Complement factor H variant increases the risk of age-related macular degeneration.
paper
Cited
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- Authors
- Haines, Jonathan L; Hauser, Michael A; Schmidt, Silke; Scott, William K; Olson, Lana M; Gallins, Paul; Spencer, Kylee L; Kwan, Shu Ying; Noureddine, Maher; Gilbert, John R; Schnetz-Boutaud, Nathalie; Agarwal, Anita; Postel, Eric A; Pericak-Vance, Margaret A
- Year
- 2005
- Journal
- Science (New York, N.Y.)
- PMID
- 15761120
- DOI
- 10.1126/science.1110359
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD. We used single-nucleotide polymorphisms to interrogate this region and identified a strongly associated haplotype in two independent data sets. DNA resequencing of the complement factor H gene within this haplotype revealed a common coding variant, Y402H, that significantly increases the risk for AMD with odds ratios between 2.45 and 5.57. This common variant likely explains approximately 43% of AMD in older adults.
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| Gene Therapy for Neovascular Macular Degeneration, Diabetic Retinopathy, and Diabetic Macular Edema. | Mellen PL et al. | — | 2021 | → |
| Genetic and environmental risk factors for reticular pseudodrusen in the EUGENDA study. | Altay L et al. | — | 2021 | → |
| Genetic Association between <i>MMP9</i> and Choroidal Neovascularization in Age-Related Macular Degeneration. | Sohn EH et al. | — | 2021 | → |
| Genetic Mechanism Revealed of Age-Related Macular Degeneration Based on Fusion of Statistics and Machine Learning Method. | Du Y et al. | — | 2021 | → |
| Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World. | Bhatwadekar AD et al. | — | 2021 | → |
| High Myopia and the Complement System: Factor H in Myopic Maculopathy. | García-Gen E et al. | — | 2021 | → |
| Hijacking Factor H for Complement Immune Evasion. | Moore SR et al. | — | 2021 | → |
| IL-1/IL-1R signaling induced by all-trans-retinal contributes to complement alternative pathway activation in retinal pigment epithelium. | Cheng X et al. | — | 2021 | → |
| Implementation and implications for polygenic risk scores in healthcare. | Slunecka JL et al. | — | 2021 | → |
| Implications of genetic variation in the complement system in age-related macular degeneration. | de Jong S et al. | — | 2021 | → |
| Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration. | Hu ML et al. | — | 2021 | → |
| Interlink between Inflammation and Oxidative Stress in Age-Related Macular Degeneration: Role of Complement Factor H. | Romero-Vazquez S et al. | — | 2021 | → |
| Investigational Agents in Development for the Treatment of Geographic Atrophy Secondary to Age-Related Macular Degeneration. | Yu HJ et al. | — | 2021 | → |
| Molecular genetics of inherited retinal degenerations in Icelandic patients. | Thorsteinsson DA et al. | — | 2021 | → |
| Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degeneration. | May A et al. | — | 2021 | → |
| Prevalence and phenotype associations of complement factor I mutations in geographic atrophy. | Khan AH et al. | — | 2021 | → |
| Progress in developing rodent models of age-related macular degeneration (AMD). | Soundara Pandi SP et al. | — | 2021 | → |
| Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants. | Tzoumas N et al. | — | 2021 | → |
| Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene Therapy. | Varin J et al. | — | 2021 | → |
| Semi-Quantitative Multiplex Profiling of the Complement System Identifies Associations of Complement Proteins with Genetic Variants and Metabolites in Age-Related Macular Degeneration. | Acar IE et al. | — | 2021 | → |
| Sensitization of ON-bipolar cells with ambient light activatable multi-characteristic opsin rescues vision in mice. | Batabyal S et al. | — | 2021 | → |
| Single-cell RNA sequencing in vision research: Insights into human retinal health and disease. | Voigt AP et al. | — | 2021 | → |
| Sphingolipids as critical players in retinal physiology and pathology. | Simon MV et al. | — | 2021 | → |
| Sustained suppression of VEGF for treatment of retinal/choroidal vascular diseases. | Campochiaro PA et al. | — | 2021 | → |
| Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions. | Kim BJ et al. | — | 2021 | → |
| Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration. | Chae JB et al. | — | 2021 | → |
| The 100 most-cited papers on age-related macular degeneration: a bibliographic perspective. | Grzybowski A et al. | — | 2021 | → |
| The Benefits of Complement Measurements for the Clinical Practice. | Grunenwald A et al. | — | 2021 | → |
| The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD. | Lu ZG et al. | — | 2021 | → |
| The pathogenesis of age-related macular degeneration is not inflammatory mediated but is instead due to immunosenescence-related failure of tissue repair. | Kent D | — | 2021 | → |
| Therapeutic Options Under Development for Nonneovascular Age-Related Macular Degeneration and Geographic Atrophy. | Kim JB et al. | — | 2021 | → |
| The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade. | McMahon O et al. | — | 2021 | → |
| The Role of Electronic Health Records in Advancing Genomic Medicine. | Linder JE et al. | — | 2021 | → |
| Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration. | Deng Y et al. | — | 2021 | → |
| 2018 Langley Award for Basic Research on Nicotine and Tobacco: Bringing Precision Medicine to Smoking Cessation. | Bierut LJ | — | 2020 | → |
| Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. | Efstathiou NE et al. | — | 2020 | → |
| Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier <i>in vitro</i>: implications for age-related macular degeneration. | Romero-Vázquez S et al. | — | 2020 | → |
| Age-related macular degeneration among the elderly: The 5th National Health and Nutrition Examination Survey, 2010 through 2012. | Kim CG et al. | — | 2020 | → |
| Age-related macular degeneration: A two-level model hypothesis. | Rozing MP et al. | — | 2020 | → |
| Age-related Macular Degeneration: Nutrition, Genes and Deep Learning-The LXXVI Edward Jackson Memorial Lecture. | Chew EY | — | 2020 | → |
| Age-Related Macular Degeneration Preferred Practice Pattern®. | Flaxel CJ et al. | — | 2020 | → |
| An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration. | Dabouz R et al. | — | 2020 | → |
| Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities. | Oguchi Y et al. | — | 2020 | → |
| Apolipoprotein E Triggers Complement Activation in Joint Synovial Fluid of Rheumatoid Arthritis Patients by Binding C1q. | Vogt LM et al. | — | 2020 | → |
| A unique <i>PRDM13</i>-associated variant in a Georgian Jewish family with probable North Carolina macular dystrophy and the possible contribution of a unique <i>CFH</i> variant. | Namburi P et al. | — | 2020 | → |
| Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors. | Camelo S et al. | — | 2020 | → |
| Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models. | Abokyi S et al. | — | 2020 | → |
| Coculture techniques for modeling retinal development and disease, and enabling regenerative medicine. | Ghareeb AE et al. | — | 2020 | → |
| Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection. | van den Broek B et al. | — | 2020 | → |
| Comparison of machine learning tools for the prediction of AMD based on genetic, age, and diabetes-related variables in the Chinese population. | Hao S et al. | — | 2020 | → |
| Complement-Related Proteins and Their Measurements: The Current Status of Clinical Investigation. | Ohtani K | — | 2020 | → |
| Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration. | Stravalaci M et al. | — | 2020 | → |
| CXCR5/NRF2 double knockout mice develop retinal degeneration phenotype at early adult age. | Huang H et al. | — | 2020 | → |
| Dengue virus and the complement alternative pathway. | Carr JM et al. | — | 2020 | → |
| Disentangling the genetics of sarcopenia: prioritization of NUDT3 and KLF5 as genes for lean mass & HLA-DQB1-AS1 for hand grip strength with the associated enhancing SNPs & a scoring system. | Singh AN et al. | — | 2020 | → |
| Do Genomic Factors Play a Role in Diabetic Retinopathy? | Cabrera AP et al. | — | 2020 | → |
| Evidence for Activation of Lectin and Classical Pathway Complement Components in Aqueous Humor of Neovascular Age-Related Macular Degeneration. | Omori T et al. | — | 2020 | → |
| Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes. | Hu J et al. | — | 2020 | → |
| Family-based exome sequencing identifies rare coding variants in age-related macular degeneration. | Ratnapriya R et al. | — | 2020 | → |
| Functional Characterization of Rare Genetic Variants in the N-Terminus of Complement Factor H in aHUS, C3G, and AMD. | Wong EKS et al. | — | 2020 | → |
| Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B. | Pilotti C et al. | — | 2020 | → |
| Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits. | Meri S et al. | — | 2020 | → |
| Gene, Cell and Antibody-Based Therapies for the Treatment of Age-Related Macular Degeneration. | Akyol E et al. | — | 2020 | → |
| Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology. | Eslam M et al. | — | 2020 | → |
| Genome-wide association study of multiple yield traits in a diversity panel of polyploid sugarcane (Saccharum spp.). | Yang X et al. | — | 2020 | → |
| Genotypes and Phenotypes: A Search for Influential Genes in Diabetic Retinopathy. | Cabrera AP et al. | — | 2020 | → |
| Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions. | Bonilha VL et al. | — | 2020 | → |
| High-density lipoproteins are a potential therapeutic target for age-related macular degeneration. | Kelly UL et al. | — | 2020 | → |
| Identification of therapeutic targets from genetic association studies using hierarchical component analysis. | Lee HC et al. | — | 2020 | → |
| Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration. | Cipriani V et al. | — | 2020 | → |
| Investigation of genetic base in the treatment of age-related macular degeneration. | Gourgouli K et al. | — | 2020 | → |
| LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target. | Choudhary M et al. | — | 2020 | → |
| Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration. | Little K et al. | — | 2020 | → |
| Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease. | Caruso A et al. | — | 2020 | → |
| NEI-Supported Age-Related Macular Degeneration Research: Past, Present, and Future. | Wright C et al. | — | 2020 | → |
| Neovascular Age-Related Macular Degeneration: Therapeutic Management and New-Upcoming Approaches. | Ricci F et al. | — | 2020 | → |
| New Technologies to Study Functional Genomics of Age-Related Macular Degeneration. | Nguyen T et al. | — | 2020 | → |
| Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration. | Tong Y et al. | — | 2020 | → |
| Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates. | Hughes S et al. | — | 2020 | → |
| Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration. | Hallam TM et al. | — | 2020 | → |
| Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways. | Wang L et al. | — | 2020 | → |
| Sequence Variants Linked to Key Traits in Interspecific Crosses between African and Asian Rice. | Badro H et al. | — | 2020 | → |
| Systemic activation of the complement system in patients with advanced age-related macular degeneration. | Lynch AM et al. | — | 2020 | → |
| Systemic Inflammation by Collagen-Induced Arthritis Affects the Progression of Age-Related Macular Degeneration Differently in Two Mouse Models of the Disease. | Schnabolk G et al. | — | 2020 | → |
| The Relationship Between Cognitive Status and Known Single Nucleotide Polymorphisms in Age-Related Macular Degeneration. | Murphy C et al. | — | 2020 | → |
| Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions. | Mannes M et al. | — | 2020 | → |
| Adaptive and Maladaptive Complement Activation in the Retina. | Silverman SM et al. | — | 2019 | → |
| Age-related macular degeneration (AMD) mitochondria modulate epigenetic mechanisms in retinal pigment epithelial cells. | Nashine S et al. | — | 2019 | → |
