Neuroscience of alcoholism: molecular and cellular mechanisms.
paper
Cited
Public
Unavailable
- Authors
- Moonat, Sachin; Starkman, Bela G; Sakharkar, Amul; Pandey, Subhash C
- Year
- 2010
- Journal
- Cellular and molecular life sciences : CMLS
- PMID
- 19756388
- DOI
- 10.1007/s00018-009-0135-y
- PMCID
- PMC3747955
Alcohol use and abuse appear to be related to neuroadaptive changes at functional, neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown to modulate function of the activity-dependent gene transcription factor, cAMP-responsive element binding (CREB) protein in the brain, which may be associated with the development of alcoholism. Study of the downstream effectors of CREB have identified several important CREB-related genes, such as neuropeptide Y, brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein, and corticotrophin-releasing factor, that may play a crucial role in the behavioral effects of ethanol and molecular changes in the specific neurocircuitry that underlie both alcohol addiction and a genetic predisposition to alcoholism. Brain chromatin remodeling due to histone covalent modifications may also be involved in mediating the behavioral effects and neuroadaptive changes that occur during ethanol exposure. This review outlines progressive neuroscience research into molecular and epigenetic mechanisms of alcoholism.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Molecular targets of oleoylethanolamide in the pathogenesis of alcohol use disorder: Mechanisms of central and peripheral action. | Ivashkevich D et al. | β | 2026 | β |
| Binge alcohol and the neuroendocrinology of the aging female. | Leasure JL et al. | β | 2025 | β |
| Alcohol Consumption During Adolescence Alters the Cognitive Function in Adult Male Mice by Persistently Increasing Levels of DUSP6. | Sun M et al. | β | 2024 | β |
| cAMP-PKA signaling pathway and anxiety: Where do we go next? | Chen D et al. | β | 2024 | β |
| Deciphering the Role of the PAI_1-mBDNF Pathway in Alcohol Use Disorder: Insights into Pathogenesis and Abstinence Treatment Efficacy | Liu S et al. | β | 2024 | β |
| Drug Treatments for Neurodevelopmental Disorders: Targeting Signaling Pathways and Homeostasis. | Kaufmann WE et al. | β | 2024 | β |
| Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies. | Hilal FF et al. | β | 2024 | β |
| Advances in DNA, histone, and RNA methylation mechanisms in the pathophysiology of alcohol use disorder. | Cruise TM et al. | β | 2023 | β |
| A Rat Model of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism Shows Attenuated Motivation for Alcohol Self-Administration and Diminished Propensity for Cue-Induced Relapse in Females. | Jaehne EJ et al. | β | 2023 | β |
| Korean Red Ginseng extract attenuates alcohol-induced addictive responses and cognitive impairments by alleviating neuroinflammation. | Kim HJ et al. | β | 2023 | β |
| Neuropharmacology of Alcohol Addiction with Special Emphasis on Proteomic Approaches for Identification of Novel Therapeutic Targets. | Ray SK et al. | β | 2023 | β |
| Non-coding RNA in alcohol use disorder by affecting synaptic plasticity. | Zhu S et al. | β | 2022 | β |
| Prolonged ethanol exposure alters glutamate uptake leading to astrogliosis and neuroinflammation in adult zebrafish brain. | Vizuete AFK et al. | β | 2022 | β |
| Study on influence of external factors on the electrical excitability of PC12 quasi-neuronal networks through Voltage Threshold Measurement Method. | LΓΌ XY et al. | β | 2022 | β |
| CB1R Promotes Chronic Alcohol-Induced Neuronal Necroptosis in Mice Prefrontal Cortex. | Ye L et al. | β | 2021 | β |
| Nutritional Ketosis as a Potential Treatment for Alcohol Use Disorder. | Mahajan VR et al. | β | 2021 | β |
| The Role of Melanocortin Plasticity in Pain-Related Outcomes After Alcohol Exposure. | Sharfman N et al. | β | 2021 | β |
| 7,8-Dihydroxyflavone Enhances Cue-Conditioned Alcohol Reinstatement in Rats. | Hogarth SJ et al. | β | 2020 | β |
