Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG.
paper
Cited
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- Authors
- Bäckström, Pia; Hyytiä, Petri
- Year
- 2005
- Journal
- European journal of pharmacology
- PMID
- 16324694
- DOI
- 10.1016/j.ejphar.2005.10.051
Glutamatergic neurotransmission has been suggested to modulate cue-induced drug-seeking behavior. Here we examined the effects of metabotropic glutamate receptor agonists on alcohol self-administration and cue-induced reinstatement. Rats were trained to self-administer 10% w/v ethanol under an FR1 schedule of reinforcement during 30-min sessions. In the reinstatement experiments, ethanol and a non-rewarding quinine solution (available on alternating days) were paired with olfactory stimuli (S+/S-) as well as light (CS+) or tone (CS-) stimuli. Following extinction training, reinstatement of responding was induced by the ethanol-associated stimuli (S+/CS+). The mGlu2/3 receptor agonist LY379268 (0, 1, 3 and 5 mg/kg i.p.) and the mGlu8 receptor agonist (S)-3,4-DCPG (0, 5, 10 and 15 mg/kg i.p.) attenuated alcohol self-administration and reinstatement at doses that decreased also spontaneous locomotor activity. The results suggest that metabotropic glutamate receptors may have a role in the modulation of alcohol seeking and self-administration. However, further studies with ligands with fewer motor-suppressant side effects are needed.
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| Metabotropic group II glutamate receptors mediate cue-triggered increases in reward-seeking behaviour. | Garceau C et al. | — | 2023 | → |
| Roles of metabotropic glutamate receptor 8 in neuropsychiatric and neurological disorders. | Mao LM et al. | — | 2023 | → |
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| Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease. | Luessen DJ et al. | — | 2022 | → |
| Clinical investigations of compounds targeting metabotropic glutamate receptors. | Witkin JM et al. | — | 2022 | → |
| Diet-induced deficits in goal-directed control are rescued by agonism of group II metabotropic glutamate receptors in the dorsomedial striatum. | Shipman ML et al. | — | 2022 | → |
| mGlu2 mechanism-based interventions to treat alcohol relapse. | Vengeliene V et al. | — | 2022 | → |
| Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases. | Li SH et al. | — | 2022 | → |
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| Control of impulsivity by G<sub>i</sub>-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex. | van der Veen B et al. | — | 2021 | → |
| Metabotropic group II glutamate receptors in the basolateral amygdala mediate cue-triggered increases in incentive motivation. | Garceau C et al. | — | 2021 | → |
| Neurobiology of alcohol seeking behavior. | Domi E et al. | — | 2021 | → |
| The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats. | Kahvandi N et al. | — | 2021 | → |
| Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure. | Johnson KA et al. | — | 2020 | → |
| Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations. | Johnson KA et al. | — | 2020 | → |
| The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum. | Boccella S et al. | — | 2020 | → |
| Effects of group II metabotropic glutamate receptor modulation on ethanol- and sucrose-seeking and consumption in the rat. | Windisch KA et al. | — | 2018 | → |
| Metabotropic Glutamate Receptors in Alcohol Use Disorder: Physiology, Plasticity, and Promising Pharmacotherapies. | Joffe ME et al. | — | 2018 | → |
| Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat. | Lebourgeois S et al. | — | 2018 | → |
| Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking. | Lovinger DM | — | 2018 | → |
| Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence. | Alasmari F et al. | — | 2018 | → |
| Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist. | Hajasova Z et al. | — | 2018 | → |
| Effects of alcohol on c-Myc protein in the brain. | Akinyeke T et al. | — | 2017 | → |
| Glutamate plasticity woven through the progression to alcohol use disorder: a multi-circuit perspective. | Hwa L et al. | — | 2017 | → |
| Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder. | Goodwani S et al. | — | 2017 | → |
| NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication. | Olszewski RT et al. | — | 2017 | → |