| ASSOCIATION BETWEEN ORAL IRON SUPPLEMENTATION AND RETINAL OR SUBRETINAL HEMORRHAGE IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENT TRIALS. | Song D et al. | — | 2019 | → |
| Association of rs10490924 in ARMS2/HTRA1 with age-related macular degeneration in the Pakistani population. | Ayub H et al. | — | 2019 | → |
| A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. | Handa JT et al. | — | 2019 | → |
| Big DNA as a tool to dissect an age-related macular degeneration-associated haplotype. | Laurent JM et al. | — | 2019 | → |
| CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex. | Borras C et al. | — | 2019 | → |
| Characterization of Retinal Pigment Epithelial Melanin and Degraded Synthetic Melanin Using Mass Spectrometry and In Vitro Biochemical Diagnostics. | Yacout SM et al. | — | 2019 | → |
| Clinical promise of next-generation complement therapeutics. | Mastellos DC et al. | — | 2019 | → |
| Compendium of current complement therapeutics. | Zelek WM et al. | — | 2019 | → |
| Complement inhibition as a therapeutic strategy in retinal disorders. | Kassa E et al. | — | 2019 | → |
| Development and characterization of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species. | Zelek WM et al. | — | 2019 | → |
| Early local activation of complement in aqueous humour of patients with age-related macular degeneration. | Altay L et al. | — | 2019 | → |
| EXIT STRATEGY IN A TREAT-AND-EXTEND REGIMEN FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION. | Arendt P et al. | — | 2019 | → |
| Functional Genomics of the Retina to Elucidate its Construction and Deconstruction. | Blond F et al. | — | 2019 | → |
| Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. | Halladay CW et al. | — | 2019 | → |
| Genetic Survey of Adult-Onset Idiopathic Intracranial Hypertension. | Kuehn MH et al. | — | 2019 | → |
| Genome-wide Association Studies in Rice: How to Solve the Low Power Problems? | Zhou X et al. | — | 2019 | → |
| Genomic and Phenomic Research in the 21st Century. | Hebbring S | — | 2019 | → |
| HMGCLL1 is a predictive biomarker for deep molecular response to imatinib therapy in chronic myeloid leukemia. | Park JH et al. | — | 2019 | → |
| Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice. | Landowski M et al. | — | 2019 | → |
| Increased Nonexudative Age-Related Macular Degeneration Diagnosis Among Medicare Beneficiaries With Rheumatoid Arthritis. | Schnabolk G et al. | — | 2019 | → |
| Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions. | Lipecz A et al. | — | 2019 | → |
| Molecular Mechanisms of Complement System Proteins and Matrix Metalloproteinases in the Pathogenesis of Age-Related Macular Degeneration. | Mansoor N et al. | — | 2019 | → |
| On the origin of proteins in human drusen: The meet, greet and stick hypothesis. | Bergen AA et al. | — | 2019 | → |
| Oxidative stress in patients with neovascular macular degeneration. | Cinq Frais C et al. | — | 2019 | → |
| Periodontal Diseases and Age-Related Macular Degeneration: Is There a Link? A Review. | Pockpa ZAD et al. | — | 2019 | → |
| Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment. | Hagbi-Levi S et al. | — | 2019 | → |
| Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide. | Hazim RA et al. | — | 2019 | → |
| Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility. | Lee AS et al. | — | 2019 | → |
| Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish. | Waksmunski AR et al. | — | 2019 | → |
| Regulation of regulators: Role of the complement factor H-related proteins. | Cserhalmi M et al. | — | 2019 | → |
| Regulation of the Complement System by Pentraxins. | Haapasalo K et al. | — | 2019 | → |
| Role of the Choroid in Age-related Macular Degeneration: A Current Review. | Farazdaghi MK et al. | — | 2019 | → |
| Systemic expression of Alu RNA in patients with geographic atrophy secondary to age-related macular degeneration. | Yoshida H et al. | — | 2019 | → |
| The ARMS2 A69S Polymorphism Is Associated with Delayed Rod-Mediated Dark Adaptation in Eyes at Risk for Incident Age-Related Macular Degeneration. | Mullins RF et al. | — | 2019 | → |
| The association between complement factor H rs1061170 polymorphism and age-related macular degeneration: a comprehensive meta-analysis stratified by stage of disease and ethnicity. | Maugeri A et al. | — | 2019 | → |
| The Challenges and Promise of Complement Therapeutics for Ocular Diseases. | Park DH et al. | — | 2019 | → |
| The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration. | Brown EE et al. | — | 2019 | → |
| The impact of lipids, lipid oxidation, and inflammation on AMD, and the potential role of miRNAs on lipid metabolism in the RPE. | Jun S et al. | — | 2019 | → |
| Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention. | Nusinovici S et al. | — | 2019 | → |
| Zinc Nutrition and Inflammation in the Aging Retina. | Gilbert R et al. | — | 2019 | → |
| A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells. | Parmar VM et al. | — | 2018 | → |
| Activation of the ERK1/2-MAPK Signaling Pathway by Complement Serum in UV-POS-Pretreated ARPE-19 Cells. | Busch M et al. | — | 2018 | → |
| Analysis of the association between CFH Y402H polymorphism and response to intravitreal ranibizumab in patients with neovascular age-related macular degeneration (nAMD). | Mohamad NA et al. | — | 2018 | → |
| A Perspective of AMD Through the Eyes of Immunology. | Copland DA et al. | — | 2018 | → |
| A phylogenetic method to perform genome-wide association studies in microbes that accounts for population structure and recombination. | Collins C et al. | — | 2018 | → |
| Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration. | Cobos E et al. | — | 2018 | → |
| Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis. | Zhang J et al. | — | 2018 | → |
| Association of coding and UTR variants in the known regions with wet age-related macular degeneration in Han Chinese population. | Huang L et al. | — | 2018 | → |
| Big DNA as a tool to dissect an age-related macular degeneration-associated haplotype | Laurent JM et al. | — | 2018 | — |
| Calf melanin immunomodulates RPE cell attachment to extracellular matrix protein. | Yacout SM et al. | — | 2018 | → |
| Cell Transplantation for Retinal Degeneration: Transition from Rodent to Nonhuman Primate Models. | McGill TJ et al. | — | 2018 | → |
| Changing vision: a review of pharmacogenetic studies for treatment response in age-related macular degeneration patients. | Arslan J et al. | — | 2018 | → |
| Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy. | Katschke KJ et al. | — | 2018 | → |
| Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects. | Kim Y et al. | — | 2018 | → |
| Complement factor H in AMD: Bridging genetic associations and pathobiology. | Toomey CB et al. | — | 2018 | → |
| Complement Factor H Inhibits Anti-Neutrophil Cytoplasmic Autoantibody-Induced Neutrophil Activation by Interacting With Neutrophils. | Chen SF et al. | — | 2018 | → |
| Complement in cancer: untangling an intricate relationship. | Reis ES et al. | — | 2018 | → |
| Complement in the pathogenesis of Alzheimer's disease. | Morgan BP | — | 2018 | → |
| Complement regulation and kidney diseases: recent knowledge of the double-edged roles of complement activation in nephrology. | Mizuno M et al. | — | 2018 | → |
| Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine. | Maugeri A et al. | — | 2018 | → |
| Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy. | Wu X et al. | — | 2018 | → |
| C-Reactive Protein As a Mediator of Complement Activation and Inflammatory Signaling in Age-Related Macular Degeneration. | Chirco KR et al. | — | 2018 | → |
| C-Reactive Protein as a Therapeutic Target in Age-Related Macular Degeneration. | Molins B et al. | — | 2018 | → |
| Developments in anti-complement therapy; from disease to clinical trial. | Harris CL et al. | — | 2018 | → |
| Distribution of exogenous complement factor H in mice in vivo. | Koskinen AR et al. | — | 2018 | → |
| Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome. | Natoli R et al. | — | 2018 | → |
| [Epigenetics in age-related macular degeneration (AMD) - French translation of the article]. | Desmettre T | — | 2018 | → |
| Extracellular Vesicles: Packages Sent With Complement. | Karasu E et al. | — | 2018 | → |
| Extracting Complementary Insights from Molecular Phenotypes for Prioritization of Disease-Associated Mutations. | Wierbowski SD et al. | — | 2018 | → |
| Fishing forward and reverse: Advances in zebrafish phenomics. | Fuentes R et al. | — | 2018 | → |
| From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results. | Cirillo E et al. | — | 2018 | → |
| Full genetic analysis for genome-wide association study of Fangji: a powerful approach for effectively dissecting the molecular architecture of personalized traditional Chinese medicine. | Chen G et al. | — | 2018 | → |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | — | 2018 | → |
| Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders. | Singh M et al. | — | 2018 | → |
| Genetics and genetic testing for age-related macular degeneration. | Warwick A et al. | — | 2018 | → |
| How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? | McCarty CA et al. | — | 2018 | → |
| HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1. | Lin MK et al. | — | 2018 | → |
| Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice. | Kim HS et al. | — | 2018 | → |
| Intravitreal injection of aflibercept, an anti-VEGF antagonist, down-regulates plasma von Willebrand factor in patients with age-related macular degeneration. | Yamashita M et al. | — | 2018 | → |
| MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina. | Chu-Tan JA et al. | — | 2018 | → |
| Models of retinal diseases and their applicability in drug discovery. | Malek G et al. | — | 2018 | → |
| Myopia in Chinese families shows linkage to 10q26.13. | Musolf AM et al. | — | 2018 | → |
| [Next generation biobanking: the challenge of data]. | Dagher G et al. | — | 2018 | → |
| Novel Association of High C-Reactive Protein Levels and A69S at Risk Alleles in Wet Age-Related Macular Degeneration Women. | Fernandez-Robredo P et al. | — | 2018 | → |
| Omics, big data and machine learning as tools to propel understanding of biological mechanisms and to discover novel diagnostics and therapeutics. | Perakakis N et al. | — | 2018 | → |
| Osmotic and hypoxic induction of the complement factor C9 in cultured human retinal pigment epithelial cells: Regulation of VEGF and NLRP3 expression. | Hollborn M et al. | — | 2018 | → |
| Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium. | Ebrahimi KB et al. | — | 2018 | → |
| Personalised Medicine: The Odyssey from Hope to Practice. | Visvikis-Siest S et al. | — | 2018 | → |
| Pharmacogenetic Aspect of Intravitreal Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Five-Year Follow-Up. | Sengul EA et al. | — | 2018 | → |
| Physiological Roles of Metallothioneins in Central Nervous System Diseases. | Nakamura S et al. | — | 2018 | → |
| Plasma levels of hypoxia-regulated factors in patients with age-related macular degeneration. | Ioanna Z et al. | — | 2018 | → |
| Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population. | Connolly E et al. | — | 2018 | → |
| Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration. | Arya S et al. | — | 2018 | → |
| Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (<i>CFH</i>) gene family. | Cantsilieris S et al. | — | 2018 | → |
| Retinal pigment epithelium in the pathogenesis of age-related macular degeneration and photobiomodulation as a potential therapy? | Ao J et al. | — | 2018 | → |
| Selective permeability of mouse blood-aqueous barrier as determined by <sup>15</sup>N-heavy isotope tracing and mass spectrometry. | Liu P et al. | — | 2018 | → |
| Significant Association Between Variant in SGCD and Age-Related Macular Degeneration. | Perez-Ortiz AC et al. | — | 2018 | → |
| Systemic immunosuppression and risk of age-related macular degeneration. | Sandhu HS et al. | — | 2018 | → |