| Assessment of relationship between farmer's syndrome and neurotoxic symptoms in farming couples. | Choi J et al. | β | 2020 | β |
| Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes. | Pozhidayeva DY et al. | β | 2020 | β |
| Human Plasma BDNF Is Associated With Amygdala-Prefrontal Cortex Functional Connectivity and Problem Drinking Behaviors. | Gorka SM et al. | β | 2020 | β |
| Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models. | MΓΌller TE et al. | β | 2020 | β |
| Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation. | Pucci M et al. | β | 2019 | β |
| Histone deacetylases inhibitor trichostatin A reverses anxiety-like symptoms and memory impairments induced by maternal binge alcohol drinking in mice. | Montagud-Romero S et al. | β | 2019 | β |
| Pharmacoepigenetics and Pharmacoepigenomics: An Overview. | Peedicayil J | β | 2019 | β |
| Deep sequencing and miRNA profiles in alcohol-induced neuroinflammation and the TLR4 response in mice cerebral cortex. | UreΓ±a-Peralta JR et al. | β | 2018 | β |
| Drinking in the morning versus evening: Time-dependent differential effects of acute alcohol administration on the behavior of zebrafish. | Tsang B et al. | β | 2018 | β |
| Histone Deacetylase Inhibitor Suberanilohydroxamic Acid Treatment Reverses Hyposensitivity to Ξ³-Aminobutyric Acid in the Ventral Tegmental Area During Ethanol Withdrawal. | You C et al. | β | 2018 | β |
| Inhibition of phosphodiesterase 2 by Bay 60-7550 decreases ethanol intake and preference in mice. | Shi J et al. | β | 2018 | β |
| Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity. | Balan I et al. | β | 2018 | β |
| N-Docosahexaenoylethanolamine: A neurotrophic and neuroprotective metabolite of docosahexaenoic acid. | Kim HY et al. | β | 2018 | β |
| ProBDNF/p75NTR/sortilin pathway is activated in peripheral blood of patients with alcohol dependence. | Zhou L et al. | β | 2018 | β |
| Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3. | Getachew B et al. | β | 2018 | β |
| Quantitative evaluation of extrinsic factors influencing electrical excitability in neuronal networks: Voltage Threshold Measurement Method (VTMM). | An S et al. | β | 2018 | β |
| Sex differences in hippocampal damage, cognitive impairment, and trophic factor expression in an animal model of an alcohol use disorder. | Maynard ME et al. | β | 2018 | β |
| Alcohol amplifies ketamine-induced apoptosis in primary cultured cortical neurons and PC12 cells through down-regulating CREB-related signaling pathways. | Zuo D et al. | β | 2017 | β |
| Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. | Gong MF et al. | β | 2017 | β |
| Epigenetic basis of the dark side of alcohol addiction. | Pandey SC et al. | β | 2017 | β |
| Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells. | Huang J et al. | β | 2017 | β |
| Study of acetylcholinesterase activity and apoptosis in SH-SY5Y cells and mice exposed to ethanol. | Sun W et al. | β | 2017 | β |
| Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence. | Wen RT et al. | β | 2017 | β |
| A Critical Role of Brain-Derived Neurotrophic Factor in Alcohol Consumption. | Pandey SC | β | 2016 | β |
| Acute Ethanol Inhibition of Ξ³ Oscillations Is Mediated by Akt and GSK3Ξ². | Wang J et al. | β | 2016 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Alcohol-induced suppression of KDM6B dysregulates the mineralization potential in dental pulp stem cells. | Hoang M et al. | β | 2016 | β |
| Behavioral Neuroadaptation to Alcohol: From Glucocorticoids to Histone Acetylation. | Mons N et al. | β | 2016 | β |
| Beneficial effects of chlorogenic acid on alcohol-induced damage in PC12 cells. | Fang SQ et al. | β | 2016 | β |
| Contingent and non-contingent recreational-like exposure to ethanol alters BDNF expression and signaling in the cortico-accumbal network differently. | OrrΓΉ A et al. | β | 2016 | β |
| Effects of cigarette smoking and alcohol use on neurocognition and BDNF levels in a Chinese population. | Zhang XY et al. | β | 2016 | β |
