Ethanol opens G-protein-activated inwardly rectifying K+ channels.
paper
Cited
Public
Unavailable
- Authors
- Kobayashi, T; Ikeda, K; Kojima, H; Niki, H; Yano, R; Yoshioka, T; Kumanishi, T
- Year
- 1999
- Journal
- Nature neuroscience
- PMID
- 10570486
- DOI
- 10.1038/16019
Ethanol affects many functions of the brain and peripheral organs. Here we show that ethanol opens G-protein-activated, inwardly rectifying K + (GIRK) channels, which has important implications for inhibitory regulation of neuronal excitability and heart rate. At pharmacologically relevant concentrations, ethanol activated both brain-type GIRK1/2 and cardiac-type GIRK1/4 channels without interaction with G proteins or second messengers. Moreover, weaver mutant mice, which have a missense mutation in the GIRK2 channel, showed a loss of ethanol-induced analgesia. These results suggest that the GIRK channels in the brain and heart are important target sites for ethanol.
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