| The Association Between Variants of Receptor for Advanced Glycation End Products (RAGE) Gene Polymorphisms and Age-Related Macular Degeneration. | Banevicius M et al. | — | 2018 | → |
| The effects of zinc supplementation on primary human retinal pigment epithelium. | Pao PJ et al. | — | 2018 | → |
| The eye as a complement dysregulation hotspot. | Clark SJ et al. | — | 2018 | → |
| The Post-GWAS Era: From Association to Function. | Gallagher MD et al. | — | 2018 | → |
| The use of the vaccinia virus complement control protein (VCP) in the rat retina. | Fernando N et al. | — | 2018 | → |
| Treatment of Geographic Atrophy with Intravitreal Sirolimus: The Age-Related Eye Disease Study 2 Ancillary Study. | Gensler G et al. | — | 2018 | → |
| Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces. | Osborne AJ et al. | — | 2018 | → |
| A decade of age-related macular degeneration risk models: What have we learned from them and where are we going? | Zhang M et al. | — | 2017 | → |
| Advances in Age-related Macular Degeneration Understanding and Therapy. | Miller JW et al. | — | 2017 | → |
| Age-Related Macular Degeneration: A Connection between Human Herpes Virus-6A-Induced CD46 Downregulation and Complement Activation? | Fierz W | — | 2017 | → |
| Age-related macular degeneration and mortality: the Melbourne Collaborative Cohort Study. | McGuinness MB et al. | — | 2017 | → |
| Age-related macular degeneration in patients with uveitis. | Fox AR et al. | — | 2017 | → |
| Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. | Huang H et al. | — | 2017 | → |
| AICAR suppresses TNF-α-induced complement factor B in RPE cells. | Chung EJ et al. | — | 2017 | → |
| Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration. | Krogh Nielsen M et al. | — | 2017 | → |
| A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1-5 in human plasma. | Zhang P et al. | — | 2017 | → |
| A Proinflammatory Function of Toll-Like Receptor 2 in the Retinal Pigment Epithelium as a Novel Target for Reducing Choroidal Neovascularization in Age-Related Macular Degeneration. | Feng L et al. | — | 2017 | → |
| A Review of Current and Future Management of Geographic Atrophy. | Sacconi R et al. | — | 2017 | → |
| A review of human diseases caused or exacerbated by aberrant complement activation. | McGeer PL et al. | — | 2017 | → |
| Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis. | Zhou YL et al. | — | 2017 | → |
| Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration. | Cipriani V et al. | — | 2017 | → |
| Can innate and autoimmune reactivity forecast early and advance stages of age-related macular degeneration? | Adamus G | — | 2017 | → |
| CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure. | Kuse Y et al. | — | 2017 | → |
| Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases. | Jones MK et al. | — | 2017 | → |
| Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration. | Song D et al. | — | 2017 | → |
| Complement Dysregulation and Disease: Insights from Contemporary Genetics. | Liszewski MK et al. | — | 2017 | → |
| C-reactive protein isoforms differentially affect outer blood-retinal barrier integrity and function. | Molins B et al. | — | 2017 | → |
| Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development. | Li H et al. | — | 2017 | → |
| Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation. | Kerr H et al. | — | 2017 | → |
| Dry Age-Related Macular Degeneration Pharmacology. | Wright CB et al. | — | 2017 | → |
| Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue: Imaging Zinc as a Biomarker for Age-Related Macular Degeneration (An American Ophthalmological Society Thesis). | van Kuijk FJGM et al. | — | 2017 | → |
| Enhancing the efficacy of AREDS antioxidants in light-induced retinal degeneration. | Wong P et al. | — | 2017 | → |
| From compliment to insult: genetics of the complement system in physiology and disease in the human retina. | Mullins RF et al. | — | 2017 | → |
| Functional SNP allele discovery (fSNPd): an approach to find highly penetrant, environmental-triggered genotypes underlying complex human phenotypes. | Stouffer K et al. | — | 2017 | → |
| Gene therapy for age-related macular degeneration. | Moore NA et al. | — | 2017 | → |
| Genetics of age-related macular degeneration (AMD). | DeAngelis MM et al. | — | 2017 | → |
| Genetic studies of alcohol dependence in the context of the addiction cycle. | Reilly MT et al. | — | 2017 | → |
| Genetic variants in FH are associated with renal histopathologic subtypes of lupus nephritis: a large cohort study from China. | Tan M et al. | — | 2017 | → |
| Genome-wide expression differences in anti-Vegf and dexamethasone treatment of inflammatory angiogenesis in the rat cornea. | Mirabelli P et al. | — | 2017 | → |
| Human induced pluripotent stem cells illuminate pathways and novel treatment targets for age-related macular degeneration. | Farrer LA et al. | — | 2017 | → |
| Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress. | Fanelli G et al. | — | 2017 | → |
| Induced pluripotent stem cell-based therapy for age-related macular degeneration. | Bracha P et al. | — | 2017 | → |
| Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration. | Handa JT et al. | — | 2017 | → |
| Local complement activation in aqueous humor in patients with age-related macular degeneration. | Schick T et al. | — | 2017 | → |
| Macular Degeneration Epidemiology: Nature-Nurture, Lifestyle Factors, Genetic Risk, and Gene-Environment Interactions - The Weisenfeld Award Lecture. | Seddon JM | — | 2017 | → |
| Major review: Molecular genetics of primary open-angle glaucoma. | Liu Y et al. | — | 2017 | → |
| Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. | Ueda Y et al. | — | 2017 | → |
| New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement. | Schnabolk G et al. | — | 2017 | → |
| Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration. | Krilis M et al. | — | 2017 | → |
| Non-invasive objective and contemporary methods for measuring ocular surface inflammation in soft contact lens wearers - A review. | Chao C et al. | — | 2017 | → |
| No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration. | Popp NA et al. | — | 2017 | → |
| Novel mechanisms and functions of complement. | Hajishengallis G et al. | — | 2017 | → |
| On phagocytes and macular degeneration. | Guillonneau X et al. | — | 2017 | → |
| Proangiogenic characteristics of activated macrophages from patients with age-related macular degeneration. | Hagbi-Levi S et al. | — | 2017 | → |
| Recent advances in the management of dry age-related macular degeneration: A review. | Bandello F et al. | — | 2017 | → |
| Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide. | Grossman TR et al. | — | 2017 | → |
| Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration. | Iannaccone A et al. | — | 2017 | → |
| RNA expression in human retina. | Li M et al. | — | 2017 | → |
| Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians. | Fan Q et al. | — | 2017 | → |
| Structural and molecular changes in the aging choroid: implications for age-related macular degeneration. | Chirco KR et al. | — | 2017 | → |
| The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment. | Geerlings MJ et al. | — | 2017 | → |
| The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age-related macular degeneration. | Tuuminen R et al. | — | 2017 | → |
| The functional activities of complement factor H are impaired in patients with ANCA-positive vasculitis. | Chen SF et al. | — | 2017 | → |
| The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. | Datta S et al. | — | 2017 | → |
| The link between morphology and complement in ocular disease. | Mohlin C et al. | — | 2017 | → |
| The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation. | Manthiram K et al. | — | 2017 | → |
| THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET. | Boyer DS et al. | — | 2017 | → |
| Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population. | Jiang T et al. | — | 2017 | → |
| VEGF regulates local inhibitory complement proteins in the eye and kidney. | Keir LS et al. | — | 2017 | → |
| Adrenomedullin: A potential therapeutic target for retinochoroidal disease. | Iesato Y et al. | — | 2016 | → |
| Age-related macular degeneration: Complement in action. | van Lookeren Campagne M et al. | — | 2016 | → |
| Age-related macular degeneration: genome-wide association studies to translation. | Black JR et al. | — | 2016 | → |
| A glimpse at the aging eye. | Lin JB et al. | — | 2016 | → |
| AMD and the alternative complement pathway: genetics and functional implications. | Tan PL et al. | — | 2016 | → |
| A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy. | Huang L et al. | — | 2016 | → |
| Amyloidosis in Retinal Neurodegenerative Diseases. | Masuzzo A et al. | — | 2016 | → |
| Analysis of copy number variation at DMBT1 and age-related macular degeneration. | Polley S et al. | — | 2016 | → |
| Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis. | Nishiguchi KM et al. | — | 2016 | → |
| Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration. | Saksens NT et al. | — | 2016 | → |
| Annexin A2 Enhances Complement Activation by Inhibiting Factor H. | Renner B et al. | — | 2016 | → |
| A novel approach for multi-SNP GWAS and its application in Alzheimer's disease. | Bodily PM et al. | — | 2016 | → |
| Anti-complement activity of the Ixodes scapularis salivary protein Salp20. | Hourcade DE et al. | — | 2016 | → |
| Application of multiplex immunoassay technology to investigations of ocular disease. | Jones VS et al. | — | 2016 | → |
| Are Interactions between cis-Regulatory Variants Evidence for Biological Epistasis or Statistical Artifacts? | Fish AE et al. | — | 2016 | → |
| Association of age-related macular degeneration and reticular macular disease with cardiovascular disease. | Rastogi N et al. | — | 2016 | → |
| Association of Combined Complement Factor H Y402H and ARMS/LOC387715 A69S Polymorphisms with Age-related Macular Degeneration: A Meta-analysis. | Jabbarpoor Bonyadi MH et al. | — | 2016 | → |
| Association of Two Polymorphisms, rs1061170 and rs1410996, in Complement Factor H with Age-Related Macular Degeneration in an Asian Population: A Meta-Analysis. | Wu M et al. | — | 2016 | → |
| Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans. | Al Gwairi O et al. | — | 2016 | → |
| CFH Y402H and VEGF Polymorphisms and Anti-VEGF Treatment Response in Exudative Age-Related Macular Degeneration. | Kepez Yildiz B et al. | — | 2016 | → |
| Combination analysis of genome-wide association and transcriptome sequencing of residual feed intake in quality chickens. | Xu Z et al. | — | 2016 | → |
| Complement Activation and Inhibition in Retinal Diseases. | Kleinman ME et al. | — | 2016 | → |
| Complement factor H and LOC387715/ARMS2/HTRA1 variant's frequencies and phenotypic associations in neovascular age-related macular degeneration, a pilot study. | Karkhane R et al. | — | 2016 | → |
| Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants. | Molins B et al. | — | 2016 | → |
| Complement genetics and susceptibility to inflammatory disease. Lessons from genotype-phenotype correlations. | de Córdoba SR | — | 2016 | → |
| Complement in removal of the dead - balancing inflammation. | Martin M et al. | — | 2016 | → |
| Complement pathway biomarkers and age-related macular degeneration. | Gemenetzi M et al. | — | 2016 | → |
| Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention. | Mastellos DC et al. | — | 2016 | → |
| Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells. | Coughlin B et al. | — | 2016 | → |
| Context for Protons as Adjunctive Therapy in Neovascular Age-Related Macular Degeneration: A Review. | Rice SR et al. | — | 2016 | → |
| Current therapeutic developments in atrophic age-related macular degeneration. | Hanus J et al. | — | 2016 | → |
| CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration. | Sakiene R et al. | — | 2016 | → |
| Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae. | Wong SM et al. | — | 2016 | → |
| Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids. | Nashine S et al. | — | 2016 | → |
| Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes. | Khan KN et al. | — | 2016 | → |
| Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration. | McLeod DS et al. | — | 2016 | → |
| Does the use of acetylsalicylic acid have an influence on our vision? | Michalska-Małecka K et al. | — | 2016 | → |
| Drusen maculopathy: a risk factor for visual deterioration. | Algvere PV et al. | — | 2016 | → |
| Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. | Estrago-Franco MF et al. | — | 2016 | → |
| eSNPO: An eQTL-based SNP Ontology and SNP functional enrichment analysis platform. | Li J et al. | — | 2016 | → |
| Evaluation of CC-cytokine ligand 2 and complementary factor H Y402H polymorphisms and their interactional association with age-related macular degeneration. | Bonyadi M et al. | — | 2016 | → |
| Factors Associated With Poor Response to Aflibercept After Switching From Ranibizumab or Bevacizumab in Neovascular Age-related Macular Degeneration. | Cheng S et al. | — | 2016 | → |
| Fibulin-1 purification from human plasma using affinity chromatography on Factor H-Sepharose. | DiScipio RG et al. | — | 2016 | → |
| Genetic Association Analysis of Drusen Progression. | Hoffman JD et al. | — | 2016 | → |
| Genetic components in diabetic retinopathy. | Mishra B et al. | — | 2016 | → |
| Genetic factors associated with the development of age-related macular degeneration. | Sergejeva O et al. | — | 2016 | → |
| Genetics and age-related macular degeneration: a practical review for the clinician. | Schwartz SG et al. | — | 2016 | → |
| Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism. | Woo HJ et al. | — | 2016 | → |
| Hypersensitivity toward bacterial stimuli in patients with age-related macular degeneration. | Chen JJ et al. | — | 2016 | → |
| Imaging mass spectrometry of the visual system: Advancing the molecular understanding of retina degenerations. | Bowrey HE et al. | — | 2016 | → |
| Inflammation and its role in age-related macular degeneration. | Kauppinen A et al. | — | 2016 | → |
| Inhibition of development of laser-induced choroidal neovascularization with suppression of infiltration of macrophages in Smad3-null mice. | Iwanishi H et al. | — | 2016 | → |
| Innate sensing of oxidation-specific epitopes in health and disease. | Binder CJ et al. | — | 2016 | → |
| Investigating the CFH Gene Polymorphisms as a Risk Factor for Age-related Macular Degeneration in an Iranian Population. | Babanejad M et al. | — | 2016 | → |
| Lysosomes: Regulators of autophagy in the retinal pigmented epithelium. | Sinha D et al. | — | 2016 | → |
| Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD. | Wagner EK et al. | — | 2016 | → |
| Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases. | Recalde S et al. | — | 2016 | → |
| Molecular Genomics of Eye Diseases. | Pang CP | — | 2016 | → |
| Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration. | Zeng S et al. | — | 2016 | → |
| Monomeric C-reactive protein and inflammation in age-related macular degeneration. | Chirco KR et al. | — | 2016 | → |
| Overview of Laboratory Testing and Clinical Presentations of Complement Deficiencies and Dysregulation. | Frazer-Abel A et al. | — | 2016 | → |
| Pathway-based variant enrichment analysis on the example of dilated cardiomyopathy. | Backes C et al. | — | 2016 | → |
| Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation. | Wang L et al. | — | 2016 | → |
| Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. | Mohan RR et al. | — | 2016 | → |
| Pluripotent Stem Cell-Based Therapies in Combination with Substrate for the Treatment of Age-Related Macular Degeneration. | Pennington BO et al. | — | 2016 | → |
| Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus. | Sardell RJ et al. | — | 2016 | → |
| Protection of host cells by complement regulators. | Schmidt CQ et al. | — | 2016 | → |
| Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†. | Yu Y et al. | — | 2016 | → |
| Random Projection for Fast and Efficient Multivariate Correlation Analysis of High-Dimensional Data: A New Approach. | Grellmann C et al. | — | 2016 | → |
| Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina. | Williams JA et al. | — | 2016 | → |
| Risk factors and biomarkers of age-related macular degeneration. | Lambert NG et al. | — | 2016 | → |
| Self-nonself discrimination by the complement system. | Meri S | — | 2016 | → |
| Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk. | Hughes AE et al. | — | 2016 | → |
| Seventeen years of statin pharmacogenetics: a systematic review. | Leusink M et al. | — | 2016 | → |
| The continuum of causality in human genetic disorders. | Katsanis N | — | 2016 | → |
| TRIC: an automated alignment strategy for reproducible protein quantification in targeted proteomics. | Röst HL et al. | — | 2016 | → |
| Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae. | Ram S et al. | — | 2016 | → |
| Whole exome sequencing of extreme age-related macular degeneration phenotypes. | Sardell RJ et al. | — | 2016 | → |
| A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice. | Aredo B et al. | — | 2015 | → |
| A composite method for mapping quantitative trait loci without interference of female achiasmatic and gender effects in silkworm, Bombyx mori. | Li C et al. | — | 2015 | → |
| Activated complement classical pathway in a murine model of oxygen-induced retinopathy. | Tao XY et al. | — | 2015 | → |
| Advances in pharmacotherapy for wet age-related macular degeneration. | Santarelli M et al. | — | 2015 | → |
| Age-related macular degeneration and the role of the complement system. | McHarg S et al. | — | 2015 | → |
| Age-Related Macular Degeneration-Associated Genes in Alzheimer Disease. | Williams MA et al. | — | 2015 | → |
| Age-related macular degeneration phenotypes associated with mutually exclusive homozygous risk variants in CFH and HTRA1 genes. | Chong EW et al. | — | 2015 | → |
| Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. | Hart AB et al. | — | 2015 | → |
| A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families. | Wang YT et al. | — | 2015 | → |
| Analysis of Genetic and Environmental Risk Factors and Their Interactions in Korean Patients with Age-Related Macular Degeneration. | Woo SJ et al. | — | 2015 | → |
| Analysis of rare variants in the CFH gene in patients with the cuticular drusen subtype of age-related macular degeneration. | Duvvari MR et al. | — | 2015 | → |
| Ancestry of the Timorese: age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world. | Morrison MA et al. | — | 2015 | → |
| Antibody therapies and their challenges in the treatment of age-related macular degeneration. | Volz C et al. | — | 2015 | → |
| Anti-mouse properdin TSR 5/6 monoclonal antibodies block complement alternative pathway-dependent pathogenesis. | Bertram P et al. | — | 2015 | → |
| Association of complement factor H gene polymorphisms with age-related macular egeneration susceptibility. | Hao XF et al. | — | 2015 | → |
| Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-analysis. | Ma L et al. | — | 2015 | → |
| Association of Htra1 gene polymorphisms with the risk of developing AMD in Iranian population. | Askari M et al. | — | 2015 | → |
| At the interface of sensory and motor dysfunctions and Alzheimer's disease. | Albers MW et al. | — | 2015 | → |
| Cellular strategies for retinal repair by photoreceptor replacement. | Jayakody SA et al. | — | 2015 | → |
| CETP Gene may be Associated with Advanced Age-Related Macular Degeneration in the Chinese Population. | Wang D et al. | — | 2015 | → |
| CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration. | Wang YF et al. | — | 2015 | → |
| CFH Y402H and ARMS2 A69S Polymorphisms and Oral Supplementation with Docosahexaenoic Acid in Neovascular Age-Related Macular Degeneration Patients: The NAT2 Study. | Merle BM et al. | — | 2015 | → |
| CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye. | Wang JC et al. | — | 2015 | → |
| Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis. | Iannaccone A et al. | — | 2015 | → |
| Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degeneration. | Sohn EH et al. | — | 2015 | → |
| Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. | Whitmore SS et al. | — | 2015 | → |
| Complement Activation in Placental Malaria. | McDonald CR et al. | — | 2015 | → |
| Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement. | Herbert AP et al. | — | 2015 | → |
| Complement Factor H Expressed by Retinal Pigment Epithelium Cells Can Suppress Neovascularization of Human Umbilical Vein Endothelial Cells: An in vitro Study. | Zhang Y et al. | — | 2015 | → |
| Complement in therapy and disease: Regulating the complement system with antibody-based therapeutics. | Melis JP et al. | — | 2015 | → |
| Complement regulators in human disease: lessons from modern genetics. | Liszewski MK et al. | — | 2015 | → |
| Complement System Part II: Role in Immunity. | Merle NS et al. | — | 2015 | → |
| Complement System Part I - Molecular Mechanisms of Activation and Regulation. | Merle NS et al. | — | 2015 | → |
| Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. | Mastellos DC et al. | — | 2015 | → |
| CONDITIONAL DISTANCE CORRELATION. | Wang X et al. | — | 2015 | → |
| Cross Sectional and Longitudinal Associations between Cardiovascular Risk Factors and Age Related Macular Degeneration in the EPIC-Norfolk Eye Study. | Yip JL et al. | — | 2015 | → |
| Current knowledge on reticular pseudodrusen in age-related macular degeneration. | Alten F et al. | — | 2015 | → |
| Dietary modification and supplementation for the treatment of age-related macular degeneration. | Broadhead GK et al. | — | 2015 | → |
| Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes. | Shen L et al. | — | 2015 | → |
| Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. | Perusek L et al. | — | 2015 | → |
| Drugs in Phase II clinical trials for the treatment of age-related macular degeneration. | Tolentino MJ et al. | — | 2015 | → |
| Effects of adiponectin polymorphisms on the risk of advanced age-related macular degeneration. | Cao G et al. | — | 2015 | → |
| Enrichment of Bruch's Membrane from Human Donor Eyes. | McHarg S et al. | — | 2015 | → |
| Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models. | Hall JB et al. | — | 2015 | → |
| Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. | Ding JD et al. | — | 2015 | → |
| Extracting research-quality phenotypes from electronic health records to support precision medicine. | Wei WQ et al. | — | 2015 | → |
| Factor H-related proteins determine complement-activating surfaces. | Józsi M et al. | — | 2015 | → |
| Genetic predictive biomarkers of anti-VEGF treatment response in patients with neovascular age-related macular degeneration. | Fauser S et al. | — | 2015 | → |
| HIF1A as a major vascular endothelial growth factor regulator: do its polymorphisms have an association with age-related macular degeneration? | Okur V et al. | — | 2015 | → |
| Histological Characterization of the Dicer1 Mutant Zebrafish Retina. | Akhtar S et al. | — | 2015 | → |
| Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. | Yu J et al. | — | 2015 | → |
| Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR). | De R et al. | — | 2015 | → |
| Immune mechanisms in inflammatory and degenerative eye disease. | Perez VL et al. | — | 2015 | → |
| Inflammatory Mechanisms of Age-related Macular Degeneration. | Knickelbein JE et al. | — | 2015 | → |
| Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid. | Lee M et al. | — | 2015 | → |
| Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium. | Li Y et al. | — | 2015 | → |
| Joint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population. | Fang K et al. | — | 2015 | → |
| Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. | Wong CW et al. | — | 2015 | → |