| Exploration of Core Symptoms for the Diagnosis of Alcohol Dependence in the ICD-10. | Yoshimura A et al. | β | 2016 | β |
| Guardian of Genetic Messenger-RNA-Binding Proteins. | Anji A et al. | β | 2016 | β |
| Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects. | Sun WL et al. | β | 2016 | β |
| Molecular mechanisms underlying alcohol-drinking behaviours. | Ron D et al. | β | 2016 | β |
| N-Docosahexaenoylethanolamine ameliorates ethanol-induced impairment of neural stem cell neurogenic differentiation. | Rashid MA et al. | β | 2016 | β |
| Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism. | Rahman S et al. | β | 2016 | β |
| Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression. | Gofman L et al. | β | 2016 | β |
| Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. | Dominguez G et al. | β | 2016 | β |
| The association of HTR3A mRNA expression and craving in Han Chinese alcohol-dependent patients: a preliminary study. | Xu YH et al. | β | 2016 | β |
| The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis. | Teppen TL et al. | β | 2016 | β |
| Up-Regulation of PKR Signaling Pathway by Ethanol Displays an Age of Onset-Dependent Relationship. | Duncan JW et al. | β | 2016 | β |
| Different Subjective and Objective Responses to Alcohol Among Heavy and Light Drinkers of Han and Uyghur Nationalities in China. | Hu HX et al. | β | 2015 | β |
| DNA methyltransferase expressions in Japanese rice fish (Oryzias latipes) embryogenesis is developmentally regulated and modulated by ethanol and 5-azacytidine. | Dasmahapatra AK et al. | β | 2015 | β |
| Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. | Caputi FF et al. | β | 2015 | β |
| Epigenetic mechanisms: A possible link between autism spectrum disorders and fetal alcohol spectrum disorders. | Varadinova M et al. | β | 2015 | β |
| Ethanol during adolescence decreased the BDNF levels in the hippocampus in adult male Wistar rats, but did not alter aggressive and anxiety-like behaviors. | Scheidt L et al. | β | 2015 | β |
| Ethanol-induced epigenetic regulations at the Bdnf gene in C57BL/6J mice. | Stragier E et al. | β | 2015 | β |
| Increased serum neurotrophin levels related to alcohol use disorder in a young population sample. | Lhullier AC et al. | β | 2015 | β |
| Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex. | Finegersh A et al. | β | 2014 | β |
| Adenosine and glutamate in neuroglial interaction: implications for circadian disorders and alcoholism. | Ruby CL et al. | β | 2014 | β |
| Alcohol and adult hippocampal neurogenesis: promiscuous drug, wanton effects. | Geil CR et al. | β | 2014 | β |
| Chronic light deprivation inhibits appetitive associative learning induced by ethanol and its respective c-Fos and pCREB expression. | Varela P et al. | β | 2014 | β |
| Effects of ethanol and acetaldehyde in zebrafish brain structures: an in vitro approach on glutamate uptake and on toxicity-related parameters. | Zenki KC et al. | β | 2014 | β |
| Fetal alcohol programming of hypothalamic proopiomelanocortin system by epigenetic mechanisms and later life vulnerability to stress. | Bekdash R et al. | β | 2014 | β |
| Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes. | Harlaar N et al. | β | 2014 | β |
| Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning. | Hovens IB et al. | β | 2014 | β |
| The epigenetic landscape of alcoholism. | Krishnan HR et al. | β | 2014 | β |
| Alcohol and NMDA receptor: current research and future direction. | Chandrasekar R | β | 2013 | β |
| Alcohol and the methylome: design and analysis considerations for research using human samples. | Harlaar N et al. | β | 2013 | β |
| Alcohol modulates expression of DNA methyltranferases and methyl CpG-/CpG domain-binding proteins in murine embryonic fibroblasts. | Mukhopadhyay P et al. | β | 2013 | β |
| Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. | Kos MZ et al. | β | 2013 | β |
