twins. | Quinn PD et al. | — | 2016 | → |
| Dopamine and serotonin genetic risk scores predicting substance and nicotine use in attention deficit/hyperactivity disorder. | Groenman AP et al. | — | 2016 | → |
| Cigarette smoking in obsessive-compulsive disorder and unaffected parents of OCD patients. | Abramovitch A et al. | — | 2015 | → |
| Attention-deficit/hyperactivity disorder and adverse health outcomes in adults. | Spencer TJ et al. | — | 2014 | → |
| Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring. | Skoglund C et al. | — | 2014 | → |
| A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. | Wang JC et al. | — | 2013 | → |
| Attention deficit/hyperactivity disorder symptoms and depression symptoms as mediators in the intergenerational transmission of smoking. | Zoloto A et al. | — | 2012 | → |
| The effects of childhood ADHD symptoms on early-onset substance use: a Swedish twin study. | Chang Z et al. | — | 2012 | → |
| Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: a meta-analytic review. | Lee SS et al. | — | 2011 | → |
| ADHD after fetal exposure to maternal smoking. | Lindblad F et al. | — | 2010 | → |
| Emotional, behavioural problems and cigarette smoking in adolescence: findings of a Greek cross-sectional study. | Giannakopoulos G et al. | — | 2010 | → |
| Genome-wide association study of smoking initiation and current smoking. | Vink JM et al. | — | 2009 | → |