| Lipoprotein(A) with An Intact Lysine Binding Site Protects the Retina From an Age-Related Macular Degeneration Phenotype in Mice (An American Ophthalmological Society Thesis). | Handa JT et al. | — | 2015 | → |
| Local production of the alternative pathway component factor B is sufficient to promote laser-induced choroidal neovascularization. | Schnabolk G et al. | — | 2015 | → |
| Long non-coding RNAs as regulators of the endocrine system. | Knoll M et al. | — | 2015 | → |
| Lutein and Factor D: two intriguing players in the field of age-related macular degeneration. | Tian Y et al. | — | 2015 | → |
| Management of neovascular age-related macular degeneration: current state-of-the-art care for optimizing visual outcomes and therapies in development. | Agarwal A et al. | — | 2015 | → |
| Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light. | Calaza KC et al. | — | 2015 | → |
| Mitochondrial variation and the risk of age-related macular degeneration across diverse populations. | Restrepo NA et al. | — | 2015 | → |
| Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. | Kanan Y et al. | — | 2015 | → |
| Nonsynonymous single nucleotide polymorphisms in the complement component 3 gene are associated with risk of age-related macular degeneration: a meta-analysis. | Qian-Qian Y et al. | — | 2015 | → |
| Of mice and men: The factor H protein family and complement regulation. | Pouw RB et al. | — | 2015 | → |
| Pachychoroid neovasculopathy and age-related macular degeneration. | Miyake M et al. | — | 2015 | → |
| Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases. | Wiley LA et al. | — | 2015 | → |
| PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. | Stiles M et al. | — | 2015 | → |
| Pharmacogenetic Effect of Complement Factor H Gene Polymorphism in Response to the Initial Intravitreal Injection of Bevacizumab for Wet Age-Related Macular Degeneration. | Medina FM et al. | — | 2015 | → |
| Pharmacogenetics of Complement Factor H Y402H Polymorphism and Treatment of Neovascular AMD with Anti-VEGF Agents: A Meta-Analysis. | Chen G et al. | — | 2015 | → |
| Pharmacogenomics of response to anti-VEGF therapy in exudative age-related macular degeneration. | Dedania VS et al. | — | 2015 | → |
| Phenotypic Characterization of Complement Factor H R1210C Rare Genetic Variant in Age-Related Macular Degeneration. | Ferrara D et al. | — | 2015 | → |
| Rare genetic variants in Tunisian Jewish patients suffering from age-related macular degeneration. | Pras E et al. | — | 2015 | → |
| Rare Variants in the Functional Domains of Complement Factor H Are Associated With Age-Related Macular Degeneration. | Triebwasser MP et al. | — | 2015 | → |
| Regulation of age-related macular degeneration-like pathology by complement factor H. | Toomey CB et al. | — | 2015 | → |
| Relationship between the complement system, risk factors and prediction models in age-related macular degeneration. | Bora NS et al. | — | 2015 | → |
| Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration. | Radeke MJ et al. | — | 2015 | → |
| Retinal microglia: just bystander or target for therapy? | Karlstetter M et al. | — | 2015 | → |
| Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9. | Georgiannakis A et al. | — | 2015 | → |
| Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration. | Clark SJ et al. | — | 2015 | → |
| Role of tyrosine-sulfated proteins in retinal structure and function. | Kanan Y et al. | — | 2015 | → |
| RPE necroptosis in response to oxidative stress and in AMD. | Hanus J et al. | — | 2015 | → |
| Serum inflammatory markers after rupture retinal laser injury in mice. | Paulus YM et al. | — | 2015 | → |
| Stem cell based therapies for age-related macular degeneration: The promises and the challenges. | Nazari H et al. | — | 2015 | → |
| Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein. | Bradley DT et al. | — | 2015 | → |
| The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood. | Madelung CF et al. | — | 2015 | → |
| The genetic variant rs4073 A→T of the Interleukin-8 promoter region is associated with the earlier onset of exudative age-related macular degeneration. | Hautamäki A et al. | — | 2015 | → |
| The reduction of serum soluble Flt-1 in patients with neovascular age-related macular degeneration. | Uehara H et al. | — | 2015 | → |
| The stereotypical molecular cascade in neovascular age-related macular degeneration: the role of dynamic reciprocity. | Kent D | — | 2015 | → |
| The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody. | Ciferri C et al. | — | 2015 | → |
| Thrombotic Microangiopathy with Complement Factor H Gene Mutations Unassociated with Atypical Hemolytic Uremic Syndrome. | Oymak Y et al. | — | 2015 | → |
| Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice. | Hoh Kam J et al. | — | 2015 | → |
| Vision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and disease. | Yang HJ et al. | — | 2015 | → |
| AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice. | Birke MT et al. | — | 2014 | → |
| Accounting for linkage disequilibrium in association analysis of diverse populations. | Charles BA et al. | — | 2014 | → |
| A dietary-wide association study (DWAS) of environmental metal exposure in US children and adults. | Davis MA et al. | — | 2014 | → |
| Adrenomedullin signaling pathway polymorphisms and adverse pregnancy outcomes. | Lenhart PM et al. | — | 2014 | → |
| Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation? | Warwick A et al. | — | 2014 | → |
| Age-related macular degeneration and changes in the extracellular matrix. | Nita M et al. | — | 2014 | → |
| Age-related macular degeneration: beyond anti-angiogenesis. | Kent DL | — | 2014 | → |
| Age-related macular degeneration: genetics and biology coming together. | Fritsche LG et al. | — | 2014 | → |
| Age-related macular degeneration: insights into inflammatory genes. | Cascella R et al. | — | 2014 | → |
| Age-related macular degeneration in the aspect of chronic low-grade inflammation (pathophysiological parainflammation). | Nita M et al. | — | 2014 | → |
| Association between complement factor H Val62Ile polymorphism and age-related macular degeneration susceptibility: a meta-analysis. | Wang X et al. | — | 2014 | → |
| Association between polymorphism of the DNA repair SMUG1 and UNG genes and age-related macular degeneration. | Synowiec E et al. | — | 2014 | → |
| Association mapping across numerous traits reveals patterns of functional variation in maize. | Wallace JG et al. | — | 2014 | → |
| Association of specific genetic polymorphisms with age-related macular degeneration in a northern Chinese population. | Zhuang W et al. | — | 2014 | → |
| Atrial fibrillation genomics: time to take the next step. | Roden DM | — | 2014 | → |
| Bioactive lipids in pathological retinopathy. | Ma Q et al. | — | 2014 | → |
| Bioactive lysophospholipids generated by hepatic lipase degradation of lipoproteins lead to complement activation via the classical pathway. | Ma W et al. | — | 2014 | → |
| Bioinformatics challenges in genome-wide association studies (GWAS). | De R et al. | — | 2014 | → |
| Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype. | Radu RA et al. | — | 2014 | → |
| C3 glomerulopathy: clinicopathologic features and predictors of outcome. | Medjeral-Thomas NR et al. | — | 2014 | → |
| Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice. | Rowan S et al. | — | 2014 | → |
| Chromosome 10q26 locus and age-related macular degeneration: a progress update. | Wang G | — | 2014 | → |
| Common variant rs10033900 near the complement factor I gene is associated with age-related macular degeneration risk in Han Chinese population. | Qian D et al. | — | 2014 | → |
| Common variants in the complement factor H gene confer genetic susceptibility to central serous chorioretinopathy. | Miki A et al. | — | 2014 | → |
| Complement expression in the retina is not influenced by short-term pressure elevation. | Astafurov K et al. | — | 2014 | → |
| Complement factor B polymorphism and the phenotype of early age-related macular degeneration. | Mantel I et al. | — | 2014 | → |
| Complement factor H and related proteins in age-related macular degeneration. | Calippe B et al. | — | 2014 | → |
| Complement factor H, vitronectin, and opticin are tyrosine-sulfated proteins of the retinal pigment epithelium. | Kanan Y et al. | — | 2014 | → |
| Complement Factor H Y402H and LOC387715 A69S Polymorphisms in Association with Age-Related Macular Degeneration in Iran. | Nazari Khanamiri H et al. | — | 2014 | → |
| Complement inhibitors for age-related macular degeneration. | Williams MA et al. | — | 2014 | → |
| Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue. | Kawa MP et al. | — | 2014 | → |
| Current knowledge and trends in age-related macular degeneration: genetics, epidemiology, and prevention. | Velez-Montoya R et al. | — | 2014 | → |
| Dark matter RNA illuminates the puzzle of genome-wide association studies. | St Laurent G et al. | — | 2014 | → |
| Differential Gene Expression in Age-Related Macular Degeneration. | Morgan DJ et al. | — | 2014 | → |
| Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration. | Malek G et al. | — | 2014 | → |
| Endophenotypes for Age-Related Macular Degeneration: Extending Our Reach into the Preclinical Stages of Disease. | Gorin MB et al. | — | 2014 | → |
| (Epi)Genetic analyses of age-related macular degeneration: case-control and discordant twin studies. | Hutchinson JN et al. | — | 2014 | → |
| Epimacular brachytherapy for wet AMD: current perspectives. | Casaroli-Marano RP et al. | — | 2014 | → |
| Exploitation of the complement system by oncogenic Kaposi's sarcoma-associated herpesvirus for cell survival and persistent infection. | Lee MS et al. | — | 2014 | → |
| Flicker-induced retinal vasodilatation is not dependent on complement factor H polymorphism in healthy young subjects. | Told R et al. | — | 2014 | → |
| Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study. | Restrepo NA et al. | — | 2014 | → |
| Genetic factors associated with response to intravitreal ranibizumab in Korean patients with neovascular age-related macular degeneration. | Park UC et al. | — | 2014 | → |
| Genetic testing for inherited ocular disease: delivering on the promise at last? | Gillespie RL et al. | — | 2014 | → |
| Genetic variants in the complement system predisposing to age-related macular degeneration: a review. | Schramm EC et al. | — | 2014 | → |
| Genome-wide association studies: applications and insights gained in Ophthalmology. | Chandra A et al. | — | 2014 | → |
| Genome-wide association studies: getting to pathogenesis, the role of inflammation/complement in age-related macular degeneration. | Cooke Bailey JN et al. | — | 2014 | → |
| Genome-wide association study success in ophthalmology. | Mackey DA et al. | — | 2014 | → |
| Genomic aspects of age-related macular degeneration. | Horie-Inoue K et al. | — | 2014 | → |
| Geographic atrophy progression in eyes with age-related macular degeneration: role of fundus autofluorescence patterns, fellow eye and baseline atrophy area. | Batıoğlu F et al. | — | 2014 | → |
| Highly penetrant alleles in age-related macular degeneration. | den Hollander AI et al. | — | 2014 | → |
| How genetic studies have advanced our understanding of age-related macular degeneration and their impact on patient care: a review. | Baird PN et al. | — | 2014 | → |
| Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells. | Weinberger AW et al. | — | 2014 | → |
| Humanized cobra venom factor: structure, activity, and therapeutic efficacy in preclinical disease models. | Vogel CW et al. | — | 2014 | → |
| Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration. | Clark SJ et al. | — | 2014 | → |
| IKK2 inhibition attenuates laser-induced choroidal neovascularization. | Lu H et al. | — | 2014 | → |
| Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels. | Ristau T et al. | — | 2014 | → |
| Impairment of the ubiquitin-proteasome pathway in RPE alters the expression of inflammation related genes. | Liu Z et al. | — | 2014 | → |