| Rat animal models for screening medications to treat alcohol use disorders. | Bell RL et al. | — | 2017 | → |
| Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys. | Justinova Z et al. | — | 2016 | → |
| The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats. | Augier E et al. | — | 2016 | → |
| Activation of mGluR2/3 following stress hormone exposure restores sensitivity to alcohol in rats. | Jaramillo AA et al. | — | 2015 | → |
| Glutamatergic transmission in drug reward: implications for drug addiction. | D'Souza MS | — | 2015 | → |
| Increased metabotropic glutamate 2/3 receptor binding in the perigenual anterior cingulate cortex of Cloninger type 2 alcoholics: a whole-hemisphere autoradiography study. | Laukkanen V et al. | — | 2015 | → |
| Nucleus accumbens injections of the mGluR2/3 agonist LY379268 increase cue-induced sucrose seeking following adult, but not adolescent sucrose self-administration. | Myal S et al. | — | 2015 | → |
| Postdependent state in rats as a model for medication development in alcoholism. | Meinhardt MW et al. | — | 2015 | → |
| Association of single-nucleotide polymorphisms in a metabotropic glutamate receptor GRM3 gene subunit to alcohol-dependent male subjects. | Xia Y et al. | — | 2014 | → |
| Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models. | Jupp B et al. | — | 2014 | → |
| Exploring the role of central astrocytic glutamate uptake in ethanol reward in mice. | Smith KL et al. | — | 2014 | → |
| Group III metabotropic glutamate receptors: pharmacology, physiology and therapeutic potential. | Mercier MS et al. | — | 2014 | → |
| Metabotropic glutamate receptor 3 is associated with heroin dependence but not depression or schizophrenia in a Chinese population. | Jia W et al. | — | 2014 | → |
| Repeated alcohol extinction sessions in conjunction with MK-801, but not yohimbine or propranolol, reduces subsequent alcohol cue-induced responding in rats. | Williams KL et al. | — | 2014 | → |
| Role of cues and contexts on drug-seeking behaviour. | Perry CJ et al. | — | 2014 | → |
| Role of glutamate transporter 1 in the attenuation of alcohol intake. | Sari Y | — | 2014 | → |
| Supraspinal metabotropic glutamate receptor subtype 8: a switch to turn off pain. | Palazzo E et al. | — | 2014 | → |
| Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration. | Kufahl PR et al. | — | 2013 | → |
| Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus. | Mercier MS et al. | — | 2013 | → |
| Glutamatergic targets for new alcohol medications. | Holmes A et al. | — | 2013 | → |
| Group III metabotropic glutamate receptors and drug addiction. | Mao L et al. | — | 2013 | → |
| mGlu3 receptor and astrocytes: partners in neuroprotection. | Durand D et al. | — | 2013 | → |
| Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders. | Gregory KJ et al. | — | 2013 | → |
| Regulation of the brain-gut axis by group III metabotropic glutamate receptors. | Julio-Pieper M et al. | — | 2013 | → |
| The group II metabotropic glutamate receptor agonist, LY379268, decreases methamphetamine self-administration in rats. | Crawford JT et al. | — | 2013 | → |
| (-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking. | Martin-Fardon R et al. | — | 2012 | → |
| Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. | Bell RL et al. | — | 2012 | → |
| Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate levels and neurocognition in non-smoking, active alcoholics. | Xia Y et al. | — | 2012 | → |
| Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens. | Marty VN et al. | — | 2012 | → |
| Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. | Wolen AR et al. | — | 2012 | → |
| mGlu receptors and drug addiction. | Cleva RM et al. | — | 2012 | → |
| Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats. | Bahi A et al. | — | 2012 | → |
| Therapeutic potential of metabotropic glutamate receptor modulators. | Hovelsø N et al. | — | 2012 | → |
| The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 prevents reinstatement of extinguished ethanol-induced conditioned place preference in mice. | Bahi A | — | 2012 | → |
| Activation of group II metabotropic glutamate receptors inhibits the discriminative stimulus effects of alcohol via selective activity within the amygdala. | Cannady R et al. | — | 2011 | → |
| Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors. | Gass JT et al. | — | 2011 | → |
| Allosteric modulation of metabotropic glutamate receptors. | Sheffler DJ et al. | — | 2011 | → |
| Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats. | Sari Y et al. | — | 2011 | → |
| Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence. | Kufahl PR et al. | — | 2011 | → |
| Retracted article: Selective activation of the metabotropic glutamate receptor subtype 7 "mGluR7" attenuates acquisition, expression, and reinstatement of ethanol place preference. | Bahi A | — | 2011 | → |
| Retracted: The pre-synaptic metabotropic glutamate receptor 7 "mGluR7" is a critical modulator of ethanol sensitivity in mice. | Bahi A | — | 2011 | → |
| The influence of selection for ethanol withdrawal severity on traits associated with ethanol self-administration and reinforcement. | Ford MM et al. | — | 2011 | → |
| Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence. | Sidhpura N et al. | — | 2010 | → |
| Genome-wide association scan of trait depression. | Terracciano A et al. | — | 2010 | → |
| Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction. | Moussawi K et al. | — | 2010 | → |
| Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake. | Besheer J et al. | — | 2010 | → |
| N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. | Xi ZX et al. | — | 2010 | → |
| New horizons for therapeutics in drug and alcohol abuse. | Jupp B et al. | — | 2010 | → |
| The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats. | Jin X et al. | — | 2010 | → |
| The Potent Effect of Environmental Context on Relapse to Alcohol-Seeking After Extinction. | Janak PH et al. | — | 2010 | → |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | — | 2009 | → |
| Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. | Chen AC et al. | — | 2009 | → |
| Development of pharmacotherapies for drug addiction: a Rosetta stone approach. | Koob GF et al. | — | 2009 | → |
| Effects of (RS)-3,4-DCPG, a mixed AMPA antagonist/mGluR8 agonist, on aggressive behavior in mice. | Navarro JF et al. | — | 2009 | → |
| Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. | Besheer J et al. | — | 2009 | → |
| Metabotropic glutamate receptor ligands as potential therapeutics for addiction. | Olive MF | — | 2009 | → |
| Effect of naltrexone during extinction of alcohol-reinforced responding and during repeated cue-conditioned reinstatement sessions in a cue exposure style treatment. | Williams KL et al. | — | 2008 | → |
| Glutamatergic substrates of drug addiction and alcoholism. | Gass JT et al. | — | 2008 | → |
| Homers regulate drug-induced neuroplasticity: implications for addiction. | Szumlinski KK et al. | — | 2008 | → |
| How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective. | Clapp P et al. | — | 2008 | → |
| Neuropharmacology of alcohol addiction. | Vengeliene V et al. | — | 2008 | → |
| Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082. | Salling MC et al. | — | 2008 | → |
| Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. | Bowers MS et al. | — | 2008 | → |
| Role of the glutamatergic system in nicotine dependence : implications for the discovery and development of new pharmacological smoking cessation therapies. | Liechti ME et al. | — | 2008 | → |
| Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intake. | Kapasova Z et al. | — | 2008 | → |
| Synergistic effects of the dopaminergic and glutamatergic system on hippocampal volume in alcohol-dependent patients. | Puls I et al. | — | 2008 | → |
| Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. | Marabese I et al. | — | 2007 | → |
| Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41). | Finn DA et al. | — | 2007 | → |
| Metabotropic glutamate 2/3 receptor activation induced reward deficits but did not aggravate brain reward deficits associated with spontaneous nicotine withdrawal in rats. | Liechti ME et al. | — | 2007 | → |
| Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. | Liechti ME et al. | — | 2007 | → |
| The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268. | Imre G | — | 2007 | → |
| Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala. | Zhao Y et al. | — | 2006 | → |
| Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys. | Adewale AS et al. | — | 2006 | → |