| Decreased expression of nardilysin in SH-SY5Y cells under ethanol stress and reduced density of nardilysin-expressing neurons in brains of alcoholics. | Bernstein HG et al. | β | 2013 | β |
| Epigenetic control of gene expression in the alcoholic brain. | Ponomarev I | β | 2013 | β |
| Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. | Arora DS et al. | β | 2013 | β |
| Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence. | Nunez YO et al. | β | 2013 | β |
| Taok2 controls behavioral response to ethanol in mice. | Kapfhamer D et al. | β | 2013 | β |
| Work-family conflict and alcohol use: examination of a moderated mediation model. | Wolff JM et al. | β | 2013 | β |
| Ξ²-Arrestin-2 inhibits preference for alcohol in mice and suppresses Akt signaling in the dorsal striatum. | Li H et al. | β | 2013 | β |
| An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction. | Dayas CV et al. | β | 2012 | β |
| Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. | Bell RL et al. | β | 2012 | β |
| Epigenetics-beyond the genome in alcoholism. | Starkman BG et al. | β | 2012 | β |
| Ethanol-induced loss-of-righting response during ethanol withdrawal in male and female rats: associations with alterations in Arc labeling. | Walls SA et al. | β | 2012 | β |
| Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain. | Contet C | β | 2012 | β |
| Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes. | Xu K et al. | β | 2012 | β |
| Histone acetylation of the htr3a gene in the prefrontal cortex of Wistar rats regulates ethanol-seeking behavior. | Xu Y et al. | β | 2012 | β |
| Long-term daily access to alcohol alters dopamine-related synthesis and signaling proteins in the rat striatum. | Kashem MA et al. | β | 2012 | β |
| Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review. | Hurley LL et al. | β | 2012 | β |
| Running wheel activity protects against increased seizure susceptibility in ethanol withdrawn male rats. | McCulley WD et al. | β | 2012 | β |
| Serum and plasma brain-derived neurotrophic factor (BDNF) in abstinent alcoholics and social drinkers. | D'Sa C et al. | β | 2012 | β |
| Stress, epigenetics, and alcoholism. | Moonat S et al. | β | 2012 | β |
| The phosphodiesterase-4 (PDE4) inhibitor rolipram decreases ethanol seeking and consumption in alcohol-preferring Fawn-Hooded rats. | Wen RT et al. | β | 2012 | β |
| Zebrafish: a model for the study of addiction genetics. | Klee EW et al. | β | 2012 | β |
| Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation. | Zhou FC et al. | β | 2011 | β |
| Alterations of brain-derived neurotrophic factor serum levels in patients with alcohol dependence. | Zanardini R et al. | β | 2011 | β |
| Brain-derived neurotrophic factor serum levels in alcohol-dependent subjects 6 months after alcohol withdrawal. | Costa MA et al. | β | 2011 | β |
| Differentiating heavy from light drinkers by neural responses to visual alcohol cues and other motivational stimuli. | Ihssen N et al. | β | 2011 | β |
| Epigenetic regulation of gene expression in physiological and pathological brain processes. | GrΓ€ff J et al. | β | 2011 | β |
| Ethanol-induced increases in extracellular dopamine are blunted in brain-derived neurotrophic factor heterozygous mice. | Bosse KE et al. | β | 2011 | β |
| Glypican Gene GPC5 Participates in the Behavioral Response to Ethanol: Evidence from Humans, Mice, and Fruit Flies. | Joslyn G et al. | β | 2011 | β |
| Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampus. | Zink M et al. | β | 2011 | β |
| The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism. | Moonat S et al. | β | 2011 | β |
| An essential role for adenosine signaling in alcohol abuse. | Ruby CL et al. | β | 2010 | β |
| Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. | He DY et al. | β | 2010 | β |
| Genetic and epigenetic insights into fetal alcohol spectrum disorders. | Ramsay M | β | 2010 | β |
| Nicotine: alcohol reward interactions. | Lajtha A et al. | β | 2010 | β |