| Inflammaging in skin and other tissues - the roles of complement system and macrophage. | Zhuang Y et al. | — | 2014 | → |
| Inflammation and Cell Death in Age-Related Macular Degeneration: An Immunopathological and Ultrastructural Model. | Ardeljan CP et al. | — | 2014 | → |
| Inflammatory biomarkers for AMD. | Stanton CM et al. | — | 2014 | → |
| Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions. | Kenney MC et al. | — | 2014 | → |
| Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial. | Petrou PA et al. | — | 2014 | → |
| Is renal function associated with early age-related macular degeneration? | Chong EW et al. | — | 2014 | → |
| Macular dystrophies mimicking age-related macular degeneration. | Saksens NT et al. | — | 2014 | → |
| Markers of inflammation, oxidative stress, and endothelial dysfunction and the 20-year cumulative incidence of early age-related macular degeneration: the Beaver Dam Eye Study. | Klein R et al. | — | 2014 | → |
| Mechanisms of age-related macular degeneration and therapeutic opportunities. | van Lookeren Campagne M et al. | — | 2014 | → |
| Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans. | Shen L et al. | — | 2014 | → |
| Mini-cognitive testing in patients with age-related macular degeneration. | Al-Salem KM et al. | — | 2014 | → |
| Misclassification can explain most apparent regression of age-related macular degeneration: results from multistate models with misclassification. | Gangnon RE et al. | — | 2014 | → |
| Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration. | Garland DL et al. | — | 2014 | → |
| Nature and nurture- genes and environment- predict onset and progression of macular degeneration. | Sobrin L et al. | — | 2014 | → |
| Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells. | Wang L et al. | — | 2014 | → |
| Ocular surface temperature in age-related macular degeneration. | Sodi A et al. | — | 2014 | → |
| Oxidized low-density-lipoprotein-induced injury in retinal pigment epithelium alters expression of the membrane complement regulatory factors CD46 and CD59 through exosomal and apoptotic bleb release. | Ebrahimi KB et al. | — | 2014 | → |
| Polypoidal choroidal vasculopathy: clinical features and genetic predisposition. | Honda S et al. | — | 2014 | → |
| Potential Sources and Roles of Adaptive Immunity in Age-Related Macular Degeneration: Shall We Rename AMD into Autoimmune Macular Disease? | Camelo S | — | 2014 | → |
| Prognostic phenotypic and genotypic factors associated with photodynamic therapy response in patients with age-related macular degeneration. | Tsuchihashi T et al. | — | 2014 | → |
| Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. | Murakami Y et al. | — | 2014 | → |
| Rare complement factor H variant associated with age-related macular degeneration in the Amish. | Hoffman JD et al. | — | 2014 | → |
| Recent developments in the treatment of age-related macular degeneration. | Holz FG et al. | — | 2014 | → |
| [Reticular drusen over time with SD-OCT]. | Auge J et al. | — | 2014 | → |
| Reticular macular lesions: a review of the phenotypic hallmarks and their clinical significance. | Saade C et al. | — | 2014 | → |
| Retinal angiomatous proliferation associated with risk alleles of ARMS2/HTRA1 gene polymorphisms in Japanese patients. | Ohkuma Y et al. | — | 2014 | → |
| Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. | Yang P et al. | — | 2014 | → |
| Return of results in the genomic medicine projects of the eMERGE network. | Kullo IJ et al. | — | 2014 | → |
| Risk factors for exudative age-related macular degeneration in a large French case-control study. | Zerbib J et al. | — | 2014 | → |
| Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways. | Logue MW et al. | — | 2014 | → |
| Set-based joint test of interaction between SNPs in the VEGF pathway and exogenous estrogen finds association with age-related macular degeneration. | Courtenay MD et al. | — | 2014 | → |
| Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation. | Kunchithapautham K et al. | — | 2014 | → |
| Stem cells as tools for studying the genetics of inherited retinal degenerations. | Wiley LA et al. | — | 2014 | → |
| Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina. | Rutar M et al. | — | 2014 | → |
| Systematic permutation testing in GWAS pathway analyses: identification of genetic networks in dilated cardiomyopathy and ulcerative colitis. | Backes C et al. | — | 2014 | → |
| Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study. | Yehoshua Z et al. | — | 2014 | → |
| T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. | Cruz-Guilloty F et al. | — | 2014 | → |
| The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration. | Dietzel M et al. | — | 2014 | → |
| The Immune System and AMD. | Frederick PA et al. | — | 2014 | → |
| The impact of large-scale genomic methods in orthopaedic disorders: insights from genome-wide association studies. | Paria N et al. | — | 2014 | → |
| The impact of the human genome project on complex disease. | Bailey JN et al. | — | 2014 | → |
| The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning. | Mullins RF et al. | — | 2014 | → |
| The proteomics of drusen. | Crabb JW | — | 2014 | → |
| The role of the complement system in age-related macular degeneration. | Weber BH et al. | — | 2014 | → |
| Unbiased approaches to biomarker discovery in neurodegenerative diseases. | Chen-Plotkin AS | — | 2014 | → |
| Vitreoretinal interface changes in geographic atrophy. | Abdillahi H et al. | — | 2014 | → |
| Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration. | Yu Y et al. | — | 2014 | → |
| Zinc supplementation inhibits complement activation in age-related macular degeneration. | Smailhodzic D et al. | — | 2014 | → |
| 670 nm LED ameliorates inflammation in the CFH(-/-) mouse neural retina. | Kokkinopoulos I | — | 2013 | → |
| A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome. | Anderson OA et al. | — | 2013 | → |
| Adeno-associated virus mediated delivery of a non-membrane targeted human soluble CD59 attenuates some aspects of diabetic retinopathy in mice. | Adhi M et al. | — | 2013 | → |
| Advances in the genomics of common eye diseases. | Cooke Bailey JN et al. | — | 2013 | → |
| Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice. | Chen M et al. | — | 2013 | → |
| A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci. | Scheetz TE et al. | — | 2013 | → |
| Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations. | Keilhauer CN et al. | — | 2013 | → |
| Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation. | Khandhadia S et al. | — | 2013 | → |
| Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. | Jacobo SM et al. | — | 2013 | → |
| Age-related macular degeneration-clinical review and genetics update. | Ratnapriya R et al. | — | 2013 | → |
| Age-related macular degeneration revisited--piecing the puzzle: the LXIX Edward Jackson memorial lecture. | Miller JW | — | 2013 | → |
| Aging is not a disease: distinguishing age-related macular degeneration from aging. | Ardeljan D et al. | — | 2013 | → |
| All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death. | Berchuck JE et al. | — | 2013 | → |
| Alterations of choroidal blood flow regulation in young healthy subjects with complement factor H polymorphism. | Told R et al. | — | 2013 | → |
| Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells. | Whitmore SS et al. | — | 2013 | → |
| Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury. | Woodell A et al. | — | 2013 | → |
| ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study. | Chakravarthy U et al. | — | 2013 | → |
| ARMS2 interference leads to decrease of proinflammatory mediators. | Zeng F et al. | — | 2013 | → |
| Association analysis of CFH and ARMS2 gene polymorphisms in a Brazilian cohort with age-related macular degeneration. | Almeida LN et al. | — | 2013 | → |
| Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population. | Wu L et al. | — | 2013 | → |
| Association of complement factor H tyrosine 402 histidine genotype with posterior involvement in sarcoid-related uveitis. | Thompson IA et al. | — | 2013 | → |
| Association of single nucleotide polymorphisms in CFH, ARMS2 and HTRA1 genes with risk of age-related macular degeneration in Egyptian patients. | Abbas RO et al. | — | 2013 | → |
| Associations of the C2-CFB-RDBP-SKIV2L locus with age-related macular degeneration and polypoidal choroidal vasculopathy. | Liu K et al. | — | 2013 | → |
| Aurintricarboxylic acid inhibits complement activation, membrane attack complex, and choroidal neovascularization in a model of macular degeneration. | Lipo E et al. | — | 2013 | → |
| CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. | Sennlaub F et al. | — | 2013 | → |
| CEP biomarkers as potential tools for monitoring therapeutics. | Renganathan K et al. | — | 2013 | → |
| Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration. | Hoh Kam J et al. | — | 2013 | → |
| Complement factor B polymorphism (rs641153) and susceptibility to age-related macular degeneration: evidence from published studies. | Wang X et al. | — | 2013 | → |
| Complement regulation in renal disease models. | Naik A et al. | — | 2013 | → |
| C-reactive protein and the incidence of macular degeneration: pooled analysis of 5 cohorts. | Mitta VP et al. | — | 2013 | → |
| Cumulative association between age-related macular degeneration and less studied genetic variants in PLEKHA1/ARMS2/HTRA1: a meta and gene-cluster analysis. | Yu W et al. | — | 2013 | → |
| Cuticular drusen: stars in the sky. | Boon CJ et al. | — | 2013 | → |
| Deciphering the complex: methodological overview of statistical models to derive OMICS-based biomarkers. | Chadeau-Hyam M et al. | — | 2013 | → |
| Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration. | Ebrahimi KB et al. | — | 2013 | → |
| Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches. | Zipfel PF et al. | — | 2013 | → |
| Detection of Chlamydia and complement factors in neovascular membranes of patients with age-related macular degeneration. | Wolf-Schnurrbusch UE et al. | — | 2013 | → |
| Diagnostics for personalized medicine: what will change in the era of large-scale genomics studies? | Grewal A et al. | — | 2013 | → |
| Diminishing risk for age-related macular degeneration with nutrition: a current view. | Schleicher M et al. | — | 2013 | → |
| Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay. | Sofat R et al. | — | 2013 | → |
| Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. | Bowes Rickman C et al. | — | 2013 | → |
| Exon-level expression profiling of ocular tissues. | Wagner AH et al. | — | 2013 | → |
| eyeGENE®: a vision community resource facilitating patient care and paving the path for research through molecular diagnostic testing. | Blain D et al. | — | 2013 | → |
| From interaction to co-association --a Fisher r-to-z transformation-based simple statistic for real world genome-wide association study. | Yuan Z et al. | — | 2013 | → |
| Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report. | Marangoni D et al. | — | 2013 | → |
| Gene-gene interactions of CFH and LOC387715/ARMS2 with Korean exudative age-related macular degeneration patients. | Kim YH et al. | — | 2013 | → |
| Genetic and environmental factors associated with reticular pseudodrusen in age-related macular degeneration. | Puche N et al. | — | 2013 | → |
| Genetic and Epigenetic Regulation in Age-related Macular Degeneration. | Wei L et al. | — | 2013 | → |
| Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration. | Tilleul J et al. | — | 2013 | → |
| Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. | Naj AC et al. | — | 2013 | → |
| Genetic influences on the outcome of anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration. | Abedi F et al. | — | 2013 | → |
| Genetic risk, ethnic variations and pharmacogenetic biomarkers in age-related macular degeneration and polypoidal choroidal vasculopathy. | Kuo JZ et al. | — | 2013 | → |
| High-risk populations for vision loss and eye care underutilization: a review of the literature and ideas on moving forward. | Elam AR et al. | — | 2013 | → |
| Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. | Zhan X et al. | — | 2013 | → |
| Immunology of age-related macular degeneration. | Ambati J et al. | — | 2013 | → |
| Implementation studies of ranibizumab for neovascular age-related macular degeneration. | Bloch SB | — | 2013 | → |
| Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration. | Cruz-Guilloty F et al. | — | 2013 | → |
| Inflammation in retinal disease. | Whitcup SM et al. | — | 2013 | → |
| Influence of CFH, HTRA1 and ARMS2 haplotype polymorphisms in the development of age-related macular disease. | Cruz-González F et al. | — | 2013 | → |
| Innate immune network in the retina activated by optic nerve crush. | Templeton JP et al. | — | 2013 | → |
| Interaction of complement factor h and fibulin3 in age-related macular degeneration. | Wyatt MK et al. | — | 2013 | → |
| Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks. | Parmeggiani F et al. | — | 2013 | → |
| Microbes bind complement inhibitor factor H via a common site. | Meri T et al. | — | 2013 | → |
| Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study. | Kenney MC et al. | — | 2013 | → |
| Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. | Kenney MC et al. | — | 2013 | → |
| Molecular genetic testing and the future of clinical genomics. | Katsanis SH et al. | — | 2013 | → |
| Neuroimaging as a potential biomarker to optimize psychiatric research and treatment. | Walton E et al. | — | 2013 | → |
| No association of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 or complement factor H polymorphisms with early age-related maculopathy in a Chinese cohort. | Chen JH et al. | — | 2013 | → |
| Pathway-PDT: a flexible pathway analysis tool for nuclear families. | Park YS et al. | — | 2013 | → |
| Pentraxins: structure, function, and role in inflammation. | Du Clos TW | — | 2013 | → |
| Pharmacogenetic association with early response to intravitreal ranibizumab for age-related macular degeneration in a Korean population. | Chang W et al. | — | 2013 | → |
| Pharmacogenetics of the treatment response of age-related macular degeneration with ranibizumab and bevacizumab. | Kanoff J et al. | — | 2013 | → |
| Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. | Kohno H et al. | — | 2013 | → |
| Prevalence and genomic association of reticular pseudodrusen in age-related macular degeneration. | Ueda-Arakawa N et al. | — | 2013 | → |
| Prevention of retinal light damage by zinc oxide combined with rosemary extract. | Organisciak DT et al. | — | 2013 | → |
| Prioritization of retinal disease genes: an integrative approach. | Wagner AH et al. | — | 2013 | → |
| RAD51 gene is associated with advanced age-related macular degeneration in Chinese population. | Zhou J et al. | — | 2013 | → |
| Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration. | Cao S et al. | — | 2013 | → |
| Retinal changes precede visual dysfunction in the complement factor H knockout mouse. | Williams JA et al. | — | 2013 | → |
| Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review. | Barnett BP et al. | — | 2013 | → |
| Risk alleles in CFH and ARMS2 and the long-term natural history of age-related macular degeneration: the Beaver Dam Eye Study. | Klein R et al. | — | 2013 | → |
| Role of heparan sulfate in ocular diseases. | Park PJ et al. | — | 2013 | → |
| Seven new loci associated with age-related macular degeneration. | Fritsche LG et al. | — | 2013 | → |
| Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degeneration. | Melville H et al. | — | 2013 | → |
| Stem cells in retinal regeneration: past, present and future. | Ramsden CM et al. | — | 2013 | → |
| Targeting inflammation in emerging therapies for genetic retinal disease. | Viringipurampeer IA et al. | — | 2013 | → |
| Targeting the complement system in systemic lupus erythematosus and other diseases. | Barilla-Labarca ML et al. | — | 2013 | → |
| The Contribution of the Framingham Heart Study to Gene Identification for Cardiovascular Risk Factors and Coronary Heart Disease. | Ehret GB | — | 2013 | → |
| The eye as a model of ageing in translational research--molecular, epigenetic and clinical aspects. | Pathai S et al. | — | 2013 | → |
| The eye: A window to the soul of the immune system. | Perez VL et al. | — | 2013 | → |
| The golden era of ocular disease gene discovery: race to the finish. | Swaroop A et al. | — | 2013 | → |
| The immunological basis of degenerative diseases of the eye. | Nussenblatt RB et al. | — | 2013 | → |
| The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables. | Wiggs JL et al. | — | 2013 | → |
| Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease. | McDowell RE et al. | — | 2013 | → |
| The relationship between vascular endothelial growth factor -2578C/A polymorphism and age-related macular degeneration. | Lucotte G et al. | — | 2013 | → |
| The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model. | Jawad S et al. | — | 2013 | → |
| The role of the immune response in age-related macular degeneration. | Whitcup SM et al. | — | 2013 | → |
| Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. | Clark SJ et al. | — | 2013 | → |
| Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration. | Birke K et al. | — | 2013 | → |
| Topical nonsteroidal anti-inflammatory drugs for macular edema. | Russo A et al. | — | 2013 | → |
| Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model. | Begum R et al. | — | 2013 | → |
| Validation of a prediction algorithm for progression to advanced macular degeneration subtypes. | Seddon JM et al. | — | 2013 | → |
| VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population. | Cruz-González F et al. | — | 2013 | → |
| Y402H polymorphism in complement factor H and age-related macular degeneration in the Tunisian population. | Habibi I et al. | — | 2013 | → |
| Younger siblings, C-reactive protein, and risk of age-related macular degeneration. | Cohn AC et al. | — | 2013 | → |
| Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. | Nan R et al. | — | 2013 | → |
| 670-nm light treatment reduces complement propagation following retinal degeneration. | Rutar M et al. | — | 2012 | → |
| Acquisition of complement factor H is important for pathogenesis of Streptococcus pyogenes infections: evidence from bacterial in vitro survival and human genetic association. | Haapasalo K et al. | — | 2012 | → |
| Adrenomedullin inhibits choroidal neovascularization via CCL2 in the retinal pigment epithelium. | Yuda K et al. | — | 2012 | → |
| Age-related macular degeneration. | Khandhadia S et al. | — | 2012 | → |
| Age-related macular degeneration and association of CFH Y402H and LOC387715 A69S polymorphisms in a Turkish population. | Soysal Y et al. | — | 2012 | → |
| Age-related macular degeneration and the complement system. | Khandhadia S et al. | — | 2012 | → |
| Altered expression of CD46 and CD59 on leukocytes in neovascular age-related macular degeneration. | Singh A et al. | — | 2012 | → |
| Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. | Proitsi P et al. | — | 2012 | → |
| Animal models of age related macular degeneration. | Pennesi ME et al. | — | 2012 | → |
| A novel role of complement in retinal degeneration. | Yu M et al. | — | 2012 | → |
| A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration. | Yoon KD et al. | — | 2012 | → |
| Asian age-related macular degeneration phenotyping study: rationale, design and protocol of a prospective cohort study. | Cheung CM et al. | — | 2012 | → |
| Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration. | van de Ven JP et al. | — | 2012 | → |
| Association between high-risk disease loci and response to anti-vascular endothelial growth factor treatment for wet age-related macular degeneration. | Orlin A et al. | — | 2012 | → |
| Association between polymorphisms of the DNA base excision repair genes MUTYH and hOGG1 and age-related macular degeneration. | Synowiec E et al. | — | 2012 | → |
| Association between variant Y402H in age-related macular degeneration (AMD) susceptibility gene CFH and treatment response of AMD: a meta-analysis. | Chen H et al. | — | 2012 | → |
| Association of ARMS2/HTRA1 variants with polypoidal choroidal vasculopathy phenotype in a Korean population. | Park DH et al. | — | 2012 | → |
| Association of CFH Y402H polymorphism with both forms of advanced age-related macular degeneration in Turkish patients. | Yücel D et al. | — | 2012 | → |
| Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. | Kim SJ et al. | — | 2012 | → |
| Association of sequence variation in the CX3CR1 gene with geographic atrophy age-related macular degeneration in a Greek population. | Anastasopoulos E et al. | — | 2012 | → |
| Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population. | Gan W et al. | — | 2012 | → |
| Autoimmunity: homeostasis of innate immunity gone awry. | Park HJ et al. | — | 2012 | → |
| Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin. | Khan S et al. | — | 2012 | → |
| C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa. | Humphries MM et al. | — | 2012 | → |
| Can genetic associations change with age? CFH and age-related macular degeneration. | Adams MK et al. | — | 2012 | → |
| CFB/C2 gene polymorphisms and risk of age-related macular degeneration: a systematic review and meta-analysis. | Sun C et al. | — | 2012 | → |
| Chapter 11: Genome-wide association studies. | Bush WS et al. | — | 2012 | → |
| Chlamydia infection status, genotype, and age-related macular degeneration. | Khandhadia S et al. | — | 2012 | → |
| Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration. | Suzuki M et al. | — | 2012 | → |
| Complement activation as a biomarker for Alzheimer's disease. | Aiyaz M et al. | — | 2012 | → |
| Complement dysregulation and disease: from genes and proteins to diagnostics and drugs. | de Cordoba SR et al. | — | 2012 | → |
| Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. | Sparrow JR et al. | — | 2012 | → |
| Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. | Sofat R et al. | — | 2012 | → |
| Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. | Shaw PX et al. | — | 2012 | → |
| Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance. | Tortajada A et al. | — | 2012 | → |
| Complement involvement in neovascular ocular diseases. | Yanai R et al. | — | 2012 | → |
| Complement polymorphisms: geographical distribution and relevance to disease. | Ermini L et al. | — | 2012 | → |
| Complement system activation and endothelial dysfunction in patients with age-related macular degeneration (AMD): possible relationship between AMD and atherosclerosis. | Machalińska A et al. | — | 2012 | → |
| Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes. | Nishio N et al. | — | 2012 | → |
| Deciphering the complexities of human diseases and disorders by coupling induced-pluripotent stem cells and systems genetics. | Chang WY et al. | — | 2012 | → |
| Development and application of a next-generation-sequencing (NGS) approach to detect known and novel gene defects underlying retinal diseases. | Audo I et al. | — | 2012 | → |
| Dry age-related macular degeneration: A currently unmet clinical need. | Girmens JF et al. | — | 2012 | → |
| Early age-related macular degeneration in patients with myocardial infarction. | Liutkeviciene R et al. | — | 2012 | → |
| Effect of the Gas6 c.834+7G>A polymorphism and the interaction of known risk factors on AMD pathogenesis in Hungarian patients. | Losonczy G et al. | — | 2012 | → |
| Effect of the Y402H variant in the complement factor H gene on the incidence and progression of age-related macular degeneration: results from multistate models applied to the Beaver Dam Eye Study. | Gangnon RE et al. | — | 2012 | → |
| Electronic restoration of vision in those with photoreceptor degenerations. | O'Brien EE et al. | — | 2012 | → |
| Exome sequencing and complex disease: practical aspects of rare variant association studies. | Do R et al. | — | 2012 | → |
| Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD. | Malek G et al. | — | 2012 | → |
| Factor h: a complement regulator in health and disease, and a mediator of cellular interactions. | Kopp A et al. | — | 2012 | → |
| Genetic associations in polypoidal choroidal vasculopathy: a systematic review and meta-analysis. | Chen H et al. | — | 2012 | → |
| Genetic factors for choroidal neovascularization associated with high myopia. | Leveziel N et al. | — | 2012 | → |
| Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics. | Liu MM et al. | — | 2012 | → |
| Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration. | Synowiec E et al. | — | 2012 | → |
| Genetics of immunological and inflammatory components in age-related macular degeneration. | Tuo J et al. | — | 2012 | → |
| Genetic variation in complement regulators and susceptibility to age-related macular degeneration. | Cipriani V et al. | — | 2012 | → |
| Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. | Cipriani V et al. | — | 2012 | → |
| Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. | Sobrin L et al. | — | 2012 | → |
| How does the macula protect itself from oxidative stress? | Handa JT | — | 2012 | → |
| IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn. | Hasegawa E et al. | — | 2012 | → |
| Impact of loading phase, initial response and CFH genotype on the long-term outcome of treatment for neovascular age-related macular degeneration. | Menghini M et al. | — | 2012 | → |
| Interleukin 27 induces the expression of complement factor H (CFH) in the retina. | Amadi-Obi A et al. | — | 2012 | → |
| Low-dose lipopolysaccharide pretreatment suppresses choroidal neovascularization via IL-10 induction. | Matsumura N et al. | — | 2012 | → |
| Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. | Bian Q et al. | — | 2012 | → |
| Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularization. | Cousins SW et al. | — | 2012 | → |
| Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complement. | Bandyopadhyay M et al. | — | 2012 | → |
| Mechanism of inflammation in age-related macular degeneration. | Parmeggiani F et al. | — | 2012 | → |
| miRNAs as potential therapeutic targets for age-related macular degeneration. | Wang S et al. | — | 2012 | → |
| Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. | Kinnunen K et al. | — | 2012 | → |
| Neuroprotective effects of lutein in the retina. | Ozawa Y et al. | — | 2012 | → |
| Next-generation therapeutic solutions for age-related macular degeneration. | Cunnusamy K et al. | — | 2012 | → |
| Nutritional modulation of age-related macular degeneration. | Weikel KA et al. | — | 2012 | → |
| Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma. | Zhang K et al. | — | 2012 | → |
| Patients with neovascular age-related macular degeneration in Spain display a high cardiovascular risk. | Olea JL et al. | — | 2012 | → |
| Pharmacogenetic influence of LOC387715/HTRA1 on the efficacy of bevacizumab treatment for age-related macular degeneration in a Korean population. | Kang HK et al. | — | 2012 | → |
| Pharmacogenetics of antiangiogenic and antineovascular therapies of age-related macular degeneration. | Agosta E et al. | — | 2012 | → |
| Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. | Brantley MA et al. | — | 2012 | → |
| Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism. | Silva AS et al. | — | 2012 | → |
| Pluripotent human stem cells for the treatment of retinal disease. | Rowland TJ et al. | — | 2012 | → |
| Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study. | Sundaresan P et al. | — | 2012 | → |
| Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma. | Li S et al. | — | 2012 | → |
| Population-based case-control association studies. | Hancock DB et al. | — | 2012 | → |
| Prevalence and risk factors of early-stage age-related macular degeneration in patients examined at a health promotion center in Korea. | Moon BG et al. | — | 2012 | → |
| Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. | Yu Y et al. | — | 2012 | → |
| Proteomic analysis of the aqueous humor in age-related macular degeneration (AMD) patients. | Kim TW et al. | — | 2012 | → |
| Purification and biochemical characterization of functional complement factor H from human plasma fractions. | Brandstätter H et al. | — | 2012 | → |
| Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration. | Nagineni CN et al. | — | 2012 | → |
| Retinal function and CFH-ARMS2 polymorphisms analysis: a pilot study in Italian AMD patients. | Capoluongo E et al. | — | 2012 | → |
| Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration. | Smailhodzic D et al. | — | 2012 | → |
| RPE cell senescence: a key contributor to age-related macular degeneration. | Kozlowski MR | — | 2012 | → |
| Serum autoantibody biomarkers for age-related macular degeneration and possible regulators of neovascularization. | Morohoshi K et al. | — | 2012 | → |
| Short-term changes of Basal laminar drusen on spectral-domain optical coherence tomography. | van de Ven JP et al. | — | 2012 | → |
| Structural and functional characterization of the product of disease-related factor H gene conversion. | Herbert AP et al. | — | 2012 | → |
| Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells. | Kunchithapautham K et al. | — | 2012 | → |
| Subretinal drusenoid deposits associated with pigment epithelium detachment in age-related macular degeneration. | Alten F et al. | — | 2012 | → |
| Susceptibility genes and pharmacogenetics in ocular inflammatory disorders. | Liu B et al. | — | 2012 | → |
| Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population. | Buentello-Volante B et al. | — | 2012 | → |
| Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization. | Rohrer B et al. | — | 2012 | → |
| Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. | Newman AM et al. | — | 2012 | → |
| Technical brief: isolation of total DNA from postmortem human eye tissues and quality comparison between iris and retina. | Wang JC et al. | — | 2012 | → |
| The ARMS2 A69S variant and bilateral advanced age-related macular degeneration. | Schwartz SG et al. | — | 2012 | → |
| The bisretinoids of retinal pigment epithelium. | Sparrow JR et al. | — | 2012 | → |
| The chromosome 10q26 susceptibility locus in age-related macular degeneration. | Stanton CM et al. | — | 2012 | → |
| The complotype: dictating risk for inflammation and infection. | Harris CL et al. | — | 2012 | → |
| The innate immune response to products of phospholipid peroxidation. | Weismann D et al. | — | 2012 | → |
| Therapeutic targeting of the complement system in age-related macular degeneration: a review. | Troutbeck R et al. | — | 2012 | → |
| The role of amyloid-β in retinal degeneration. | Bruban J et al. | — | 2012 | → |
| The role of CRP and inflammation in the pathogenesis of age-related macular degeneration. | Colak E et al. | — | 2012 | → |
| Tissue factor with age-related macular degeneration. | Wang GF et al. | — | 2012 | → |
| Truncated and full-length thioredoxin-1 have opposing activating and inhibitory properties for human complement with relevance to endothelial surfaces. | King BC et al. | — | 2012 | → |
| Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. | Bhutto I et al. | — | 2012 | → |
| WITHDRAWN: Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. | Sparrow JR et al. | — | 2012 | → |
| A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. | Sivakumaran TA et al. | — | 2011 | → |
| A blueprint for advancing genetics-based cancer therapy. | Sellers WR | — | 2011 | → |
| Access to the complement factor B scissile bond is facilitated by association of factor B with C3b protein. | Hourcade DE et al. | — | 2011 | → |
| A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population. | Yanagisawa S et al. | — | 2011 | → |
| A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci. | Singleton A et al. | — | 2011 | → |
| Age-related macular degeneration: current treatment and future options. | Moutray T et al. | — | 2011 | → |
| Age-related macular degeneration with discordant late stage phenotypes in monozygotic twins. | Keilhauer CN et al. | — | 2011 | → |
| Almost total protection from age-related macular degeneration by haplotypes of the Regulators of Complement Activation. | Williamson JF et al. | — | 2011 | → |
| A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. | Raychaudhuri S et al. | — | 2011 | → |
| Association assessment of copy number polymorphism and risk of age-related macular degeneration. | Sawitzke J et al. | — | 2011 | → |
| Complement factor H 402H variant and reticular macular disease. | Smith RT et al. | — | 2011 | → |
| Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. | Weismann D et al. | — | 2011 | → |
| Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant. | Lauer N et al. | — | 2011 | → |
| Copy number variation in the complement factor H-related genes and age-related macular degeneration. | Kubista KE et al. | — | 2011 | → |
| Current gene discovery strategies for ocular conditions. | Duggal P et al. | — | 2011 | → |
| Difference between age-related macular degeneration and polypoidal choroidal vasculopathy in the hereditary contribution of the A69S variant of the age-related maculopathy susceptibility 2 gene (ARMS2). | Yanagisawa S et al. | — | 2011 | → |
| Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids. | Salomon RG et al. | — | 2011 | → |
| Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. | Bazan NG et al. | — | 2011 | → |
| Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. | Chen M et al. | — | 2011 | → |
| Effects of smoking on ocular health. | Galor A et al. | — | 2011 | → |
| Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) Study. | Peter I et al. | — | 2011 | → |
| Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. | McKay GJ et al. | — | 2011 | → |
| Genetic factors and AMD. | Macdonald I et al. | — | 2011 | → |
| Genetic factors associated with age-related macular degeneration. | Leveziel N et al. | — | 2011 | → |
| Genetic predictors of response to photodynamictherapy. | Parmeggiani F et al. | — | 2011 | → |
| Genetic variations strongly influence phenotypic outcome in the mouse retina. | Jelcick AS et al. | — | 2011 | → |
| Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence. | Johnson C et al. | — | 2011 | → |
| Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3. | Ebrahem Q et al. | — | 2011 | → |
| Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology. | Jun G et al. | — | 2011 | → |
| Interaction of human complement factor H variants Tyr⁴⁰² and His⁴⁰² with Leptospira spp. | Silva AS et al. | — | 2011 | → |
| Is bilateral age-related macular degeneration less common in Asians than Caucasians? | Kawasaki R et al. | — | 2011 | → |
| Lipids, lipoproteins, and age-related macular degeneration. | Ebrahimi KB et al. | — | 2011 | → |
| Mitochondrial dysfunction in retinal diseases. | Barot M et al. | — | 2011 | → |
| Molecular medicine: Defence against oxidative damage. | Cruz-Guilloty F et al. | — | 2011 | → |
| Pharmacogenetics and age-related macular degeneration. | Schwartz SG et al. | — | 2011 | → |
| Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. | Seddon JM et al. | — | 2011 | → |
| Sifting the wheat from the chaff: prioritizing GWAS results by identifying consistency across analytical methods. | Oldmeadow C et al. | — | 2011 | → |
| Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. | Morrison MA et al. | — | 2011 | → |
| Systems genetics for drug target discovery. | Penrod NM et al. | — | 2011 | → |
| The influence of genetics on response to treatment with ranibizumab (Lucentis) for age-related macular degeneration: the Lucentis Genotype Study (an American Ophthalmological Society thesis). | Francis PJ | — | 2011 | → |
| The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA). | Trouw LA et al. | — | 2011 | → |
| Update on the role of genetics in the onset of age-related macular degeneration. | Francis PJ et al. | — | 2011 | → |